DE3787332T2 - Immunassaysystem mit Verwendung von Licht-Streuung. - Google Patents

Immunassaysystem mit Verwendung von Licht-Streuung.

Info

Publication number
DE3787332T2
DE3787332T2 DE87305669T DE3787332T DE3787332T2 DE 3787332 T2 DE3787332 T2 DE 3787332T2 DE 87305669 T DE87305669 T DE 87305669T DE 3787332 T DE3787332 T DE 3787332T DE 3787332 T2 DE3787332 T2 DE 3787332T2
Authority
DE
Germany
Prior art keywords
immunoassay system
interface
detection
evanescent wave
light scattering
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE87305669T
Other languages
English (en)
Other versions
DE3787332D1 (de
Inventor
Ernest G Schutt
Richard S Dondero
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Clinical Diagnostics Inc
Original Assignee
Ortho Diagnostic Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Diagnostic Systems Inc filed Critical Ortho Diagnostic Systems Inc
Application granted granted Critical
Publication of DE3787332D1 publication Critical patent/DE3787332D1/de
Publication of DE3787332T2 publication Critical patent/DE3787332T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/557—Immunoassay; Biospecific binding assay; Materials therefor using kinetic measurement, i.e. time rate of progress of an antigen-antibody interaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4704—Angular selective
    • G01N2021/4709—Backscatter
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Optical Measuring Cells (AREA)
DE87305669T 1986-06-26 1987-06-25 Immunassaysystem mit Verwendung von Licht-Streuung. Expired - Lifetime DE3787332T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87923686A 1986-06-26 1986-06-26

Publications (2)

Publication Number Publication Date
DE3787332D1 DE3787332D1 (de) 1993-10-14
DE3787332T2 true DE3787332T2 (de) 1994-04-07

Family

ID=25373704

Family Applications (1)

Application Number Title Priority Date Filing Date
DE87305669T Expired - Lifetime DE3787332T2 (de) 1986-06-26 1987-06-25 Immunassaysystem mit Verwendung von Licht-Streuung.

Country Status (7)

Country Link
EP (1) EP0254430B1 (de)
JP (1) JP2591750B2 (de)
AT (1) ATE94285T1 (de)
AU (1) AU597077B2 (de)
CA (1) CA1288689C (de)
DE (1) DE3787332T2 (de)
MX (1) MX169795B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5017009A (en) * 1986-06-26 1991-05-21 Ortho Diagnostic Systems, Inc. Scattered total internal reflectance immunoassay system
SE462408B (sv) * 1988-11-10 1990-06-18 Pharmacia Ab Optiskt biosensorsystem utnyttjande ytplasmonresonans foer detektering av en specific biomolekyl, saett att kalibrera sensoranordningen samt saett att korrigera foer baslinjedrift i systemet
SE462454B (sv) * 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
US5350697A (en) * 1990-08-28 1994-09-27 Akzo N.V. Scattered light detection apparatus
US5192510A (en) * 1991-01-30 1993-03-09 E. I. Du Pont De Nemours And Company Apparatus for performing fluorescent assays which separates bulk and evanescent fluorescence
US5750410A (en) * 1994-08-26 1998-05-12 Kyoto Dai-Ichi Kagaku Co., Ltd. Method of and apparatus for immune analysis
JP3436982B2 (ja) * 1994-08-03 2003-08-18 アークレイ株式会社 免疫測定方法及びその装置
US6887430B1 (en) 1996-01-26 2005-05-03 Kyoto Dai-Ichi Kagaku Co., Ltd. Apparatus for immune analysis
CN1122181C (zh) * 1996-03-11 2003-09-24 株式会社京都第一科学 用于免疫分析的方法及装置
DE19640121B4 (de) * 1996-09-28 2007-04-26 Dade Behring Marburg Gmbh Verfahren zur Bestimmung einer sich zeitabhängig ändernden Meßgröße
EP1141762A1 (de) 1998-12-17 2001-10-10 Leica Microsystems Heidelberg GmbH Verfahren zur differenzierten untersuchung unterschiedlicher strukturen in vorzugsweise biologischen präparaten
GR1004119B (en) * 2000-07-26 2003-01-23 Αυτοματοι Αναλυτες Και Διαγνωστικα Αντιδραστηρια Medicon Hellas Α.Ε. DEVELOPMENT OF A NEW HOMOGENEOUS IMMUNOENZYMIC METHOD FOR THE PRODUCTION OF A CLINICAL LABORATORY TEST SYSTEM (kit) FOR THE QUANTIFICATION OF THYROXINE AND TRIIODOTHYRONINE IN HUMAN SERUM, UTILIZINGPOLYIODOTHYRONINE CONJUGATED WITH GLYCOGEN PHOSPHO....
CN104764724A (zh) * 2006-12-12 2015-07-08 皇家飞利浦电子股份有限公司 用于检测标记颗粒的微电子传感器装置

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3939350A (en) * 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
NL7807532A (nl) * 1978-07-13 1980-01-15 Akzo Nv Metaal-immunotest.
JPS5694244A (en) * 1979-12-27 1981-07-30 Chugai Pharmaceut Co Ltd Quantitative apparatus for determining reaction product of antigen antibody utilizing laser light
NL185309C (nl) * 1980-07-28 1990-03-01 Akzo Nv Methode voor het bepalen van antigenen met behulp van twee of meer monoklonale antilichamen alsmede immuunreagens.
JPS57175957A (en) * 1981-04-24 1982-10-29 Chugai Pharmaceut Co Ltd Measuring method and device for antigen- antibody reaction
EP0075353B1 (de) * 1981-09-18 1987-08-19 Battelle Memorial Institute Verfahren und Vorrichtung zur Bestimmung von gelösten Stoffen mit Hilfe eines optischen Wellenleiters
US4766083A (en) * 1982-04-04 1988-08-23 Wako Pure Chemical Industries, Ltd. Method for the photometric determination of biological agglutination
JPS58187869A (ja) * 1982-04-28 1983-11-02 Hitachi Denshi Ltd 電池電圧の低下表示方法
GB2141553B (en) * 1983-06-14 1987-06-03 Standard Telephones Cables Ltd Scatter cells for photo sensors
CA1246891A (en) * 1984-06-13 1988-12-20 Alan M. Smith Photometric instruments, their use in methods of optical analysis, and ancillary devices therefor
US4647544A (en) * 1984-06-25 1987-03-03 Nicoli David F Immunoassay using optical interference detection
DE19525301A1 (de) * 1995-07-12 1997-01-16 Basf Ag Verfahren zur Herstellung Isocyanuratgruppen enthaltender Polyole

Also Published As

Publication number Publication date
EP0254430A3 (en) 1988-10-05
EP0254430A2 (de) 1988-01-27
CA1288689C (en) 1991-09-10
MX169795B (es) 1993-07-27
ATE94285T1 (de) 1993-09-15
EP0254430B1 (de) 1993-09-08
AU597077B2 (en) 1990-05-24
JPS638560A (ja) 1988-01-14
JP2591750B2 (ja) 1997-03-19
DE3787332D1 (de) 1993-10-14
AU7478387A (en) 1988-01-07

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