DE3741199A1 - Verwendung von ultraschallkontrastmitteln fuer die ultraschall-lithotripsie - Google Patents

Verwendung von ultraschallkontrastmitteln fuer die ultraschall-lithotripsie

Info

Publication number
DE3741199A1
DE3741199A1 DE19873741199 DE3741199A DE3741199A1 DE 3741199 A1 DE3741199 A1 DE 3741199A1 DE 19873741199 DE19873741199 DE 19873741199 DE 3741199 A DE3741199 A DE 3741199A DE 3741199 A1 DE3741199 A1 DE 3741199A1
Authority
DE
Germany
Prior art keywords
agent according
surfactant
microparticles
weight
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19873741199
Other languages
German (de)
English (en)
Other versions
DE3741199C2 (https=
Inventor
Thomas Dr Fritzsch
Joachim Dr Siegert
Volkmar Dr Uhlendorf
Reinhard Dr Schlief
Hans Peter Dr Niendorf
Eckehard Dipl Phys Dr Cramer
Hans Dr Poland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DE19873741199 priority Critical patent/DE3741199A1/de
Priority to JP1500022A priority patent/JPH03505723A/ja
Priority to EP88730269A priority patent/EP0322350A1/de
Priority to PCT/DE1988/000751 priority patent/WO1989005160A1/de
Priority to EP89900109A priority patent/EP0397671A1/de
Publication of DE3741199A1 publication Critical patent/DE3741199A1/de
Application granted granted Critical
Publication of DE3741199C2 publication Critical patent/DE3741199C2/de
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/481—Diagnostic techniques involving the use of contrast agents, e.g. microbubbles introduced into the bloodstream
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A61B2017/22088—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance ultrasound absorbing, drug activated by ultrasound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A61B2017/22089—Gas-bubbles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Acoustics & Sound (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Surgical Instruments (AREA)
DE19873741199 1987-12-02 1987-12-02 Verwendung von ultraschallkontrastmitteln fuer die ultraschall-lithotripsie Granted DE3741199A1 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE19873741199 DE3741199A1 (de) 1987-12-02 1987-12-02 Verwendung von ultraschallkontrastmitteln fuer die ultraschall-lithotripsie
JP1500022A JPH03505723A (ja) 1987-12-02 1988-12-02 衝撃波及び超音波治療に対する泡含有媒体の使用
EP88730269A EP0322350A1 (de) 1987-12-02 1988-12-02 Verwendung von bläschenhaltigen Medien für die Stosswellen- und Ultraschalltherapie
PCT/DE1988/000751 WO1989005160A1 (fr) 1987-12-02 1988-12-02 Ultilisation de milieux contenant des bulles en therapie aux ondes de choc et aux ultra-sons
EP89900109A EP0397671A1 (de) 1987-12-02 1988-12-02 Verwendung von bläschenhaltigen medien für die stosswellen- und ultraschalltherapie

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873741199 DE3741199A1 (de) 1987-12-02 1987-12-02 Verwendung von ultraschallkontrastmitteln fuer die ultraschall-lithotripsie

Publications (2)

Publication Number Publication Date
DE3741199A1 true DE3741199A1 (de) 1989-08-17
DE3741199C2 DE3741199C2 (https=) 1989-11-23

Family

ID=6341916

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19873741199 Granted DE3741199A1 (de) 1987-12-02 1987-12-02 Verwendung von ultraschallkontrastmitteln fuer die ultraschall-lithotripsie

Country Status (4)

Country Link
EP (2) EP0397671A1 (https=)
JP (1) JPH03505723A (https=)
DE (1) DE3741199A1 (https=)
WO (1) WO1989005160A1 (https=)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020150539A1 (en) 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5149319A (en) * 1990-09-11 1992-09-22 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US7083778B2 (en) 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US6989141B2 (en) 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
IN172208B (https=) 1990-04-02 1993-05-01 Sint Sa
US5215680A (en) * 1990-07-10 1993-06-01 Cavitation-Control Technology, Inc. Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles
ATE146073T1 (de) * 1991-03-22 1996-12-15 Katsuro Tachibana Verstärker zur ultraschalltherapie von erkrankungen sowie diesen enthaltende flüssige arzneimittelzusammensetzungen
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
EP1550464A1 (en) 1993-07-30 2005-07-06 IMCOR Pharmaceutical Co. Stabilized microbubble composition for ultrasound
DE4406474A1 (de) * 1994-02-23 1995-08-24 Schering Ag Gas enthaltende Mikropartikel, diese enthaltende Mittel, deren Verwendung in der Ultraschalldiagnostik, sowie Verfahren zur Herstellung der Partikel und Mittel
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
US5804162A (en) * 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
US6582392B1 (en) 1998-05-01 2003-06-24 Ekos Corporation Ultrasound assembly for use with a catheter
GB9800813D0 (en) 1998-01-16 1998-03-11 Andaris Ltd Improved ultrasound contrast imaging method and apparatus
EP1453425B1 (en) 2001-12-03 2006-03-08 Ekos Corporation Catheter with multiple ultrasound radiating members
US8226629B1 (en) 2002-04-01 2012-07-24 Ekos Corporation Ultrasonic catheter power control
US7341569B2 (en) 2004-01-30 2008-03-11 Ekos Corporation Treatment of vascular occlusions using ultrasonic energy and microbubbles
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
US8518069B2 (en) 2005-09-07 2013-08-27 Cabochon Aesthetics, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US10548659B2 (en) 2006-01-17 2020-02-04 Ulthera, Inc. High pressure pre-burst for improved fluid delivery
US7967763B2 (en) 2005-09-07 2011-06-28 Cabochon Aesthetics, Inc. Method for treating subcutaneous tissues
US9486274B2 (en) 2005-09-07 2016-11-08 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9358033B2 (en) 2005-09-07 2016-06-07 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
US7885793B2 (en) 2007-05-22 2011-02-08 International Business Machines Corporation Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution
US9248317B2 (en) 2005-12-02 2016-02-02 Ulthera, Inc. Devices and methods for selectively lysing cells
EP2015846A2 (en) 2006-04-24 2009-01-21 Ekos Corporation Ultrasound therapy system
US10182833B2 (en) 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
EP2494932B1 (en) 2007-06-22 2020-05-20 Ekos Corporation Apparatus for treatment of intracranial hemorrhages
US8439940B2 (en) 2010-12-22 2013-05-14 Cabochon Aesthetics, Inc. Dissection handpiece with aspiration means for reducing the appearance of cellulite
US9358064B2 (en) 2009-08-07 2016-06-07 Ulthera, Inc. Handpiece and methods for performing subcutaneous surgery
US11096708B2 (en) 2009-08-07 2021-08-24 Ulthera, Inc. Devices and methods for performing subcutaneous surgery
WO2016201136A1 (en) 2015-06-10 2016-12-15 Ekos Corporation Ultrasound catheter

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0077752A2 (de) * 1981-10-16 1983-04-27 Schering Aktiengesellschaft Flüssige Mischung zur Aufnahme und Stabilisierung von Gasbläschen zur Verwendung als Kontrastmittel für die Ultraschalldiagnostik und deren Herstellung
EP0122624A2 (de) * 1983-04-15 1984-10-24 Schering Aktiengesellschaft Mikropartikel und Gasbläschen enthaltendes Ultraschallkontrastmittel
EP0123235A2 (de) * 1983-04-15 1984-10-31 Schering Aktiengesellschaft Mikropartikel und Gasblächen enthaltendes Ultraschall-Kontrastmittel
EP0131540A2 (de) * 1983-07-06 1985-01-16 Schering Aktiengesellschaft Ultraschallkontrastmittel sowie dessen Herstellung
DE3707567A1 (de) * 1986-03-10 1987-09-17 Olympus Optical Co Ultraschall-behandlungsgeraet

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982001642A1 (en) * 1980-11-17 1982-05-27 Med Inc Ultra Microbubble precursors and methods for their production and use
DE3637926C1 (de) * 1986-11-05 1987-11-26 Schering Ag Ultraschall-Manometrieverfahren in einer Fluessigkeit mittels Mikroblaeschen

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0077752A2 (de) * 1981-10-16 1983-04-27 Schering Aktiengesellschaft Flüssige Mischung zur Aufnahme und Stabilisierung von Gasbläschen zur Verwendung als Kontrastmittel für die Ultraschalldiagnostik und deren Herstellung
EP0122624A2 (de) * 1983-04-15 1984-10-24 Schering Aktiengesellschaft Mikropartikel und Gasbläschen enthaltendes Ultraschallkontrastmittel
EP0123235A2 (de) * 1983-04-15 1984-10-31 Schering Aktiengesellschaft Mikropartikel und Gasblächen enthaltendes Ultraschall-Kontrastmittel
EP0131540A2 (de) * 1983-07-06 1985-01-16 Schering Aktiengesellschaft Ultraschallkontrastmittel sowie dessen Herstellung
DE3707567A1 (de) * 1986-03-10 1987-09-17 Olympus Optical Co Ultraschall-behandlungsgeraet

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GASTEYER, K.H.: Die Ultraschall-Lithotripsie. In: Fortschritte der Medizin, 89.Jahrg. 1971, Nr.9, S.363-366 *
SCHMIDT- KLOIBER, Heinz: Energiewandler zur Steinzerstörung in den ableitenden Harnwegen des Menschen. In: Aktuelle Nephrologie, 1978, H.1, S.117-147, Wissenschaftliche Informationen, Fresenius-Stiftung *

Also Published As

Publication number Publication date
EP0322350A1 (de) 1989-06-28
JPH03505723A (ja) 1991-12-12
EP0397671A1 (de) 1990-11-22
WO1989005160A1 (fr) 1989-06-15
DE3741199C2 (https=) 1989-11-23

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee