DE3739284A1 - 1-naphtholphthaleinmonophosphate, verfahren zu deren herstellung sowie deren verwendung zur bestimmung der alkalischen phosphatase - Google Patents

1-naphtholphthaleinmonophosphate, verfahren zu deren herstellung sowie deren verwendung zur bestimmung der alkalischen phosphatase

Info

Publication number
DE3739284A1
DE3739284A1 DE19873739284 DE3739284A DE3739284A1 DE 3739284 A1 DE3739284 A1 DE 3739284A1 DE 19873739284 DE19873739284 DE 19873739284 DE 3739284 A DE3739284 A DE 3739284A DE 3739284 A1 DE3739284 A1 DE 3739284A1
Authority
DE
Germany
Prior art keywords
naphtholphthalein
general formula
proton
monophosphates
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19873739284
Other languages
German (de)
English (en)
Inventor
Werner Dr Rer Nat Guethlein
Hartmut Dr Rer Nat Merdes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DE19873739284 priority Critical patent/DE3739284A1/de
Priority to ES88118800T priority patent/ES2054771T3/es
Priority to DE8888118800T priority patent/DE3879107D1/de
Priority to AT88118800T priority patent/ATE86626T1/de
Priority to EP88118800A priority patent/EP0316791B1/de
Priority to US07/273,403 priority patent/US4985414A/en
Priority to JP63292551A priority patent/JPH01160990A/ja
Publication of DE3739284A1 publication Critical patent/DE3739284A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • C12Q2334/40—Triphenylmethane dye chromogens, e.g. fluorescein derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE19873739284 1987-11-20 1987-11-20 1-naphtholphthaleinmonophosphate, verfahren zu deren herstellung sowie deren verwendung zur bestimmung der alkalischen phosphatase Withdrawn DE3739284A1 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE19873739284 DE3739284A1 (de) 1987-11-20 1987-11-20 1-naphtholphthaleinmonophosphate, verfahren zu deren herstellung sowie deren verwendung zur bestimmung der alkalischen phosphatase
ES88118800T ES2054771T3 (es) 1987-11-20 1988-11-11 1-naftol-ftaleina-monofosfatos, procedimiento para su preparacion asi como su utilizacion para la determinacion de fosfatasa alcalina.
DE8888118800T DE3879107D1 (de) 1987-11-20 1988-11-11 1-naphtholphthaleinmonophosphate, verfahren zu deren herstellung sowie deren verwendung zur bestimmung der alkalischen phosphatase.
AT88118800T ATE86626T1 (de) 1987-11-20 1988-11-11 1-naphtholphthaleinmonophosphate, verfahren zu deren herstellung sowie deren verwendung zur bestimmung der alkalischen phosphatase.
EP88118800A EP0316791B1 (de) 1987-11-20 1988-11-11 1-Naphtholphthaleinmonophosphate, Verfahren zu deren Herstellung sowie deren Verwendung zur Bestimmung der alkalischen Phosphatase
US07/273,403 US4985414A (en) 1987-11-20 1988-11-18 1-naphtholphthalein monophosphates and diagnostic reagents containing them
JP63292551A JPH01160990A (ja) 1987-11-20 1988-11-21 １−ナフトールフタレインモノホスフエート、その製法、アルカリホスフアターゼの測定法及びアルカリホスフアターゼ検出用診断剤

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873739284 DE3739284A1 (de) 1987-11-20 1987-11-20 1-naphtholphthaleinmonophosphate, verfahren zu deren herstellung sowie deren verwendung zur bestimmung der alkalischen phosphatase

Publications (1)

Publication Number Publication Date
DE3739284A1 true DE3739284A1 (de) 1989-06-01

Family

ID=6340842

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19873739284 Withdrawn DE3739284A1 (de) 1987-11-20 1987-11-20 1-naphtholphthaleinmonophosphate, verfahren zu deren herstellung sowie deren verwendung zur bestimmung der alkalischen phosphatase
DE8888118800T Expired - Fee Related DE3879107D1 (de) 1987-11-20 1988-11-11 1-naphtholphthaleinmonophosphate, verfahren zu deren herstellung sowie deren verwendung zur bestimmung der alkalischen phosphatase.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8888118800T Expired - Fee Related DE3879107D1 (de) 1987-11-20 1988-11-11 1-naphtholphthaleinmonophosphate, verfahren zu deren herstellung sowie deren verwendung zur bestimmung der alkalischen phosphatase.

Country Status (6)

Country Link
US (1) US4985414A (enExample)
EP (1) EP0316791B1 (enExample)
JP (1) JPH01160990A (enExample)
AT (1) ATE86626T1 (enExample)
DE (2) DE3739284A1 (enExample)
ES (1) ES2054771T3 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119935989A (zh) * 2024-12-19 2025-05-06 卡秋(江苏)生物科技有限公司 一种适用于全自动免疫组化染色液的碱性磷酸酶显色液

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2646814B2 (ja) * 1990-08-07 1997-08-27 アイシン精機株式会社 核酸等の検定方法
DE19632432A1 (de) * 1996-08-12 1998-02-19 Boehringer Mannheim Gmbh Stabile Mischung zum Nachweis alkalischer Phosphatase mit einem Salz der o-Kresolphthaleinmonophosphorsäure
BR102013023221B1 (pt) * 2013-09-11 2021-08-17 Universidade Federal Do Rio De Janeiro Processo de síntese de fenolftaleína bisfosfato tetrassódio e kit

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3331862A (en) * 1964-06-05 1967-07-18 Warner Lambert Pharmaceutical Phenolphthalein-mono-phosphate derivatives
US3331857A (en) * 1964-10-01 1967-07-18 Warner Lambert Pharmaceutical Phenolphthalein monophosphate derivatives
US3823071A (en) * 1970-12-21 1974-07-09 Worthington Biochem Corp Prostatic acid phosphatase determination
US3931228A (en) * 1971-01-21 1976-01-06 Polaroid Corporation Process for preparing phthalide and naphthalide indicator dyes
US4035391A (en) * 1974-02-28 1977-07-12 Polaroid Corporation Phthalide and naphthalide derivatives
US3975405A (en) * 1974-08-01 1976-08-17 Coulter Diagnostics, Inc. Monophosphate salt of o-cresolphthalein
US4032545A (en) * 1975-09-29 1977-06-28 Polaroid Corporation Phthalides and naphthalides

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119935989A (zh) * 2024-12-19 2025-05-06 卡秋(江苏)生物科技有限公司 一种适用于全自动免疫组化染色液的碱性磷酸酶显色液

Also Published As

Publication number Publication date
JPH0513958B2 (enExample) 1993-02-23
EP0316791B1 (de) 1993-03-10
ATE86626T1 (de) 1993-03-15
DE3879107D1 (de) 1993-04-15
US4985414A (en) 1991-01-15
EP0316791A3 (en) 1990-06-13
EP0316791A2 (de) 1989-05-24
ES2054771T3 (es) 1994-08-16
JPH01160990A (ja) 1989-06-23

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Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee