DE3686927D1 - Neovaskularisierungsinhibitoren und deren herstellung. - Google Patents

Neovaskularisierungsinhibitoren und deren herstellung.

Info

Publication number
DE3686927D1
DE3686927D1 DE8686901626T DE3686927T DE3686927D1 DE 3686927 D1 DE3686927 D1 DE 3686927D1 DE 8686901626 T DE8686901626 T DE 8686901626T DE 3686927 T DE3686927 T DE 3686927T DE 3686927 D1 DE3686927 D1 DE 3686927D1
Authority
DE
Germany
Prior art keywords
production
neovascularization inhibitors
cells
polypeptides
neovascularization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686901626T
Other languages
English (en)
Other versions
DE3686927T2 (de
Inventor
Bert M Glaser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University filed Critical Johns Hopkins University
Publication of DE3686927D1 publication Critical patent/DE3686927D1/de
Application granted granted Critical
Publication of DE3686927T2 publication Critical patent/DE3686927T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/849—Eyes; vessels; umbilical cord
DE8686901626T 1985-02-26 1986-02-14 Neovaskularisierungsinhibitoren und deren herstellung. Expired - Fee Related DE3686927T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70625985A 1985-02-26 1985-02-26
PCT/US1986/000312 WO1986004783A1 (en) 1985-02-26 1986-02-14 Neovascularization inhibitors and methods for their production and use

Publications (2)

Publication Number Publication Date
DE3686927D1 true DE3686927D1 (de) 1992-11-12
DE3686927T2 DE3686927T2 (de) 1993-03-25

Family

ID=24836851

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686901626T Expired - Fee Related DE3686927T2 (de) 1985-02-26 1986-02-14 Neovaskularisierungsinhibitoren und deren herstellung.

Country Status (12)

Country Link
US (1) US4996159A (de)
EP (1) EP0213180B1 (de)
JP (1) JPS61246132A (de)
AT (1) ATE81254T1 (de)
AU (1) AU590872B2 (de)
DE (1) DE3686927T2 (de)
DK (1) DK509286D0 (de)
FI (1) FI864293A0 (de)
NO (1) NO864254L (de)
NZ (1) NZ215195A (de)
WO (1) WO1986004783A1 (de)
ZA (1) ZA861403B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1329123C (en) * 1987-10-13 1994-05-03 Moses Judah Folkman Inhibitor of angiogenesis
JPH04178328A (ja) * 1990-11-08 1992-06-25 Unitika Ltd 血管新生阻害剤
US5853746A (en) * 1991-01-31 1998-12-29 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier
JPH08500255A (ja) * 1992-04-01 1996-01-16 バクスター・インターナショナル・インコーポレーテッド 血管形成組織移植システムおよびその方法
US6319687B1 (en) 1992-09-24 2001-11-20 The United States Of America As Represented By The Department Of Health And Human Services Pigment epithelium-derived factor: characterization, genomic organization and sequence of PEDF gene
US5840686A (en) * 1992-09-24 1998-11-24 The United States Of America As Represented By The Department Of Health And Human Services Pigment epithelium-derived factor: characterization of its novel biological activity and sequences encoding and expressing the protein and methods of use
US6451763B1 (en) * 1992-06-04 2002-09-17 The United States Of America As Represented By The Department Of Health And Human Services Retinal pigmented epithelium derived neurotrophic factor and methods of use
US5716981A (en) * 1993-07-19 1998-02-10 Angiogenesis Technologies, Inc. Anti-angiogenic compositions and methods of use
US5985330A (en) * 1996-08-05 1999-11-16 Coastside Bio Resources Inhibition of angiogenesis by sea cucumber fractions
CA2276183C (en) 1996-12-31 2009-06-09 Antioxidant Pharmaceuticals Corporation Pharmaceutical preparations of glutathione and methods of administration thereof
US6797691B1 (en) 1997-07-23 2004-09-28 Northwestern University Methods and compositions for inhibiting angiogenesis
JP2001510804A (ja) 1997-07-23 2001-08-07 ノースウエスタン・ユニバーシテイ 血管新生を阻害するための方法及び組成物
US7105496B2 (en) 1998-07-23 2006-09-12 Northwestern University Methods and compositions for inhibiting angiogenesis
US7828827B2 (en) * 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US6875165B2 (en) * 2001-02-22 2005-04-05 Retinalabs, Inc. Method of radiation delivery to the eye
US7070554B2 (en) 2003-01-15 2006-07-04 Theragenics Corporation Brachytherapy devices and methods of using them
BRPI0507690A (pt) * 2004-02-12 2007-07-24 Neovista Inc métodos e aparelho para a braquiterapia intra-ocular
US7563222B2 (en) 2004-02-12 2009-07-21 Neovista, Inc. Methods and apparatus for intraocular brachytherapy
CA2629648A1 (en) * 2005-11-15 2007-05-24 Neovista Inc. Methods and apparatus for intraocular brachytherapy
EP2121111B1 (de) * 2007-01-22 2018-03-14 Corium International, Inc. Applikator für mikronadelanordnung
EP2146689B1 (de) 2007-04-16 2020-08-12 Corium, Inc. Einen wirkstoff enthaltende lösungsmittel-gegossene mikronadelanordnungen
US8911749B2 (en) * 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
US8353812B2 (en) 2008-06-04 2013-01-15 Neovista, Inc. Handheld radiation delivery system
EP2429627B1 (de) * 2009-04-24 2017-06-14 Corium International, Inc. Verfahren zur herstellung von mikroprojektionsarrays
ES2719595T3 (es) 2010-05-04 2019-07-11 Corium Int Inc Método y dispositivo para la administración transdérmica de la hormona paratiroidea usando una matriz de microproyección
US11052231B2 (en) 2012-12-21 2021-07-06 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
RU2674083C2 (ru) 2013-03-12 2018-12-04 Кориум Интернэшнл, Инк. Аппликаторы с микровыступами
AU2014233695A1 (en) 2013-03-15 2015-10-01 Corium International, Inc. Microarray for delivery of therapeutic agent and methods of use
WO2014150285A2 (en) 2013-03-15 2014-09-25 Corium International, Inc. Multiple impact microprojection applicators and methods of use
EP2968116A1 (de) 2013-03-15 2016-01-20 Corium International, Inc. Mikroarray mit polymerfreien mikrostrukturen, verfahren zur herstellung und verfahren zur verwendung
ES2761580T3 (es) 2013-03-15 2020-05-20 Corium Inc Micromatrices para suministro de agente terapéutico, métodos de uso y métodos de fabricación
WO2016036866A1 (en) 2014-09-04 2016-03-10 Corium International, Inc. Microstructure array, methods of making, and methods of use
US20160367620A1 (en) 2015-06-19 2016-12-22 Harry B. Demopoulos Glutathione
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US30239A (en) * 1860-10-02 Improvement in machines for stem m ing corn-husks
US4042457A (en) * 1975-11-10 1977-08-16 Rush-Presbyterian-St. Luke's Medical Center Preparation of tissue invasion inhibitor and method of treatment utilizing the inhibitor
USRE30239E (en) * 1975-11-10 1980-03-25 Cell proliferation and tissue invasion inhibitor
US4182753A (en) * 1978-03-29 1980-01-08 Saltarelli Cora G Sarcoma 180 tumor inhibitor and method of making same
US4176177A (en) * 1978-11-16 1979-11-27 Rush-Presbyterian-St. Luke's Medical Center Inhibition of bone resorption
US4356261A (en) * 1980-04-22 1982-10-26 Rush-Presbyterian-St. Luke's Medical Center Anti-invasion factor containing cultures
US4534967A (en) * 1982-08-03 1985-08-13 Boston Biomedical Research Institute Cell proliferation inhibitor and method of preparation

Also Published As

Publication number Publication date
AU590872B2 (en) 1989-11-23
US4996159A (en) 1991-02-26
EP0213180B1 (de) 1992-10-07
DK509286A (da) 1986-10-24
NZ215195A (en) 1991-11-26
WO1986004783A1 (en) 1986-08-28
NO864254L (no) 1986-10-23
EP0213180A4 (de) 1988-12-28
FI864293A (fi) 1986-10-23
AU5455386A (en) 1986-09-10
ATE81254T1 (de) 1992-10-15
JPS61246132A (ja) 1986-11-01
DK509286D0 (da) 1986-10-24
FI864293A0 (fi) 1986-10-23
ZA861403B (en) 1986-12-30
EP0213180A1 (de) 1987-03-11
DE3686927T2 (de) 1993-03-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee