DE3684561D1 - Vorrichtung und verfahren zur kultivierung von zellen zum abfuehren von rueckstand und zur konzentration des produktes. - Google Patents

Vorrichtung und verfahren zur kultivierung von zellen zum abfuehren von rueckstand und zur konzentration des produktes.

Info

Publication number
DE3684561D1
DE3684561D1 DE8686115226T DE3684561T DE3684561D1 DE 3684561 D1 DE3684561 D1 DE 3684561D1 DE 8686115226 T DE8686115226 T DE 8686115226T DE 3684561 T DE3684561 T DE 3684561T DE 3684561 D1 DE3684561 D1 DE 3684561D1
Authority
DE
Germany
Prior art keywords
medium
reservoir
waste
membrane
concentrating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686115226T
Other languages
German (de)
English (en)
Inventor
William H Harm
Mark D Hirschel
Michael L Gruenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Endotronics Inc
Original Assignee
Endotronics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endotronics Inc filed Critical Endotronics Inc
Application granted granted Critical
Publication of DE3684561D1 publication Critical patent/DE3684561D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/42—Integrated assemblies, e.g. cassettes or cartridges
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE8686115226T 1985-11-04 1986-11-03 Vorrichtung und verfahren zur kultivierung von zellen zum abfuehren von rueckstand und zur konzentration des produktes. Expired - Fee Related DE3684561D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/794,627 US4722902A (en) 1985-11-04 1985-11-04 Apparatus and method for culturing cells, removing waste and concentrating product

Publications (1)

Publication Number Publication Date
DE3684561D1 true DE3684561D1 (de) 1992-04-30

Family

ID=25163183

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686115226T Expired - Fee Related DE3684561D1 (de) 1985-11-04 1986-11-03 Vorrichtung und verfahren zur kultivierung von zellen zum abfuehren von rueckstand und zur konzentration des produktes.

Country Status (7)

Country Link
US (1) US4722902A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0224734B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS62171669A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE74158T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU6463286A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1270455A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3684561D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

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DE3641826A1 (de) * 1986-12-06 1988-06-16 Bayer Ag Verfahren zur kultivierung von saeugerzellen in einer suspensionskultur, vorrichtung zur durchfuehrung des verfahrens und verwendung bei der herstellung von proteinen
US4921792A (en) * 1987-11-27 1990-05-01 Miles Inc. Continuous cell dispersion, cultivation and substance recovery process
JPH0646937B2 (ja) * 1988-10-17 1994-06-22 雪印乳業株式会社 培養液の濃縮装置
US5002890A (en) * 1988-11-29 1991-03-26 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Spiral vane bioreactor
JP2777385B2 (ja) * 1988-11-30 1998-07-16 株式会社日立製作所 生物細胞の培養方法，培養システム及び培養装置
US5102790A (en) * 1988-12-19 1992-04-07 Baxter International Inc. Method for culturing animal cells
US5187095A (en) * 1988-12-19 1993-02-16 Baxter International Inc. Apparatus for culturing animal cells
FR2640638B1 (fr) * 1988-12-20 1991-02-15 Commissariat Energie Atomique Bioreacteur et dispositif pour la culture de cellules animales
EP0455757B1 (en) * 1989-08-04 1999-03-31 GRANDICS, Peter An integrated cell culture-protein purification system for the automated production and purification of cell culture products
US5346826A (en) * 1989-10-18 1994-09-13 Andrews Franklin T Process for conducting biochemical reactions
JPH03175949A (ja) * 1989-12-05 1991-07-31 Hokkaido Prefecture 膜法によるスティックウォーターからの天然調味料の製造方法
US5268298A (en) * 1991-04-26 1993-12-07 Life Technologies, Inc. System for delivering oxygen to a cell culture medium
DE4116727C2 (de) 1991-05-17 1995-09-07 Uwe Dr Marx Verfahren und Vorrichtung zur gleichzeitigen Kultivierung unterschiedlicher Säugerzellen
US5330915A (en) * 1991-10-18 1994-07-19 Endotronics, Inc. Pressure control system for a bioreactor
US5353745A (en) * 1992-09-29 1994-10-11 Fahs Ii Richard W Aquaculture system and methods for using the same
US5424209A (en) * 1993-03-19 1995-06-13 Kearney; George P. Automated cell culture and testing system
US20050266548A1 (en) * 1995-03-28 2005-12-01 Kbi Biopharma, Inc. Biocatalyst chamber encapsulation system for bioremediation and fermentation with improved rotor
US6133019A (en) * 1995-03-28 2000-10-17 Kinetic Biosystems, Inc. Centrifugal fermentation process
US6214617B1 (en) 1995-03-28 2001-04-10 Kinetic Biosystems, Inc. Centrifugal fermentation process
US6660509B1 (en) 1995-03-28 2003-12-09 Kinetic Biosystems, Inc. Methods and devices for remediation and fermentation
US6916652B2 (en) * 1995-03-28 2005-07-12 Kinetic Biosystems, Inc. Biocatalyst chamber encapsulation system for bioremediation and fermentation
US5622819A (en) * 1995-03-28 1997-04-22 Kinetic Biosystems, Inc. Centrifugal fermentation process
US5728581A (en) * 1995-06-07 1998-03-17 Systemix, Inc. Method of expanding hematopoietic stem cells, reagents and bioreactors for use therein
US20020182730A1 (en) * 1995-07-26 2002-12-05 Micheal L. Gruenberg Autologous immune cell therapy: cell compositions, methods and applications to treatment of human disease
US5627070A (en) * 1995-07-26 1997-05-06 Celltherapy, Inc. Cell growing device for in vitro cell population expansion
DE19727731A1 (de) * 1997-06-30 1999-01-07 Forschungszentrum Juelich Gmbh Verfahren und Vorrichtung zum Eintrag von Reagenzien in Reaktoren
WO2001055296A1 (en) 2000-01-31 2001-08-02 Kinetic Biosystems, Inc. Methods and devices for remediation and fermentation
US20020146817A1 (en) * 2000-10-02 2002-10-10 Cannon Thomas F. Automated bioculture and bioculture experiments system
EP1325110A4 (en) * 2000-10-02 2009-03-25 Thomas F Cannon AUTOMATED BIOCULTURE AND BIOCULTURAL EXPERIENCE SYSTEM
FR2821947B1 (fr) * 2001-03-12 2003-05-16 Canon Kk Procede et dispositif de validation de parametres definissant une image
US20030134415A1 (en) * 2001-09-19 2003-07-17 Gruenberg Micheal L. Th1 cell adoptive immunotherapy
US20030134341A1 (en) * 2001-09-19 2003-07-17 Medcell Biologics, Llc. Th1 cell adoptive immunotherapy
US20030175272A1 (en) * 2002-03-07 2003-09-18 Medcell Biologics, Inc. Re-activated T-cells for adoptive immunotherapy
US7695627B2 (en) * 2002-06-19 2010-04-13 Northwest Biotherapeutics, Inc. Tangential flow filtration devices and methods for leukocyte enrichment
US7790039B2 (en) * 2003-11-24 2010-09-07 Northwest Biotherapeutics, Inc. Tangential flow filtration devices and methods for stem cell enrichment
EP1786894A4 (en) * 2004-09-10 2007-12-12 Unisearch Ltd DEVICE AND METHOD FOR PREVENTING CULTURE MEDIA REMOVAL
JP2010519936A (ja) * 2007-03-05 2010-06-10 カリディアンビーシーティー、インコーポレーテッド 中空繊維バイオリアクター内における細胞の動きを制御する方法
CA2680130C (en) 2007-03-05 2016-01-12 Caridianbct, Inc. Cell expansion system and methods of use
US8906688B2 (en) * 2007-04-13 2014-12-09 Terumo Bct, Inc. Cell expansion system and methods of use
WO2010003759A2 (en) * 2008-06-17 2010-01-14 Dsm Ip Assets B.V. Cell culturing method
US8778669B2 (en) 2009-07-22 2014-07-15 Corning Incorporated Multilayer tissue culture vessel
WO2011140231A1 (en) 2010-05-05 2011-11-10 Caridianbct, Inc. Method of reseeding adherent cells grown in a hollow fiber bioreactor system
WO2012048298A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
EP2649016B1 (en) * 2010-12-06 2020-06-10 Pall Corporation Continuous processing methods for biological products
JP6466841B2 (ja) 2012-08-20 2019-02-06 テルモ ビーシーティー、インコーポレーテッド 細胞増殖システムのバイオリアクターにおける細胞の投入・分配方法
US9005550B2 (en) 2012-10-29 2015-04-14 Corning Incorporated Multi-layered cell culture vessel with manifold grips
WO2015073913A1 (en) 2013-11-16 2015-05-21 Terumo Bct, Inc. Expanding cells in a bioreactor
CN106232800B (zh) 2014-03-25 2020-07-03 泰尔茂比司特公司 介质的被动替代
WO2015164808A1 (en) 2014-04-24 2015-10-29 Terumo Bct, Inc. Measuring flow rate
US20160090569A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled Feed
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
SG11201803013YA (en) * 2015-10-26 2018-05-30 Lonza Ag A manufacturing facility for the production of biopharmaceuticals
WO2017193075A1 (en) * 2016-05-05 2017-11-09 Terumo Bct, Inc. Automated production and collection
CN109415696A (zh) 2016-05-25 2019-03-01 泰尔茂比司特公司 细胞扩增
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
EP3601521A2 (en) 2017-03-31 2020-02-05 Terumo BCT, Inc. Cell expansion
JP6911919B2 (ja) 2017-07-03 2021-07-28 株式会社村田製作所 濃縮装置

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US3186917A (en) * 1962-04-18 1965-06-01 Biochemical Processes Inc Process and apparatus for dialysis fermentation
US3969190A (en) * 1971-05-17 1976-07-13 Martin Marietta Corporation Apparatus and method for microbial fermentation in a zero gravity environment
US3883393A (en) * 1972-05-18 1975-05-13 Us Health Education & Welfare Cell culture on semi-permeable tubular membranes
US3992301A (en) * 1973-11-19 1976-11-16 Raypak, Inc. Automatic flushing system for membrane separation machines such as reverse osmosis machines
DE2726313C3 (de) * 1977-06-10 1980-02-07 Battelle-Institut E.V., 6000 Frankfurt Verfahren zur in-vitro-Biosynthese von Hormonen, insbesondere von Insulin
US4420398A (en) * 1981-08-13 1983-12-13 American National Red Cross Filteration method for cell produced antiviral substances
GB2168617B (en) * 1984-12-12 1988-08-10 Bo Gustav Mattiasson A procedure and an apparatus for continuous separation and purification of reaction products

Also Published As

Publication number Publication date
US4722902A (en) 1988-02-02
EP0224734A1 (en) 1987-06-10
AU6463286A (en) 1987-05-07
JPS62171669A (ja) 1987-07-28
JPH0120866B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1989-04-18
CA1270455A (en) 1990-06-19
ATE74158T1 (de) 1992-04-15
EP0224734B1 (en) 1992-03-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee