DE3683956D1 - In einem serumfreien medium in suspension kultivierte humane monozyten. - Google Patents
In einem serumfreien medium in suspension kultivierte humane monozyten.Info
- Publication number
- DE3683956D1 DE3683956D1 DE8686401250T DE3683956T DE3683956D1 DE 3683956 D1 DE3683956 D1 DE 3683956D1 DE 8686401250 T DE8686401250 T DE 8686401250T DE 3683956 T DE3683956 T DE 3683956T DE 3683956 D1 DE3683956 D1 DE 3683956D1
- Authority
- DE
- Germany
- Prior art keywords
- suspension
- human monocytes
- serum
- free medium
- monocytes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000001616 monocyte Anatomy 0.000 title abstract 6
- 239000000725 suspension Substances 0.000 title abstract 2
- 239000012679 serum free medium Substances 0.000 title 1
- 238000012258 culturing Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 241000282412 Homo Species 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4614—Monocytes; Macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57446—Specifically defined cancers of stomach or intestine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/36—Lipids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/05—Adjuvants
- C12N2501/056—Immunostimulating oligonucleotides, e.g. CpG
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/24—Interferons [IFN]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74357085A | 1985-06-11 | 1985-06-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3683956D1 true DE3683956D1 (de) | 1992-04-02 |
Family
ID=24989299
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8686401250T Expired - Lifetime DE3683956D1 (de) | 1985-06-11 | 1986-06-10 | In einem serumfreien medium in suspension kultivierte humane monozyten. |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0205387B1 (de) |
JP (1) | JP2581673B2 (de) |
AT (1) | ATE72829T1 (de) |
CA (1) | CA1306966C (de) |
DE (1) | DE3683956D1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5093115A (en) * | 1985-06-11 | 1992-03-03 | The United States Of America As Represented By The Department Of Health And Human Services | Method of preparing activated killer monocytes for treating colorectal cancer |
FR2657783B1 (fr) * | 1990-02-07 | 1992-05-29 | Fondation Nale Transfusion San | Procede de preparation de derives sanguins et derives obtenus par ce procede. |
JPH04170965A (ja) * | 1990-11-01 | 1992-06-18 | Nippon Koutai Kenkyusho:Kk | リンパ球の活性化方法 |
AU2882992A (en) * | 1991-11-06 | 1993-06-07 | Arthur A. Axelrad | Cell culture medium |
DK0559425T3 (da) * | 1992-03-02 | 1999-08-30 | Japan Immuno Inc | Anvendelse af proteiner tilhørende transferrin/lactoferrinfamilien til stimulering af immunsystemet |
US5583053A (en) * | 1992-07-21 | 1996-12-10 | Kim; Think Y. | Macrophage cell line for use in the detection of antinuclear antibodies |
JP3264142B2 (ja) * | 1995-06-08 | 2002-03-11 | 富士通株式会社 | Pll制御方式 |
BRPI0407900A (pt) | 2003-02-27 | 2006-03-21 | Northwest Biotherapeutics Inc | geração de células dendrìticas de células precursoras dentrìticas monocìticas com gm-csf na ausência de citocinas adicionais |
KR101111231B1 (ko) * | 2003-09-25 | 2012-02-17 | 비바리스 | 마이크로 웰 어레이 칩 및 그 제조방법 |
CN100460504C (zh) * | 2006-12-13 | 2009-02-11 | 青岛市中心医院 | 一种增加单核细胞贴壁数量的方法 |
-
1986
- 1986-06-10 EP EP86401250A patent/EP0205387B1/de not_active Expired - Lifetime
- 1986-06-10 DE DE8686401250T patent/DE3683956D1/de not_active Expired - Lifetime
- 1986-06-10 AT AT86401250T patent/ATE72829T1/de not_active IP Right Cessation
- 1986-06-11 JP JP61135878A patent/JP2581673B2/ja not_active Expired - Lifetime
- 1986-06-11 CA CA000511359A patent/CA1306966C/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2581673B2 (ja) | 1997-02-12 |
CA1306966C (en) | 1992-09-01 |
JPS6265682A (ja) | 1987-03-24 |
ATE72829T1 (de) | 1992-03-15 |
EP0205387A2 (de) | 1986-12-17 |
EP0205387B1 (de) | 1992-02-26 |
EP0205387A3 (en) | 1989-03-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU7873187A (en) | Method of culturing leukocytes | |
DK0435321T3 (da) | Nye A-nor-steroid-3-carboxylsyrederivater | |
ATE20073T1 (de) | Homogenes human-interleukin-2 und verfahren zu seiner herstellung. | |
AU580494B2 (en) | Process for the extraction and purification of proteins from culture media producing them | |
NZ225362A (en) | Optical isomers of medetomidine and pharmaceutical compositions | |
NO161573C (no) | Fremgangsmaate til fremstilling av hyaluronsyre. | |
ES2103706T3 (es) | Receptores de interleuquina-4. | |
DE69533941D1 (de) | Verfahren zur herstellung eines arzneimittels zur behandlung des sekundärimmunmangels | |
DE3683956D1 (de) | In einem serumfreien medium in suspension kultivierte humane monozyten. | |
PT86687A (pt) | Process for the preparation of novel polyamine derivatives | |
AU2760288A (en) | In vitro culture of bovine embryos | |
KR890700609A (ko) | 정제된 혈소판으로 부터 유도한 성장 인자 및 그의 정제방법 | |
US4411992A (en) | Process for preparing murine interleukin 2 | |
IT8867773A0 (it) | Lai e simili sistema per il controllo del trasporto di parti sostitutive per te | |
PT87503A (pt) | Process for the preparation of new cathecolamine by products | |
FR2620131B1 (fr) | Procede de production de carotenoides et notamment d'astaxanthine par culture de microalgues et dispositif pour la mise en oeuvre du procede | |
EP0491851A4 (en) | Method for the production of in vitro expanded lymphoid cells for use in adoptive immunotherapy | |
ES2061558T3 (es) | Sondas de hibridacion de acidos nucleicos de papilomavirus humanos y metodos para su empleo. | |
EP0299067A4 (de) | Zuchtmedium für pflanzen. | |
NO922304L (no) | Eliminering av aktiverte lymfocytter | |
FR2587359B1 (fr) | Derives non amides de la somatocrinine et procede de preparation par genie genetique | |
IT1217825B (it) | Procedimento ed impianto per la coltura di microorganismi | |
FR2583047B1 (fr) | Procede de preparation de derives du 4-phenylpropyl indole, et intermediaires | |
IT1206039B (it) | Procedimento per la produzione di etanolo mediante ceppi di microorganismo ad elevata resistenza | |
MD73B1 (ro) | Instalatie pentru cultivarea microalgelor |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |