DE3587523D1 - Carbapeneme und 1-methylcarbapeneme mit einem heteroaryliumaliphatischen substituenten in 2-stellung. - Google Patents

Carbapeneme und 1-methylcarbapeneme mit einem heteroaryliumaliphatischen substituenten in 2-stellung.

Info

Publication number
DE3587523D1
DE3587523D1 DE8585115845T DE3587523T DE3587523D1 DE 3587523 D1 DE3587523 D1 DE 3587523D1 DE 8585115845 T DE8585115845 T DE 8585115845T DE 3587523 T DE3587523 T DE 3587523T DE 3587523 D1 DE3587523 D1 DE 3587523D1
Authority
DE
Germany
Prior art keywords
methylcarbapeneme
carbapeneme
heteroarylium
aliphatic substituent
substituent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8585115845T
Other languages
English (en)
Inventor
Burton G Christensen
Thomas N Salzmann
James V Heck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3587523D1 publication Critical patent/DE3587523D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE8585115845T 1984-12-13 1985-12-12 Carbapeneme und 1-methylcarbapeneme mit einem heteroaryliumaliphatischen substituenten in 2-stellung. Expired - Lifetime DE3587523D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/681,180 US4680292A (en) 1984-12-13 1984-12-13 Carbapenems and 1-methylcarbapenems having a 2-heteroaryliumaliphatic substituent

Publications (1)

Publication Number Publication Date
DE3587523D1 true DE3587523D1 (de) 1993-09-16

Family

ID=24734172

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585115845T Expired - Lifetime DE3587523D1 (de) 1984-12-13 1985-12-12 Carbapeneme und 1-methylcarbapeneme mit einem heteroaryliumaliphatischen substituenten in 2-stellung.

Country Status (4)

Country Link
US (1) US4680292A (de)
EP (1) EP0185315B1 (de)
JP (1) JPS61151191A (de)
DE (1) DE3587523D1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4729993A (en) * 1984-12-13 1988-03-08 Merck & Co., Inc. Carbapenems and 1-methylcarbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkyl substituent
US4952397A (en) * 1985-06-17 1990-08-28 Merck & Co., Inc. 2-quaternary heteroarylalkylthio carbapenems having an acid moiety substituent
EP0277743A1 (de) * 1987-02-02 1988-08-10 Merck & Co. Inc. 2-(Heteroaryliumalkyl)phenyl-carbapeneme als antibakterielle Mittel
US4866171A (en) * 1987-04-11 1989-09-12 Lederle (Japan), Ltd. (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio-6-[R-1-hydroxyethyl]-1-methyl-carbapenum-3-carboxylate
JPS63255283A (ja) * 1987-04-11 1988-10-21 Nippon Redarii Kk （１ｒ，５ｓ，６ｓ）−２−〔（３−置換イミダゾリニウム−１−イル）アルキル〕チオ−６−〔（ｒ）−１−ヒドロキシエチル〕−１−メチル−カルバペネム−３−カルボキシレ−ト
CA2023144A1 (en) * 1989-08-21 1991-02-22 Frank P. Dininno 2-(quinoliniumalkyl and isoquinoliniumalkyl)-phenyl carbapenem antibacterial agents
JPH03120280A (ja) * 1989-10-03 1991-05-22 Shionogi & Co Ltd ハロメチルカルバペネム化合物の製法
ZA912279B (en) * 1990-04-09 1992-02-26 Hoffmann La Roche Carbapenem compounds
US5382575A (en) * 1991-10-17 1995-01-17 Merck & Co., Inc. (N-pyridiniumphenyl)-carbapenems
EP0538017A1 (de) * 1991-10-17 1993-04-21 Merck & Co. Inc. 2-(N-Imidazoliumphenyl)-Carbapeneme
EP0538018A1 (de) * 1991-10-17 1993-04-21 Merck & Co. Inc. (N-Pyridiniumphenyl)-Carbapeneme
US5276149A (en) * 1991-10-17 1994-01-04 Merck & Co., Inc. 2-(N-imidazoliumphenyl)-carbapenems
WO1993016080A1 (en) * 1992-02-06 1993-08-19 Yamanouchi Pharmaceutical Co., Ltd. Novel carbapenem derivative
US5496816A (en) * 1994-03-14 1996-03-05 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
DE69622801T2 (de) * 1995-03-10 2003-03-27 Meiji Seika K.K., Tokio/Tokyo Neue carbapenemderivate
US6294528B1 (en) * 1998-06-25 2001-09-25 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and method of treatment
KR101862041B1 (ko) * 2010-06-18 2018-05-29 포브 신세시스 그람음성 활성을 갖는 카바페넴 항균제

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4348320A (en) * 1976-11-19 1982-09-07 Merck & Co., Inc. Substituted azetidiones
US4189493A (en) * 1977-12-28 1980-02-19 Merck & Co., Inc. N-heterocyclic derivatives of thienamycin
US4218459A (en) * 1977-12-28 1980-08-19 Merck & Co., Inc. 6-Amido-1-carba-2-penem-3-carboxylic acid
AR244550A1 (es) * 1978-07-24 1993-11-30 Merck & Co Inc Procedimiento para obtener una composicion de antibioticos del tipo de la tienamicina con inhibidores de la dipeptidasa
US4465632A (en) * 1978-10-24 1984-08-14 Merck & Co., Inc. Process for preparing 1-6-and 2-substituted-1-carba-2-penem-3-carboxylic acids
US4260627A (en) * 1978-10-24 1981-04-07 Merck & Co., Inc. 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids
JPS5660852A (en) * 1979-10-18 1981-05-26 Isuzu Motors Ltd Distributing type pump
US4262011A (en) * 1979-12-03 1981-04-14 Merck & Co., Inc. 1-1-Disubstituted-pen-2-em-3-carboxylic acids
US4312871A (en) * 1979-12-03 1982-01-26 Merck & Co., Inc. 6-, 1- And 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids
GR72296B (de) * 1979-12-03 1983-10-18 Merck & Co Inc
US4262009A (en) * 1979-12-03 1981-04-14 Merck & Co., Inc. 6- And 1,1-disubstituted-1-carbadethiapen-2-em-3-carboxylic acid
US4347355A (en) * 1980-02-21 1982-08-31 Abbott Laboratories Inhibitors of transpeptidase
JPS56122379A (en) * 1980-03-03 1981-09-25 Sankyo Co Ltd 1-carba-2-penem-3-carboxylic acid derivative
US4341706A (en) * 1980-10-10 1982-07-27 Merck & Co., Inc. Process for the preparation of carbapenem antibiotics
CA1179675A (en) * 1981-01-30 1984-12-18 Erwin Gotschi 7-oxo-1-azabicyclo ¬3,2,0| heptene-2-derivatives
US4347183A (en) * 1981-02-02 1982-08-31 Schering Corporation Process for the synthesis of penems and carbapenems
JPS57145087A (en) * 1981-02-27 1982-09-07 Hitachi Metals Ltd Clad ceramic tool
JPS57145086A (en) * 1981-02-27 1982-09-07 Hitachi Metals Ltd Clad ceramic tool
NZ201471A (en) * 1981-08-10 1985-09-13 Merck & Co Inc Antibacterial compositions containing penems and dipeptidase inhibitors
US4552696A (en) * 1982-04-09 1985-11-12 Bristol-Myers Company Carbapenem antibiotics
US4536335A (en) * 1982-06-18 1985-08-20 Bristol-Myers Company Carbapenem antibiotics
CA1269978A (en) * 1982-09-28 1990-06-05 Choung U. Kim Carbapenem antibiotics

Also Published As

Publication number Publication date
EP0185315B1 (de) 1993-08-11
EP0185315A1 (de) 1986-06-25
JPS61151191A (ja) 1986-07-09
US4680292A (en) 1987-07-14
JPH0438755B2 (de) 1992-06-25

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Legal Events

Date Code Title Description
8332 No legal effect for de