DE3581967D1 - Dihydropyridin-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. - Google Patents
Dihydropyridin-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.Info
- Publication number
- DE3581967D1 DE3581967D1 DE8585304646T DE3581967T DE3581967D1 DE 3581967 D1 DE3581967 D1 DE 3581967D1 DE 8585304646 T DE8585304646 T DE 8585304646T DE 3581967 T DE3581967 T DE 3581967T DE 3581967 D1 DE3581967 D1 DE 3581967D1
- Authority
- DE
- Germany
- Prior art keywords
- same
- different
- alkyl groups
- group
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 125000002723 alicyclic group Chemical group 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 102000012740 beta Adrenergic Receptors Human genes 0.000 abstract 1
- 108010079452 beta Adrenergic Receptors Proteins 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- -1 dihydropyridine compound Chemical class 0.000 abstract 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
- 125000005677 ethinylene group Chemical group [*:2]C#C[*:1] 0.000 abstract 1
- 208000031225 myocardial ischemia Diseases 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59133650A JPS6112662A (ja) | 1984-06-28 | 1984-06-28 | ジヒドロピリジン誘導体及びその製法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3581967D1 true DE3581967D1 (de) | 1991-04-11 |
Family
ID=15109748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8585304646T Expired - Fee Related DE3581967D1 (de) | 1984-06-28 | 1985-06-28 | Dihydropyridin-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4727082A (en:Method) |
| EP (1) | EP0167371B1 (en:Method) |
| JP (1) | JPS6112662A (en:Method) |
| KR (1) | KR900005019B1 (en:Method) |
| AT (1) | ATE61356T1 (en:Method) |
| AU (1) | AU569161B2 (en:Method) |
| CA (2) | CA1300157C (en:Method) |
| DE (1) | DE3581967D1 (en:Method) |
| ES (3) | ES8707933A1 (en:Method) |
| GR (1) | GR851568B (en:Method) |
| MX (2) | MX7533E (en:Method) |
| PT (1) | PT80714B (en:Method) |
| SU (1) | SU1342413A3 (en:Method) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8503427D0 (en) * | 1985-02-11 | 1985-03-13 | Ici Plc | Basic compounds |
| GB8503425D0 (en) * | 1985-02-11 | 1985-03-13 | Ici Plc | Alkanolamine derivatives |
| EP0276552A1 (en) * | 1986-12-08 | 1988-08-03 | Yamanouchi Pharmaceutical Co. Ltd. | 1,4-dihydropyridine derivatives and their production |
| US4843085A (en) * | 1987-07-01 | 1989-06-27 | Yamanouchi Pharmaceutical Co., Ltd. | Pyridine derivatives, process for production thereof and pharmaceutical compositions useful as anti-arhytmics |
| GB9102031D0 (en) * | 1991-01-30 | 1991-03-13 | Fujisawa Pharmaceutical Co | Dihydropyridine compounds,and process for their preparation |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2753946A1 (de) * | 1977-12-03 | 1979-06-13 | Bayer Ag | 1-n-aryl-1,4-dihydropyridine und ihre verwendung als arzneimittel |
| US4285955A (en) * | 1978-10-31 | 1981-08-25 | Bayer Aktiengesellschaft | 1,4-Dihydropyridinecarboxylic acids |
| NZ201395A (en) * | 1981-07-30 | 1987-02-20 | Bayer Ag | Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines |
| DE3207982A1 (de) * | 1982-03-05 | 1983-09-08 | Bayer Ag, 5090 Leverkusen | Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln |
| HU192166B (en) * | 1982-08-06 | 1987-05-28 | Banyu Pharma Co Ltd | Process for producing 2-carbamoyl-oxy-alkyl-1,4-dihydro-pyridine derivatives |
| US4500527A (en) * | 1983-06-22 | 1985-02-19 | Usv Pharmaceutical Corporation | Antihypertensive 4[(3-alkylamino-2-hydroxypropyl)-oxyiminomethyl phenyl]-1,4-dihydropyridines |
| NO854021L (no) * | 1984-10-26 | 1986-04-28 | Bayer Ag | 1,4-dihydropyridin-hydroksyaminer og fremgangsmaate til fremstilling derav. |
| GB8503425D0 (en) * | 1985-02-11 | 1985-03-13 | Ici Plc | Alkanolamine derivatives |
-
1984
- 1984-06-28 JP JP59133650A patent/JPS6112662A/ja active Granted
-
1985
- 1985-06-21 AU AU43967/85A patent/AU569161B2/en not_active Ceased
- 1985-06-26 GR GR851568A patent/GR851568B/el unknown
- 1985-06-26 PT PT80714A patent/PT80714B/pt not_active IP Right Cessation
- 1985-06-27 SU SU853915847A patent/SU1342413A3/ru active
- 1985-06-27 KR KR1019850004583A patent/KR900005019B1/ko not_active Expired
- 1985-06-27 ES ES544647A patent/ES8707933A1/es not_active Expired
- 1985-06-28 EP EP85304646A patent/EP0167371B1/en not_active Expired - Lifetime
- 1985-06-28 CA CA000485923A patent/CA1300157C/en not_active Expired - Fee Related
- 1985-06-28 MX MX8511595U patent/MX7533E/es unknown
- 1985-06-28 AT AT85304646T patent/ATE61356T1/de not_active IP Right Cessation
- 1985-06-28 DE DE8585304646T patent/DE3581967D1/de not_active Expired - Fee Related
-
1986
- 1986-02-24 ES ES552336A patent/ES8704899A1/es not_active Expired
- 1986-02-24 ES ES552335A patent/ES8704898A1/es not_active Expired
- 1986-09-17 US US06/908,350 patent/US4727082A/en not_active Expired - Fee Related
-
1988
- 1988-07-06 CA CA000571338A patent/CA1312085C/en not_active Expired - Fee Related
- 1988-07-20 MX MX26687A patent/MX26687A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SU1342413A3 (ru) | 1987-09-30 |
| ES544647A0 (es) | 1987-09-01 |
| CA1312085C (en) | 1992-12-29 |
| ES552335A0 (es) | 1987-04-16 |
| ES552336A0 (es) | 1987-04-16 |
| GR851568B (en:Method) | 1985-11-25 |
| ES8707933A1 (es) | 1987-09-01 |
| EP0167371B1 (en) | 1991-03-06 |
| CA1300157C (en) | 1992-05-05 |
| PT80714A (en) | 1985-07-01 |
| JPS6112662A (ja) | 1986-01-21 |
| EP0167371A2 (en) | 1986-01-08 |
| ES8704898A1 (es) | 1987-04-16 |
| ATE61356T1 (de) | 1991-03-15 |
| AU4396785A (en) | 1986-01-02 |
| MX7533E (es) | 1989-08-15 |
| ES8704899A1 (es) | 1987-04-16 |
| US4727082A (en) | 1988-02-23 |
| MX26687A (es) | 1994-03-31 |
| JPH0123463B2 (en:Method) | 1989-05-02 |
| KR860000261A (ko) | 1986-01-27 |
| EP0167371A3 (en) | 1987-06-16 |
| AU569161B2 (en) | 1988-01-21 |
| KR900005019B1 (ko) | 1990-07-18 |
| PT80714B (en) | 1986-12-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |