DE3580169D1 - Verfahren zur herstellung von 2,6-substituierten 9-(1,3-dihydroxy-2-propoxymethyl)-purinen und einige derivate. - Google Patents

Verfahren zur herstellung von 2,6-substituierten 9-(1,3-dihydroxy-2-propoxymethyl)-purinen und einige derivate.

Info

Publication number
DE3580169D1
DE3580169D1 DE8585102000T DE3580169T DE3580169D1 DE 3580169 D1 DE3580169 D1 DE 3580169D1 DE 8585102000 T DE8585102000 T DE 8585102000T DE 3580169 T DE3580169 T DE 3580169T DE 3580169 D1 DE3580169 D1 DE 3580169D1
Authority
DE
Germany
Prior art keywords
propoxymethyl
purines
dihydroxy
derivatives
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8585102000T
Other languages
German (de)
English (en)
Inventor
Julien P H Verheyden
John C Martin
Gee Daniel P C Mc
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Application granted granted Critical
Publication of DE3580169D1 publication Critical patent/DE3580169D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
    • C07C43/1785—Unsaturated ethers containing hydroxy or O-metal groups having more than one ether bound

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE8585102000T 1984-02-23 1985-02-22 Verfahren zur herstellung von 2,6-substituierten 9-(1,3-dihydroxy-2-propoxymethyl)-purinen und einige derivate. Expired - Lifetime DE3580169D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/582,696 US4621140A (en) 1984-02-23 1984-02-23 Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxymethyl)-purines and certain derivatives

Publications (1)

Publication Number Publication Date
DE3580169D1 true DE3580169D1 (de) 1990-11-29

Family

ID=24330156

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585102000T Expired - Lifetime DE3580169D1 (de) 1984-02-23 1985-02-22 Verfahren zur herstellung von 2,6-substituierten 9-(1,3-dihydroxy-2-propoxymethyl)-purinen und einige derivate.

Country Status (5)

Country Link
US (1) US4621140A (ja)
EP (1) EP0152965B1 (ja)
JP (1) JPH064631B2 (ja)
AT (1) ATE57703T1 (ja)
DE (1) DE3580169D1 (ja)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826981A (en) * 1984-12-22 1989-05-02 Krka Process for preparing 9-(2-hydroxyethoxymethyl)-guanine
DE3627024A1 (de) * 1985-09-24 1987-04-02 Hoechst Ag In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
US4965270A (en) * 1987-05-30 1990-10-23 Beecham Group P.L.C. Purine derivatives
US5334395A (en) * 1988-08-04 1994-08-02 Kremers-Urban Company Method of treating an epstein-barr viral infection
US5284664A (en) * 1988-08-04 1994-02-08 Kremers-Urban Company Method of treating the symptoms of Alzheimer's disease
US5316775A (en) * 1988-08-04 1994-05-31 Kremers-Urban Company Method of treating hepatitis B infection
US5055296A (en) * 1988-08-04 1991-10-08 Wagle Sudhakar S Method of treating chronic fatigue syndrome
DE4020481A1 (de) * 1990-06-27 1992-01-02 Hoechst Ag Verfahren zur herstellung von substituierten acyclischen nukleosiden und dabei auftretende zwischenprodukte
US5233041A (en) * 1991-10-07 1993-08-03 Glaxo Group Limited Synthesis of a 3,4-dihydroxy-1-cyclopentanylpurinone from a 2,3-unsaturated-1-cyclopentanylpurinone
CA2076886C (en) * 1991-11-22 2002-06-11 Masami Igi Method for production of 2-amino-6-halogenopurine and synthesis intermediate therefor
US5329008A (en) * 1993-04-07 1994-07-12 Glaxo Inc. Synthesis of a 3,4-dihydroxy-1-cyclopentanylpurinone
US5565565A (en) * 1994-08-04 1996-10-15 Syntex (U.S.A.) Inc. Preparation of N-9 substituted guanine compounds
US6359114B1 (en) * 1995-06-07 2002-03-19 Aphton Corp. System for method for the modification and purification of proteins
WO2001030739A1 (fr) * 1999-10-27 2001-05-03 Daicel Chemical Industries, Ltd. Procede de production de (meth)acrylates d'adamantyle
CN1091445C (zh) * 1999-12-29 2002-09-25 湖北省医药工业研究院 抗病毒药物中间体、它们的制备及应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4423050A (en) * 1981-05-21 1983-12-27 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
US4355032B2 (en) * 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
AU569462B2 (en) * 1981-08-11 1988-02-04 Wellcome Foundation Limited, The Antiviral purine derivatives

Also Published As

Publication number Publication date
ATE57703T1 (de) 1990-11-15
JPH064631B2 (ja) 1994-01-19
JPS60208954A (ja) 1985-10-21
EP0152965B1 (en) 1990-10-24
US4621140A (en) 1986-11-04
EP0152965A3 (en) 1986-07-23
EP0152965A2 (en) 1985-08-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Free format text: BARZ, P., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 80803 MUENCHEN