DE3573601D1 - Sulfate of 5,6,7,8-tetrahydro-l-erythro-biopterin and process for preparing the same - Google Patents

Sulfate of 5,6,7,8-tetrahydro-l-erythro-biopterin and process for preparing the same

Info

Publication number
DE3573601D1
DE3573601D1 DE8585103417T DE3573601T DE3573601D1 DE 3573601 D1 DE3573601 D1 DE 3573601D1 DE 8585103417 T DE8585103417 T DE 8585103417T DE 3573601 T DE3573601 T DE 3573601T DE 3573601 D1 DE3573601 D1 DE 3573601D1
Authority
DE
Germany
Prior art keywords
sulfate
preparing
same
biopterin
erythro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8585103417T
Other languages
English (en)
Inventor
Hayashi Uchino
Masaaki Azuma
Takehisa Ohashi
Kiyoshi Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanegafuchi Chemical Industry Co Ltd
Original Assignee
Kanegafuchi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanegafuchi Chemical Industry Co Ltd filed Critical Kanegafuchi Chemical Industry Co Ltd
Application granted granted Critical
Publication of DE3573601D1 publication Critical patent/DE3573601D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE8585103417T 1984-03-24 1985-03-22 Sulfate of 5,6,7,8-tetrahydro-l-erythro-biopterin and process for preparing the same Expired DE3573601D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59056584A JPS60199889A (ja) 1984-03-24 1984-03-24 ５，６，７，８−テトラヒドロ−ｌ−エリスロ−ビオプテリンの硫酸塩およびその製法

Publications (1)

Publication Number Publication Date
DE3573601D1 true DE3573601D1 (en) 1989-11-16

Family

ID=13031220

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585103417T Expired DE3573601D1 (en) 1984-03-24 1985-03-22 Sulfate of 5,6,7,8-tetrahydro-l-erythro-biopterin and process for preparing the same

Country Status (7)

Country Link
US (1) US4649197A (de)
EP (1) EP0156330B1 (de)
JP (1) JPS60199889A (de)
AT (1) ATE47141T1 (de)
CA (1) CA1250837A (de)
DE (1) DE3573601D1 (de)
ES (1) ES8607255A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1334654C (en) * 1987-11-30 1995-03-07 Masayasu Kurono Intermediates for synthesizing bh _and its derivatives
US7442372B2 (en) 2003-08-29 2008-10-28 Biomarin Pharmaceutical Inc. Delivery of therapeutic compounds to the brain and other tissues
AU2004291149C1 (en) 2003-11-17 2021-01-21 Biomarin Pharmaceutical Inc. Methods and Compositions for the Treatment of Metabolic Disorders
US8003126B2 (en) 2004-11-17 2011-08-23 Biomarin Pharmaceutical Inc. Stable tablet formulation
CA2588994A1 (en) * 2004-12-08 2006-06-15 Biomarin Pharmaceutical Inc. Methods and compositions for the treatment of pulmonary hypertension of the newborn
EP1965803A1 (de) * 2005-12-05 2008-09-10 Biomarin Pharmaceutical Inc. Verfahren und zusammensetzungen zur behandlung von krankheiten
WO2008089148A1 (en) * 2007-01-12 2008-07-24 Biomarin Pharmaceutical Inc. Method of treating a metabolic or neuropsychiatry disorder with a bh4 derivative prodrug
EP2114944A2 (de) * 2007-01-12 2009-11-11 BioMarin Pharmaceutical Inc. Tetrahydrobiopterin-prodrugs
PT2545939T (pt) 2007-04-11 2021-02-17 Biomarin Pharm Inc Métodos de administração de tetra-hidrobiopterina, composições associadas, e métodos de medição
CN101969953B (zh) * 2008-01-03 2013-01-09 生物马林药物股份有限公司 用于治疗bh4反应性疾病的喋呤类似物
CN101959891A (zh) * 2008-01-07 2011-01-26 生物马林药物股份有限公司 合成四氢生物蝶呤的方法
CN102443006B (zh) 2010-10-13 2016-02-24 因华生技制药股份有限公司 (6r)-四氢生物喋呤盐酸盐的制备方法
US9216178B2 (en) 2011-11-02 2015-12-22 Biomarin Pharmaceutical Inc. Dry blend formulation of tetrahydrobiopterin
WO2019175328A1 (en) 2018-03-14 2019-09-19 Imba - Institut Für Molekulare Biotechnologie Gmbh Bh4pathwayactivationandusethereoffortreatingcancer
WO2019175332A1 (en) 2018-03-14 2019-09-19 Imba - Institut Für Molekulare Biotechnologie Gmbh Bh4 pathway inhibition and use thereof for treating t-cell mediated autoimmune diseases or hypersensitivity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA487930A (en) * 1952-11-11 Roth Barbara Salts of substituted pteridines and method of preparing the same
US3468886A (en) * 1967-10-23 1969-09-23 Us Health Education & Welfare Tetrahydrohomofolic acid sulfate and synthesis thereof
EP0012444B1 (de) * 1978-12-18 1984-07-25 Wachter, Helmut, Univ.-Prof. Dr. Diagnostizierverfahren, insbesondere zur Früherkennung von malignen Tumoren und/oder viralen Erkrankungen und Mittel zu seiner Durchführung
JPS5883691A (ja) * 1981-11-13 1983-05-19 Kanegafuchi Chem Ind Co Ltd １′，２′−ジアシル−（６ｒ，ｓ）−５，６，７，８−テトラヒドロ−ｌ−ビオプテリンおよびその製法
JPS60178887A (ja) * 1984-02-23 1985-09-12 Kanegafuchi Chem Ind Co Ltd ５，６，７，８−テトラヒドロ−ｌ−ビオプテリンの製造法

Also Published As

Publication number Publication date
JPH0469157B2 (de) 1992-11-05
ES8607255A1 (es) 1986-05-16
EP0156330A3 (en) 1986-10-08
JPS60199889A (ja) 1985-10-09
EP0156330A2 (de) 1985-10-02
ATE47141T1 (de) 1989-10-15
ES541445A0 (es) 1986-05-16
EP0156330B1 (de) 1989-10-11
US4649197A (en) 1987-03-10
CA1250837A (en) 1989-03-07

Similar Documents

Publication Publication Date Title
DE3573601D1 (en) Sulfate of 5,6,7,8-tetrahydro-l-erythro-biopterin and process for preparing the same
DE3465293D1 (en) Process for producing gluconic acid
HU911186D0 (en) Process for producing ammonium salts of n-methyl-5,6,7,8-tetrahydropholic acid, for separation of (6rs) diastereomer mixtures and for producing (6r)- and (6s)-alcaline metal and alcaline earth metal salts
EP0274177A3 (en) Process for the production of highly concentrated phosphoric acid
GB9220327D0 (en) Process
DE3562013D1 (en) Process for the separation and purification of salts of diphenylphosphinephenyl-m-sulphonic acid, phenylphospine-di(m-phenylsulphonic acid) and/or triphenylphosphine-tri-(m-sulphonic acid)
HU206669B (en) Process for producing new salts of diphenyl-acetic acid and aryl-propanol-amines
ZA857432B (en) Process for the preparation of 2,4-dichloro-5-fluoro-benzoic acid
EP0266690A3 (en) Method for the production of 2,2-disubstituted 3-chlorpropionic acid esters
DE3261468D1 (en) Process for the isolation of 2-naphthylamine-4,8-disulphonic acid
DE3461528D1 (en) Process for the preparation of n,n'-bis(2-hydroxyethyl) oxamide
YU109684A (en) Process for making derivatives of bicyclo-(3,2,1)-octancarboxylic acid
DE3560900D1 (en) Process for the preparation of salts of alkaline or earth-alkaline metals of benzaldehyde-2,4-disulfonic acid
HK38291A (en) Process for the preparation of asymmetric 1,4-dihydropyridine-carboxylic acid esters
ES8304138A1 (es) Un procedimiento para la produccion de amoxicilina sodica solida.
DE3561154D1 (en) Process for the preparation of storage stable, aqueous melamine-formaldehyde-resin solutions
DE3561460D1 (en) Process for the production of 1-amino-2-naphthol-4-sulphonic acid
GB2137527B (en) Process for preventing the gelation of concentrated aqueous photoactivator solutions
HUT37408A (en) Process for the production of new 3-mercapto-1,2,4-triazole-derivatives
PT85270B (en) Process for the production of vinyldiphosphonic acid and its salts
ES8706703A1 (es) Procedimiento de hemisintesis de vincristina
PL238107A1 (en) Process for preparing pure 6,6-diiodopenicillanic acid
EP0473020A3 (en) Process for the preparation of alkali metal salts of 2-phosphonobutane-1,2,4-tricarboxylic acid
DE3264143D1 (en) Process for the elimination of molybdenum from aqueous solutions of manganese salts
IL86644A (en) Process for the production of salts of aminomalonodinitrile from malonic acid dinitrile by nitrosation, hydrogenation and precipitation with an acid

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee