ATE47141T1 - Sulfat von 5,6,7,8-tetrahydro-l-erythro-biopterin und verfahren zu seiner herstellung. - Google Patents

Sulfat von 5,6,7,8-tetrahydro-l-erythro-biopterin und verfahren zu seiner herstellung.

Info

Publication number
ATE47141T1
ATE47141T1 AT85103417T AT85103417T ATE47141T1 AT E47141 T1 ATE47141 T1 AT E47141T1 AT 85103417 T AT85103417 T AT 85103417T AT 85103417 T AT85103417 T AT 85103417T AT E47141 T1 ATE47141 T1 AT E47141T1
Authority
AT
Austria
Prior art keywords
sulfate
biopterin
erythro
tetrahydro
production
Prior art date
Application number
AT85103417T
Other languages
English (en)
Inventor
Hayashi Uchino
Masaaki Azuma
Takehisa Ohashi
Kiyoshi Watanabe
Original Assignee
Kanegafuchi Chemical Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanegafuchi Chemical Ind filed Critical Kanegafuchi Chemical Ind
Application granted granted Critical
Publication of ATE47141T1 publication Critical patent/ATE47141T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D475/00Heterocyclic compounds containing pteridine ring systems
    • C07D475/02Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT85103417T 1984-03-24 1985-03-22 Sulfat von 5,6,7,8-tetrahydro-l-erythro-biopterin und verfahren zu seiner herstellung. ATE47141T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP59056584A JPS60199889A (ja) 1984-03-24 1984-03-24 5,6,7,8−テトラヒドロ−l−エリスロ−ビオプテリンの硫酸塩およびその製法
EP85103417A EP0156330B1 (de) 1984-03-24 1985-03-22 Sulfat von 5,6,7,8-Tetrahydro-L-erythro-biopterin und Verfahren zu seiner Herstellung

Publications (1)

Publication Number Publication Date
ATE47141T1 true ATE47141T1 (de) 1989-10-15

Family

ID=13031220

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85103417T ATE47141T1 (de) 1984-03-24 1985-03-22 Sulfat von 5,6,7,8-tetrahydro-l-erythro-biopterin und verfahren zu seiner herstellung.

Country Status (7)

Country Link
US (1) US4649197A (de)
EP (1) EP0156330B1 (de)
JP (1) JPS60199889A (de)
AT (1) ATE47141T1 (de)
CA (1) CA1250837A (de)
DE (1) DE3573601D1 (de)
ES (1) ES8607255A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3853711T2 (de) * 1987-11-30 1996-01-11 Vitamin Kenkyusho Kk Zwischenverbindungen für die Synthese von 5,6,7,8-Tetrahydro-L-erythro-biopterin und seiner Derivate.
US7442372B2 (en) 2003-08-29 2008-10-28 Biomarin Pharmaceutical Inc. Delivery of therapeutic compounds to the brain and other tissues
EP1708690B1 (de) * 2003-11-17 2016-07-20 BioMarin Pharmaceutical Inc. Behandlung von phenylketonurie mit bh4
CN101132776A (zh) 2004-11-17 2008-02-27 生物马林药物股份有限公司 稳定的四氢生物喋呤片剂制剂
US20100130500A1 (en) * 2004-12-08 2010-05-27 Biomarin Pharmaceutical Inc. Methods and compositions for the treatment of pulmonary hypertension of the newborn
JP2009518415A (ja) * 2005-12-05 2009-05-07 バイオマリン ファーマシューティカル インコーポレイテッド 疾患の処置のための方法および組成物
JP2010515747A (ja) * 2007-01-12 2010-05-13 ビオマリン プハルマセウトイカル インコーポレイテッド テトラヒドロビオプテリンプロドラッグ
WO2008089148A1 (en) * 2007-01-12 2008-07-24 Biomarin Pharmaceutical Inc. Method of treating a metabolic or neuropsychiatry disorder with a bh4 derivative prodrug
HUE058030T2 (hu) 2007-04-11 2022-06-28 Biomarin Pharm Inc Tetrahidrobiopterin emelt fenilalanin szintekkel összefüggõ állapotok kezelésében történõ alkalmazásra
AU2008347005B2 (en) 2008-01-03 2013-10-03 Biomarin Pharmaceutical Inc. Pterin analog for treating BH4 responsive condition
MX2010007452A (es) * 2008-01-07 2010-08-18 Biomarin Pharm Inc Metodo para sintetizar tetrahidrobiopterin.
CN102443006B (zh) 2010-10-13 2016-02-24 因华生技制药股份有限公司 (6r)-四氢生物喋呤盐酸盐的制备方法
US9216178B2 (en) 2011-11-02 2015-12-22 Biomarin Pharmaceutical Inc. Dry blend formulation of tetrahydrobiopterin
WO2019175332A1 (en) 2018-03-14 2019-09-19 Imba - Institut Für Molekulare Biotechnologie Gmbh Bh4 pathway inhibition and use thereof for treating t-cell mediated autoimmune diseases or hypersensitivity
WO2019175328A1 (en) 2018-03-14 2019-09-19 Imba - Institut Für Molekulare Biotechnologie Gmbh Bh4pathwayactivationandusethereoffortreatingcancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA487930A (en) * 1952-11-11 Roth Barbara Salts of substituted pteridines and method of preparing the same
US3468886A (en) * 1967-10-23 1969-09-23 Us Health Education & Welfare Tetrahydrohomofolic acid sulfate and synthesis thereof
DE2967143D1 (en) * 1978-12-18 1984-08-30 Wachter Helmut Diagnostic method, especially for the early recognition of malignant tumors and/or viral diseases, and means to carry it out
JPS5883691A (ja) * 1981-11-13 1983-05-19 Kanegafuchi Chem Ind Co Ltd 1′,2′−ジアシル−(6r,s)−5,6,7,8−テトラヒドロ−l−ビオプテリンおよびその製法
JPS60178887A (ja) * 1984-02-23 1985-09-12 Kanegafuchi Chem Ind Co Ltd 5,6,7,8−テトラヒドロ−l−ビオプテリンの製造法

Also Published As

Publication number Publication date
US4649197A (en) 1987-03-10
JPS60199889A (ja) 1985-10-09
JPH0469157B2 (de) 1992-11-05
ES8607255A1 (es) 1986-05-16
DE3573601D1 (en) 1989-11-16
EP0156330A3 (en) 1986-10-08
EP0156330B1 (de) 1989-10-11
ES541445A0 (es) 1986-05-16
CA1250837A (en) 1989-03-07
EP0156330A2 (de) 1985-10-02

Similar Documents

Publication Publication Date Title
ATE47141T1 (de) Sulfat von 5,6,7,8-tetrahydro-l-erythro-biopterin und verfahren zu seiner herstellung.
PT87355A (pt) Process for the production of folinic acid
ATE123777T1 (de) Verfahren zur herstellung von (6s)- und (6r)- tetrahydrofolsäure.
ATE30049T1 (de) Verfahren zur herstellung von d-milchsaeure unter verwendung von lactobacillus bulgaricus dsm 2129.
DE3578687D1 (de) N-substituierte neuraminsaeure-derivate und verfahren zu ihrer herstellung.
ATE47861T1 (de) Verfahren zur herstellung von nphosphonomethylglycin.
DE59003697D1 (de) Verfahren zur Herstellung von Chromsäure.
ATE36528T1 (de) Verfahren zur herstellung von lagerstabilen benzothiazolsulfenamiden.
ATE116636T1 (de) Verfahren zur herstellung von 2,6- dichlordiphenylaminessigsäurederivaten.
DE3678139D1 (de) Neue kristalline salze von aryloxy-propanolaminen, verfahren zu ihrer herstellung und ihre verwendung.
EP0266690A3 (en) Method for the production of 2,2-disubstituted 3-chlorpropionic acid esters
DE3883911D1 (de) Verfahren zur Herstellung von Orotsäure durch Fermentierung.
ATE23989T1 (de) Verfahren zur herstellung von n,n'-bis(2hydroxyethyl)oxamid.
DE3578862D1 (de) Verfahren zur herstellung von 5,6,7,8-tetrahydrofolsaeure.
ATE32718T1 (de) Verfahren zur herstellung von (s)glyceraldehydacetonid.
ATE40986T1 (de) Photochemisches verfahren zur herstellung von aminen.
DE69004244D1 (de) Verfahren zur Herstellung von hohen Anteilen des trans,trans-Isomeren enthaltenden 4,4'-Diisocyanatodicyclohexylmethan.
DE59003699D1 (de) Verfahren zur Herstellung von Chromsäure.
ATE17487T1 (de) Reine 6,6-diiodopenicillansaeure und verfahren zu deren herstellung.
DE3672926D1 (de) Verfahren zur herstellung von 6-amino-penicillansaeure-1,1-dioxyd durch oxydation von 6-amino-penicillansaeure.
ATE28621T1 (de) Verfahren zur herstellung von pharmakologisch aktiven verbindungen die eine sulfoxidgruppe enthalten.
DE3870737D1 (de) Verfahren zur herstellung von hochreiner weinsaeure.
IL86644A (en) Process for the production of salts of aminomalonodinitrile from malonic acid dinitrile by nitrosation, hydrogenation and precipitation with an acid
ATE50795T1 (de) Verfahren zur bakteriellen herstellung von gluconsaeure.
DE69000437D1 (de) Verfahren zur herstellung von nichtionischen oberflaechenaktiven mitteln aus 1,2-isopropyliden-3-epoxypropylglycerol und einer carbonsaeure, nichtionische oberflaechenaktive mittel und ihre anwendung.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee