DE3561599D1 - Process for the preparation of fluoroalkoxy-amino-pyrimidines - Google Patents
Process for the preparation of fluoroalkoxy-amino-pyrimidinesInfo
- Publication number
- DE3561599D1 DE3561599D1 DE8585810120T DE3561599T DE3561599D1 DE 3561599 D1 DE3561599 D1 DE 3561599D1 DE 8585810120 T DE8585810120 T DE 8585810120T DE 3561599 T DE3561599 T DE 3561599T DE 3561599 D1 DE3561599 D1 DE 3561599D1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- image
- alkyl
- hydrogen
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- -1 bromofluoromethyl Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 abstract 1
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- VOPWNXZWBYDODV-UHFFFAOYSA-N Chlorodifluoromethane Chemical compound FC(F)Cl VOPWNXZWBYDODV-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- GRCDJFHYVYUNHM-UHFFFAOYSA-N bromodifluoromethane Chemical compound FC(F)Br GRCDJFHYVYUNHM-UHFFFAOYSA-N 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 125000004773 chlorofluoromethyl group Chemical group [H]C(F)(Cl)* 0.000 abstract 1
- UUAGAQFQZIEFAH-UHFFFAOYSA-N chlorotrifluoroethylene Chemical group FC(F)=C(F)Cl UUAGAQFQZIEFAH-UHFFFAOYSA-N 0.000 abstract 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- HBCQSNAFLVXVAY-UHFFFAOYSA-N pyrimidine-2-thiol Chemical compound SC1=NC=CC=N1 HBCQSNAFLVXVAY-UHFFFAOYSA-N 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical group FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/593,218 US4542216A (en) | 1984-03-27 | 1984-03-27 | Process for producing fluoroalkoxyaminopyrimidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3561599D1 true DE3561599D1 (en) | 1988-03-17 |
Family
ID=24373885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8585810120T Expired DE3561599D1 (en) | 1984-03-27 | 1985-03-21 | Process for the preparation of fluoroalkoxy-amino-pyrimidines |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4542216A (enrdf_load_stackoverflow) |
| EP (1) | EP0158594B1 (enrdf_load_stackoverflow) |
| JP (1) | JPS60218378A (enrdf_load_stackoverflow) |
| AT (1) | ATE32460T1 (enrdf_load_stackoverflow) |
| DE (1) | DE3561599D1 (enrdf_load_stackoverflow) |
| IL (1) | IL74708A (enrdf_load_stackoverflow) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4692524A (en) * | 1986-05-02 | 1987-09-08 | Ciba-Geigy Corporation | Process for the preparation of pyrimidine derivatives |
| US4900827A (en) * | 1988-12-22 | 1990-02-13 | Ciba-Geigy Corporation | Process for the preparation of pyrimidine derivatives |
| JPH0662588B2 (ja) * | 1989-01-24 | 1994-08-17 | 川口化学工業株式会社 | ４，６―ビス（ジフルオロメトキシ）―２―メチルチオピリミジンの製造法 |
| HU203736B (en) * | 1989-04-06 | 1991-09-30 | Gyogyszerkutato Intezet | Process for producing new thiouracil-derivatives and pharmaceutical compositions containing them |
| US4904762A (en) * | 1989-08-21 | 1990-02-27 | Xerox Corporation | Toner compositions with charge enhancing additives |
| DE4007316A1 (de) * | 1990-03-08 | 1991-09-12 | Basf Ag | 2-amino-(fluoralkoxy-pyrimidine) und verfahren zu ihrer herstellung |
| DE4024761A1 (de) * | 1990-08-03 | 1992-02-06 | Basf Ag | 2-amino-(fluoralkoxy-1,3,5-triazine) und verfahren zu ihrer herstellung |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD109170A1 (enrdf_load_stackoverflow) * | 1974-01-24 | 1974-10-20 | ||
| GB1523274A (en) * | 1974-08-05 | 1978-08-31 | Ici Ltd | Herbicidal compositions containing substituted pyrimidine |
| US4480101A (en) * | 1981-07-16 | 1984-10-30 | Ciba-Geigy Corporation | Fluoroalkoxy-aminopyrimidines |
| US4443243A (en) * | 1981-07-16 | 1984-04-17 | Ciba-Geigy Corporation | N-Phenylsulfonyl-N-triazinylureas |
| IT1211096B (it) * | 1981-08-20 | 1989-09-29 | Lpb Ist Farm | Pirimidine e s.triazinici adattivita' ipolipidemizzante. |
| MA19680A1 (fr) * | 1982-01-11 | 1983-10-01 | Novartis Ag | N- arylsulfonyl - n' - pyrimidinylurees. |
| BR8302396A (pt) * | 1982-05-12 | 1984-01-10 | Du Pont | Composto;composicao e processo adequados para controlar o crescimento de vegetacao indesejada |
-
1984
- 1984-03-27 US US06/593,218 patent/US4542216A/en not_active Expired - Lifetime
-
1985
- 1985-03-21 EP EP85810120A patent/EP0158594B1/de not_active Expired
- 1985-03-21 AT AT85810120T patent/ATE32460T1/de not_active IP Right Cessation
- 1985-03-21 DE DE8585810120T patent/DE3561599D1/de not_active Expired
- 1985-03-25 IL IL74708A patent/IL74708A/xx not_active IP Right Cessation
- 1985-03-27 JP JP60063178A patent/JPS60218378A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| IL74708A0 (en) | 1985-06-30 |
| EP0158594B1 (de) | 1988-02-10 |
| JPH0550514B2 (enrdf_load_stackoverflow) | 1993-07-29 |
| ATE32460T1 (de) | 1988-02-15 |
| IL74708A (en) | 1988-05-31 |
| JPS60218378A (ja) | 1985-11-01 |
| EP0158594A1 (de) | 1985-10-16 |
| US4542216A (en) | 1985-09-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR960008665B1 (en) | Process for preparing florfenicol, its analogs and oxazoline intermediates thereto | |
| IL71664A0 (en) | Fluoroalkoxy compounds,process for their preparation,and pharmaceutical composition containing the same | |
| HUT68166A (en) | Process for preparing substituted piperidines | |
| HU9401584D0 (en) | Preparation of substituted piperidines | |
| DE3561599D1 (en) | Process for the preparation of fluoroalkoxy-amino-pyrimidines | |
| IL92152A (en) | Process and intermediates for the preparation of 3,5-dimethyl-4- methoxypyridine derivatives | |
| DK111982A (da) | N-(2,2,2-trifluorethyl)-n-alkylazolyloxyeddikesureamider,fremgangsmaade og mellemprodukter til deres fremstilling og deres anvendelse som herbicider | |
| ZA888571B (en) | New substituted dicarboxylic acid-bis(3,5-dicarbamoyl-2,4,6-triiodoanilides),process for their production as well as x-ray contrast media containing them | |
| HU908020D0 (en) | Process for producing benzaldehydes | |
| GR3005520T3 (enrdf_load_stackoverflow) | ||
| NO932952L (no) | Natriumhydrosulfittfremstilling med höyt utbytte | |
| GR3018765T3 (en) | Process for the preparation of N-(2-hydroxyethyl)-2-hydroxymethyl-3,4,5-trihydroxy-piperidine and of intermediates. | |
| DE3160639D1 (en) | Fluor-containing azomethines, preparation thereof and use thereof as intermediates | |
| GB8522156D0 (en) | Producing chemical compounds | |
| DE3361174D1 (en) | Process for the preparation of alphaalkylaminoaldehydes | |
| ZA907974B (en) | 3-aroyl-2-oxindole-1-carboximides | |
| AT383811B (de) | Verfahren zur herstellung von monoalkalisalzen von 7-amino-3-cephem-4-carbonsaeurederivaten | |
| FR2592377A1 (fr) | Procede de preparation de chloroformiate de trichloromethylphenyle | |
| GR3015725T3 (en) | Intermediates in the preparation of 4,5-difluoroanthranilic acid. | |
| ES8608534A1 (es) | Procedimiento para la fabricacion de etoposido. | |
| FI882824L (fi) | Nya heterocykliska foereningar och deras framstaellning. | |
| ES535991A0 (es) | Un procedimiento para preparar un 10-ftalil-1, 5-diprotegido-1, 5, 10-triazadecano |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: NOVARTIS AG, BASEL, CH |
|
| 8339 | Ceased/non-payment of the annual fee |