DE3543221C2 - Cosmetic compositions for the scalp and hair treatment procedures - Google Patents

Description

The present invention relates to new, cosmetic Compositions for the scalp, which is a combination based on acidic mucopolysaccharides and of Containing peptides in association with a placental extract as well as a hair treatment procedure.

There are already numerous cosmetic products for hair hygiene and for combating hair loss on the market.

These products often include biotin, vitamin B₆, pantothenic acid or a derivative thereof, the role of which enzymatic stimulation in terms of growth Phaneren is well known.

The sulfur-containing amino acid cystine, which is responsible for the Synthesis of keratin, the hair protein, is indispensable, is also used in this type of products.

Certain products contain plant extracts, such as essential oils.

Other cosmetic products contain one of the substances which comprises the compositions according to the invention are and will be described later.  

They include, for example, either a placental Extract alone or sulfopolysaccharides alone.

According to the invention, it has now been found that a particularly effective composition can be obtained by providing the association described below. The invention thus relates to cosmetic compositions for use on the scalp, which are characterized in that they comprise a combination A comprising the following four products:
Acid mucopolysaccharides extracted from animal connective tissue,
a bacterial cell proteolysate derived from the culture of a bacteria of the family Bacillaceae in controlled environments,
Peptides from calf serum and
Peptides of embryonic skin,
wherein this combination A is associated with an animal placental extract.

The combination A associates with mucopolysaccharides Low molecular weight peptides that are to peptides of calf serum and of embryonic skin and are peptides of the bacterial proteolysate.

The beneficial effect of the low molecular weight peptides in the field of hygiene of the hair follicle or the hair follicle has been shown. As a matter of fact was the existence of interactions between the Follicle cells and epidermal cells via skin inducers demonstrated (R. Fleischmajer and R. E. Billingham, "Epithelial-Mesenchymal Interactions" Williams and Wilkins - Baltimore 1968).  

It is thus likely that cell physiology of human skin affected by an induction factor becomes.

This induction factor has a proteinic nature (N.K. Wessels, Proc Natu. Acad Sci., USA 1964, 52, 252) and a low molecular weight (R.A. Briggaman and C.E. Wheeler, J. Invest. Derm. 1968, 51, 454).

All this explains the presence of low-peptides Molecular weight in combination A.

In addition, the acidic mucopolysaccharides of the Connective tissue normally attached to proteins, in particular Collages, bound.

The combination A thus gives this complementarity of the Protein mucopolysaccharide action again.

Moreover, the sulfated mucopolysaccharides bring the organic sulfur, which is responsible for keratin protein synthesis it is essential, since it is the stable disulfide Bindings of the hair ensures.

In fact, in humans, every metabolic disorder, to one with the exogenous supply of sulfur or the recovery of the same associated defect leads to the expiration of the pilar cycle back.

In addition, everyone's hair folliness became of the four products in combination A. shown.  

The characteristics of each of the products of the combination give her an effectiveness in terms of Regulation of seborrhea, reduction of dandruff and in terms of preventing excessive Hair loss.

The combination A stimulates cell growth and the Cell respiration and thus the cell metabolism of Hair follicle.

In addition, the beneficial effects of Placenta extracts are known in cosmetology. you are especially on their mitotic activity, their fortune, to increase the oxygen consumption of epidermal cells and to stimulate the microcirculation of the scalp, due.

In the compositions according to the invention are the properties the combination A and the placental extract combined to improve the food intake of the Hair Salts as well as a better rinsed out and one Stimulation of cell turnover ("turn over") too lead, resulting in an increase in oxygen consumption expressing the cells.

In addition, thanks to the mineral elements and the amino acids it contains, the placental extract to an increased cell metabolism.

The combination A and the placenta extract thus act mutually and jointly in the invention Compositions to be a very effective, biostimulating Taking effect on the regrowth of the hair, taking the addition of a placental extract improves the effectiveness  the combination A through a synergy and a complementary Reinforced effect.

The cosmetic compositions according to the invention are hygiene or care products that are for relief are determined by capillary defects. Among these can hyperseborrhea, the appearance of dandruff and as a more serious problem, more or less call advanced hair loss. These inconveniences are sometimes due to hormonal imbalances, in particular in the case of hyperseborrhea, due, are however, often the result of poor hair hygiene or care, such. B. the use of very aggressive alkaline shampoos. Especially with hair loss the influence of heredity plays a significant role. Hair loss can also be as a result of taking certain Medicines, a childbirth or infectious Diseases occur. Nevertheless, in all these cases the role of hair care in the development of Do not deny hair loss.

Thanks to the association of the combination A with a placental Extract containing them are the invention Compositions relating to inhibition Hair loss particularly effective. They favor also the regrowth of the hair stronger, diminish the seborrhoea and improve the overall appearance of the hair.

The invention particularly relates to cosmetic compositions, characterized in that the Combination A contains:

10 to 30% by weight of mucopolysaccharides,
20 to 30% by weight of bacterial cell proteolysate,
2 to 10 wt .-% of calf serum peptides and
20 to 30% by weight peptides of embryonic skin,

and in particular cosmetic compositions resulting therefrom characterized in that they are 2 to 20 wt .-% of Combination A with 1 to 10 wt .-% placental extract.

The mucopolysaccharides contained in the combination A. are water-soluble sulfated polysaccharides which form the connective tissue. Among the most common you can to name hyaluronic acid and chondroitin sulfuric acids.

The invention also relates in particular to cosmetic compositions, which are characterized in that the mucopolysaccharides they contain, the antrum Pylorus region and cartilage substances of cattle and derive from the duodenum of the pig.

The invention also relates to cosmetic compositions, characterized in that the bacterial Cell proteolysate they contain from small peptides exists and bacteria of the genus Bacillus comes from, which were cultivated on organic environments, with flour or meal from under the mane of the horse enriched skin tissues are enriched.

These special fragments are released by bacteria, during their growth phase, that in the cultural milieu metabolize present cell meal.

The invention relates above all to cosmetic compositions, characterized in that the Peptides of embryonic skin originate from bovine fetuses and  that the placental extract they contain bovine comes.

The calf serum peptides and the peptides are embryonic Skin is made from protein substrates using standard techniques obtained by enzymatic proteolysis.

For example, the placenta extracts become pregnant Cow according to that described in FR-PS 1 440 616 Method removed.

More particularly, the invention relates to cosmetic compositions characterized in that the combination A is a product marketed under the name "Trichopeptide®" comprising the following components:
Tissue extract of veal,
hydrolyzed mucopolysaccharides,
Serum albumin and
Tissue extract from the horse.
(Trichopeptide® is a product sold by the company Sederma and corresponds to a name of the registered trademark.)

The present invention also relates to a hair treatment method to combat hair loss, in it consists of being on the scalp, especially through Massage, an effective amount of a cosmetic composition of the invention applies.

The cosmetic compositions according to the invention can in the usual way in cosmetology for hair care products used forms. they lay for example, in the form of hair creams or in the form aqueous or aqueous-alcoholic lotions or in Form of gels in front. You can also use preservatives and fragrance-emitting substances.

The invention particularly relates to compositions, characterized in that they are in the form of  Lotions, whether in vials or in ampoules, are present.

The lotion is preferably in small applicator Plastic vial with clamp with a content of For example, 7 ml ago, which is very practical in the application are.

The contents of the vial applicator will be crested to the bottom of the hair and over the entire scalp distributed in the evening and in the morning.

The consumer must until the complete penetration of the Massage the product gently.

The treatment of the seizure is a vial every two days for six weeks to use what Conservation treatment with two vials per Week for one to two months.

The treatment must be done once or twice a year (spring and autumn).

The above, various, cosmetic Shapes can be made by usual methods, as on this Be applied.

The following examples illustrate the invention.

example 1 hair lotion G Combination A [Trichopeptide®] 10 Placenta extract 3 propylene glycol 1   ethyl alcohol 10 preservative 0.1 scent-imparting composition 0.2 purified water q.s.p. 100

Example 2 hair cream G Combination A [Trichopeptide®] 5 Placenta extract 6 glyceryl stearate 4 propylene glycol 4 preservative 0.3 scent-imparting composition 0.2 purified water q.s.p. 100

Example 3

Examination of a lotion against hair loss analogous to those of Example 1 in a hospital service of Dermatology.

One examined the effect of the lotion against hair loss in 60 patients. This group sat down on the following Way together:

12 patients of female sex, whose age ranges from 24 to 62 years,
48 male patients whose age ranges from 19 to 50 years.

These two patient groups were on the following Split way.

Patients of the female sex

Regarding the importance of her hair loss could these patients are divided into two main groups:

Seborrheic hair loss, which is so pronounced that the scalp becomes clearly visible in the area of the temporal and temporal extensions of the crown 5 cases severely advanced, seborrheic hair loss with a loss of more than 2/3 of the hair, with the scalp clearly visible in the entire area of the crown 7 cases in terms of the severity of seborrhoea, these 12 patients are distributed in the following way: @ moderate seborrhoea, which requires shampooing per week 1st case Seborrhoea, which requires two shampooings a week 4 cases Seborrhea, with intense secretion that requires shampooing every 2 to 3 days 7 cases

Male patients

Distribute with regard to the severity of your hair loss the male patients are as follows:

Seborrheic hair loss corresponding to stage I seborrheic hair loss 10 cases serborrheic hair loss corresponding to stage II seborrheic hair loss 27 cases seborrheic hair loss corresponding to stage III seborrheic hair loss 11 cases in terms of severity of seborrhoea, these 48 patients are divided as follows: @ considerable seborrhoea 14 cases Seborrhoea with intense secretion 34 cases

Technique of treatment - period of use of the product

In all patients, the hair product was used during one Period of 4 months with a frequency of 3 applications applied per week. The presentation of the product made in the form of bottles with drop counting its use easy. It becomes the product here applied to the scalp by looking at the zones of the Scalp on which the hair is less dense, more intense treated and massaged to the best possible penetration to reach.

In these patients, no additional local was done or general treatment other than the setting of Shampooing detergents, a requirement associated with all patients one year before receiving this treatment was realized.

All of these patients were assessed once a month. At each of these check-ups one tried the look and quality of the hair and more or to evaluate less seborrheic appearance of the scalp (it being understood that the patients at least Appraised 3 to 4 days after their last shampooing were).

Above all, one noted the nature and meaning of one eventual regrowth.

Results

In this group of 60 patients, one patient had to Interrupt treatment due to itching of the scalp. In the 59 patients, during a period 4 months the examined lotion against hair loss used, one could notice the following:  

Regarding the regrowth of the hair

A good effect in 21 cases,
an average effect in 35 cases,
no effect in 3 cases.

Regarding the greasy and seborrheic appearance the scalp

A good effect in 4 cases
an average effect in 39 cases,
no effect in 16 cases.

Remarks Importance of hair loss

This parameter was not included in the observations, because he is too subjective and too difficult to assess is seen. However, it must be pointed out very often, as patients do both Sex since the end of the first month of treatment a very significant slowdown in the Hair loss occurs.

Effect on hair regrowth

Regarding regrowth of hair, the following were Results determined:

in 12 female patients:
8 good results
4 average results

in 48 male patients:
13 good results
31 average results
3 without result
1 unregistered result

Women have a tendency to regrow first on the periphery of the scalp in the area of Forehead and temples by appearance smaller, thinner and close together hair.

The thickening of the hair then gradually took over Center to where during the months the bald zone of the vertex was reduced.

At men it was observed at favorable cases regrowth at the periphery of the zones of hair loss of small, thin hair and then on the zones the hair loss itself, with the regrowth of a thin and closely spaced fluff gradually increased in strength and turned into fine but normal hair in the area of the peripheral zones.

It must be pointed out that this process in the generally only from the third or fourth month can be observed and that he is slow and gradual expires, taking in the most favorable among women Cases received a complete renewal of the hair can. He is less complete with the men and progresses very slowly.

Regarding the seborrheic appearance of the scalp

To date, you have no truly reliable and precise scientific criterion for the measurement Seborrhoea in the scalp area. The experiments were performed with the help of the "sebum test" and varied from one measurement or rating to another Results. Moreover, numerous Intervene factors that are capable of intervening the meaning  to modify the seborrhoeic outflow, for example Nutritional factors as well as the period cycle the women.

All of these reasons made you feel like this time to settle for that, the evaluation partly on to support the opinion of the patient due to the Possibility judged he had to his shampooing agent to apply more or less frequently, and partly to rely on the clinical examination, always 3 or 4 days after the last shampooing was carried out.

Again, it is the women who have the results more striking were:

good effect 2 cases avg. effect 8 cases no effect 2 cases

The man was obtained in the 47 patients in whom one had continued this treatment for 4 months, the following results:

good effect 2 cases avg. effect 31 cases no effect 14 cases

tolerance

The tolerance of the examined lotion against hair loss was perfect in 59 of our patients. Only in In one case, the treatment had to be interrupted, the patient has a recurrent itch a few days after he stopped using the Products had resumed, complained. During the examination the scalp was erythematous, with some Grindige places were present.  

This unique observation did not represent the excellent Total tolerance of the product in question.

Conclusion

The totality of the results can be the following way be summarized.

Effect on the regrowth of the hair good results 21 avg. Results 35 negative results 3

Effect on seborrhoea good results 4 avg. Results 39 negative results 16

These results can be considered extremely favorable become.

Incidentally, the tolerance except this one was Patients in all other patients completely. The Compatibility of the product was good and his performance was rated as practical and easy to use.

Claims (8)

Cosmetic compositions for use on the scalp, characterized in that they comprise a combination A comprising the following four products:
Acid mucopolysaccharides extracted from animal connective tissue,
a bacterial cell proteolysate derived from the culture of a bacterium of the Bacillaceae family from controlled environments,
Peptides of calf serum and
Peptides of embryonic skin,
wherein this combination A is associated with an animal placental extract. 2. Cosmetic compositions according to claim 1, characterized in that they contain 2 to 20 wt .-% of the combination A with 1 to 10 wt .-% placental extract, and that the combination A comprises: 10 to 30 wt .-% mucopolysaccharides,
20 to 30% by weight of bacterial cell proteolysate,
2 to 10 wt .-% of calf serum peptides and
20 to 30% by weight of peptides of embryonic skin. 3. Cosmetic compositions according to one of Claims 1 or 2, characterized in that the mucopolysaccharides, containing them, the antrum pylorus Region and cartilage of cattle and the duodenum of Pigs come from. 4. Cosmetic compositions according to one of Claims 1 to 3, characterized in that the bacterial Cell proteolysate they contain from small Peptides exists and bacteria of the genus Bacillus comes from organic, flour or meal of skin tissue under the mane of the horse enriched environments have been cultivated. 5. Cosmetic compositions according to one of Claims 1 to 4, characterized in that the Peptides of embryonic skin originate from bovine fetuses. 6. Cosmetic compositions according to one of Claims 1 to 5, characterized in that the Placenta extract, which they contain, originates from cattle.   7. Cosmetic compositions according to one of Claims 1 to 6, characterized in that they in the form of lotions. 8. Hair treatment process for combating Hair loss, characterized in that one on the Scalp, especially by massages, a sufficient Amount of a cosmetic composition according to one of claims 1 to 7 applies.