DE3543221A1 - NEW COSMETIC COMPOSITIONS FOR THE SCALP - Google Patents

Description

FiOUSSEL-UCLAF
Paris, France

New cosmetic compositions for the scalp

description

The present invention relates to new cosmetic compositions for the scalp which comprise a combination based on acidic mucopolysaccharides and peptides in association with a placenta extract.

There are already numerous cosmetic products for hair hygiene and for combating hair loss on the market.

These products often include biotin, vitamin Bg, pantothenic acid, or a derivative thereof, whose role is played by enzymatic ^ stimulation with regard to the growth of Phaneren is well known.

The sulfur-containing amino acid cystine, which is essential for the synthesis of keratin, the hair protein, is also used in this type of product.

Certain products contain plant extracts, such as essential oils.

Other cosmetic products contain one of the substances included in the compositions of the invention and which will be described later.

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For example, they either include a placenta extract alone or sulfopolysaccharides alone.

According to the invention it has now been found that you have a special effective composition can be obtained by providing the association described below. The invention thus relates to cosmetic compositions for use on the scalp, which are characterized are that they comprise a combination A that contains the following four products:

Acid mucopolysaccharides extracted from animal connective tissue,

a bacterial cell proteolysate that controlled the culture of a bacteria of the Bacillaceae family Milieus comes from,

Peptides from calf serum and Embryonic skin peptides,

this combination A being associated with an animal placenta extract.

Combination A associates mucopolysaccharides with low molecular weight peptides, which are peptides from calf serum and embryonic chew and peptides from bacterial proteolysate.

The beneficial effects of low molecular weight peptides in the field of the hygiene of the hair follicle or the hair follicle has been shown. As a matter of fact became the existence of interactions between the follicular cells and the epidermal cells via skin inductors proven (R. Fleischmajer and R.E.Billingham, "Epithelial-Mesenchymal Interactions" Williams and Wilkins - Baltimore 1968).

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It is thus likely that the cell physiology of the human skin is influenced by an induction factor.

This induction factor has a proteinaceous nature (N.K.V / essels, Proc.Natu.Acad.8ci.USA 1964, 52, 252) and a low molecular weight (R.A. Briggaman and CE. Wheeler, J. Invest.Derm. 1968, 51, 454).

All of this explains the presence of low molecular weight peptides in the combination A.

In addition, the acidic mucopolysaccharides of connective tissue are normally attached to proteins, in particular to Collages, bound.

The combination A thus gives this complementarity to the Protein mucopolysaccharide effect again.

In addition, the sulfated mucopolysaccharides bring in the organic sulfur, which is necessary for keratin protein synthesis is essential because it ensures the stable disulfide bonds of the hair.

In fact, in humans, any metabolic disorder that results in an exogenous intake of sulfur or falls the recovery of the same connected defect leads back to the expiry of the Pilar cycle.

In addition, the hair follicle-forming faculty of everyone became of the four products contained in combination A are shown.

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The characteristics of one, each of the products of the combination make it effective in regulating seborrhea and reducing dandruff and in terms of preventing excessive hair loss.

Combination A stimulates cell growth and cell respiration and thus the cell metabolism Hair follicles.

In addition, the beneficial effects of placenta extracts are known in cosmetology. they are mainly due to their mitotic activity, their ability to increase the oxygen consumption of the epidermal cells and stimulate the microcirculation of the scalp, to be returned *

In the compositions according to the invention are the properties Combination A and placenta extract combined to improve the supply of air to the Hair follicles as well as better rinsed out and a stimulation of cell renewal ("turn over") lead, which is expressed in an increase in the oxygen consumption of the cells.

In addition, thanks to the mineral elements and the amino acids it contains, the placenta bears: ibo contributes to an increased cell metabolism.

The combination A and the I'lacenta extract thus work reciprocally and jointly in the compositions according to the invention, to obtain a very effective, bio-stimulating effect on hair regrowth, whereby the addition of a placenta extract increases the effectiveness

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the coordination A dura j a synergy and a complement tary effect intensified.

The cosmetic compositions according to the invention are hygiene and care products that are intended to relieve capillary drooping. Among these can one has hyperseborrhea, the appearance of dandruff and, as a more serious problem, more or less advanced hair loss. This uncomfortable Occasionally, problems can be traced back to hormonal disorders, especially in the case of hyperseborrhea however, it is often the result of poor hair hygiene or care, such as the use of very aggressive hair products alkaline shampoos. Heredity plays a particularly important role in hair loss. The hair loss can also result from the use of certain medications, a childbirth or from infectious Diseases occur. Still, in all of these cases, the role of hair care in developing the hair care Hair loss cannot be denied.

Thanks to the association of combination A with a placenta extract, they contain the compositions of the invention in terms of inhibition particularly effective against hair loss. They also encourage hair regrowth stronger, diminish the seborrhea and improve the general appearance of the hair.

The invention relates in particular to cosmetic compositions, which are characterized in that the combination A contains:

10 to 30 wt / mucopolysaccharide, 20 to 30 wt. ^c / o bacterial cell proteolysate,

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? - up to 10% by weight of peptides from calf serum and ? .O to 30 Gev /./ a peptides of embryonic skin, and in particular cosmetic compositions which are characterized in that they contain 2 to 20% by weight Contains combination A with 1 to 10% by weight placenta extract.

The mucopolysaccharides contained in combination A are water-soluble, sulfated polysaccharides that form the connective tissue. Among the most common are hyaluronic acid and chondroitin sulfuric acids.

The invention also relates in particular to cosmetic compositions, which are characterized in that the mucopolysaccharides they contain are from the antrum-pyloric region and cartilage substances come from cattle and the duodenum of the pig.

The invention also relates to cosmetic compositions which are characterized in that the bacterial cell per teolysat, which they contain, consists of small peptides and comes from bacteria of the genus Bacillus, that were cultivated in organic environments, with flour or meal from under the horse's mane located skin tissues are enriched.

These special fragments are released by bacteria that live in the TuI tower environment during their growth phase metabolize any cell meal present.

The invention relates primarily to cosmetic compositions, which are characterized in that the peptides of embryonic skin are derived from bovine fGten and

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that the placenta extract they contain is cattle comes from.

The calf serum peptides and the embryonic peptides Skins are obtained from protein substrates using conventional enzymatic proteolysis techniques.

The placenta extracts, for example, are used in pregnant women Cow removed by the method described in FR-PS 1,440,616.

The invention relates above all to cosmetic compositions which are characterized in that combination A is a product marketed under the name "Trichopeptide ^ '". Trichopeptides ^v; is a product sold by Sederma and corresponds to a designation of the registered trademark.

The present invention also relates to a hair treatment method to combat hair loss, which consists in acting on the scalp, especially through Massage, applying an effective amount of a cosmetic composition of the invention.

The cosmetic compositions according to the invention can be used in a customary manner in cosmetology for hair care products forms used. They are, for example, in the form of hair creams or in the form aqueous or aqueous-alcoholic lotions or in the form of gels. You can also use preservatives and contain fragrance-imparting substances.

The invention particularly relates to compositions characterized in that they are in the form of

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■ η

Lotions, whether in vials or ampoules, are present.

The lotion is preferably in a small applicator ^: 'plastic bottle with a clamp with a content of

? for example 7 ml, which is very practical to use

* are dung.

ι The contents of the vial applicator are parted

to the base of the hair and all over the scalp

* Distributed in the evening and in the morning.

j The consumer must until the

Massage the product gently.

j Treatment of the seizure is to give a vial

I use every two days during six weeks at what

I underwent maintenance treatment with two vials per

! Week for one to two months.

I The treatment must be carried out once or twice a year (spring

I and Herbst) are repeated.

I The various cosmetic ones mentioned above

f Shapes can be made by standard methods such as those on this

I area applied to be preserved.

I The following examples illustrate the invention.

I example 1

I hair lotion g

I combination A [Trichopeptide ^] 10

$ Placenta extract 3

Propylene glycol 1

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10 Ethyl alcohol 0.1 Preservatives 0.2 fragrance-imparting composition 100 purified water q.s.p. Example 2 K Hair cream ■ mMmi
5 Combination A [Trichopeptide ^] 6th Placenta extract 4th Glycerine stearate 4th Propylene glycol 1 0.3 Preservatives 0.2 fragrance-imparting composition 100 purified water q.s.p. Example 3

Investigation of a lotion against hair loss analogous to that of Example 1 in a hospital service of Dermatology.

The effect of the lotion against hair loss was examined in 60 patients. This group sat on the following Way together:

12 female patients aged 24 to 62 years

48 male patients ranging in age from 19 to 50 years.

These two patient groups were divided in the following way.

Female patients

With regard to the importance of their hair loss, these patients could be divided into two main groups:

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Seborrheic hair loss so severe that the scalp is clearly in the area the temporal-forehead enlargement of the vertex becomes visible 5 cases

very advanced seborrheic hair loss with a loss of more than 2/3 the Hair, with the scalp clearly visible over the entire area of the parting 7 cases; With regard to the severity of seborrhea, these 12 patients are divided into the following Way:

moderate seborrhea that ever a shampoo

Week requires 1 case

Seborrhea, the two shampoos each

Week requires 4 cases

Seborrhea, with intense discharge.

requires shampooing every 2 to 3 days

lich makes 7 cases

Male patients

With regard to the severity of their hair loss, the male patients are distributed as follows:

Seborrheic hair loss corresponding to level I seborrheic hair loss 10 cases seborrheic hair loss! level II seborrheic hair loss 27 cases seborrheic hair loss corresponding to level III seborrheic hair loss 11 cases;

With regard to the severity of seborrhea, these 48 patients are distributed as follows:

considerable seborrhea 14 cases

Seborrhea with intense discharge, 34 cases.

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Technique of treatment - time of use of the product

All patients were given the hair product with a frequency of 3 applications over a 4 month period applied per week. The presentation of the product made in the form of vials with drop counting its easy to use. The product is applied to the scalp by touching the areas of the Scalp, on which the hair is less dense, treated more intensively and then massaged for the best possible penetration to reach.

No additional local or general treatment other than discontinuation of was given in these patients Shampoo detergents, a requirement in all patients one year prior to starting this treatment was realized.

All of these patients were assessed once a month. On each of these check-ups, the attempt was made to Assess the appearance and quality of the hair and the more or less seborrheic appearance of the scalp (It will be understood that the patient will be assessed at least 3 to 4 days after their last shampoo became).

Above all, one noted the nature and the importance of a possible regrowth.

Results

In this group of 60 patients, one patient had to discontinue treatment due to scalp itching. In the 59 patients who received the tested hair loss lotion for a period of 4 months used, one could determine the following:

Regarding hair regrowth :

[ A good effect in 21 cases

an average effect in 35 cases no effect in 3 cases.

' Regarding the greasy and seborrheic appearance

j of the scalp:

I A good effect in 4 cases

.I an average effect in 39 cases

j no effect in 16 cases.

^: i remarks

J importance of hair loss

J This parameter was not included in the observations.

j concluded that he was too subjective and difficult

is considered worthwhile. It must be pointed out, however, that very often, like the patient, both Gender indicated, a very significant slowdown in the Hair loss occurs.

Effect on hair regrowth

With regard to hair regrowth, the following results were obtained: in 12 female patients: 8 good results

I 4 average he

results

in 48 male patients: 13 good results

31 average results 3 with no result

j 1 unregistered

j result.

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In women, the tendency to regrowth is first expressed on the periphery of the scalp in the area of the Forehead and temples due to the appearance of small, thin and closely spaced hairs.

The thickening of the hair then gradually increased towards the middle, with the bald area as the months went on of the parting was reduced.

In the men, in the favorable cases, regrowth was observed on the periphery of the zones of hair loss from small, thin hair and then to the zones of hair loss itself, whereby the regrowth of one thin and closely spaced fluff gradually increased in strength and turned into fine but normal hair converted in the area of the peripheral zones.

It should be noted that this process generally only begins in the third or fourth month can be observed and that it proceeds slowly and gradually, which is the most favorable for women Cases can receive a complete renewal of the hair. It is less complete with men and progresses very slowly.

Regarding the seborrheic appearance of the scalp :

To date, there is no truly reliable and precise scientific criterion for measurement the seborrhea in the scalp area. The tests were carried out with the help of the "sebum test" and gave different results from one measurement or evaluation to another. In addition, numerous Intervene factors that are capable of meaning

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modify seborrheic discharge, for example Nutritional factors as well as the period cycle the women.

All these reasons meant that this time one had to be satisfied with, on the one hand, up the evaluation to support the opinion of the patient who was judged by the opportunity he had to use his shampoo to be used more or less frequently, and otherwise based on the clinical examination, always 3 or 4 days after the last shampooing was carried out.

] Here, too, it is women who get the results

more resounding were:

'■ good effect 2 cases

through chn. Effect 8 cases
: no effect 2 cases.

In men, in the 47 patients who had continued this treatment for 4 months, the following results:

J good effect 2 cases

average .. effect. 31 cases

J no effect 14 cases.

tolerance

The tolerance of the studied lotion to hair loss was perfect in 59 of our patients. Treatment had to be interrupted in only one case, the patient having a recurrent itch every few days after stopping the use of the Product had resumed complained. On examination, the scalp was erythematous, with some gritty places were present.

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This singular observation did not constitute an excellent one Overall tolerance of the product in question.

Conclusion

The entirety of the results can be summarized in the following way.

Effect on hair regrowth good results 21 average results 35 negative results 3

Effect on seborrhea good results 4 average results 39 negative results 16.

These results can be considered extremely favorable.

Otherwise, with the exception of this one patient, tolerance was perfect in all other patients. the The tolerability of the product was good and its performance was rated as practical and easy to use.

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Claims (1)

Dr. F. Zumstein aera. - Dr: E. Ässmann Dipl.-Ing. F. Klingseisen - Dr. F. Zumstein jun. PATENT Attorney; APPROVED REPRESENTATIVES AT E IJ R ■ JPA! £ 5 CH Γ ^f i PA Γ Γ; f; - Λ ■. '"REPRESENTATIVES BEPORE THi-. DUH ö PEANPA'i t: T ..Ft · .; L I Cas 2115 / D j claims I 1. Cosmetic compositions for use I on the scalp, characterized in that they have a I combination A include the following four products \ contains: I extracted from animal connective tissue, acidic I mucopolysaccharides, i a bacterial cell proteolysate, which the KuI- I found a bacterium of the Bacillaceae family [comes from trolled milieus, f peptides from calf serum and i peptides of embryonic skin, I: where this combination A with an animal placenta I extract is associated. i 2. Cosmetic compositions according to claim 1, I characterized in that the combination A comprises: I 10 to 30% by weight of mucopolysaccharides, f 20 to 30% by weight bacterial cell proteolysate, BATH ORIGINAL 2 "to 10 wt.% Peptides from calf serum and 0 to 30 wt. % Peptides from embryonic skin. 3. Cosmetic compositions according to claim 1 or 2, characterized in that they contain 2 to 20% by weight of combination A with 1 to 10% by weight placenta extract contain. 4. Cosmetic compositions according to any one of claims 1 to 3, characterized in that the mucopolysaccharides, which they contain, the antrum-pyloric region and cartilage of cattle and the duodenum of Pigs come from. 5. Cosnetic compositions according to one of the Claims 1 to 4, characterized in that the bacterial cell proteolysate which they contain consists of small Peptides consists and bacteria of the genus Bacillus originates, which on organic, with flour or meal have been cultivated by environments enriched by skin tissue lying under the horse's mane. 6. Cosmetic compositions according to any one of claims 1 to 5, characterized in that the Embryonic skin peptides are derived from bovine fetuses. 7. Cosmetic compositions according to any one of claims 1 to 6, characterized in that the Placenta extract, which they contain, comes from cattle. 8. Cosmetic compositions according to any one of claims 1 to 7, characterized in that the Combination A is called a trichopeptide (R) is a product placed on the market. BAD ORfGINAL 9. Cosmetic compositions according to any one of claims 1 to 8, characterized in that they in the form of lotions. 10. Hair treatment method to combat Hair loss, characterized in that the scalp, in particular by massages, is sufficient Amount of a cosmetic composition according to any one of claims 1 to 9 applies.