DE3533024A1 - Verfahren und vorrichtung zum dosieren, verduennen und enteiweissen von biologischen fluessigkeiten - Google Patents
Verfahren und vorrichtung zum dosieren, verduennen und enteiweissen von biologischen fluessigkeitenInfo
- Publication number
- DE3533024A1 DE3533024A1 DE19853533024 DE3533024A DE3533024A1 DE 3533024 A1 DE3533024 A1 DE 3533024A1 DE 19853533024 DE19853533024 DE 19853533024 DE 3533024 A DE3533024 A DE 3533024A DE 3533024 A1 DE3533024 A1 DE 3533024A1
- Authority
- DE
- Germany
- Prior art keywords
- cannula
- sample
- reagent
- liquid
- metering
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims abstract description 23
- 238000010790 dilution Methods 0.000 title claims abstract description 9
- 239000012895 dilution Substances 0.000 title claims abstract description 9
- 239000013060 biological fluid Substances 0.000 title abstract 2
- 239000000243 solution Substances 0.000 claims abstract description 14
- 238000004140 cleaning Methods 0.000 claims abstract description 4
- 239000003153 chemical reaction reagent Substances 0.000 claims description 37
- 239000007788 liquid Substances 0.000 claims description 28
- 239000008280 blood Substances 0.000 claims description 18
- 210000004369 blood Anatomy 0.000 claims description 18
- 238000007789 sealing Methods 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 230000003213 activating effect Effects 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 230000002949 hemolytic effect Effects 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 230000001360 synchronised effect Effects 0.000 claims 1
- 238000007865 diluting Methods 0.000 abstract 2
- 230000002452 interceptive effect Effects 0.000 abstract 1
- 239000000523 sample Substances 0.000 description 26
- 239000003795 chemical substances by application Substances 0.000 description 5
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 5
- 238000005259 measurement Methods 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 206010018910 Haemolysis Diseases 0.000 description 2
- GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000008588 hemolysis Effects 0.000 description 2
- 238000003345 scintillation counting Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 241001631457 Cannula Species 0.000 description 1
- 241001453233 Doodia media Species 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000005464 sample preparation method Methods 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/34—Purifying; Cleaning
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
- G01N2001/382—Diluting, dispersing or mixing samples using pistons of different sections
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1004—Cleaning sample transfer devices
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19853533024 DE3533024A1 (de) | 1985-09-16 | 1985-09-16 | Verfahren und vorrichtung zum dosieren, verduennen und enteiweissen von biologischen fluessigkeiten |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19853533024 DE3533024A1 (de) | 1985-09-16 | 1985-09-16 | Verfahren und vorrichtung zum dosieren, verduennen und enteiweissen von biologischen fluessigkeiten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3533024A1 true DE3533024A1 (de) | 1987-03-26 |
| DE3533024C2 DE3533024C2 (enrdf_load_stackoverflow) | 1988-06-30 |
Family
ID=6281100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19853533024 Granted DE3533024A1 (de) | 1985-09-16 | 1985-09-16 | Verfahren und vorrichtung zum dosieren, verduennen und enteiweissen von biologischen fluessigkeiten |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE3533024A1 (enrdf_load_stackoverflow) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0388018A3 (en) * | 1989-03-13 | 1991-06-05 | Beckman Instruments, Inc. | Sample injection cell |
| DE4130742A1 (de) * | 1991-09-16 | 1993-03-18 | Inst Diabetestechnologie Gemei | Verfahren und anordnung zur bestimmung der konzentration von inhaltsstoffen in koerperfluessigkeiten |
| EP1541986A1 (de) * | 2003-12-12 | 2005-06-15 | Boehringer Ingelheim microParts GmbH | Probennahmeeinrichtung und System zur Untersuchung von Probenflüssigkeit |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4017868A1 (de) * | 1990-06-02 | 1990-10-31 | Siegfried Dipl Phys Stiller | Mischkammer zur verduennung und haemolyse von blut |
| DE4419721C2 (de) * | 1994-06-06 | 1998-01-29 | Siemens Ag | Anordnung zur Führung eines Probenfluides sowie Verfahren zur Analyse eines Probenfluids |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4053284A (en) * | 1976-03-10 | 1977-10-11 | Akzona Incorporated | Continuous flow apparatus for biological testing |
| EP0095291A2 (en) * | 1982-05-15 | 1983-11-30 | Kabushiki Kaisha Kyoto Daiichi Kagaku | Continuous measurement of the concentration of a predetermined ingredient in a diluted liquid |
-
1985
- 1985-09-16 DE DE19853533024 patent/DE3533024A1/de active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4053284A (en) * | 1976-03-10 | 1977-10-11 | Akzona Incorporated | Continuous flow apparatus for biological testing |
| EP0095291A2 (en) * | 1982-05-15 | 1983-11-30 | Kabushiki Kaisha Kyoto Daiichi Kagaku | Continuous measurement of the concentration of a predetermined ingredient in a diluted liquid |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0388018A3 (en) * | 1989-03-13 | 1991-06-05 | Beckman Instruments, Inc. | Sample injection cell |
| DE4130742A1 (de) * | 1991-09-16 | 1993-03-18 | Inst Diabetestechnologie Gemei | Verfahren und anordnung zur bestimmung der konzentration von inhaltsstoffen in koerperfluessigkeiten |
| EP1541986A1 (de) * | 2003-12-12 | 2005-06-15 | Boehringer Ingelheim microParts GmbH | Probennahmeeinrichtung und System zur Untersuchung von Probenflüssigkeit |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3533024C2 (enrdf_load_stackoverflow) | 1988-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OP8 | Request for examination as to paragraph 44 patent law | ||
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |