DE346521C - - Google Patents
Info
- Publication number
- DE346521C DE346521C DENDAT346521D DE346521DA DE346521C DE 346521 C DE346521 C DE 346521C DE NDAT346521 D DENDAT346521 D DE NDAT346521D DE 346521D A DE346521D A DE 346521DA DE 346521 C DE346521 C DE 346521C
- Authority
- DE
- Germany
- Prior art keywords
- lactic acid
- salt
- salts
- moles
- lime
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 28
- 239000004310 lactic acid Substances 0.000 claims description 23
- 235000014655 lactic acid Nutrition 0.000 claims description 23
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 239000011780 sodium chloride Substances 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- 159000000003 magnesium salts Chemical class 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 150000003751 zinc Chemical class 0.000 claims description 2
- 229910003002 lithium salt Inorganic materials 0.000 claims 1
- 159000000002 lithium salts Chemical class 0.000 claims 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 4
- 235000015450 Tilia cordata Nutrition 0.000 description 4
- 235000011941 Tilia x europaea Nutrition 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 239000004571 lime Substances 0.000 description 4
- 150000007513 acids Chemical class 0.000 description 3
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L Calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 239000001527 calcium lactate Substances 0.000 description 2
- 229960002401 calcium lactate Drugs 0.000 description 2
- 235000011086 calcium lactate Nutrition 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 229960003563 Calcium Carbonate Drugs 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N Carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 150000008043 acidic salts Chemical class 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- SMHNUIFHMAGAFL-UHFFFAOYSA-N calcium;2-hydroxypropanoic acid Chemical compound [Ca].CC(O)C(O)=O SMHNUIFHMAGAFL-UHFFFAOYSA-N 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 230000001264 neutralization Effects 0.000 description 1
- 229920000747 poly(lactic acid) polymer Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
- C07C59/08—Lactic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Herstellung fester lWilchsäurepräparate. Milchsäure kristallisiert bekanntlich schwer und schmilzt äußerst leicht.Process for the production of solid lactic acid preparations. Lactic acid is known to crystallize with difficulty and melts extremely easily.
Vorliegende Erfindung bezieht sich nun auf ein Verfahren zur Herstellung von Milchsäure in fester Form, d. h. .es gelingt nach ihr, die Milchsäure in eine beständige, nicht hygroskopische Verbindung überzuführen, die hart ist und sich leicht pulverisieren läßt. Dies nel:ngt durch Einverleibung freier Milchsäure in milchsaure Salze, z. B. Erdalkalisalze der Milchsäure, Magnesiumsalze und Zinksalze <derselben, .in so großen Mengen, daß auf i Mol. milchsauren Salzes mehr als 2 Mol. Milchsäure kommen. Man hat bereits vorgeschlagen, aus Calciumlaktat und Milchsäure ein sogenanntes saures milchsaures Calcium herzu .The present invention now relates to a method of manufacture of lactic acid in solid form, d. H. According to her, it succeeds in converting lactic acid into one to transfer permanent, non-hygroscopic connection that is hard and self easy to pulverize. This is done by incorporating free lactic acid into lactic acid salts, e.g. B. alkaline earth salts of lactic acid, magnesium salts and zinc salts of the same, in such large quantities that for 1 mol of lactic acid salt more than 2 moles of lactic acid come. It has already been proposed to make calcium lactate and lactic acid a so-called lactic acid calcium.
stellen, das auf i Mol. Salz 2 Mol. Milchsäure enthält. Die vorliegende Erfindung aber vermittelt die nicht zu erwartende Tatsache, claß es gelingt, 3, 4 und mehr Mol. Milchsäure i Mol. milchsauren Salzes einzuverleiben.that contains 2 moles of lactic acid for every 1 mole of salt. The present Invention, however, conveys the unexpected fact that it succeeds 3, To incorporate 4 or more moles of lactic acid in 1 mole of lactic acid salt.
Die neuen Verbindungen sind als sogenannte übersaure Salze aufzufassen. Die Herstellung solcher übersauren Salze gelingt auch; wenn man direkt von .den Säuren und cien betreffenden Basen ausgeht und die freien Säuren nur so weit neutralisiert, daß neben dem entstehenden neutralen milchsauren Salz mehr als 2 Mol. Milchsäure frei bleiben und beim Eindampfen in die übersaure Verbin--dung übergehen.The new compounds are to be understood as so-called over-acidic salts. The production of such acidic salts is also successful; if you come directly from the Acids and the bases concerned runs out and the free acids are only neutralized to the extent that that in addition to the resulting neutral lactic acid salt, more than 2 moles of lactic acid remain free and convert into the acidic compound on evaporation.
Diese neuen Milchsäureabkömmlinge .dürften keine Absorptions-, sondern wirkliche chemische Verbindungen darstellen, da sie im Gegensatz zu der sehr hygroskopischen Milchsäure nicht im geringsten hygroskopisch sind und sich leicht pulverisieren lassen. Möglicherweise sind diese neuen Verbindungen auch als Salze von Polylaktylsäuren aufzufassen.These new lactic acid derivatives should not be absorbed but rather represent real chemical compounds as they are in contrast to the very hygroscopic Lactic acid are not in the least hygroscopic and easily pulverize permit. Possibly these new compounds are also available as salts of polylactic acids to grasp.
rDie nach dem Verfahren der Erfindung hergestellten Verbindungen sollen Verwendung finden für technische und pharmazeutische Zwecke.rThe compounds prepared by the method of the invention should Find use for technical and pharmaceutical purposes.
Be. isp,ie1:e.Be. isp, ie1: e.
i. In 287,5 g Milchsäure von 94 Prozent CH3 . CH OH # CO OH wurden 308,2 g milchsaurer Kalk eingetragen und innig verrührt. Die Masse ist zunächst flüssig, wird dann immer zäher und erstarrt plötzlich zu einer festen Masse, die sich fein pulverisieren läßt 2. 3o8,2 g milchsaurer Kalk wurden in 18o ccm Wasser heiß gelöst und in 287,5 g heiße Milchsäure (94prozentig) eingerührt. Die klare Lösung wurde unter ständigem Rühren auf kleiner Flamme eingedampft. Zuletzt entsteht ein zäher Brei, .der beim Erkalten hart und spröde wird und sich leicht pulverisieren läßt.i. In 287.5 g lactic acid of 94 percent CH3. CH OH # CO OH 308.2 g of lactic acid lime were added and thoroughly stirred. The mass is initially liquid, then becomes more and more viscous and suddenly solidifies to a solid mass, which can be finely pulverized. 2.308.2 g of lactic acid lime were dissolved in 180 ccm of hot water and stirred into 287.5 g of hot lactic acid (94%) . The clear solution was evaporated on a low flame with constant stirring. In the end a viscous pulp is produced, which becomes hard and brittle on cooling and can be easily pulverized.
3. In 383,4 g Milchsäure (94prozentig), die zum Sieden erhitzt war, wurden 3o8,2 g milchsaurer Kalk allmählich verrührt. Der Kalk löst sich auf, das Reaktionsgemisch wird bei weiterem Erhitzen zäh und erkaltet zu einer glasigen Masse, die gut pulverisierbar ist.3. In 383.4 g of lactic acid (94 percent), which was heated to the boil, 308.2 g of lactic acid lime were gradually stirred up. The lime dissolves, that The reaction mixture becomes viscous and cools to a glassy mass on further heating, which is easy to pulverize.
4. In eine ätherische Lösung von 383,4 g Milchsäure (94prozentig) werden 308,2 g Ca-Laktat eingerührt und der Äther verdunstet. Es entsteht ein trockenes Pulver. 4. 308.2 g calcium lactate are stirred into an ethereal solution of 383.4 g lactic acid (94%) and the ether evaporates. A dry powder is produced.
g. 479,2 g Milchsäure (94prozentig) werden mit ioo g Calciumcarbonat versetzt und die Lösung durch Kochen von .der Kohlensäure befreit, .dann bis zu zäher Konsistenz eingedampft. Beim Erkalten erstarrt die Masse und läßt sich pulvern..G. 479.2 g of lactic acid (94 percent) are mixed with 100 g of calcium carbonate added and the solution freed of .the carbonic acid by boiling, .then up to evaporated to a thick consistency. When it cools, the mass solidifies and can be powdered.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE346521C true DE346521C (en) |
Family
ID=574269
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT346521D Active DE346521C (en) |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE346521C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE745526C (en) * | 1939-10-06 | 1944-04-19 | Dr Ernst Komm | Process for the production of solid lactic acid preparations |
| US2420255A (en) * | 1944-06-22 | 1947-05-06 | Howards & Sons Ltd | Manufacture of addition compounds of lactic acid salts with acetic acid |
| DE905842C (en) * | 1937-04-10 | 1954-03-08 | Ruckdeschel & Soehne K G J | Process for producing a dry acid |
| DE2820942A1 (en) * | 1978-05-12 | 1979-11-22 | Sueddeutsche Kalkstickstoff | OVERACIDIC SOLID METAL ACTATES, METHOD OF PREPARATION AND USE |
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0
- DE DENDAT346521D patent/DE346521C/de active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE905842C (en) * | 1937-04-10 | 1954-03-08 | Ruckdeschel & Soehne K G J | Process for producing a dry acid |
| DE745526C (en) * | 1939-10-06 | 1944-04-19 | Dr Ernst Komm | Process for the production of solid lactic acid preparations |
| US2420255A (en) * | 1944-06-22 | 1947-05-06 | Howards & Sons Ltd | Manufacture of addition compounds of lactic acid salts with acetic acid |
| DE2820942A1 (en) * | 1978-05-12 | 1979-11-22 | Sueddeutsche Kalkstickstoff | OVERACIDIC SOLID METAL ACTATES, METHOD OF PREPARATION AND USE |
| FR2425421A1 (en) * | 1978-05-12 | 1979-12-07 | Sueddeutsche Kalkstickstoff |
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