DE345062C - - Google Patents
Info
- Publication number
- DE345062C DE345062C DENDAT345062D DE345062DA DE345062C DE 345062 C DE345062 C DE 345062C DE NDAT345062 D DENDAT345062 D DE NDAT345062D DE 345062D A DE345062D A DE 345062DA DE 345062 C DE345062 C DE 345062C
- Authority
- DE
- Germany
- Prior art keywords
- solutions
- calcium
- solution
- water
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229940095618 Calcium Glycerophosphate Drugs 0.000 claims description 12
- UHHRFSOMMCWGSO-UHFFFAOYSA-L Calcium glycerylphosphate Chemical compound [Ca+2].OCC(CO)OP([O-])([O-])=O UHHRFSOMMCWGSO-UHFFFAOYSA-L 0.000 claims description 12
- 239000001736 Calcium glycerylphosphate Substances 0.000 claims description 12
- 235000019299 calcium glycerylphosphate Nutrition 0.000 claims description 12
- 235000008733 Citrus aurantifolia Nutrition 0.000 claims description 8
- 235000015450 Tilia cordata Nutrition 0.000 claims description 8
- 235000011941 Tilia x europaea Nutrition 0.000 claims description 8
- 239000004571 lime Substances 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 6
- 239000011780 sodium chloride Substances 0.000 claims description 6
- 229940005581 Sodium Lactate Drugs 0.000 claims description 5
- NGSFWBMYFKHRBD-UHFFFAOYSA-M Sodium lactate Chemical compound [Na+].CC(O)C([O-])=O NGSFWBMYFKHRBD-UHFFFAOYSA-M 0.000 claims description 5
- XYZZKVRWGOWVGO-UHFFFAOYSA-N phosphoric acid;propane-1,2,3-triol Chemical compound OP(O)(O)=O.OCC(O)CO XYZZKVRWGOWVGO-UHFFFAOYSA-N 0.000 claims description 5
- 239000001540 sodium lactate Substances 0.000 claims description 5
- 235000011088 sodium lactate Nutrition 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 3
- VMHLLURERBWHNL-UHFFFAOYSA-M sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 2
- 239000001632 sodium acetate Substances 0.000 claims description 2
- 235000017281 sodium acetate Nutrition 0.000 claims description 2
- 239000000243 solution Substances 0.000 description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 238000001816 cooling Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 159000000000 sodium salts Chemical class 0.000 description 3
- 230000001954 sterilising Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- VSGNNIFQASZAOI-UHFFFAOYSA-L Calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 2
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L Calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 2
- 229960002901 Sodium glycerophosphate Drugs 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L cacl2 Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- 239000001639 calcium acetate Substances 0.000 description 2
- 235000011092 calcium acetate Nutrition 0.000 description 2
- 229960005147 calcium acetate Drugs 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- 229960002713 calcium chloride Drugs 0.000 description 2
- 235000011148 calcium chloride Nutrition 0.000 description 2
- 239000001527 calcium lactate Substances 0.000 description 2
- 235000011086 calcium lactate Nutrition 0.000 description 2
- 229960002401 calcium lactate Drugs 0.000 description 2
- 159000000007 calcium salts Chemical class 0.000 description 2
- OFNNKPAERNWEDD-UHFFFAOYSA-L disodium;2,3-dihydroxypropyl phosphate;hydrate Chemical compound O.[Na+].[Na+].OCC(O)COP([O-])([O-])=O OFNNKPAERNWEDD-UHFFFAOYSA-L 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 239000008174 sterile solution Substances 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N Carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 230000036826 Excretion Effects 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000005755 formation reaction Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 150000003893 lactate salts Chemical class 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001225 therapeutic Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
Description
Verfahren zur Herstellung sterilisierbarer Lösungen des glyzerinphosphorsauren Kalks. Es ist bekannt, :daß glyzerinphosphorsaurer Kalk sscli in cler Hitze weniger löst als in der Kälte. Erhitzt man Lösungen desselben, so fällt ein Teil des Salzes aus und geht beim Erkalten zum :größten Teil wieder :in Lösung. Es bleibt jedoch ein gewisser Rückstand, der sich nicht wieder auflöst.Process for the preparation of sterilizable solutions of glycerol phosphoric acid Lime. It is known that: lime glycerinophosphate is less in the heat resolves than in the cold. If solutions of the same are heated, part of the salt falls and when it cools it goes: for the most part again: in solution. However, it remains a certain residue that does not dissolve again.
Lösungen des glyzerinphosphorsauren Kalks lassen sich daher nicht in strömendem Dampf sterilisieren; selbst bei fraktionierter Sterilisation bis 85° C bleibt häufig ein unlöslicher Niederschlag beim Erkalten bestehen. Es ist daher mit großen Schwierigkeiten verbunden, klare und sterile Lösungen des glyzerinphosphorsauren Kalks herzustellen, welche sich zur parenteralen Einverleibung eignen.Solutions of the glycerol phosphoric acid lime cannot therefore be used sterilize in flowing steam; even with fractional sterilization up to 85 ° C an insoluble precipitate often remains on cooling. It is therefore associated with great difficulty, clear and sterile solutions of glycerol phosphoric acid To produce lime suitable for parenteral incorporation.
Es wurde nun gefunden, daß sich der durch Erhitzen ausgeschiedene glyzerinphosphorsaure Kalk zu einer wasserklaren Lösung beim Erkalten bei Gegenwart milchsauren oder essigsauren Natrons wieder auflöst. Es liegt hier offenbar die Bildung-von Doppelsalzen vor, die eine leichtere Löslichkeit bedingen. Diese Lösungen lassen -sich auf übliche Weise in strömendem Dampf sterilisieren, werden zuerst trübe und scheiden hei höherer Temperatur einen . Niederschlag aus. Beim Abkühlen verschwindet der Niederschlag bald, eine Trübung bleibt jedoch zuerst noch bestehen, um nach kurzer Zeit vollständig zu verschwinden. Die so erhaltenen sterilen Lösungen sind wasserklar und können wiederholt sterilisiert werden.It has now been found that the precipitated by heating glycerol phosphoric acid lime to a water-clear solution when cooling in the presence dissolves lactic acid or acetic acid soda again. It is obviously the one here Formation of double salts, which cause easier solubility. These solutions let yourself be sterilized in the usual way in flowing steam, first turbid and separate at a higher temperature. Precipitation from. When cooling down the precipitation soon disappears, but a cloudiness remains at first, to disappear completely after a short time. The sterile solutions thus obtained are water-clear and can be sterilized repeatedly.
Das Verhältnis des Natronsalzes zum Kalksalz kann verschieden gewählt werden; in :den meisten Fällen genügt eine Menge von i bis 2 Molekülen Natriumsalz auf i Molekül Kalksalz. Es lassen sich aber oft auch geringere Mengen Natronsalz mit gleich gutem Erfolg anwenden. Ferner ist es möglich, den Natriumazetat oder Natriumlactat enthaltenden Kalziumglyzerophosphatlösungen andere lösliche Kalksalze, . wie z. B. Chlorkalzium, Kalziumazetat oder Kalziumlactat zuzusetzen, ohne daß beim Sterilisieren bleibende Niederschläge oder Trübungen entständen.The ratio of the sodium salt to the lime salt can be chosen differently will; in: in most cases an amount of 1 to 2 molecules of sodium salt is sufficient on i molecule of calcium salt. However, smaller amounts of sodium salt can often also be used apply with equal success. It is also possible to use the sodium acetate or Calcium glycerophosphate solutions containing sodium lactate, other soluble calcium salts, . such as B. to add calcium chloride, calcium acetate or calcium lactate without permanent precipitates or cloudiness arise during sterilization.
An Stelle .des Kalziumglyzerophosphats und Natriumlactats läßt sich jedoch auch Natriumglyzerophosphat und Kalziumlactat oder -azetat anwenden. Es .zeigt sich, .daß hierbei Kalziumglyzerophosphat entsteht, da diese Lösung beim Erhitzen eine Ausscheidung jenes Salzes aufweist. Es lassen sich sterilisierbare Kalziumglyzerophosphatlösungen unter Verwendung der obengenannten Salze auf verschiedene Weise herstellen, was nach dem bekannten Verhalten .der Kalziumglyzerophosphatlösungen nicht zu erwarten war.Instead of calcium glycerophosphate and sodium lactate, however, also use sodium glycerophosphate and calcium lactate or acetate. It shows that this creates calcium glycerophosphate, since this solution is heated when it is heated exhibits an excretion of that salt. It can be sterilized calcium glycerophosphate solutions using the above salts in various ways to prepare what Not to be expected according to the known behavior of the calcium glycerophosphate solutions was.
Die die Sterilisation der Lösungen des Kalziumglyzerophosphats ermöglichenden Azetate und Lactate sind gegen :den Organismus indifferent, so daß die Lösungen nur die Wirkung des Kalziumglyzerophosphats entfalten.They allow the calcium glycerophosphate solutions to be sterilized Acetates and lactates are against: the organism indifferent, so that the solutions only develop the effect of the calcium glycerophosphate.
Die nach vorliegendem Verfahren erhaltenen Kalziumglyzerophosphatlösungen sollen therapeutischen Zwecken dienen.The calcium glycerophosphate solutions obtained by the present process should serve therapeutic purposes.
Beispiel z: 25 g Kalziumglyzerophosphat werden kalt in 700 9 Wasser gelöst, zu der klar filtrierten Lösung 1q. g Natriumlactat, in 70 g Wasser gelöst, zugegeben und die gemischten Lösungen auf 8oo g ,mit Wasser verdünnt. Die Lösung wird nochmals sorgfältig filtriert, in Ampullen abgefüllt und - im strömenden Dampf sterilisiert. Die heiße Lösung zeigt eine flockige Ausscheidung, die beim Erkalten sich vollständig löst. Man erhält so eine sterile klare Lösung, die in ioo g etwa 3 g Kalziumglyzerophosphat enthält.Example z: 25 g of calcium glycerophosphate are dissolved cold in 700 g of water, 1q to the clear, filtered solution. g sodium lactate dissolved in 70 g water is added and the mixed solutions diluted to 800 g with water. The solution is carefully filtered again, filled into ampoules and - sterilized in the flowing steam. The hot solution shows a flaky precipitate that dissolves completely when it cools. This gives a sterile clear solution which contains about 3 g of calcium glycerophosphate in 100 g.
Beispiel 2: ' 25 g Natriumglyzerophosphat werden in 300 g Wasser gelöst, 25 g Natriumlactat, in Zoo .g Wasser gelöst, zugesetzt und dann eine Lösung von 33 g kri-' stallisiertem Chlorkalzium in ioo g Wasser zugegeben. Nun wird mit Wasser auf 8oo g verdünnt und die filtrierte Lösung in Ampullen abgefüllt. Durch Sterilisieren in strömendem Dampf erhält man eine in -der Hitze flockige, nach dem Abkühlen jedoch völlig klare Lösung mit einem Gehalt von etwa 3 g Kalziumglyzerophosphat in ioo g.Example 2: 25 g of sodium glycerophosphate are dissolved in 300 g of water, 25 g of sodium lactate, dissolved in zoo .g of water, are added and then a solution of 33 g of crystallized calcium chloride in 100 g of water is added. It is now diluted to 800 g with water and the filtered solution is filled into ampoules. Sterilization in flowing steam gives a solution that is fluffy in the heat, but completely clear after cooling, with a content of about 3 g of calcium glycerophosphate in 100 g.
Claims (1)
Publications (1)
Publication Number | Publication Date |
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DE345062C true DE345062C (en) |
Family
ID=573560
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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DENDAT345062D Active DE345062C (en) |
Country Status (1)
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DE (1) | DE345062C (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2657172A (en) * | 1950-06-22 | 1953-10-27 | Carlton Corp | Therapeutic solution of calcium lactate and calcium glycerophosphate |
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0
- DE DENDAT345062D patent/DE345062C/de active Active
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2657172A (en) * | 1950-06-22 | 1953-10-27 | Carlton Corp | Therapeutic solution of calcium lactate and calcium glycerophosphate |
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