DE3440864A1 - Process for the stabilisation of camomile extracts and their constituents - Google Patents
Process for the stabilisation of camomile extracts and their constituentsInfo
- Publication number
- DE3440864A1 DE3440864A1 DE19843440864 DE3440864A DE3440864A1 DE 3440864 A1 DE3440864 A1 DE 3440864A1 DE 19843440864 DE19843440864 DE 19843440864 DE 3440864 A DE3440864 A DE 3440864A DE 3440864 A1 DE3440864 A1 DE 3440864A1
- Authority
- DE
- Germany
- Prior art keywords
- chamomile
- extract
- extracts
- stabilisation
- constituents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000284 extract Substances 0.000 title claims abstract description 12
- 238000000034 method Methods 0.000 title claims abstract description 8
- 230000006641 stabilisation Effects 0.000 title claims abstract description 8
- 239000000470 constituent Substances 0.000 title description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 14
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 5
- 239000001301 oxygen Substances 0.000 claims abstract description 5
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 5
- 235000020221 chamomile extract Nutrition 0.000 claims description 18
- 238000011105 stabilization Methods 0.000 claims description 6
- 230000001476 alcoholic effect Effects 0.000 claims description 2
- 229940119217 chamomile extract Drugs 0.000 description 7
- GXGJIOMUZAGVEH-UHFFFAOYSA-N Chamazulene Chemical compound CCC1=CC=C(C)C2=CC=C(C)C2=C1 GXGJIOMUZAGVEH-UHFFFAOYSA-N 0.000 description 5
- PMRJYBALQVLLSJ-UHFFFAOYSA-N chamazulene Natural products CCC1=CC2=C(C)CCC2=CC=C1 PMRJYBALQVLLSJ-UHFFFAOYSA-N 0.000 description 4
- 229910001873 dinitrogen Inorganic materials 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000000341 volatile oil Substances 0.000 description 4
- 239000007789 gas Substances 0.000 description 3
- SYTRJRUSWMMZLV-UHFFFAOYSA-N matricin Chemical compound C1=CC(O)(C)C2C1=C(C)CC(OC(C)=O)C1C2OC(=O)C1C SYTRJRUSWMMZLV-UHFFFAOYSA-N 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 240000003538 Chamaemelum nobile Species 0.000 description 2
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 2
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 239000010628 chamomile oil Substances 0.000 description 2
- 235000019480 chamomile oil Nutrition 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000011261 inert gas Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 description 1
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 1
- XMTQQYYKAHVGBJ-UHFFFAOYSA-N 3-(3,4-DICHLOROPHENYL)-1,1-DIMETHYLUREA Chemical compound CN(C)C(=O)NC1=CC=C(Cl)C(Cl)=C1 XMTQQYYKAHVGBJ-UHFFFAOYSA-N 0.000 description 1
- DBZHHRPNWDNKNX-UHFFFAOYSA-N Chamazulen Natural products CC1=CC=C2C=C(C=CC(=C12)C(C)C)C DBZHHRPNWDNKNX-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 description 1
- -1 analgesic Substances 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000002921 anti-spasmodic effect Effects 0.000 description 1
- 235000019568 aromas Nutrition 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 229940036350 bisabolol Drugs 0.000 description 1
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000005293 duran Substances 0.000 description 1
- 238000005429 filling process Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000003958 fumigation Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Verfahren zur Stabilisierung Method of stabilization
von Kamillenextrakten und seinen Inhaltsstoffen Die Erfindung betrifft ein Verfahren zur Stabilisierung von Kamillenextrakten, insbesondere den darin enthaltenen ätherischen Ölen. Besonders den ätherischen Ölen wird die entzündungshemmende, reizmildernde, schmerzstillende, desinfizierende, desodorierende, krampflösende, verdauungsfördernde und Sekret verflüssigende Wirkung der Kamillenextrakte zugeschrieben. Neben auch heute noch nicht restlos aufgeklärten Bestandteilen der ätherischen Öle in Kamillenextrakten, besitzen das Bisabolol und das Chamazulen bzw. Prochamazulen ausgeprägte antiphlogistische Wirkung.of chamomile extracts and its ingredients the The invention relates to a method for stabilizing chamomile extracts, in particular the essential oils it contains. Especially the essential oils will anti-inflammatory, anti-irritant, analgesic, disinfectant, deodorant, Antispasmodic, digestive and secretion-liquefying effects of chamomile extracts attributed to. In addition to components of the essential oils in chamomile extracts have bisabolol and chamazulene or Prochamazulen pronounced anti-inflammatory effect.
Es ist bekannt, daß insbesondere das Chamazulen bzw. Prochamazulen als Bestandteile der ätherischen Öle in Kamillenextrakten sehr instabil ist und im Laufe der Lagerung abgebaut wird.It is known that in particular Chamazulen or Prochamazulen as a constituent of the essential oils in chamomile extracts is very unstable and is degraded in the course of storage.
Es hat nicht an Versuchen gefehlt, die instabilen Bestandteile der ätherischen Kamillenöle durch geeignete Maßnahmen zu stabilisieren.There has been no lack of attempts to identify the unstable components of the to stabilize essential chamomile oils through suitable measures.
Es wird in der DE-PS 21 23 928 vorgeschlagen, Kamillenextrakte dadurch haltbarer zu machen, daß man den Kamillenextrakt in Wasser, oder einem mit Wasser mischbaren organischen Lösungsmittel löst, die Lösung mit Aluminiumoxid behandelt und dieses durch Filtration wiederum abtrennt.It is proposed in DE-PS 21 23 928, chamomile extracts thereby To make it more durable, the chamomile extract can be mixed with water, or one with water dissolves miscible organic solvent, the solution is treated with aluminum oxide and this again separated by filtration.
In der DE-PS 23 40 940 wird ein Verfahren beschrieben, welches zur verbesserten Haltbarkeit von proazulenhaltigen Drogenextrakten den Zusatz von Dimethylbenzylamoniumchlorid verlangt.In DE-PS 23 40 940 a method is described which is used for improved shelf life of drug extracts containing proazulen the addition of dimethylbenzylammonium chloride demands.
In der DD-PS 1 46 893 wird zur Stabilisierung der Wirkstoffe, Aromen und Duftstoffe der Kamille die Herstellung von Cyclodextrin-Kamillenkomplexen empfohlen.In DD-PS 1 46 893, aromas are used to stabilize the active ingredients and chamomile fragrances, the manufacture of cyclodextrin-chamomile complexes is recommended.
Alle diese Vorschläge sind mit dem Nachteil behaftet, daß die Stabilisierung der wirksamen Bestandteile der Kamillenextrakte nur durch großen technischen und zeitlichen Aufwand zu erreichen ist. Besonders nachteilig wirkt sich der Kontakt der empfindlichen Kamillenölbestandteile mit extraktfremden Substanzen aus. Derartig hergestellte Kamillenprodukte können demnach nicht mehr als "natürlich" angesehen werden. Insbesondere der Verbraucher setzt bei der Verwendung eines Kamillenextraktes voraus, daß dieser naturbelassen ist, das heißt, daß neben den Extraktionsmitteln Wasser und Alkohol, bzw. Gemischen davon, weder chemische Zusätze enthalten sind, noch der Extrakt mit anderen, extraktfremden Substanzen in Berührung gekommen ist.All of these proposals have the disadvantage that stabilization the effective components of chamomile extracts only through great technical and time expenditure is to be achieved. Contact is particularly detrimental the sensitive chamomile oil components with foreign substances. Such Manufactured chamomile products can therefore no longer be regarded as "natural" will. In particular, the consumer relies on the use of a chamomile extract in advance, that this is natural, that is, that in addition to the extracting agents, water and alcohol, or mixtures thereof, neither contain nor chemical additives the extract has come into contact with other substances that are foreign to the extract.
Es wurde nun überraschend gefunden, daß sich die Stabilität des besonders instabilen Chamazulens bzw. Prochamazulens wesentlich verbessern läßt, wenn man die wässrigen Kamillenextrakte oder alkoholisch/wässrigen Kamillenextrakte nach Gewinnung mit inertem Stickstoffgas begast.It has now been found, surprisingly, that the stability of the particularly unstable Chamazulens or Prochamazulens can be improved significantly if one the aqueous chamomile extracts or alcoholic / aqueous chamomile extracts Recovery gassed with inert nitrogen gas.
Der Stabilisierungseffekt durch die Stickstoffbegasung wird besonders dann erreicht, wenn der Sauerstoffgehalt der Extrakte weniger als 2 mg pro Liter, insbesondere weniger als 1 mg pro Liter beträgt.The stabilizing effect due to the nitrogen gassing becomes special reached when the oxygen content of the extracts is less than 2 mg per liter, in particular is less than 1 mg per liter.
Erfindungsgemäß kann der erforderliche Restsauerstoffgehalt dadurch erreicht werden, daß der Kamillenextrakt unmittelbar nach Herstellung mit Stickstoff durchperlt wird, wobei anschließend dafür Sorge zu tragen ist, daß nach der Stickstoffbegasung ein erneuter Luftzutritt nicht mehr möglich ist. Ein derart stabilisierter Kamillenextrakt ist naturbelassen, da Stickstoffgas bekanntlich keinerlei Reaktivität aufweist.According to the invention, the required residual oxygen content can thereby can be achieved that the chamomile extract immediately after preparation with nitrogen is bubbled through, then care must be taken that after the nitrogen gas flush a renewed entry of air is no longer possible. Such a stabilized chamomile extract is natural, as nitrogen gas is known to have no reactivity.
Derartiger Kamillenextrakt ist hinsichtlich seines Chamazulen- bzw.Such chamomile extract is known for its chamazulene or
Prochamazulengehaltes über längere Zeit stabil und kann nach üblichen Verfahren in für den Endverbraucher bestimmte Behältnisse abgefüllt werden. Es ist lediglich darauf zu achten, daß nach dem Abfülivorgang der über dem Flüssigkeitsspiegel befindliche Gastraum vor dem Verschliessen des Behältnisses nochmals mit Stockstoff gespült wird.Prochamazulene content is stable over a long period of time and can be adjusted according to the usual Process are filled into containers intended for the end user. It is just make sure that after the filling process the above the liquid level Located in the guest room before closing the container again with stick material is rinsed.
Be i 5 p i e 1 2.000 1 Kamillenextrakt werden in einem gegen Luft dichtverschließbaren Behälter vorgelegt. Für 20 Minuten wird der Extrakt mit reinem Stickstoffgas, bei einem Überdruck von 0,5 bar begast, wobei das Schutzgas über eine Begasungsfritte, die am Boden des Behälters angebracht ist (z.B. Duran 4, 90 x 6,6 mm, mittlere Porenweite 10 - 16 ,u), eingeleitet wird. Nach dieser Begasungszeit beträgt der Restsauerstoffgehalt der Lösung weniger als 1 mg pro Liter. Be i 5 p i e 1 2,000 1 chamomile extract in a against air presented in a tightly sealable container. For 20 minutes the extract becomes pure with Nitrogen gas, gassed at an overpressure of 0.5 bar, with the protective gas over a gas frit attached to the bottom of the container (e.g. Duran 4, 90 x 6.6 mm, mean pore size 10 - 16, u). After this fumigation time the residual oxygen content of the solution is less than 1 mg per liter.
Die Lösung wird maschinell in Braunglasflaschen zu 200 ml Volumen abgefüllt. Nach dem Befüllen der Flaschen wird, unmittelbar vor Einsetzen eines Tropfers, das über dem Flüssigkeitsspiegel befindliche Gasvolumen durch Aufblasen von Stickstoff sauerstoffrei gemacht.The solution is mechanically put into amber glass bottles with a volume of 200 ml bottled. After filling the bottles, immediately before inserting one Dropper, the volume of gas above the liquid level by inflating it oxygenated by nitrogen.
Die nachstehende Abb. 1 zeigt den erreichten Stabilisierungseffekt des erfindungsgemäßen Gegenstandes. Ein wässrig-alkoholischer Kamillenextrakt mit einem Chamazulen-/Prochamazulengehalt von 7,1 mg pro 100 g wurde sowohl ohne Inertgasstabilisierung als auch mit Inertgasstabilisierung bei Raumtemperatur bis zu 14 Wochen gelagert.The following Fig. 1 shows the stabilization effect achieved of the article according to the invention. A watery-alcoholic chamomile extract with a chamazulene / prochamazulene content of 7.1 mg per 100 g was both without inert gas stabilization as well as with inert gas stabilization at room temperature for up to 14 weeks.
Die erfindungsgemäß stabilisierte Probe zeigt nach zwölfwöchiger Lagerung noch einen Chamazulen-/Prochamazulengehalt von 5,7 mg pro 100 g während bei der nicht behandelten Probe bereits nach zweiwöchiger Lagerung der Gehalt auf 4,16 mg pro 100 g Extrakt abgesunken ist.The sample stabilized according to the invention shows after storage for twelve weeks still a chamazulene / prochamazulene content of 5.7 mg per 100 g during the untreated sample already after two weeks of storage the content to 4.16 mg per 100 g of extract has decreased.
Mit dem erfindungsgemäßen Gegenstand steht nunmehr ein einfaches Verfahren zur Verfügung, um Lösungen von Kamillenextrakten, insbesondere den darin enthaltenen wirksamen Bestandteilen, über längere Zeit zu stabilisieren, ohne daß es der Verwendung von extraktfremden, reaktiven Chemikalien bedarf.With the subject matter according to the invention, there is now a simple method available to solutions of chamomile extracts, especially those contained therein effective ingredients to stabilize over long periods of time without the need for use of non-extract, reactive chemicals.
- Leerseite -- blank page -
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19843440864 DE3440864A1 (en) | 1984-11-08 | 1984-11-08 | Process for the stabilisation of camomile extracts and their constituents |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19843440864 DE3440864A1 (en) | 1984-11-08 | 1984-11-08 | Process for the stabilisation of camomile extracts and their constituents |
Publications (1)
Publication Number | Publication Date |
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DE3440864A1 true DE3440864A1 (en) | 1986-05-15 |
Family
ID=6249827
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19843440864 Pending DE3440864A1 (en) | 1984-11-08 | 1984-11-08 | Process for the stabilisation of camomile extracts and their constituents |
Country Status (1)
Country | Link |
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DE (1) | DE3440864A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106278877A (en) * | 2016-07-20 | 2017-01-04 | 中国科学院南海海洋研究所 | One class novel structure sesquiterpenoid and the application in preparing anti-inflammatory drug thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3301685A (en) * | 1962-07-09 | 1967-01-31 | Union Carbide Corp | Process for producing stable juice pulp and stable juices containing said stable juice pulp |
GB1156417A (en) * | 1966-09-28 | 1969-06-25 | British Oxygen Co Ltd | Deoxygenation of Liquids |
-
1984
- 1984-11-08 DE DE19843440864 patent/DE3440864A1/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3301685A (en) * | 1962-07-09 | 1967-01-31 | Union Carbide Corp | Process for producing stable juice pulp and stable juices containing said stable juice pulp |
GB1156417A (en) * | 1966-09-28 | 1969-06-25 | British Oxygen Co Ltd | Deoxygenation of Liquids |
Non-Patent Citations (1)
Title |
---|
TROOST, G.: Technologie des Weins, 5. Aufl. Ulmer Stuttgart 1990, S. 242 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106278877A (en) * | 2016-07-20 | 2017-01-04 | 中国科学院南海海洋研究所 | One class novel structure sesquiterpenoid and the application in preparing anti-inflammatory drug thereof |
CN106278877B (en) * | 2016-07-20 | 2019-03-08 | 中国科学院南海海洋研究所 | A kind of novel structure sesquiterpenoid and its application in preparing anti-inflammatory drugs |
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8110 | Request for examination paragraph 44 |