DE3436638C2 - Verwendung von Interferon-gamma (IFN-gamma) enthaltenden Präparationen zur Behandlung rheumatischer Erkrankungen - Google Patents
Verwendung von Interferon-gamma (IFN-gamma) enthaltenden Präparationen zur Behandlung rheumatischer ErkrankungenInfo
- Publication number
- DE3436638C2 DE3436638C2 DE3436638A DE3436638A DE3436638C2 DE 3436638 C2 DE3436638 C2 DE 3436638C2 DE 3436638 A DE3436638 A DE 3436638A DE 3436638 A DE3436638 A DE 3436638A DE 3436638 C2 DE3436638 C2 DE 3436638C2
- Authority
- DE
- Germany
- Prior art keywords
- gamma
- ifn
- treatment
- containing interferon
- preparations containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108010074328 Interferon-gamma Proteins 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 102000008070 Interferon-gamma Human genes 0.000 title claims abstract description 10
- 208000025747 Rheumatic disease Diseases 0.000 title claims abstract description 8
- 229960003130 interferon gamma Drugs 0.000 title claims description 8
- 102000014150 Interferons Human genes 0.000 claims description 10
- 108010050904 Interferons Proteins 0.000 claims description 10
- 210000000265 leukocyte Anatomy 0.000 claims description 8
- 229940047124 interferons Drugs 0.000 claims description 7
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 7
- 238000007920 subcutaneous administration Methods 0.000 claims description 3
- 239000002552 dosage form Substances 0.000 claims description 2
- 238000007918 intramuscular administration Methods 0.000 claims description 2
- 230000003412 degenerative effect Effects 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 229940044627 gamma-interferon Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 description 15
- 208000002193 Pain Diseases 0.000 description 14
- 239000004480 active ingredient Substances 0.000 description 14
- 102100037850 Interferon gamma Human genes 0.000 description 13
- 101000599940 Homo sapiens Interferon gamma Proteins 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 239000000126 substance Substances 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 7
- 238000003745 diagnosis Methods 0.000 description 6
- 108010047761 Interferon-alpha Proteins 0.000 description 5
- 102000006992 Interferon-alpha Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 description 4
- 102100026720 Interferon beta Human genes 0.000 description 3
- 108090000467 Interferon-beta Proteins 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229940079322 interferon Drugs 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 2
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 2
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 2
- IOUUIFSIQMVYKP-UHFFFAOYSA-N Tetradecyl acetate Chemical compound CCCCCCCCCCCCCCOC(C)=O IOUUIFSIQMVYKP-UHFFFAOYSA-N 0.000 description 2
- 229940124599 anti-inflammatory drug Drugs 0.000 description 2
- 230000001028 anti-proliverative effect Effects 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- 206010003246 arthritis Diseases 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 239000005289 controlled pore glass Substances 0.000 description 2
- 229960004544 cortisone Drugs 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 239000003226 mitogen Substances 0.000 description 2
- 210000001179 synovial fluid Anatomy 0.000 description 2
- QGVLYPPODPLXMB-UBTYZVCOSA-N (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b,9,9a-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-5H-cyclopropa[3,4]benzo[1,2-e]azulen-5-one Chemical compound C1=C(CO)C[C@]2(O)C(=O)C(C)=C[C@H]2[C@@]2(O)[C@H](C)[C@@H](O)[C@@]3(O)C(C)(C)[C@H]3[C@@H]21 QGVLYPPODPLXMB-UBTYZVCOSA-N 0.000 description 1
- WHTVZRBIWZFKQO-AWEZNQCLSA-N (S)-chloroquine Chemical compound ClC1=CC=C2C(N[C@@H](C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-AWEZNQCLSA-N 0.000 description 1
- 102100027324 2-hydroxyacyl-CoA lyase 1 Human genes 0.000 description 1
- 101710186708 Agglutinin Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000020084 Bone disease Diseases 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- VVNCNSJFMMFHPL-VKHMYHEASA-N D-penicillamine Chemical compound CC(C)(S)[C@@H](N)C(O)=O VVNCNSJFMMFHPL-VKHMYHEASA-N 0.000 description 1
- -1 Gold Chemical compound 0.000 description 1
- 101001009252 Homo sapiens 2-hydroxyacyl-CoA lyase 1 Proteins 0.000 description 1
- 101710146024 Horcolin Proteins 0.000 description 1
- 208000012659 Joint disease Diseases 0.000 description 1
- 208000003456 Juvenile Arthritis Diseases 0.000 description 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 description 1
- 101710189395 Lectin Proteins 0.000 description 1
- 101710179758 Mannose-specific lectin Proteins 0.000 description 1
- 101710150763 Mannose-specific lectin 1 Proteins 0.000 description 1
- 101710150745 Mannose-specific lectin 2 Proteins 0.000 description 1
- 206010064584 Myosclerosis Diseases 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 206010034464 Periarthritis Diseases 0.000 description 1
- 206010036030 Polyarthritis Diseases 0.000 description 1
- 208000008765 Sciatica Diseases 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 208000016247 Soft tissue disease Diseases 0.000 description 1
- 208000020307 Spinal disease Diseases 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 239000000910 agglutinin Substances 0.000 description 1
- 150000001413 amino acids Chemical group 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000003356 anti-rheumatic effect Effects 0.000 description 1
- 239000003435 antirheumatic agent Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 1
- 229960003677 chloroquine Drugs 0.000 description 1
- WHTVZRBIWZFKQO-UHFFFAOYSA-N chloroquine Natural products ClC1=CC=C2C(NC(C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-UHFFFAOYSA-N 0.000 description 1
- 230000037029 cross reaction Effects 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000003137 locomotive effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000002346 musculoskeletal system Anatomy 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 229960001639 penicillamine Drugs 0.000 description 1
- QGVLYPPODPLXMB-QXYKVGAMSA-N phorbol Natural products C[C@@H]1[C@@H](O)[C@]2(O)[C@H]([C@H]3C=C(CO)C[C@@]4(O)[C@H](C=C(C)C4=O)[C@@]13O)C2(C)C QGVLYPPODPLXMB-QXYKVGAMSA-N 0.000 description 1
- PHEDXBVPIONUQT-RGYGYFBISA-N phorbol 13-acetate 12-myristate Chemical compound C([C@]1(O)C(=O)C(C)=C[C@H]1[C@@]1(O)[C@H](C)[C@H]2OC(=O)CCCCCCCCCCCCC)C(CO)=C[C@H]1[C@H]1[C@]2(OC(C)=O)C1(C)C PHEDXBVPIONUQT-RGYGYFBISA-N 0.000 description 1
- 239000002644 phorbol ester Substances 0.000 description 1
- 208000030428 polyarticular arthritis Diseases 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 201000003068 rheumatic fever Diseases 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/217—IFN-gamma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Priority Applications (22)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3436638A DE3436638C2 (de) | 1984-10-05 | 1984-10-05 | Verwendung von Interferon-gamma (IFN-gamma) enthaltenden Präparationen zur Behandlung rheumatischer Erkrankungen |
| IL76591A IL76591A0 (en) | 1984-10-05 | 1984-10-06 | Pharmaceutical compositions containing ifn-ypsilon and processes for the preparation thereof |
| JP60188689A JPS6191135A (ja) | 1984-10-05 | 1985-08-29 | γ−インタフエロン（γ−ＩＦＮ）を含有するリユ−マチ症治療剤 |
| EP85111184A EP0181455B2 (de) | 1984-10-05 | 1985-09-04 | Verwendung von Interferon-gamma (IFN-gamma) enthaltenden Präparationen zur systemischen Behandlung von verschiedenen Erkrankungen des Menschen in niedriger Dosierung |
| EP85111183A EP0180737B1 (de) | 1984-10-05 | 1985-09-04 | Verwendung von Interferon gamma (IFN-gamma) zur Herstellung von Präparationen zur Behandlung rheumatischer Erkrankungen |
| AT85111183T ATE45675T1 (de) | 1984-10-05 | 1985-09-04 | Verwendung von interferon gamma (ifn-gamma) zur herstellung von praeparationen zur behandlung rheumatischer erkrankungen. |
| DE8585111184T DE3583849D1 (de) | 1984-10-05 | 1985-09-04 | Verwendung von interferon-gamma (ifn-gamma) enthaltenden praeparationen zur systemischen behandlung von verschiedenen erkrankungen des menschen in niedriger dosierung. |
| DE8585111183T DE3572441D1 (en) | 1984-10-05 | 1985-09-04 | Use of interferon gamma (ifn-gamma) for the production of preparations for treating rheumatic diseases |
| AT85111184T ATE66375T1 (de) | 1984-10-05 | 1985-09-04 | Verwendung von interferon-gamma (ifn-gamma) enthaltenden praeparationen zur systemischen behandlung von verschiedenen erkrankungen des menschen in niedriger dosierung. |
| US06/782,221 US4946674A (en) | 1984-10-05 | 1985-09-30 | Process for treatment of rheumatic diseases |
| JP60218143A JP2662214B2 (ja) | 1984-10-05 | 1985-10-02 | 低投与量にてヒトの筋萎縮性側索硬化症を系統的に治療するためのγ―インターフェロン含有組成物 |
| IL76561A IL76561A (en) | 1984-10-05 | 1985-10-04 | Pharmaceutical compositions containing ifn-ypsilon for the treatment of rheumatic diseases |
| DK198504524A DK174585B1 (da) | 1984-10-05 | 1985-10-04 | Anvendelse af gamma-inteferon til fremstilling af farmaceutiske præparater til systemisk behandling af forskellige sygdomme hos mennesker i lave doser |
| EP85112625A EP0177910A3 (de) | 1984-10-05 | 1985-10-04 | Verwendung von Interferon-gamma (IFN-gamma) enthaltenden Präparationen zur systemischen Behandlung von verschiedenen Erkrankungen des Menschen in niedriger Dosierung |
| IL76591A IL76591A (en) | 1984-10-05 | 1985-10-06 | Pharmaceutical compositions containing ifn-ypsilon for the treatment or prevention of malignant or viral diseases |
| AU48412/85A AU588547C (en) | 1984-10-05 | 1985-10-07 | Process for treatment of diseases |
| ZA857721A ZA857721B (en) | 1984-10-05 | 1985-10-07 | Process for treatment of rheumatic diseases |
| AU48408/85A AU581027C (en) | 1984-10-05 | 1985-10-07 | Process for treatment of rheumatic diseases using gamma interferon |
| CA000492377A CA1288694C (en) | 1984-10-05 | 1985-10-07 | Process for treatment of diseases |
| US07/510,714 US5145677A (en) | 1984-10-05 | 1990-04-18 | Process for treatment of diseases |
| JP9061337A JP3048533B2 (ja) | 1984-10-05 | 1997-03-14 | 低投与量にてアレルギー疾患を系統的に治療するための組換えヒトγ−インタフェロン含有組成物 |
| JP10339113A JPH11255665A (ja) | 1984-10-05 | 1998-11-30 | 低投与量にて腫瘍性または新生組織性細胞増殖を系統的に治療するための組換えヒトγ―インタフェロン含有組成物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3436638A DE3436638C2 (de) | 1984-10-05 | 1984-10-05 | Verwendung von Interferon-gamma (IFN-gamma) enthaltenden Präparationen zur Behandlung rheumatischer Erkrankungen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3436638A1 DE3436638A1 (de) | 1986-04-17 |
| DE3436638C2 true DE3436638C2 (de) | 1992-10-08 |
Family
ID=6247225
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3436638A Expired - Lifetime DE3436638C2 (de) | 1984-10-05 | 1984-10-05 | Verwendung von Interferon-gamma (IFN-gamma) enthaltenden Präparationen zur Behandlung rheumatischer Erkrankungen |
| DE8585111183T Expired DE3572441D1 (en) | 1984-10-05 | 1985-09-04 | Use of interferon gamma (ifn-gamma) for the production of preparations for treating rheumatic diseases |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8585111183T Expired DE3572441D1 (en) | 1984-10-05 | 1985-09-04 | Use of interferon gamma (ifn-gamma) for the production of preparations for treating rheumatic diseases |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0180737B1 (enExample) |
| JP (1) | JPS6191135A (enExample) |
| AT (1) | ATE45675T1 (enExample) |
| DE (2) | DE3436638C2 (enExample) |
| ZA (1) | ZA857721B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5910304A (en) * | 1982-12-13 | 1999-06-08 | Texas A&M University System | Low-dose oral administration of interferons |
| DE3519361A1 (de) * | 1985-05-30 | 1986-12-04 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | (gamma)-ifn als wirkstoff zur hemmung (verhinderung) von abbauprozessen im knochen |
| EP0311616B1 (en) * | 1986-06-17 | 1991-09-25 | Biogen, Inc. | Combinations of gamma interferons and anti-inflammatory or anti-pyretic agents for treating diseases |
| CA1320905C (en) * | 1986-11-06 | 1993-08-03 | Joseph M. Cummins | Treatment of immuno-resistant disease |
| AU2855189A (en) * | 1988-01-25 | 1989-07-27 | Baker Cummins Dermatologicals, Inc. | Method of treating fibrotic disorders |
| DE4238159A1 (en) * | 1992-11-12 | 1993-04-29 | Josef Dr Med Mueller | Treatment of prim. chronic polyarthritis and diabetes mellitus - comprises administration of gamma-interferon |
| JP2850293B2 (ja) * | 1996-10-25 | 1999-01-27 | 株式会社林原生物化学研究所 | γ−インターフェロン感受性疾患剤 |
| US6299871B1 (en) * | 1998-07-24 | 2001-10-09 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Orally-administrable therapeutic and/or prophylactic agent for HTLV-1-related diseases |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5527168A (en) * | 1978-04-11 | 1980-02-27 | Verronmay Ltd | Drug composition |
| JPS5598118A (en) * | 1979-01-18 | 1980-07-25 | Hayashibara Takeshi | Preparation of type-2 interferon and drug containing the same |
| CA1190148A (en) * | 1981-10-13 | 1985-07-09 | Samuel S. Asculai | Interferon-containing compositions |
| EP0305551A3 (en) * | 1981-10-13 | 1990-01-10 | Exovir, Inc. | Pharmaceutical compositions for topical application |
| AU561343B2 (en) * | 1981-10-19 | 1987-05-07 | Genentech Inc. | Human immune interferon by recombinant dna |
| DE3380200D1 (en) * | 1982-09-16 | 1989-08-24 | William Alvin Carter | Anti-proliferative action of dsnras on tumor cells |
| DE3381553D1 (de) * | 1982-10-25 | 1990-06-21 | Genentech Inc | Synergistische humaninterferonaktivitaet. |
| US4483849A (en) * | 1983-01-07 | 1984-11-20 | Carter William A | Stabilization and purification of interferon with propylene glycol, resulting in a non-toxic product |
| JP3108538B2 (ja) * | 1992-08-13 | 2000-11-13 | 松下電工株式会社 | 平面トランス |
-
1984
- 1984-10-05 DE DE3436638A patent/DE3436638C2/de not_active Expired - Lifetime
-
1985
- 1985-08-29 JP JP60188689A patent/JPS6191135A/ja active Granted
- 1985-09-04 AT AT85111183T patent/ATE45675T1/de not_active IP Right Cessation
- 1985-09-04 EP EP85111183A patent/EP0180737B1/de not_active Expired
- 1985-09-04 DE DE8585111183T patent/DE3572441D1/de not_active Expired
- 1985-10-07 ZA ZA857721A patent/ZA857721B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE45675T1 (de) | 1989-09-15 |
| EP0180737A2 (de) | 1986-05-14 |
| EP0180737A3 (en) | 1986-05-28 |
| DE3436638A1 (de) | 1986-04-17 |
| EP0180737B1 (de) | 1989-08-23 |
| JPS6191135A (ja) | 1986-05-09 |
| ZA857721B (en) | 1986-09-24 |
| JPH0544930B2 (enExample) | 1993-07-07 |
| DE3572441D1 (en) | 1989-09-28 |
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