DE3390091C1 - Antispasmodic preparation made from a plaster that can be attached to the skin, process for its production and its use - Google Patents

Description

This invention relates to an antispasmodic preparation from a plaster that can be attached to the skin Has carriers and in particular muscle cramps Has properties. This invention further relates to a Process for the preparation of such a preparation as well as a particularly favorable use.

It is known that the basic function of the Living beings and also of the human body numerous phenomena that are controlled with the Electricity, chemistry and electrochemistry related. Such groups include the brain and nerve activity, the electrolytic and osmotic Currents, diffusion and others, so far not perfect clarified biological processes between the cells Processes (e.g. acupuncture).

It is also known to have numerous diseases due to the lack of chemical elements and trace elements are caused. Such shortages can be supplied to the body by various methods be, the application either for bedridden Patient, or being another, lengthy therapeutic procedure is used that requires medical attention or surveillance makes.

DE-GBM 17 98 343 is a bandage or plaster known that provides a multilayer structure, wherein in any case an intermediate layer is required to do this serves at least two metal foils from each other separate. The manufacture of this association is very  cumbersome and complex. There is also a risk the formation of wrinkles when applied to the skin.

A dressing material is known from DE-PS 8 71 823, the is sterile and disinfectant and has a healing effect. Likewise from DE-OS 29 53 327 is a film for medical purposes known as dressing material for Wounds, burns, or surgical sites used shall be. The film contains an antibacterial Medium, where the film is impermeable to liquids, but has a high water vapor permeability.

Based on the above prior art the object of this invention is a simple one to provide antispasmodic preparation that is characterized by a simple structure and its Application to be performed by the patient himself can. In addition, a method for producing a such preparation and a particularly favorable use be specified for this.

To solve this problem, according to the invention Antispasmodic preparation made from a skin-attachable Patches suggested where the on the skin resulting sweat from the covered skin surface not easily evaporated, the patch being a carrier comprises, on which one or more metals or their Alloys and possibly deficiency and / or trace elements applied are to form an electrolytic direct current with the resulting sweat.

Particularly preferred embodiments of the invention Antispasmodic preparations are the subject of claims 2 to 11.

In addition, according to the invention, a method for manufacturing an antispasmodic preparation from one the skin-attachable plaster according to any one of claims 1 to 11, wherein the patch comprises a carrier and one or more metals or Alloys and possibly deficiency and / or trace elements applied with those that develop on the skin  Generate an electrolytic direct current, whereby one or more adhesive strips on the edges of the carrier trained and then applied to the carrier Fabrics with a removable protective layer be covered.

After removing the protective layer and before applying the carrier is preferred on the uninjured skin treated with a weak base or acid.

The anticonvulsant preparation described is especially for the treatment of muscle cramps, rheumatism, Neuralgia and suitable for pain relief.

The metals or metallic substances and / or deficiency and trace elements and possibly also drugs or active ingredients are applied to the carrier or in the form a sludge mixed in, these substances in the course application to the skin surface and with the help of that which forms under the carrier Sweat like very weak currents with an electrolyte as well as generate ions of the applied substances by the pores in the human body to some extent Can penetrate deep. This makes it possible to Eliminate muscle spasm in a short period of time. The penetrating deficiency and / or trace elements can Favor healing. If one or more metallic Fabrics used will have an antispasmodic effect only with those applied by the metallic ones Substances caused microcurrents. The substance applied to the carrier can be in the form of a Solid, in liquid or in gaseous form are present, and if a liquid or gaseous Substance is applied, this is in a container with permeable walls, e.g. B. arranged in bags.

The preparation according to the invention can be continuous bsw. be made in the form of a tape that on the cut desired or required size; it can also be in the form of any format or in Form of a single piece can be produced.  

According to the invention, a metallic substance means those Elements, their mixtures, alloys or Connections that are created with the skin Sweat can produce an electrolytic reaction and that are not toxic to the human organism. Those elements whose electrolytic potential is greater, such. B. metals, Copper, tin and alloys thereof; still zinc, Manganese, cobalt, iron, arsenic, radium, bismuth and selenium, these elements in one for human Organism compatible amount to be applied.

The substances mentioned can also be in the form of a Powder are used, the particle size is not is crucial. The only condition is that the particles do not damage the skin surface. Will Metals used can be plates, wires (in any geometric configuration), metal fibers, metal mesh or foils are used in the same way. It can at some metals may be beneficial if the substances not be used in powder form, as this is the metal can be recovered and used repeatedly. As Deficiency or trace elements become sulfur or one Sulfur ion providing substance or iodine or another Deficiency element used advantageously. From the aforementioned Metals are considered several, as mineral vitamins designated deficiency or trace elements used.

As a gas z. B. carbon monoxide or dioxide, sulfur dioxide or the mixture can be used.

In an advantageous embodiment of the invention Procedures are the substances on the Carrier applied in such a way that adhering edge strips be released and the metallic material and / or the part of the containing deficiency or trace elements Carrier with a removable protective layer (e.g. with a thin grease paper) is covered.  

From electrical accident protection it is known that the Muscles of the human body under the action of a AC at the point exposed to the current effect become spasmatic, and the person who suffers an accident - depending on their individual sensitivity and external circumstances - at a current of 5 mA conscious movement of the muscles is not mastered. In the Specialist literature is numerous data as well as the descriptions indicated by experiments.

Likewise, it deals with accident protection occupying specialist literature that with DC injuries suffered the muscles completely relax. When using the invention This phenomenon is exploited.

In the course of the experiments it could be shown that even the weakest, on the skin surface by the applied substances, currents created muscle spasm breastfeed and introduce the deficiency or trace elements can. If at the point of muscle spasm metallic material applied to the skin surface is at the interface between the metallic fabric and the skin through the continuous sweat (the sweat acts here because of the weakly acidic or basic reaction as an electrolyte) the grains of metallic cloth around a very weak electrolytic direct current generated, the under the skin surface and so penetrates into the muscles and on the nerve pathways exert an influence. Through the direct current will relax under the pavement and its environment caused existing muscles. The in this way electrolytically generated biocurrents can have various effects.

It seems particularly beneficial to be a carrier Use adhesive patches as the sweat is covered by the Skin surface does not evaporate as easily, which makes the effect can be increased.  

The electrolysis can be done by a weak base or Acid can be favored by this on the carrier of the metallic substance before application to the skin surface is applied. But it should be the skin not irritating or damaging weak bases or Acids are used. In numerous cases be proven that the muscle spasm at that time the application of the preparation subsides and within a few minutes almost completely.

As with acupuncture, when metals are known with Effect or the above-mentioned metals on those from the Acupuncture known place, on centers of the skin surface with increased tension or in the place of Pain can be applied and if advantageously as a carrier an adhesive patch is used, one with the Acupuncture is expected to have identical effects, but in this one If the treatment is not associated with pain, since neither the skin surface nor the inner Shifts are injured.

In the case of acupuncture, the pierced produce Metal needles partly with the cell juice, the blood and other juices an electrolytic voltage and lead the electricity generated on the nerve pathways. Acupuncture can only be done by a doctor. At the use of the preparation according to the invention is electrolytic current lower than with acupuncture; but the preparation can last a long time, even some Weeks to be worn on the skin without the skin surface get hurt. That way, the through the acupuncture achievable effect increases many times over will.

When using the preparation can be applied to the various Points of the body different metallic substances or deficiency and / or trace elements are applied, whereby different effects are achieved can be.  

It can also be assumed that the electrolytic process some ions of the on the Skin surface applied metallic material and Deficiency and / or trace elements as in acupuncture through the micro currents and voltages at specific points of the body penetrate, causing the biocurrents to partially and to some extent changed or that trace elements or their ions get to individual places. So can the production in both cases also the supply of the deficiency and / or trace elements are attributed.

By using the antispasmodic preparation can essentially have the following three effects be achieved:

• (a) The (powdery, liquid or gaseous substances by sticking through the diffusion over the skin surface or enter the cells through their pores;
• (b) On the taped surface can be on the skin Sweat arise with the applied fabric and causes osmotic pressure in the cell juices;
• (c) Already during the osmosis between the surface skin (the cell wall) and the two different ones Liquids (the sweat, the applied Substance and the cell juices) small potential difference that the ion exchange between the two liquids across the cell wall promotes.

Most likely these currents affect to a certain extent also those that act on the nerve pathways Flows and favor the supply of the material particles to the underlying tissues.  

In the case of deficiency and / or trace elements or known ones Medicines or their active ingredients can be their Effect can be further increased if that on the skin surface powder to be applied, the liquid, the Gas, the medication or its active ingredients Metal particles are used together with the Sweat together to produce higher Potential differences are capable and the supply of the Accelerate substance to be introduced subcutaneously. By the resulting electrolytic current also arises the previously mentioned antispasmodic effect, and it there is the possibility, in addition to the supply of the deficiency and / or trace elements also to relieve pain. Here can of course only consider such substances which are with the substance to be introduced and Active pharmaceutical ingredients are compatible with and with these do not form toxic compounds.

The effectiveness of those carried out with the preparation Treatment will of course depend on the size of yourself touching areas, from the contact pressure, the duration of the Touch, temperature, properties and quantity of the applied substance and the amount of the formed Sweat affects.

The preparation can also be used in those cases where the disease is due to the lack of one or several chemical elements or one or more Trace elements can be traced, but also in in cases where muscle cramps develop with the disease, e.g. B. rheumatism, tendonitis, disease the organs of movement, muscle cramps resulting from sports, Phlebitis, discopathy, spondylosis, lumbago, Periarthritis humeruscapularis, contusio, Sciatica, pain in scoliosis, general arthrosis, Coxarthrosis, myalgia, Bechterew's disease, joint gout, Torticollis, reduction of the bursa after Peritendinitis, trigeminal nerve, neuralgia, also acupuncture (Johannes Bischko, "Introduction to Acupuncture", Haug Verlag, 4th edition, Heidelberg [1970]) can by  correct application of the preparation can be replaced. In This book describes 358 acupuncture points. So can the preparation according to the invention against headache, Migraines, diseases of the throat, nose and ears, Hay fever, buzzing in the ears (tinnitus), trigeminal Neuralgia and facial paresis, dizziness, ophthalmology, mental illness, sexual disorders, mental instability, insomnia, convulsions, Metabolic disorders, allergies, toothache, intercostal neuralgia etc. (pages 51 to 75 of the above Literature).

In several cases it has been proven that if that Patches with the specified substances, deficiency and / or Trace elements or the mixture thereof on the specific acupuncture points is stuck on, so the stated effect stronger, weaker or hardly, but receive. For example, the following can be enumerated will:

• (a) When the plaster is in the inner recess applied to the ankle, this ensures in the case from insomnia to a calm within 20 minutes Sleep. At the same time, the Pulse rate decreased by 4 to 6. This can also be the case to weaken the accelerated, irregular Heart action can be applied.
• (b) In the event of a bile cramp, according to the determined several points above literature. During the Attempts have been made to achieve it the effect is sufficient, the plaster (even some cm²) under the right second rib. So the bile empties within a maximum of 24 hours and sets the normal function.
• (c) Many places are used to treat runny nose described in the literature. Under these places was bridging the joints of the thumb  Flat-handed and especially on the above surface Cheap. When using the invention The preparation eased during a cold epidemic the course of the disease and fell the last, yellow secretary unpleasant phase away.
• (d) If the patch is on the inner vein of the joint blood pressure is glued around 1333 to 3999 Pa increased.

With regard to the muscle spasm solution (myospamolysis) the expected result was obtained, i. that is, the invention The preparation does not only exert its effect the striated skeletal muscle, but eliminated also the cramps of the smooth muscle, so is the patch e.g. B. in the gall cramp mentioned in acupuncture, Stomach, intestinal cramps, menstrual cramps and asthmatic cramps applicable.

Due to the above information, birth cramps can also occur be alleviated if this z. B. because of a Transportes or other causes is necessary. After removal of the patch, the cramps reappear.

With operated veins, the pain can be at the site pain and swelling 3 to 4 hours after Adhesion of the patch can be eliminated, also reduced the swelling.

Many substances, by the digestive system or by injection are difficult to incorporate into the human body Organ without any harmful side effects. So z. B. iron in the case of anemia, selenium in the case of Heart attack or for its prevention, as well as the five Metal vitamins (zinc, molybdenum, manganese, copper and  Cobalt). If these metal vitamins are not or only in not sufficient quantities are present, many can Diseases occur because without these substances the organism cannot manufacture the necessary protective materials. The mentioned Metal vitamins are likely to occur as Catalysts in the manufacture of various protective substances (Immune substances, vitamins, hormones). This can the preparation according to the invention for prophylaxis and healing of many diseases used by what mentioned substances and their combination is achieved.

Attempts have been made to treat muscle spasm and Rheumatism performed as follows.

The empty plasters with the active ingredients were weighed. The results are as follows:  

Rheumatism plaster

Muscle cramp patch

At the edge of the patch, 5 mm wide strips were not treated with the active ingredients, so about 10 cm × 5 cm strips, about 0.5 / 10 ^-2 m² were sprinkled.

The amount of active ingredient can e.g. B. can be varied between 0.01 g / 10 ^-2 m² and 5.0 g / 10 ^-2 m². 0.05 to 0.6 g / 10 ^-2 m², particularly 0.01 to 0.1 g / 10 ^-2 m² of active ingredient is advantageously used.

After sticking, the rheumatism patch is applied to the Skin pressed on.

If the pain after the rheumatic or the anti-spasmodic treatment is said to come back Patches with 0.5 cm × 0.5 cm or 1 cm² surface to be brought up on the skin. So will the pain no longer occur.

The results are shown in the tables below of clinical examinations. The said Side effect (dermatitis) occurs when using others Do not put plaster on.  

Examinations with muscle cramping plasters (Cu)

Examinations with rheumatic plasters (Cu + S = 1: 2 parts by weight)

Claims (14)

1. Antispasmodic preparation made from a product on the skin attachable plaster, in which the emerging on the skin Do not sweat from the covered skin surface easily evaporated, the patch comprising a carrier, on which one or more metals or their alloys and possibly deficiency and / or trace elements are applied to form an electrolytic Direct current with the sweat. 2. Preparation according to claim 1, characterized in that it on the pavement also a known medicine or contains its active ingredient. 3. Preparation according to claim 1 or 2, characterized in that the patch is an adhesive patch. 4. Preparation according to claim 1 or 2, characterized in that the patch at the edges with one or more adhesive strips is provided. 5. Preparation according to claim 3 or 4, characterized in that the adhesive is a skin-allergic neutral adhesive. 6. Preparation according to one of the preceding claims, characterized characterized in that the metals metal powder, filing dust, in wires, plates, foils, metal fibers arranged in any form and / or metal mesh. 7. Preparation according to one of the preceding claims, characterized characterized in that the deficiency and / or trace elements in Form of a powder or as a granular material.   8. Preparation according to one of the preceding claims, characterized characterized in that the metal is one from the group Copper, zinc, tin, manganese, cobalt, molybdenum, iron, arsenic, Bismuth, radium and / or their alloys. 9. Preparation according to one of the preceding claims, characterized characterized in that iodine as a deficiency and / or trace element or sulfur ions, or non-toxic, substances that do not damage the skin are applied. 10. Preparation according to one of the preceding claims, characterized in that the plaster contains the metal, its alloy, the deficiency and / or trace element in an amount of 0.01 to 5.0 g / 10 ^-2 m² of plaster. 11. Preparation according to one of the preceding claims, characterized characterized in that the substances on the pavement are covered with a removable protective layer. 12. Method of making an antispasmodic Preparations from a plaster that can be attached to the skin according to one of claims 1 to 11, wherein the plaster comprises a carrier, characterized in that on the carrier one or more metals or their Alloys and if necessary deficiency and / or Trace elements are applied, which with the on the Skin sweat an electrolytic Generate direct current, being on the edges of the carrier one or more adhesive strips are formed and then the substances applied to the carrier be covered with a removable protective layer.   13. The method according to claim 12, characterized in that that the carrier before attaching to the uninjured Skin is treated with a weak base or acid. 14. Use of the anticonvulsant preparation after one of claims 1 to 11 for the treatment of muscle cramps, Rheumatism, neuralgia and pain relief.