DE3382244D1 - Waermeempfindliche multikopie-plasmide und dieselben enthaltende organismen, ihre herstellung und verwendung zur proteinherstellung. - Google Patents

Waermeempfindliche multikopie-plasmide und dieselben enthaltende organismen, ihre herstellung und verwendung zur proteinherstellung.

Info

Publication number
DE3382244D1
DE3382244D1 DE8383303293T DE3382244T DE3382244D1 DE 3382244 D1 DE3382244 D1 DE 3382244D1 DE 8383303293 T DE8383303293 T DE 8383303293T DE 3382244 T DE3382244 T DE 3382244T DE 3382244 D1 DE3382244 D1 DE 3382244D1
Authority
DE
Germany
Prior art keywords
production
plasmides
multicopy
sensitive
heat
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8383303293T
Other languages
English (en)
Inventor
David Harow Gelfand
Carolyn Jan Strange
Robert Malcolm Watson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Cetus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Corp filed Critical Cetus Corp
Application granted granted Critical
Publication of DE3382244D1 publication Critical patent/DE3382244D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C12N15/69—Increasing the copy number of the vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Thermistors And Varistors (AREA)
  • Pressure Sensors (AREA)
  • Measuring Temperature Or Quantity Of Heat (AREA)
  • Saccharide Compounds (AREA)
DE8383303293T 1982-06-08 1983-06-07 Waermeempfindliche multikopie-plasmide und dieselben enthaltende organismen, ihre herstellung und verwendung zur proteinherstellung. Expired - Fee Related DE3382244D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38634882A 1982-06-08 1982-06-08

Publications (1)

Publication Number Publication Date
DE3382244D1 true DE3382244D1 (de) 1991-05-16

Family

ID=23525224

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383303293T Expired - Fee Related DE3382244D1 (de) 1982-06-08 1983-06-07 Waermeempfindliche multikopie-plasmide und dieselben enthaltende organismen, ihre herstellung und verwendung zur proteinherstellung.

Country Status (6)

Country Link
EP (1) EP0096586B1 (de)
JP (1) JPS5951794A (de)
AT (1) ATE62509T1 (de)
CA (1) CA1198069A (de)
DE (1) DE3382244D1 (de)
DK (1) DK261183A (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308236D0 (en) * 1983-03-25 1983-05-05 Celltech Ltd Dna vectors
AU600885B2 (en) * 1984-05-25 1990-08-30 Zymogenetics Inc. Stable DNA constructs
EP0180192B1 (de) * 1984-10-29 1992-02-05 Research Association For Utilization Of Light Oil Plasmide
GB2166743B (en) * 1984-11-13 1989-01-05 Solvay Process for a thermo-inducible gene expression in gram positive bacteria and bacillus subtilis strains containing plasmids which induce such an expression
JPH0616711B2 (ja) * 1985-09-27 1994-03-09 メルシャン株式会社 高温で自律増殖するプラスミド
US4966841A (en) * 1987-05-22 1990-10-30 The Board Of Regents Of The University Of Washington Enhanced vector production and expression of recombinant DNA products
US7999451B2 (en) * 2006-11-10 2011-08-16 Global Oled Technology Llc Blue color filter element

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2759053A1 (de) * 1977-12-30 1979-07-12 Uhlin Verfahren zum herstellen von genprodukten von plasmid-dns
CA1198067A (en) * 1981-02-27 1985-12-17 David H. Gelfand Stable high copy number plasmids
NL8203716A (nl) * 1982-09-24 1984-04-16 Tno Dna en plasmiden.

Also Published As

Publication number Publication date
EP0096586A3 (en) 1985-11-06
DK261183A (da) 1983-12-09
JPS5951794A (ja) 1984-03-26
EP0096586A2 (de) 1983-12-21
DK261183D0 (da) 1983-06-08
EP0096586B1 (de) 1991-04-10
ATE62509T1 (de) 1991-04-15
CA1198069A (en) 1985-12-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee