DE3379200D1 - Acid salts of 1-(cyanoalkyl)-4-guanylpiperazines and methods for their preparation and use - Google Patents

Acid salts of 1-(cyanoalkyl)-4-guanylpiperazines and methods for their preparation and use

Info

Publication number
DE3379200D1
DE3379200D1 DE8383902471T DE3379200T DE3379200D1 DE 3379200 D1 DE3379200 D1 DE 3379200D1 DE 8383902471 T DE8383902471 T DE 8383902471T DE 3379200 T DE3379200 T DE 3379200T DE 3379200 D1 DE3379200 D1 DE 3379200D1
Authority
DE
Germany
Prior art keywords
guanylpiperazines
cyanoalkyl
preparation
methods
acid salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383902471T
Other languages
English (en)
Inventor
Louise Sandefur
Wojciech Slusarek
Burton Wilson
Cataldo Maggiulli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eastman Kodak Co
Original Assignee
Eastman Kodak Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eastman Kodak Co filed Critical Eastman Kodak Co
Application granted granted Critical
Publication of DE3379200D1 publication Critical patent/DE3379200D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE8383902471T 1982-08-11 1983-06-13 Acid salts of 1-(cyanoalkyl)-4-guanylpiperazines and methods for their preparation and use Expired DE3379200D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/407,215 US4620006A (en) 1982-08-11 1982-08-11 Acid salts of 1-(cyanoalkyl)-4-guanylpiperazines
PCT/US1983/000919 WO1984000752A1 (en) 1982-08-11 1983-06-13 Acid salts of 1-(cyanoalkyl)-4-guanylpiperazines and methods for their preparation and use

Publications (1)

Publication Number Publication Date
DE3379200D1 true DE3379200D1 (en) 1989-03-23

Family

ID=23611121

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383902471T Expired DE3379200D1 (en) 1982-08-11 1983-06-13 Acid salts of 1-(cyanoalkyl)-4-guanylpiperazines and methods for their preparation and use

Country Status (7)

Country Link
US (1) US4620006A (de)
EP (1) EP0115506B1 (de)
JP (1) JPS59501412A (de)
CA (1) CA1250581A (de)
DE (1) DE3379200D1 (de)
IT (1) IT1164411B (de)
WO (1) WO1984000752A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4780466A (en) * 1988-03-17 1988-10-25 Hoechst-Roussel Pharmaceuticals, Inc. Arylpiperazinylalkoxy derivatives of cyclic imides
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2227158A (en) * 1936-02-12 1940-12-31 William H Saul Packet of cigarettes
US2425341A (en) * 1944-08-11 1947-08-12 American Cyanamid Co Production of mono- and unsymmetrically disubstituted guanidines
US2904536A (en) * 1955-06-29 1959-09-15 Du Pont Polyamide containing interlinear piperazine units
US3398151A (en) * 1966-02-01 1968-08-20 Mead Johnson & Co Azaspirodecanediones and azaspiroundecanediones
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
US3976776A (en) * 1972-12-06 1976-08-24 Mead Johnson & Company Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones
US3919230A (en) * 1974-02-07 1975-11-11 Smithkline Corp {62 -Naphthylmethyl piperazinyl derivatives
JPS6028827B2 (ja) * 1974-09-27 1985-07-06 大日本製薬株式会社 １−アミジノピペラジンの製造法
ZA803339B (en) * 1979-08-09 1981-05-27 Soc D Etudes Prod Chimique Preparation of 2-isopropylamino pyrimidine
US4367335A (en) * 1981-08-03 1983-01-04 Mead Johnson & Company Thiazolidinylalkylene piperazine derivatives
JP2744157B2 (ja) * 1991-11-22 1998-04-28 株式会社東芝 マンコンベア安全装置

Also Published As

Publication number Publication date
IT8322498A0 (it) 1983-08-10
IT8322498A1 (it) 1985-02-10
CA1250581A (en) 1989-02-28
WO1984000752A1 (en) 1984-03-01
JPS59501412A (ja) 1984-08-09
EP0115506A1 (de) 1984-08-15
IT1164411B (it) 1987-04-08
EP0115506B1 (de) 1989-02-15
EP0115506A4 (de) 1985-04-23
US4620006A (en) 1986-10-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee