DE3376114D1 - Mitomycin analogues - Google Patents

Mitomycin analogues

Info

Publication number
DE3376114D1
DE3376114D1 DE8383307423T DE3376114T DE3376114D1 DE 3376114 D1 DE3376114 D1 DE 3376114D1 DE 8383307423 T DE8383307423 T DE 8383307423T DE 3376114 T DE3376114 T DE 3376114T DE 3376114 D1 DE3376114 D1 DE 3376114D1
Authority
DE
Germany
Prior art keywords
mitomycin analogues
mitomycin
analogues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383307423T
Other languages
English (en)
Inventor
Motomichi Kono
Yutaka Saito
Jyoji Goto
Kunikatsu Shirahata
Makoto Morimoto
Tadashi Ashizawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP21450982A external-priority patent/JPS59104386A/ja
Priority claimed from JP5018683A external-priority patent/JPS59175493A/ja
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Application granted granted Critical
Publication of DE3376114D1 publication Critical patent/DE3376114D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
DE8383307423T 1982-12-07 1983-12-06 Mitomycin analogues Expired DE3376114D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP21450982A JPS59104386A (ja) 1982-12-07 1982-12-07 マイトマイシン誘導体
JP5018683A JPS59175493A (ja) 1983-03-25 1983-03-25 マイトマイシン誘導体

Publications (1)

Publication Number Publication Date
DE3376114D1 true DE3376114D1 (en) 1988-05-05

Family

ID=26390634

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8383307423T Expired DE3376114D1 (en) 1982-12-07 1983-12-06 Mitomycin analogues
DE1983307423 Pending DE116208T1 (de) 1982-12-07 1983-12-06 Mitomycin-analoge.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE1983307423 Pending DE116208T1 (de) 1982-12-07 1983-12-06 Mitomycin-analoge.

Country Status (2)

Country Link
EP (1) EP0116208B1 (de)
DE (2) DE3376114D1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4803212A (en) * 1983-04-11 1989-02-07 Bristol-Myers Company Amino disulfides
US4866180A (en) * 1984-02-24 1989-09-12 Bristol-Myers Company Amino disulfide thiol exchange products
JPS60255789A (ja) * 1984-06-01 1985-12-17 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体，その製造法および抗腫瘍剤
AU581673B2 (en) * 1984-09-04 1989-03-02 Bristol-Myers Company Substituted 7-oxomitosanes
US4927943A (en) * 1984-09-04 1990-05-22 Bristol-Myers Company Substituted 7-oxomitosanes
EP0197799B1 (de) * 1985-04-10 1990-09-12 Kyowa Hakko Kogyo Kabushiki Kaisha Pharmakologisch aktive Mitomycinderivate
JPS63150282A (ja) * 1986-12-13 1988-06-22 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
ZA886812B (en) * 1987-11-23 1989-07-26 Bristol Myers Co Anti-tumor prodrugs
JPH0249786A (ja) * 1988-05-30 1990-02-20 Kyowa Hakko Kogyo Co Ltd 新規なマイトマイシン誘導体およびその中間体
US5175303A (en) * 1990-03-08 1992-12-29 Bristol-Myers Squibb Company Preparation of 7-(diphenylmethyl)oxy-9A-methoxymitosane
US5075454A (en) * 1990-03-08 1991-12-24 Bristol-Myers Squibb Company 7-(diphenylmethyl)oxy-9a-methoxymitosane
DE60231868D1 (de) 2001-04-24 2009-05-20 Purdue Research Foundation Folat-mimetika und deren folatrezeptorbindende konjugate
JP4814520B2 (ja) 2002-05-15 2011-11-16 エンドサイト，インコーポレイテッド ビタミン−マイトマイシン結合体
PT1592457E (pt) 2003-01-27 2012-11-02 Endocyte Inc Conjugados de entrega farmacológica de ligação a recetores de vitaminas
US8288557B2 (en) 2004-07-23 2012-10-16 Endocyte, Inc. Bivalent linkers and conjugates thereof
JP5289935B2 (ja) 2005-03-16 2013-09-11 エンドサイト，インコーポレイテッド プテロイン酸およびその結合体の合成と精製
KR20130113543A (ko) 2005-08-19 2013-10-15 엔도사이트, 인코포레이티드 복수-약제 리간드 공액체
WO2008101231A2 (en) 2007-02-16 2008-08-21 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
JP5829793B2 (ja) 2007-03-14 2015-12-09 エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ， Ｉｎｃ． 結合性リガンドが結合したツブリシンの薬剤送達結合体
WO2009002993A1 (en) 2007-06-25 2008-12-31 Endocyte, Inc. Conjugates containing hydrophilic spacer linkers
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
DK2187965T3 (da) 2007-08-17 2020-01-20 Purdue Research Foundation Psma-bindingsligand-linker-konjugater og fremgangsmåder til anvendelse
US9187521B2 (en) 2007-10-25 2015-11-17 Endocyte, Inc. Tubulysins and processes for preparing
US9951324B2 (en) 2010-02-25 2018-04-24 Purdue Research Foundation PSMA binding ligand-linker conjugates and methods for using
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
CA2887727A1 (en) 2012-10-16 2014-04-24 Endocyte, Inc. Drug delivery conjugates containing unnatural amino acids and methods for using
EA201890915A1 (ru) 2012-11-15 2018-09-28 Эндосайт, Инк. Конъюгаты для доставки лекарственных средств и способы лечения заболеваний, вызванных клетками, экспрессирующими psma
EP3495355A1 (de) 2013-10-18 2019-06-12 Deutsches Krebsforschungszentrum Markierte inhibitoren des prostataspezifischen membranantigens (psma), deren verwendung als kontrastmittel und pharmazeutika zur behandlung von prostatakrebs
US10188759B2 (en) 2015-01-07 2019-01-29 Endocyte, Inc. Conjugates for imaging

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3332944A (en) * 1964-11-02 1967-07-25 American Cyanamid Co Antibiotic derivatives of mitomycins a, b, c and porfiromycin
US4268676A (en) * 1979-12-05 1981-05-19 University Patents, Inc. Mitomycin analogs
NZ199617A (en) * 1981-05-15 1985-08-30 University Patents Inc Azirino(2',3',:3,4)pyrrolo(1,2-a)indole-4,7-dione derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
EP0116208B1 (de) 1988-03-30
EP0116208A1 (de) 1984-08-22
DE116208T1 (de) 1985-02-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee