DE3364253D1 - Novel azole dinucleotide compounds and methods for their production - Google Patents
Novel azole dinucleotide compounds and methods for their productionInfo
- Publication number
- DE3364253D1 DE3364253D1 DE8383103082T DE3364253T DE3364253D1 DE 3364253 D1 DE3364253 D1 DE 3364253D1 DE 8383103082 T DE8383103082 T DE 8383103082T DE 3364253 T DE3364253 T DE 3364253T DE 3364253 D1 DE3364253 D1 DE 3364253D1
- Authority
- DE
- Germany
- Prior art keywords
- production
- methods
- novel azole
- compounds
- dinucleotide compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/363,315 US4544741A (en) | 1982-03-29 | 1982-03-29 | Azole dinucleotide compounds and methods for their production |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3364253D1 true DE3364253D1 (en) | 1986-07-31 |
Family
ID=23429722
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8383103082T Expired DE3364253D1 (en) | 1982-03-29 | 1983-03-28 | Novel azole dinucleotide compounds and methods for their production |
Country Status (5)
Country | Link |
---|---|
US (1) | US4544741A (de) |
EP (1) | EP0090405B1 (de) |
JP (1) | JPS58177999A (de) |
AT (1) | ATE20529T1 (de) |
DE (1) | DE3364253D1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4544741A (en) * | 1982-03-29 | 1985-10-01 | Robins Roland K | Azole dinucleotide compounds and methods for their production |
US4594415A (en) * | 1982-03-29 | 1986-06-10 | Robins Roland K | Azole dinucleotide compositions and methods of use |
ATE271555T1 (de) | 1998-01-14 | 2004-08-15 | Uab Research Foundation | Verfahren zur herstellung und screening von inhibitoren des bakteriellen nad synthetase enzyms, verbindungen daraus und methoden zur behandlung bakterieller und mikrobieller infektionen mit diesen inhibitoren |
US6861448B2 (en) | 1998-01-14 | 2005-03-01 | Virtual Drug Development, Inc. | NAD synthetase inhibitors and uses thereof |
RU2001113268A (ru) * | 1998-10-16 | 2003-09-27 | Шеринг Корпорейшн (US) | Сочетанная терапия рибавирином и интерфероном α для удаления определяемой рнк вируса гепатита с у пациентов с хроническим гепатитом с |
US6277830B1 (en) | 1998-10-16 | 2001-08-21 | Schering Corporation | 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon |
US6403564B1 (en) | 1998-10-16 | 2002-06-11 | Schering Corporation | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection |
US6924270B2 (en) | 2000-04-20 | 2005-08-02 | Schering Corporation | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection |
JP2005229839A (ja) * | 2004-02-17 | 2005-09-02 | Sapporo Breweries Ltd | 乳酸菌の検出・識別方法 |
WO2008052722A2 (en) * | 2006-11-02 | 2008-05-08 | Heidelberg Pharma Ag | Use of ribavirin-conjugates as an anti-viral drug |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2951838A (en) * | 1959-12-30 | 1960-09-06 | American Cyanamid Co | Novel method of preparing nucleotide imidazoles |
FR2071360A5 (en) * | 1969-12-23 | 1971-09-17 | Ugine Kuhlmann | 3-cyanopyridine adenine dinucleotide - coenzyme for oxydo-reductases |
DK553781A (da) * | 1980-12-15 | 1982-06-16 | Vira Tek Inc | Fremgangsmaade til fremstilling af 2-beta-d-ribofuranosulthiazol-4-carboxid-estere |
US4544741A (en) * | 1982-03-29 | 1985-10-01 | Robins Roland K | Azole dinucleotide compounds and methods for their production |
US4446315A (en) * | 1982-09-24 | 1984-05-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adenosine 5'-triphosphate-4-carboxamide-ribofuranosylthiazole |
-
1982
- 1982-03-29 US US06/363,315 patent/US4544741A/en not_active Expired - Fee Related
-
1983
- 1983-03-28 JP JP58052293A patent/JPS58177999A/ja active Pending
- 1983-03-28 AT AT83103082T patent/ATE20529T1/de not_active IP Right Cessation
- 1983-03-28 DE DE8383103082T patent/DE3364253D1/de not_active Expired
- 1983-03-28 EP EP83103082A patent/EP0090405B1/de not_active Expired
Also Published As
Publication number | Publication date |
---|---|
EP0090405B1 (de) | 1986-06-25 |
US4544741A (en) | 1985-10-01 |
ATE20529T1 (de) | 1986-07-15 |
EP0090405A1 (de) | 1983-10-05 |
JPS58177999A (ja) | 1983-10-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |