ATE20529T1 - Azole dinukleotide und verfahren zu ihrer herstellung. - Google Patents

Azole dinukleotide und verfahren zu ihrer herstellung.

Info

Publication number
ATE20529T1
ATE20529T1 AT83103082T AT83103082T ATE20529T1 AT E20529 T1 ATE20529 T1 AT E20529T1 AT 83103082 T AT83103082 T AT 83103082T AT 83103082 T AT83103082 T AT 83103082T AT E20529 T1 ATE20529 T1 AT E20529T1
Authority
AT
Austria
Prior art keywords
production
azole
dinucleotides
compounds
class
Prior art date
Application number
AT83103082T
Other languages
English (en)
Inventor
Roland Kenith Robins
Ganapathi Ramakrishna Revankar
Original Assignee
Univ Brigham Young
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Brigham Young filed Critical Univ Brigham Young
Application granted granted Critical
Publication of ATE20529T1 publication Critical patent/ATE20529T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT83103082T 1982-03-29 1983-03-28 Azole dinukleotide und verfahren zu ihrer herstellung. ATE20529T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/363,315 US4544741A (en) 1982-03-29 1982-03-29 Azole dinucleotide compounds and methods for their production
EP83103082A EP0090405B1 (de) 1982-03-29 1983-03-28 Azole Dinukleotide und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
ATE20529T1 true ATE20529T1 (de) 1986-07-15

Family

ID=23429722

Family Applications (1)

Application Number Title Priority Date Filing Date
AT83103082T ATE20529T1 (de) 1982-03-29 1983-03-28 Azole dinukleotide und verfahren zu ihrer herstellung.

Country Status (5)

Country Link
US (1) US4544741A (de)
EP (1) EP0090405B1 (de)
JP (1) JPS58177999A (de)
AT (1) ATE20529T1 (de)
DE (1) DE3364253D1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4544741A (en) * 1982-03-29 1985-10-01 Robins Roland K Azole dinucleotide compounds and methods for their production
US4594415A (en) * 1982-03-29 1986-06-10 Robins Roland K Azole dinucleotide compositions and methods of use
US6861448B2 (en) 1998-01-14 2005-03-01 Virtual Drug Development, Inc. NAD synthetase inhibitors and uses thereof
IL137229A0 (en) 1998-01-14 2001-07-24 Uab Research Foundation Methods of synthesizing and screening inhibitors of bacterial nad synthetase enzyme, compounds thereof, and methods of treating bacterial and microbial infections with inhibitors of bacterial nad synthetase enzyme
US6277830B1 (en) 1998-10-16 2001-08-21 Schering Corporation 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon
US6403564B1 (en) 1998-10-16 2002-06-11 Schering Corporation Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
BR9915546A (pt) * 1998-10-16 2001-08-14 Schering Corp Terapia de combinação de ribavirin- interferon alfa para a erradiação de hcv-rna detectável em pacientes tendo infecção por hepatite c crÈnica
US6924270B2 (en) 2000-04-20 2005-08-02 Schering Corporation Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
JP2005229839A (ja) * 2004-02-17 2005-09-02 Sapporo Breweries Ltd 乳酸菌の検出・識別方法
WO2008052722A2 (en) * 2006-11-02 2008-05-08 Heidelberg Pharma Ag Use of ribavirin-conjugates as an anti-viral drug

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2951838A (en) * 1959-12-30 1960-09-06 American Cyanamid Co Novel method of preparing nucleotide imidazoles
FR2071360A5 (en) * 1969-12-23 1971-09-17 Ugine Kuhlmann 3-cyanopyridine adenine dinucleotide - coenzyme for oxydo-reductases
DK553781A (da) * 1980-12-15 1982-06-16 Vira Tek Inc Fremgangsmaade til fremstilling af 2-beta-d-ribofuranosulthiazol-4-carboxid-estere
US4544741A (en) * 1982-03-29 1985-10-01 Robins Roland K Azole dinucleotide compounds and methods for their production
US4446315A (en) * 1982-09-24 1984-05-01 The United States Of America As Represented By The Department Of Health And Human Services Adenosine 5'-triphosphate-4-carboxamide-ribofuranosylthiazole

Also Published As

Publication number Publication date
JPS58177999A (ja) 1983-10-18
US4544741A (en) 1985-10-01
DE3364253D1 (en) 1986-07-31
EP0090405B1 (de) 1986-06-25
EP0090405A1 (de) 1983-10-05

Similar Documents

Publication Publication Date Title
AT369750B (de) Verfahren zur herstellung des neuen 11-aza-4-0cladinosyl-6-0-desosaminyl-15-aethyl-7,13,14-
ATA469079A (de) Verfahren zur herstellung von neuen 2,2-substituierten 1,3-propandiaminplatin (ii)
ATE39928T1 (de) 4-dimethylamino-1-hydroxybutan-1,1diphosphons|ure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung.
DE58901518D1 (de) Isoxazoline, verfahren zu ihrer herstellung sowie ihre verwendung.
ATE20529T1 (de) Azole dinukleotide und verfahren zu ihrer herstellung.
DE3481917D1 (de) Flammwidrige polyolefinzusammensetzungen, gegenstaende und verfahren zur herstellung.
BG42004A3 (en) Method for preparing pyridyl compounds
BG35042A3 (en) Method for preparing benzodiazepinic compounds
BG39976A3 (en) Method for preparing benzamides
DE3779478D1 (de) In 1-stellung substituierte konjugierte (e,z)-alkadienverbindungen sowie verfahren zu ihrer herstellung.
BG40147A3 (en) Method for preparing heterocyclic compounds
BG36939A3 (en) Method for preparing macrolide
ATE8908T1 (de) Sinterfaehige, feinteilige polyvinylchloridformmasse sowie verfahren zu deren herstellung und deren verwendung.
BG38637A3 (en) Method for preparing 2- exo- hydroxy- 7- oxabicyclo [2, 2, 1] heptanes
AT363487B (de) Verfahren zum herstellen von neuen amino-pyrazolo(1,5-a)s.triazinen
BG41129A3 (en) Method for preparing acetamide derivatives
BG38939A3 (en) Method for preparing 1, 1- dioxopenicillanoyloxymethyl ester of 6- (2- amino- 2- phenylacetamido)- penicillanic acid
AT374177B (de) Verfahren zur herstellung von neuen 1-substituierten-3-cycloalkylsulfonyl-pyrrolidi -2,5-dion-derivaten sowie von deren salzen
DE3854221D1 (de) Selbstverlöschende, halogenfreie thermoplastische Formmasse, Verfahren zu deren Herstellung und ihre Verwendung.
AT375941B (de) Verfahren zur herstellung von neuen 1-aminopyrazolo (1,5-c) chinazolinderivaten
ATE18553T1 (de) Sulfinyl- und sulfonyl-azacycloheptan-2-one, verfahren zu ihrer herstellung sowie ihre verwendung als futterzusatzstoffe.
ATE34386T1 (de) 1,2,3,4-tetrahydro-1-aminomethyl-4-phenylisochinoline und verfahren zu ihrer herstellung.
DE3767435D1 (de) Glycidyl-verbindungen und verfahren zu ihrer herstellung.
BG37076A3 (en) Method for preparing 5, 6- dihydro- 2- methyl- n- phenyl- 1, 4- oxatyine- 3- carboxamide
AT376437B (de) Verfahren zur herstellung von neuen pyrido(3,4-e)-as-triazin-derivaten

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee