DE3303098A1 - Verfahren und reagenz zur glucosebestimmung im haemolysierten blut - Google Patents
Verfahren und reagenz zur glucosebestimmung im haemolysierten blutInfo
- Publication number
- DE3303098A1 DE3303098A1 DE19833303098 DE3303098A DE3303098A1 DE 3303098 A1 DE3303098 A1 DE 3303098A1 DE 19833303098 DE19833303098 DE 19833303098 DE 3303098 A DE3303098 A DE 3303098A DE 3303098 A1 DE3303098 A1 DE 3303098A1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- glucose
- reagent
- sulfate
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 title claims abstract description 35
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 31
- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 29
- 210000004369 blood Anatomy 0.000 title claims abstract description 28
- 239000008280 blood Substances 0.000 title claims abstract description 28
- 239000008103 glucose Substances 0.000 title description 26
- 239000003755 preservative agent Substances 0.000 claims abstract description 18
- 102000005548 Hexokinase Human genes 0.000 claims abstract description 16
- 108700040460 Hexokinases Proteins 0.000 claims abstract description 16
- 102100031126 6-phosphogluconolactonase Human genes 0.000 claims abstract description 12
- 108010029731 6-phosphogluconolactonase Proteins 0.000 claims abstract description 12
- 108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 claims abstract description 12
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 claims abstract description 11
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 10
- -1 Mg++ ions Chemical class 0.000 claims abstract description 9
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 8
- 238000005259 measurement Methods 0.000 claims abstract description 7
- 125000002877 alkyl aryl group Chemical group 0.000 claims abstract description 6
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims abstract description 5
- 125000001424 substituent group Chemical group 0.000 claims abstract description 5
- 210000001124 body fluid Anatomy 0.000 claims abstract description 4
- 239000010839 body fluid Substances 0.000 claims abstract description 4
- 239000000872 buffer Substances 0.000 claims abstract description 4
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 claims description 12
- 230000002335 preservative effect Effects 0.000 claims description 12
- 125000004432 carbon atom Chemical group C* 0.000 claims description 11
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 11
- 150000008051 alkyl sulfates Chemical class 0.000 claims description 8
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 claims description 7
- 229940043264 dodecyl sulfate Drugs 0.000 claims description 7
- 150000008055 alkyl aryl sulfonates Chemical class 0.000 claims description 6
- 150000001540 azides Chemical class 0.000 claims description 5
- 125000005191 hydroxyalkylamino group Chemical group 0.000 claims description 5
- LVHDAZDBGLROSI-UHFFFAOYSA-N 4,5-dihydro-1h-imidazole;urea Chemical compound NC(N)=O.C1CN=CN1 LVHDAZDBGLROSI-UHFFFAOYSA-N 0.000 claims description 4
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000003513 alkali Substances 0.000 claims description 4
- 229960003260 chlorhexidine Drugs 0.000 claims description 4
- 229910001425 magnesium ion Inorganic materials 0.000 claims description 2
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 claims 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract description 2
- JXLHNMVSKXFWAO-UHFFFAOYSA-N azane;7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid Chemical compound N.OS(=O)(=O)C1=CC=C(F)C2=NON=C12 JXLHNMVSKXFWAO-UHFFFAOYSA-N 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 206010018910 Haemolysis Diseases 0.000 description 18
- 230000008588 hemolysis Effects 0.000 description 18
- 102000004190 Enzymes Human genes 0.000 description 13
- 108090000790 Enzymes Proteins 0.000 description 13
- 239000000243 solution Substances 0.000 description 12
- 239000000203 mixture Substances 0.000 description 8
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 7
- 210000003743 erythrocyte Anatomy 0.000 description 6
- 150000003871 sulfonates Chemical class 0.000 description 6
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 5
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- 229910019142 PO4 Inorganic materials 0.000 description 4
- 238000002835 absorbance Methods 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 239000003219 hemolytic agent Substances 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 239000010452 phosphate Substances 0.000 description 4
- 238000007430 reference method Methods 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000034659 glycolysis Effects 0.000 description 3
- 230000002949 hemolytic effect Effects 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- BSJPUMYGWDFGFF-UHFFFAOYSA-N 1-dodecoxytetradecane;sulfuric acid Chemical compound OS(O)(=O)=O.CCCCCCCCCCCCCCOCCCCCCCCCCCC BSJPUMYGWDFGFF-UHFFFAOYSA-N 0.000 description 2
- LIFHMKCDDVTICL-UHFFFAOYSA-N 6-(chloromethyl)phenanthridine Chemical compound C1=CC=C2C(CCl)=NC3=CC=CC=C3C2=C1 LIFHMKCDDVTICL-UHFFFAOYSA-N 0.000 description 2
- NBSCHQHZLSJFNQ-GASJEMHNSA-N D-Glucose 6-phosphate Chemical compound OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O NBSCHQHZLSJFNQ-GASJEMHNSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- VFRROHXSMXFLSN-UHFFFAOYSA-N Glc6P Natural products OP(=O)(O)OCC(O)C(O)C(O)C(O)C=O VFRROHXSMXFLSN-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 2
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 description 2
- 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 description 2
- 150000008052 alkyl sulfonates Chemical class 0.000 description 2
- 150000003863 ammonium salts Chemical class 0.000 description 2
- CSMFSDCPJHNZRY-UHFFFAOYSA-M decyl sulfate Chemical compound CCCCCCCCCCOS([O-])(=O)=O CSMFSDCPJHNZRY-UHFFFAOYSA-M 0.000 description 2
- YRIUSKIDOIARQF-UHFFFAOYSA-N dodecyl benzenesulfonate Chemical compound CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 YRIUSKIDOIARQF-UHFFFAOYSA-N 0.000 description 2
- QVBODZPPYSSMEL-UHFFFAOYSA-N dodecyl sulfate;2-hydroxyethylazanium Chemical compound NCCO.CCCCCCCCCCCCOS(O)(=O)=O QVBODZPPYSSMEL-UHFFFAOYSA-N 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 229910052744 lithium Inorganic materials 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 229940069822 monoethanolamine lauryl sulfate Drugs 0.000 description 2
- 150000004028 organic sulfates Chemical class 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 108010020020 phosphogluconate dehydrogenase (decarboxylating) Proteins 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- URLJMZWTXZTZRR-UHFFFAOYSA-N sodium myristyl sulfate Chemical compound CCCCCCCCCCCCCCOS(O)(=O)=O URLJMZWTXZTZRR-UHFFFAOYSA-N 0.000 description 2
- 229960000776 sodium tetradecyl sulfate Drugs 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- CSMFSDCPJHNZRY-UHFFFAOYSA-N sulfuric acid monodecyl ester Natural products CCCCCCCCCCOS(O)(=O)=O CSMFSDCPJHNZRY-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- NYIQECIYDUSNRC-UHFFFAOYSA-N 1,2,3,5-tetrapropylbenzene Chemical compound CCCC1=CC(CCC)=C(CCC)C(CCC)=C1 NYIQECIYDUSNRC-UHFFFAOYSA-N 0.000 description 1
- QRLVDLBMBULFAL-UHFFFAOYSA-N Digitonin Natural products CC1CCC2(OC1)OC3C(O)C4C5CCC6CC(OC7OC(CO)C(OC8OC(CO)C(O)C(OC9OCC(O)C(O)C9OC%10OC(CO)C(O)C(OC%11OC(CO)C(O)C(O)C%11O)C%10O)C8O)C(O)C7O)C(O)CC6(C)C5CCC4(C)C3C2C QRLVDLBMBULFAL-UHFFFAOYSA-N 0.000 description 1
- 239000001744 Sodium fumarate Substances 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical group OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- BTBJBAZGXNKLQC-UHFFFAOYSA-N ammonium lauryl sulfate Chemical compound [NH4+].CCCCCCCCCCCCOS([O-])(=O)=O BTBJBAZGXNKLQC-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- UVYVLBIGDKGWPX-KUAJCENISA-N digitonin Chemical compound O([C@@H]1[C@@H]([C@]2(CC[C@@H]3[C@@]4(C)C[C@@H](O)[C@H](O[C@H]5[C@@H]([C@@H](O)[C@@H](O[C@H]6[C@@H]([C@@H](O[C@H]7[C@@H]([C@@H](O)[C@H](O)CO7)O)[C@H](O)[C@@H](CO)O6)O[C@H]6[C@@H]([C@@H](O[C@H]7[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O7)O)[C@@H](O)[C@@H](CO)O6)O)[C@@H](CO)O5)O)C[C@@H]4CC[C@H]3[C@@H]2[C@@H]1O)C)[C@@H]1C)[C@]11CC[C@@H](C)CO1 UVYVLBIGDKGWPX-KUAJCENISA-N 0.000 description 1
- UVYVLBIGDKGWPX-UHFFFAOYSA-N digitonine Natural products CC1C(C2(CCC3C4(C)CC(O)C(OC5C(C(O)C(OC6C(C(OC7C(C(O)C(O)CO7)O)C(O)C(CO)O6)OC6C(C(OC7C(C(O)C(O)C(CO)O7)O)C(O)C(CO)O6)O)C(CO)O5)O)CC4CCC3C2C2O)C)C2OC11CCC(C)CO1 UVYVLBIGDKGWPX-UHFFFAOYSA-N 0.000 description 1
- TVACALAUIQMRDF-UHFFFAOYSA-N dodecyl dihydrogen phosphate Chemical compound CCCCCCCCCCCCOP(O)(O)=O TVACALAUIQMRDF-UHFFFAOYSA-N 0.000 description 1
- JZKFHQMONDVVNF-UHFFFAOYSA-N dodecyl sulfate;tris(2-hydroxyethyl)azanium Chemical compound OCCN(CCO)CCO.CCCCCCCCCCCCOS(O)(=O)=O JZKFHQMONDVVNF-UHFFFAOYSA-N 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 150000004673 fluoride salts Chemical class 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- UPUIQOIQVMNQAP-UHFFFAOYSA-M sodium;tetradecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCOS([O-])(=O)=O UPUIQOIQVMNQAP-UHFFFAOYSA-M 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- FODHIQQNHOPUKH-UHFFFAOYSA-N tetrapropylene-benzenesulfonic acid Chemical compound CC1CC11C2=C3S(=O)(=O)OC(C)CC3=C3C(C)CC3=C2C1C FODHIQQNHOPUKH-UHFFFAOYSA-N 0.000 description 1
- SJEYEFOHSMBQIX-UHFFFAOYSA-M undecane-1-sulfonate Chemical compound CCCCCCCCCCCS([O-])(=O)=O SJEYEFOHSMBQIX-UHFFFAOYSA-M 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19833303098 DE3303098A1 (de) | 1983-01-31 | 1983-01-31 | Verfahren und reagenz zur glucosebestimmung im haemolysierten blut |
| CA000444744A CA1212022A (en) | 1983-01-31 | 1984-01-05 | Process and a reagent for the determination of blood glucose in haemolysed whole blood |
| ES529233A ES529233A0 (es) | 1983-01-31 | 1984-01-27 | Procedimiento para la determinacion de d-glucosa en un liquido corporal. |
| JP59013563A JPS59143961A (ja) | 1983-01-31 | 1984-01-30 | 体液中のｄ−グルコ−スを測定する方法及びその試薬 |
| US06/575,409 US4551427A (en) | 1983-01-31 | 1984-01-30 | Process and reagent for the determination of blood glucose in haemolysed whole blood |
| DE8484100965T DE3470063D1 (en) | 1983-01-31 | 1984-01-31 | Method and reagent for the determination of glucose in haemolised blood |
| AT84100965T ATE33149T1 (de) | 1983-01-31 | 1984-01-31 | Verfahren und reagenz zur glucosebestimmung im haemolysierten blut. |
| EP84100965A EP0120220B1 (de) | 1983-01-31 | 1984-01-31 | Verfahren und Reagenz zur Glucosebestimmung im hämolysierten Blut |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19833303098 DE3303098A1 (de) | 1983-01-31 | 1983-01-31 | Verfahren und reagenz zur glucosebestimmung im haemolysierten blut |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3303098A1 true DE3303098A1 (de) | 1984-08-02 |
Family
ID=6189618
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19833303098 Withdrawn DE3303098A1 (de) | 1983-01-31 | 1983-01-31 | Verfahren und reagenz zur glucosebestimmung im haemolysierten blut |
| DE8484100965T Expired DE3470063D1 (en) | 1983-01-31 | 1984-01-31 | Method and reagent for the determination of glucose in haemolised blood |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8484100965T Expired DE3470063D1 (en) | 1983-01-31 | 1984-01-31 | Method and reagent for the determination of glucose in haemolised blood |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4551427A (enrdf_load_stackoverflow) |
| EP (1) | EP0120220B1 (enrdf_load_stackoverflow) |
| JP (1) | JPS59143961A (enrdf_load_stackoverflow) |
| AT (1) | ATE33149T1 (enrdf_load_stackoverflow) |
| CA (1) | CA1212022A (enrdf_load_stackoverflow) |
| DE (2) | DE3303098A1 (enrdf_load_stackoverflow) |
| ES (1) | ES529233A0 (enrdf_load_stackoverflow) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0293732A3 (en) * | 1987-06-03 | 1991-03-06 | Abbott Laboratories | Simultaneous assay for glucose and urea |
| WO1997016562A1 (en) * | 1995-11-02 | 1997-05-09 | Dade Behring Marburg Gmbh | Methods for removing interferences due to endogenous dehydrogenases in enzyme assays |
| US5861269A (en) * | 1996-11-01 | 1999-01-19 | Dade Behring Marburg Gmbh | Methods for removing interferences due to endogenous dehydrogenases in enzyme assays |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3323949A1 (de) * | 1983-07-02 | 1985-01-03 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und mittel zur raschen und vollstaendigen beseitigung einer truebung in einer biologischen fluessigkeit |
| CH664975A5 (fr) * | 1985-03-15 | 1988-04-15 | Battelle Memorial Institute | Procede analytique pour la determination d'un coenzyme reduit. |
| JPH0687062B2 (ja) * | 1985-05-10 | 1994-11-02 | 株式会社京都医科学研究所 | 血液中の解糖阻止方法 |
| FI81120C (fi) * | 1988-09-26 | 1990-09-10 | Kone Oy | Foerfarande foer bestaemning av glukos ur biologiska vaetska samt reagensblandning foer tillaempning av foerfarandet. |
| SE466157B (sv) * | 1989-04-25 | 1992-01-07 | Migrata Uk Ltd | Saett att bestaemma glukoshalten hos helblod samt engaangskuvett foer detta |
| DE4022878A1 (de) * | 1990-07-18 | 1992-01-23 | Boehringer Mannheim Gmbh | Konservierung von diagnostischen tests |
| US5204267A (en) * | 1991-12-17 | 1993-04-20 | Osborn Laboratories, Inc. | Method of glucose stabilization and analysis in dried blood spot samples |
| US5448992A (en) * | 1992-12-10 | 1995-09-12 | Sunshine Medical Instruments, Inc. | Method and apparatus for non-invasive phase sensitive measurement of blood glucose concentration |
| US5398681A (en) * | 1992-12-10 | 1995-03-21 | Sunshine Medical Instruments, Inc. | Pocket-type instrument for non-invasive measurement of blood glucose concentration |
| AU666821B2 (en) * | 1993-08-05 | 1996-02-22 | Bayer Corporation | Analyte detection device and process |
| GB2293133B (en) * | 1994-03-04 | 1998-03-11 | Memtec America Corp | Large pore synthetic polymer membranes |
| US6485923B1 (en) * | 2000-02-02 | 2002-11-26 | Lifescan, Inc. | Reagent test strip for analyte determination having hemolyzing agent |
| TWI275795B (en) * | 2001-02-14 | 2007-03-11 | Sysmex Corp | Novel assay method |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3413198A (en) * | 1966-06-30 | 1968-11-26 | Calbiochem | Reagents and method for assaying biological samples |
| US4271264A (en) * | 1976-09-13 | 1981-06-02 | Modrovich Ivan Endre | Stabilized liquid enzyme and coenzyme compositions |
| DE2816229C2 (de) * | 1978-04-14 | 1983-11-10 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und Mittel zur Beseitigung von Trübungen |
| DE2850603A1 (de) * | 1978-11-22 | 1980-06-19 | Merck Patent Gmbh | Haemolysierloesung und verfahren zur haemolyse von blut |
| JPS5783287A (en) * | 1980-11-14 | 1982-05-25 | Kyowa Hakko Kogyo Co Ltd | Elimination of hydrogen peroxide |
-
1983
- 1983-01-31 DE DE19833303098 patent/DE3303098A1/de not_active Withdrawn
-
1984
- 1984-01-05 CA CA000444744A patent/CA1212022A/en not_active Expired
- 1984-01-27 ES ES529233A patent/ES529233A0/es active Granted
- 1984-01-30 US US06/575,409 patent/US4551427A/en not_active Expired - Lifetime
- 1984-01-30 JP JP59013563A patent/JPS59143961A/ja active Granted
- 1984-01-31 AT AT84100965T patent/ATE33149T1/de not_active IP Right Cessation
- 1984-01-31 DE DE8484100965T patent/DE3470063D1/de not_active Expired
- 1984-01-31 EP EP84100965A patent/EP0120220B1/de not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0293732A3 (en) * | 1987-06-03 | 1991-03-06 | Abbott Laboratories | Simultaneous assay for glucose and urea |
| WO1997016562A1 (en) * | 1995-11-02 | 1997-05-09 | Dade Behring Marburg Gmbh | Methods for removing interferences due to endogenous dehydrogenases in enzyme assays |
| US5861269A (en) * | 1996-11-01 | 1999-01-19 | Dade Behring Marburg Gmbh | Methods for removing interferences due to endogenous dehydrogenases in enzyme assays |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0120220A3 (en) | 1986-01-29 |
| US4551427A (en) | 1985-11-05 |
| JPH0425000B2 (enrdf_load_stackoverflow) | 1992-04-28 |
| EP0120220A2 (de) | 1984-10-03 |
| DE3470063D1 (en) | 1988-04-28 |
| ES8407330A1 (es) | 1984-10-01 |
| ES529233A0 (es) | 1984-10-01 |
| ATE33149T1 (de) | 1988-04-15 |
| EP0120220B1 (de) | 1988-03-23 |
| CA1212022A (en) | 1986-09-30 |
| JPS59143961A (ja) | 1984-08-17 |
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