DE3278472D1 - 6-fluoro-3-(3-(1-heterocyclo)propyl)-1,2-benzisoxazoles, a process for their preparation, pharmaceutical compositions thereof and their use as medicaments - Google Patents
6-fluoro-3-(3-(1-heterocyclo)propyl)-1,2-benzisoxazoles, a process for their preparation, pharmaceutical compositions thereof and their use as medicamentsInfo
- Publication number
- DE3278472D1 DE3278472D1 DE8282109802T DE3278472T DE3278472D1 DE 3278472 D1 DE3278472 D1 DE 3278472D1 DE 8282109802 T DE8282109802 T DE 8282109802T DE 3278472 T DE3278472 T DE 3278472T DE 3278472 D1 DE3278472 D1 DE 3278472D1
- Authority
- DE
- Germany
- Prior art keywords
- fluoro
- preparation
- heterocyclo
- benzisoxazoles
- medicaments
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/366,245 US4458075A (en) | 1982-04-09 | 1982-04-09 | 6-Fluoro-3-[3-(1-heterocyclo)propyl]-1,2-benzisoxazoles |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3278472D1 true DE3278472D1 (en) | 1988-06-16 |
Family
ID=23442245
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8282109802T Expired DE3278472D1 (en) | 1982-04-09 | 1982-10-23 | 6-fluoro-3-(3-(1-heterocyclo)propyl)-1,2-benzisoxazoles, a process for their preparation, pharmaceutical compositions thereof and their use as medicaments |
Country Status (18)
Country | Link |
---|---|
US (1) | US4458075A (de) |
EP (1) | EP0091512B1 (de) |
JP (1) | JPS58177981A (de) |
AT (1) | ATE34172T1 (de) |
AU (1) | AU560513B2 (de) |
CA (1) | CA1189858A (de) |
DE (1) | DE3278472D1 (de) |
DK (1) | DK474582A (de) |
ES (1) | ES8308560A1 (de) |
FI (1) | FI823434L (de) |
GR (1) | GR77705B (de) |
HU (1) | HU191076B (de) |
IL (1) | IL66868A (de) |
NO (1) | NO823557L (de) |
NZ (1) | NZ202045A (de) |
PH (1) | PH18365A (de) |
PT (1) | PT75728B (de) |
ZA (1) | ZA827814B (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4894461A (en) * | 1981-04-27 | 1990-01-16 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(γ-chloropropyl)-6-fluoro-1,2-benzisoxazole |
US4980365A (en) * | 1987-07-13 | 1990-12-25 | Hoechst-Roussel Pharmaceuticals Inc. | N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents |
US4914204A (en) * | 1988-03-14 | 1990-04-03 | Hoechst-Roussel Pharmaceuticals Incorporated | 4-Pentafluorophenoxypiperidines |
US4954511A (en) * | 1988-03-14 | 1990-09-04 | Hoechst-Roussell Pharmaceuticals Inc. | 4-pentafluorophenoxypiperidines |
US4861889A (en) * | 1988-03-14 | 1989-08-29 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(2,3,4,5,6-pentafluorophenoxy)-8-azabicyclo[3.2.1]octanes |
US5114936A (en) * | 1990-08-23 | 1992-05-19 | Hoechst-Roussel Pharmaceuticals Incorporated | 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -ols, compositions and pharmaceutical use |
US5750542A (en) | 1993-09-28 | 1998-05-12 | Pfizer | Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors |
CN101016296A (zh) | 2000-04-28 | 2007-08-15 | 阿卡蒂亚药品公司 | 毒蕈碱性激动剂 |
EP1535912A1 (de) * | 2000-04-28 | 2005-06-01 | Arcadia Pharmaceuticals Inc. | Muscarinagonisten |
DE102019103847A1 (de) | 2019-02-15 | 2020-08-20 | Vetron Typical Europe Gmbh | Nähmaschine |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4970963A (de) * | 1972-11-09 | 1974-07-09 | ||
GB1488003A (en) * | 1973-10-23 | 1977-10-05 | Lilly Industries Ltd | 1,2-benzisoxazole derivatives processes for their preparation and their use as pharmaceuticals |
FI60390C (fi) * | 1975-03-05 | 1982-01-11 | Sumitomo Chemical Co | Foerfarande foer framstaellning av neuroleptiska butyrofenoner |
JPS51136666A (en) * | 1975-05-19 | 1976-11-26 | Dainippon Pharmaceut Co Ltd | Process for preparing 3-aminoalkyl-1,2-benzisoxazole derivatives. |
JPS6043064B2 (ja) * | 1979-11-28 | 1985-09-26 | ウェルファイド株式会社 | 新規イソオキサゾ−ル誘導体 |
-
1982
- 1982-04-09 US US06/366,245 patent/US4458075A/en not_active Expired - Lifetime
- 1982-09-24 IL IL66868A patent/IL66868A/xx unknown
- 1982-09-30 NZ NZ202045A patent/NZ202045A/en unknown
- 1982-10-08 FI FI823434A patent/FI823434L/fi not_active Application Discontinuation
- 1982-10-22 PT PT75728A patent/PT75728B/pt unknown
- 1982-10-22 GR GR69602A patent/GR77705B/el unknown
- 1982-10-23 AT AT82109802T patent/ATE34172T1/de not_active IP Right Cessation
- 1982-10-23 DE DE8282109802T patent/DE3278472D1/de not_active Expired
- 1982-10-23 EP EP82109802A patent/EP0091512B1/de not_active Expired
- 1982-10-26 ZA ZA827814A patent/ZA827814B/xx unknown
- 1982-10-26 DK DK474582A patent/DK474582A/da not_active Application Discontinuation
- 1982-10-26 JP JP57186908A patent/JPS58177981A/ja active Pending
- 1982-10-26 NO NO823557A patent/NO823557L/no unknown
- 1982-10-26 AU AU89777/82A patent/AU560513B2/en not_active Ceased
- 1982-10-26 HU HU823416A patent/HU191076B/hu unknown
- 1982-10-26 ES ES516828A patent/ES8308560A1/es not_active Expired
- 1982-10-26 CA CA000414158A patent/CA1189858A/en not_active Expired
- 1982-10-26 PH PH28038A patent/PH18365A/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP0091512A2 (de) | 1983-10-19 |
AU8977782A (en) | 1983-10-13 |
ATE34172T1 (de) | 1988-05-15 |
US4458075A (en) | 1984-07-03 |
HU191076B (en) | 1987-01-28 |
CA1189858A (en) | 1985-07-02 |
NO823557L (no) | 1983-10-10 |
JPS58177981A (ja) | 1983-10-18 |
FI823434L (fi) | 1983-10-10 |
EP0091512A3 (en) | 1984-12-12 |
PT75728B (en) | 1985-11-11 |
AU560513B2 (en) | 1987-04-09 |
ES516828A0 (es) | 1983-09-16 |
EP0091512B1 (de) | 1988-05-11 |
ES8308560A1 (es) | 1983-09-16 |
DK474582A (da) | 1983-10-10 |
IL66868A0 (en) | 1982-12-31 |
NZ202045A (en) | 1986-03-14 |
GR77705B (de) | 1984-09-25 |
FI823434A0 (fi) | 1982-10-08 |
PT75728A (en) | 1982-11-01 |
PH18365A (en) | 1985-06-13 |
ZA827814B (en) | 1983-08-31 |
IL66868A (en) | 1987-07-31 |
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EP0080104A3 (en) | 3-(4-piperidyl)-1,2-benzisoxazoles, intermediates and process for the preparation thereof, a pharmaceutical composition comprising the same and their use as medicament | |
ES8506658A1 (es) | Procedimiento para la preparacion de 3-(1-sustituido-4-piperidil)-1, 2-bencisoxazoles | |
DE3278472D1 (en) | 6-fluoro-3-(3-(1-heterocyclo)propyl)-1,2-benzisoxazoles, a process for their preparation, pharmaceutical compositions thereof and their use as medicaments | |
EP0127167A3 (en) | 3-(4-piperidinyl)-1,2-benzisothiazoles and derivates, a process for their preparation and their use as medicaments | |
DE3278471D1 (en) | 1-(3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl)-4-(substituted)-piperazines and -piperidines, a process for the preparation thereof, pharmaceutical compositions containing the same and their use as medicaments | |
ES8401484A1 (es) | Procedimiento para preparar 1-(3-(6-fluoro-1,2-benzisoxazol-3-il)propil)-4-fenil-4-hidroxipiperidinas. | |
FI823435A0 (fi) | 8-/3-(6-fluor-1,2-benzisoxazol-3-yl),propyl/-1-fenyl-1,3,8-triazaspiro/4,5/dekan-4-oner, foerfarande foer deras framstaellning, och deras anvaendning som laekemedel | |
ZA827815B (en) | 1-(3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl)-4-(substituted)-piperazines and-piperidines,and a process for the preparation thereof,pharmaceutical compositions containing the same and their use as medicaments |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |