DE3268028D1 - Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays - Google Patents

Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays

Info

Publication number
DE3268028D1
DE3268028D1 DE8282304384T DE3268028T DE3268028D1 DE 3268028 D1 DE3268028 D1 DE 3268028D1 DE 8282304384 T DE8282304384 T DE 8282304384T DE 3268028 T DE3268028 T DE 3268028T DE 3268028 D1 DE3268028 D1 DE 3268028D1
Authority
DE
Germany
Prior art keywords
refractive index
light scattering
high refractive
covalently bonded
particle reagents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8282304384T
Other languages
English (en)
Inventor
Alan Robert Craig
William Adrian Frey
Charles Clayton Leflar
Catharine Elizabeth Looney
Michael Andrew Garrett Luddy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dade Behring Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26970688&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3268028(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Application granted granted Critical
Publication of DE3268028D1 publication Critical patent/DE3268028D1/de
Expired legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/805Optical property
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/815Test for named compound or class of compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
DE8282304384T 1981-09-01 1982-08-19 Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays Expired DE3268028D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29847381A 1981-09-01 1981-09-01
US06/315,922 US4401765A (en) 1981-09-01 1981-10-28 Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays

Publications (1)

Publication Number Publication Date
DE3268028D1 true DE3268028D1 (en) 1986-01-30

Family

ID=26970688

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8282304384T Expired DE3268028D1 (en) 1981-09-01 1982-08-19 Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays

Country Status (4)

Country Link
US (1) US4401765A (de)
EP (1) EP0073611B1 (de)
CA (1) CA1184489A (de)
DE (1) DE3268028D1 (de)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4581337A (en) * 1983-07-07 1986-04-08 E. I. Du Pont De Nemours And Company Polyether polyamines as linking agents for particle reagents useful in immunoassays
US4604365A (en) * 1981-06-02 1986-08-05 Electro-Nucleonics, Inc. Immunoprecipitation assay
US4480042A (en) * 1981-10-28 1984-10-30 E. I. Du Pont De Nemours And Company Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays
US4524025A (en) * 1982-06-30 1985-06-18 E. I. Du Pont De Nemours And Company Hybridoma cell lines and monoclonal antibodies to theophylline
US4521510A (en) * 1982-06-30 1985-06-04 E. I. Du Pont De Nemours And Company Hybridoma cell lines and monoclonal antibodies to theophylline
US4536479A (en) * 1983-03-22 1985-08-20 E. I. Du Pont De Nemours And Company Use of anti-idiotype antibodies in immunoassays
US4760030A (en) * 1984-09-10 1988-07-26 Syntex (U.S.A.) Inc. Quantitative opaque particle agglutination assay
CA1254136A (en) * 1984-11-05 1989-05-16 William A. Frey Method for detecting enzymatic activity using particle agglutination
US4812395A (en) * 1984-11-05 1989-03-14 E. I. Du Pont De Nemours And Company Method for detecting enzymatic activity using particle agglutination
US4812396A (en) * 1984-11-05 1989-03-14 E. I. Du Pont De Nemours And Company Method for detecting enzymatic activity using particle agglutination
US4703018A (en) * 1985-02-20 1987-10-27 E. I. Du Pont De Nemours And Company High refractive index haloalkyl-functional shell-core polymers and their use in light scattering immunoassays
US4735907A (en) * 1985-03-18 1988-04-05 Eastman Kodak Company Stabilized fluorescent rare earth labels and labeled physiologically reactive species
JPS61247966A (ja) * 1985-04-25 1986-11-05 Daikin Ind Ltd 抗原−抗体反応測定用試薬
US4997772A (en) * 1987-09-18 1991-03-05 Eastman Kodak Company Water-insoluble particle and immunoreactive reagent, analytical elements and methods of use
DE3850981T2 (de) * 1987-02-27 1995-03-30 Eastman Kodak Co Wasserunlösliches Teilchen und immunoreaktives Reagens, analytische Elemente und Verfahren zu ihrer Verwendung.
US5166077A (en) * 1987-04-30 1992-11-24 Nitto Denko Corporation Latex for immobilization of physiologically active substances for immuno nephelometry
JPH02500133A (ja) * 1987-07-21 1990-01-18 クールター・エレクトロニクス・インコーポレーテッド ハプテンについての改良濁り測定抑制検定法
US5177023A (en) * 1987-08-03 1993-01-05 Eastman Kodak Company Water-insoluble reagent elements containing same and methods of use
JP2565548B2 (ja) * 1987-09-18 1996-12-18 イーストマン コダック カンパニー カルバモイルオニウム化合物を用いてポリマー粒子に化合物を結合させる方法
FR2642174B1 (fr) * 1989-01-20 1994-03-25 Diagnostica Stago Particules submicroniques, utilisation dans le domaine des reactions immunologiques du type antigene
DK0386644T3 (da) * 1989-03-10 1997-10-13 Hoffmann La Roche Reagenser til bestemmelse af lægemidler
US5155166A (en) * 1990-06-18 1992-10-13 Eastman Kodak Company Use of 1-(1-pyrrolidinylcarbonyl)pyridinium salts to attach compounds to carboxylated particles and a kit containing same
US5200315A (en) * 1990-07-25 1993-04-06 Eastman Kodak Company Particulate biologically active reagent containing polyoxyalkylene side chains, analytical element and methods for use of the reagent
US5086143A (en) * 1990-07-25 1992-02-04 Eastman Kodak Company Copolymers containing polyoxyalkylene side chains
US5401633A (en) * 1992-10-01 1995-03-28 Eastman Kodak Company Biologically active reagent prepared from aldehyde-containing polymer, test kit, analytical element and methods of use
DE69331570T2 (de) * 1992-10-21 2002-10-02 Dade Behring Inc Agglutinationstest unter Anwendung eines multivalenten Liganden
US5492841A (en) 1994-02-18 1996-02-20 E. I. Du Pont De Nemours And Company Quaternary ammonium immunogenic conjugates and immunoassay reagents
US5585278A (en) * 1994-10-27 1996-12-17 Bayer Corporation Method for coupling antibody to novel latex substrate and its use in immunoassay
US5688944A (en) * 1995-06-07 1997-11-18 Dade International Inc. Carbamazepine derivatives
US5854083A (en) * 1995-08-03 1998-12-29 Dade Behring Inc. Post synthesis chemical modification of particle reagents
US6165798A (en) * 1996-10-10 2000-12-26 University Of British Columbia Optical quantification of analytes in membranes
US6379975B1 (en) * 1996-11-27 2002-04-30 T.A.C. Thrombosis And Coagulation Aktiebolag Methods and reagents for determining protein S
US5876935A (en) * 1997-01-08 1999-03-02 Dade Behring Inc. Luminescent specific binding assay
US5981296A (en) * 1997-02-18 1999-11-09 Dade Behring Inc. Stabilization of particle reagents
CA2244326C (en) * 1997-08-11 2006-03-28 Shinichi Eda Microparticle enhanced light scattering agglutination assay and microparticle reagents therefor
JP4577747B2 (ja) * 2001-06-05 2010-11-10 和光純薬工業株式会社 免疫学的測定法用凝集促進剤
DE10156612A1 (de) * 2001-11-20 2003-05-28 Markus Klotz Verfahren zum Bestimmen von Substanzen in einer flüssigen oder gasförmigen Probe
GB0229747D0 (en) * 2002-12-20 2003-01-29 Axis Shield Asa Assay
JP3954522B2 (ja) * 2003-04-18 2007-08-08 日清紡績株式会社 生物学的活性物質を固定化した素子
JP4241301B2 (ja) * 2003-09-30 2009-03-18 和光純薬工業株式会社 免疫学的測定用試薬
US7957507B2 (en) * 2005-02-28 2011-06-07 Cadman Patrick F Method and apparatus for modulating a radiation beam
US8232535B2 (en) * 2005-05-10 2012-07-31 Tomotherapy Incorporated System and method of treating a patient with radiation therapy
JP2009502250A (ja) 2005-07-22 2009-01-29 トモセラピー・インコーポレーテッド 放射線療法治療計画に関連するデータを処理するための方法およびシステム
ATE507879T1 (de) 2005-07-22 2011-05-15 Tomotherapy Inc System zur verabreichung einer strahlentherapie auf ein sich bewegendes zielgebiet
CA2616299A1 (en) 2005-07-22 2007-02-01 Tomotherapy Incorporated Method of placing constraints on a deformation map and system for implementing same
US8442287B2 (en) * 2005-07-22 2013-05-14 Tomotherapy Incorporated Method and system for evaluating quality assurance criteria in delivery of a treatment plan
CN101267858A (zh) 2005-07-22 2008-09-17 断层放疗公司 根据生物学模型修改放射疗法治疗计划的方法和系统
CA2616136A1 (en) 2005-07-22 2007-02-01 Tomotherapy Incorporated System and method of evaluating dose delivered by a radiation therapy system
US7609809B2 (en) 2005-07-22 2009-10-27 Tomo Therapy Incorporated System and method of generating contour structures using a dose volume histogram
KR20080039918A (ko) * 2005-07-22 2008-05-07 토모테라피 인코포레이티드 방사선 치료 시스템의 동작을 원격에서 분석하는 시스템 및방법
CA2616309A1 (en) * 2005-07-22 2007-02-01 Tomotherapy Incorporated Method of and system for predicting dose delivery
KR20080049716A (ko) 2005-07-22 2008-06-04 토모테라피 인코포레이티드 치료 계획의 전달과 관련된 퀄리티 보증 기준을 평가하는방법 및 시스템
CA2616304A1 (en) 2005-07-22 2007-02-01 Tomotherapy Incorporated System and method of delivering radiation therapy to a moving region of interest
CA2616301A1 (en) 2005-07-22 2007-02-01 Tomotherapy Incorporated Method and system for evaluating delivered dose
WO2007014090A2 (en) 2005-07-23 2007-02-01 Tomotherapy Incorporated Radiation therapy imaging and delivery utilizing coordinated motion of gantry and couch
US20090041200A1 (en) * 2005-07-23 2009-02-12 Tomotherapy Incorporated Radiation therapy imaging and delivery utilizing coordinated motion of jaws, gantry, and couch
GB0803107D0 (en) 2008-02-20 2008-03-26 Axis Shield Diagnostics Ltd Method
JP2010101703A (ja) * 2008-10-22 2010-05-06 Alfresa Pharma Corp 免疫学的測定方法および測定用試薬キット
CN102680712A (zh) * 2012-06-18 2012-09-19 王钊 竞争法胶乳颗粒增强免疫比浊bnp检测试剂盒及其制备方法
CN105027227B (zh) 2013-02-26 2017-09-08 安科锐公司 电磁致动的多叶准直器
EP2970938A4 (de) 2013-03-14 2016-11-09 Ran Biotechnologies Inc Verfahren und materialien zur erfassung von mikroorganismen
EP2968192B1 (de) 2013-03-14 2022-07-13 RAN Biotechnologies, Inc. Verfahren und materialien zum nachweis von biologischen stoffen
CN107614565B (zh) 2015-04-21 2021-04-09 Ran生物技术公司 氟化表面活性剂
CN105974105A (zh) * 2016-05-16 2016-09-28 河北艾驰生物科技有限公司 基质金属蛋白酶-3(mmp3)检测试剂盒
JP7161213B2 (ja) * 2017-05-24 2022-10-26 積水メディカル株式会社 測定試薬用ラテックス粒子、感作ラテックス粒子及び免疫比濁法用測定試薬

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4264766A (en) * 1877-09-19 1981-04-28 Hoffmann-La Roche Inc. Immunological diagnostic reagents
GB1276006A (en) * 1969-02-10 1972-06-01 Guinness Son & Co Ltd A Enzymes
GB1274869A (en) * 1969-02-11 1972-05-17 Guinness Son & Co Ltd A Enzymes
US4166102A (en) * 1975-04-07 1979-08-28 Becton, Dickinson And Company Immobilized immunoadsorbent
FR2321519A1 (fr) * 1975-08-22 1977-03-18 Rhone Poulenc Ind Latex de polymeres styreniques
US4210723A (en) * 1976-07-23 1980-07-01 The Dow Chemical Company Method of coupling a protein to an epoxylated latex
CH628738A5 (de) * 1977-08-03 1982-03-15 Hoffmann La Roche Immunologisches diagnose-reagenz.
CA1101330A (en) * 1977-09-19 1981-05-19 Ernst A. Fischer Immunological material bonded to carboxylated latex polymer and process for making it
US4278651A (en) * 1978-09-27 1981-07-14 Becton Dickinson & Company Supported receptor and use thereof in an assay
JPS5664788A (en) * 1979-10-27 1981-06-02 Unitika Ltd Method for imparting enzyme activity to solid surface

Also Published As

Publication number Publication date
CA1184489A (en) 1985-03-26
US4401765A (en) 1983-08-30
EP0073611A1 (de) 1983-03-09
EP0073611B1 (de) 1985-12-18

Similar Documents

Publication Publication Date Title
DE3268028D1 (en) Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays
EP0464337A3 (en) Measurement of size and refractive index of particles using the complex forward-scattered electromagnetic field
GB2120383B (en) Measuring refractive index
GB2082790B (en) Optical fibre in grooved central member type cable and manufacture
DE3173597D1 (en) Specific antibody and its use in an enzyme immuno assay
GB2111476B (en) Substituted carboxyfluoresceins and their use in fluorescence polarization immunoassay
AU578622B2 (en) Method and apparatus for determining the volume and index of refraction of particles
AU554208B2 (en) Analyzing distribution of reagent in particle suspension
IL69171A0 (en) Fibrous media containing millimicron-sized particulates and their manufacture
JPS54161620A (en) High refractive index glass having limited specific gravity for long and short distance glass lenses
JPS5793305A (en) Hybrid optical joint in loop interference meter and use thereof
DE3167600D1 (en) Expandable-styrene polymer particles and their use
DE2965820D1 (en) Polyolefines reinforced with glass fibres and their use
EP0085978A3 (en) Method of and apparatus for measuring the thickness and the refractive index of transparent materials
JPS5738337A (en) Grade refractive index optical structure element and manufacture thereof
JPS57132579A (en) Scattering classifying device
DE3476456D1 (en) Reflective particle-containing analytical device
GB8307878D0 (en) Quantitative analysis in accordance with cars
DE3163577D1 (en) Charged particle accelerator utilizing waves in the range of one meter
NO812781L (no) Karbidmateriale samt fremgangsmaate ved fremstilling av dette
GB2083922B (en) Converging light transmissive body having refractive index
AU6710790A (en) Use of polymerized immunoglobulin to reduce the incidence of false-positive responses in immunoassays
AU6694481A (en) Assessing concentration of mineral matter in coal-derived liquids
GB2077253B (en) Optically useful transparent materials and devices containing them
GB2123002B (en) 4-or 6-substituted aldosterones their production and use in immunoassay

Legal Events

Date Code Title Description
8363 Opposition against the patent
8365 Fully valid after opposition proceedings
8327 Change in the person/name/address of the patent owner

Owner name: DADE CHEMISTRY SYSTEMS INC. (N.D.GES.D. STAATES DE

8327 Change in the person/name/address of the patent owner

Owner name: DADE BEHRING, INC.(N.D.GES.DES STAATES DELAWARE),