DE3211280A1 - AGENT TO CONTROL UNWANTED MICROORGANISMS - Google Patents

Description

Means for combating undesirable microorganisms

The invention relates to an agent which is suitable for sterilizing medical, surgical, dental as well as laboratory and other objects or instruments, as well as for combating unwanted microorganisms in selected areas.

It has long been known that it is highly desirable or necessary to have certain items or articles to sterilize and essentially to keep undesirable microorganisms free, as well as the presence to prevent unwanted microorganisms in certain places. A means that spreads for Applied to this purpose, "is a formaldehyde solution, also known as formalin. The formaldehyde solution consists of about 37 wt .-? 6 formaldehyde gas in water and usually contains added

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used methanol to avoid polymerization. This solution is at full strength and is also known as Formalin 100 % or Formalin 40. The latter designation indicates that the solution contains AO g of formaldehyde in 100 ml of solution.

While the formaldehyde solution is common in medical and dental practices and clinics is used to sterilize medical, surgical and dental instruments and by research laboratories and commercial consumers to sterilize other instruments and equipment as well to disinfect certain areas are with the use certain disadvantages associated with formaldehyde solution. For example, the formaldehyde solution is usually applied starting from a previously prepared stock solution and that has the disadvantage that it is continuous Formaldehyde vapors escape from the solution, making it less effective for the intended purposes.

Another disadvantage is that the formaldehyde solution is heavy and therefore causes high transport costs, which overall increase the cost of the disinfectant. In addition, the formaldehyde solution has a relatively large volume and thus requires cumbersome packaging is easily damaged or leaks during transport.

For the reasons stated above, it is obvious that due to the disadvantages associated with previously prepared formaldehyde solutions, a decisive one There is a need for an ice cream

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Means that, if necessary, a formaldehyde solution provides which is suitable to achieve the desired results in sterilization and control of the To achieve the presence of undesirable microorganisms.

The figure of the accompanying drawing shows a perspective cut-away form of a " Means in the form of a body. 10

The expression "combating the presence of microorganisms", As used herein, means in the general context killing, preventing and / or Delaying the appearance or multiplication of microorganisms in a predetermined "environment". The expression "Environment" means a selected area such as hospital rooms, operating theaters, military areas, Laboratories, apartments, ships, railroad cars, standing water, animal shelters and bathing places, etc., in which the agent according to the invention is used to combat the presence of undesirable microorganisms will. '

The terms "biocid", "sterilize" and "disinfectant", as used here, refer to the ability of the agent according to the invention, To form formaldehyde to kill, purify, prevent "and / or retard the occurrence or multiplication of harmful unwanted microorganisms on instruments and other objects. The term "instruments" includes medical, surgical, dental laboratory, hairdressing and barber instruments. Of the

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The term "equipment" includes rubbish bins, sterile boxes, containers, containers for holding contact lenses, Urine bottles, etc.

The term "undesirable microorganisms" as used here includes bacteria, spirochetes, viruses, Spores, fungi, mycobacin, etc. The microorganisms include Aspergillus niger, Aspergillus flavus, Rhizopus nigricans, Cladosporium herbarium, Epidermophyton floccosum, Trichophyton mentagrophytes, Histoplasma capsulatum, etc. The term also includes a "Antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Proteus vulgaris, Staphylococcus aureus, Streptococcus faecalis, Klebsiella, Enterobacter aerogenes, Proteus micabilis, and the like .. The term also includes yeasts such as Saccharomyces cerevisiae, Candida albicans, etc.

The means according to the invention, indicated by way of example in FIG. 1 and denoted as 10, has a or multiple surfaces for delivery of the active ingredient and comprises a body 11 which is suitable in shape and size is to bring it into an environment for sterilizing an object. The means or the body can have any shape, it can (in plan) be square, round, rectangular, triangular, be crescent-shaped or similar. The means 10 can be used as a plate, strip, sleeve, rod, matrix, sponge, Prisms with different ground plans, such as cross-shaped or hexagonal or similar, can be produced. In the In the form shown in Figure 1, the means or the body is container-shaped and has a front end 12 and a rear end 13. The body 10 can be seen in the cut-open area 14 and comprises a polymer 15 in which a probioid 16, a foaming pair 17 and given

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if a surfactant 18 is dispersed. The body 10 has one of the requirements corresponding size and can have different dimensions. For example, when the body 10 is used as a Matrix is produced, have a length of 5 mm to 20 cm and above, a width of 5 mm to 10 cm and above and a thickness of 1 to 5mm or above. The body 10 can either be used immediately are manufactured or for a long-term use, z. B. 5 to 40 days or more.

Examples of polymers 15 that can be used to manufacture the agent or body 10 include Polymers that allow the passage of liquid, mainly ■ borrowed water. Examples of such Polymers are acrylic polymers and copolymers of methacrylate, Ethyl acrylate, ethyl methacrylate and methacrylate; Homopolymers and copolymers of vinyl chloride, such as vinyl chloride-vinyl acetate copolymers, chlorinated vinyl chloride; Polyethylene; Polypropylene; Ethylene-propylene copolymer; chlorinated polyethylene; Ethylene-vinyl acetate copolymer; Styrene-butadiene copolymer; Acrylonitrile-styrene-butadiene copolymer; Polyvinylidene chloride; Vinyl chloride-vinylidene chloride copolymers; Vinylidene chloride-acrylonitrile copolymer; Vinylidene chloride-acrylate-ester copolymers; Polybutylene terephthalate; Vinyl chloride-acrylate-ester copolymer; Polyvinyl acetals, such as polyvinyl formal, polyvinyl acetal and . Polyvinyl butyral; Polyether; Polyester; Polyurethanes; halogenated-sulfonated polyolefins; Polyisoprene; Silicone,

etc.

Probioid suitable for the purposes of the invention is a material that develops the bio-eid formaldehyde in the presence of moisture or water. One for

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Probioid suitable for these purposes is paraformaldehyde. Paraformaldehyde is a polymer selected from the group consisting of the cyclic tripolymer of the general formula (CH ₂ O) _n , in which η is 3, and a linear polymer of the general formula HO (CH ₂ O) H, where m is 3 to 200 is. These polymers depolymerize in the presence of moisture or water that penetrates the body, forming the water-soluble bio-oath and disinfectant formaldehyde. The amount of paraformaldehyde (cyclic or linear) in an agent is approximately 2 to 80% by weight based on the total weight of the agent or body and in particular approximately 30 to 60% by weight.

Another probioid that is suitable for the formation of the Bioeids and which can be built into the agent according to the invention is methenamine (hexamethylenetetramine or urothropine) and its acid addition salts and quaternary salts. The biocidal effectiveness of methenamine salts stirs from the hydrolysis of methenamine Formaldehyde and the biocidal activity of the acid group of the salt. Examples of connections are Methenamine mandelate, methenamine salicylate, methenamine sulfosalicylate and methenamine tetraiodide. The amount of methenamine salt in the composition is generally about 2 to 80% by weight based on the total weight of the By means of and especially about 30 to 60_Weight .- #>. The agent can also contain both paraformaldehyde and methenamine, the total amount being 40 to 80 wt .-? 6 of the means is.

The agent can also be polyoxymethylene esters and polyoxymethylene diesters such as polyoxymethylene diacetate and mixtures thereof with repeating oxymethylene groups,

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■ taking the ester in the presence of water and a foaming Couple release formaldehyde. The foaming couple includes an acid moiety that acts as an acid catalyst the compounds with recurring oxymethyl groups acts and leads to the formation of formaldehyde.

The foaming pair that is used for the invention. Suitable purposes is a gas-generating agent for the formation of physical activity by violent evolution of carbon dioxide gas. In the presence of the probioid and an aqueous medium entering the body, the foaming couple forms a gas that helps to transport the formaldehyde produced in the body or agent to the outside. That of that. The foaming couple also creates the physical force to mix the formaldehyde with the solution so that it can develop its biocidal effect. The foaming pair comprises at least one preferably solid acidic material and one preferably solid basic material, which generally dissolve in the aqueous medium that enters the body or react in the presence of an aqueous liquid after exiting the molded body to form foaming carbon dioxide. The foaming pair is mixed with the probioid in the form of a powder _/ crystalline or granulate and built into a polymer matrix. The acidic component of the pair includes organic acids such as malic acid, fumaric acid, tartaric acid, itaconic acid, maleic acid, citric acid, adipic acid, succinic acid, and mesaconic acid, and mixtures thereof. Inorganic acids and acid salts such as monosodium citrate, acidic potassium tartrate and potassium bitartrate can also be used in the composition. The basic component includes metal carbonates and bicarbonates, such as alkali carbonates and bicarbonates, or alkaline earth carbonates and bicarbonates and mixtures thereof. Examples of basic materials are / _

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Lithium, sodium and potassium carbonate and bicarbonate and magnesium and calcium carbonate or bicarbonate. Ammonium carbonate, ammonium bicarbonate and ammonium sesquicarbonate are also suitable. The combination of certain of these acids and bases leads to more rapid gas formation or foaming on contact with water. In particular, either citric acid or a mixture of citric acid and tartaric acid and sodium bicarbonate lead to rapid gas evolution, which is suitable The foaming couple is mixed with the probioeid in an anhydrous or dry state, preferably in substantially a stoichiometric equilibrium to achieve the combination that evolves carbon dioxide. The amount of foaming couple is approximately 1 to 40 % of the agent, especially 5 to 20 %,

The surfactants that are suitable for the purposes of the invention include those with wetting, solubilizing and commingling properties that help the probioid and evolved Carbon dioxide gas exert their effect to a greater extent. The surfactants can be cationic, anionic or be non-ionic. Examples of cationic surfactants are lauryldimethylbenzylammonium chloride, p-diisobutylphenoxyethoxyethyldimethylbenzylammonium chloride, Alkyldimethylbenzylammonium chloride, laurylisochinoiinium bromide, cetylethyldimethylammonium bromide, Stearyldimethylbenzylammonium chloride, N-soy-N-ethylmorpholinium-ethosulfate, NCAcyl-colaminoformylmethyl) -

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pyrydinium chloride, a mixture of alkyl CCgH ^ g bis C> | tH-T ^) - tolylmethyltrimethylammonium chloride and Laurylisoquinolinium bromide, coamidoalkyl betaine and N-lauryl aminopropionic acid. Examples of anionic Surfactants are linear alkylarylsulfonates, which have been produced by Friedel-Crafts reaction of an olefin with benzene, whereby the olefin has 10 to 18 carbon atoms, as well as their alkali salts and other anionic surface-active agents, such as alkyl lauryl sulfonates Capryl-imidazoline derivatives, dioctyl esters of sodium sulfosuccinic acid, sodium lauryl sulfate, Sodium salt of alkylated aryl polyether sulfate, triethanolamine salt of lauryl sulfate, triethanolamine sal ζ of alkylaryl sulfonate and their mixtures. examples for non-ionic surfactants are alkylated aryl polyether alcohol, polyethylene glycol tert-dodecyl thioether, Fatty acid acid condensates, aromatic polyglycol ether condensates, secondary amides of lauric acid, fatty acid alkanolamine condensate sorbitan monolaurate, Sorbitan monolaurate polyoxyethylene, sorbitan monooleate, Sorbitan-mono-oleate-polyoxyetheylene-derivatives, Manni d-mono-oleate-poly oxy ethylene lauryl ether, polyoxy ethyl ene esters of mixed resin and fatty acids and their mixtures and surfactants, the generally the condensation products of a linear, aliphatic alcohol having 8 to 22 carbon atoms in the aliphatic moiety and an alkylene oxide, wherein the alkylene oxide comprises about 55 to 80 wt .-% of the surface-active Means matter. Other examples of surfactants are Igepal CO-710, a nonionic agent consisting essentially of nonylphenol condensed with 10 to 11 mol of ethylene oxide, Pluro-

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nic Ρ-65, a non-ionic agent consisting mainly of hydrophilic polyoxyethylene groups and a hydrophobic polyoxypropylene group with an average molecular weight of 3,500 with 50% by weight of ethylene oxide, Pluronic P-123, a non-ionic agent with a Molecular weight of about 5,650 with 30% ethylene oxide groups, Deriphat 16O, an ampholytic disodium salt of N-lauryl-B-imino-di-propionate, etc. The amount of surfactant is sufficient to achieve the desired results. Usually the amount is in the range from 0.01 to about 5% by weight based on the total weight of all ingredients in the composition.

The invention is illustrated in more detail by the following examples.

example 1

20. A remedy was made as follows:

First, 85 g of powdery, white, solid, polymeric paraformaldehyde, 5 g citric acid and 10 g sodium bicarbonate at room temperature of 21 C in in a dry, moisture-free environment for 30 minutes to form a homogeneous mixture.

Then 40 g of the mixture were placed in a roll mixer with two rolls, into which ethylene-vinyl acetate copolymer with a vinyl content of 40 % had previously been added, within 5 to 15 minutes. Mix thoroughly for 5 to 10 minutes. Then the product was placed on a four-roll calender to produce Oir.e film. This was cut into square pieces for use in

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a predetermined environment.

Example 2

An agent was prepared by mixing in an anhydrous environment 10 % citric acid, 19 % sodium bicarbonate, 1 % surfactant (Igepal) and 70 % paraformaldehyde to form a homogeneous mixture. This mixture was blended with commercially available polyolefin, polyethylene, by processing
a Barbender plastograph with gentle heating
within 7 to 14 minutes. Then the crowd became
removed from the device and pressed under a pressure of 103 N / mm (15,000 psi) into a rectangular matrix suitable for controlling the presence of undesirable microorganisms. The agent was stored in a dry package to prevent premature contact with moisture. the
The package consisted of two opposing sheets of aluminum foil, which formed an inner space and were sealed moisture-tight at the edges.

Example 3

A composition was prepared by mixing 40 g Paraformaldehyde, 40 g meth'erfemin mandrel, 5 g citric acid and 15 g of potassium bicarbonate which slowly warmed into one over 5 minutes with continuous kneading Two-Welzenmühle was given into the previously

a copolymer of ethylene and ethyl acrylate-given v.-orden was. The resulting semicircle was removed and extruded into a solid rod that was suitable for sterile

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The agents according to the invention can be used to combat unwanted microorganisms on a commodity such as a razor, by immersing the object in a freshly prepared by dissolving an agent according to the invention in Yfasser Solution. In the presence of water, the delivery system or agent or body sets paraformaldehyde free that forms formaldehyde, as well as the couple that forms carbon dioxide gas and that forms formaldehyde Distributed throughout the solution to achieve the desired results.

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Claims (8)

Claims Λ. Means for combating undesirable microorganisms in the form of a body, consisting of a polymer in which a probioid, which forms the bioid formaldehyde on contact with water, and a foaming pair, which develops carbon dioxide on contact with water, and optionally a surface-active agent, are dispersed. 2. Means according to claim 1 * characterized in that the formaldehyde developing Compound is paraformaldehyde. 3. Composition according to claim 1, characterized in that the formaldehyde developing Compound is methenamine and / or a salt thereof. * f. Agent according to Claim 1, characterized in that the formaldehyde-forming compound . Has repeating oxymethylene units. 5. Means according to claim 1 to 4, characterized g e k e η η is characterized by the fact that it is also a surface-active substance Contains funds. . 1A-55 71- -2- 6. Composition according to claim 1 to 5, characterized in that the foaming pair is an acid as well as an alkali or alkali metal carbonate or bicarbonate. · 7. Use of the agent according to claim 1 to 6 for disinfecting objects, characterized by g e k e η η, that one dissolves the agent in "water and the objects to be treated with the solution in Brings touch. 8. Use according to claim 7, characterized in that the objects to be treated immersed in the solution. 6231