JP5924972B2 - Disinfectant - Google Patents

Description

  The present invention relates to a sterilizing material, a sterilizing material kit, and a sterilizing method.

The method of disinfection or sterilization (hereinafter collectively referred to as “sterilization”) of the medical device is appropriately selected depending on the material constituting the medical device. As an example of these sterilization methods, for example, a method using a formalin sterilizer in which calcined gypsum (CaSO ₄ · 1 / 2H ₂ O) is used as a base material and a formalin solution is soaked in crystal water existing in the base material. Is well known. In this method, the formalin disinfectant is placed in a sealed space together with a medical device and left for a certain period of time, so that the volatilized formaldehyde gas fills the sealed space, and this gas exists on the surface of the device. Sterilize bacteria. An example of a document describing such a method is Patent Document 1.

  However, when a formalin disinfectant whose base material is calcined gypsum is used, the following two problems arise. The first problem is high cost. This problem is caused by the large amount of calcined gypsum used and the high unit price of calcined gypsum. The second problem is the complexity of the disposal process. This problem is caused by the fact that the sterilizing material after use can generate hydrogen sulfide gas, and therefore it must be disposed of as first-class industrial waste.

  These problems become even more apparent especially in disaster medical settings and medical settings in underdeveloped countries. Because, in these medical sites, there is a shortage or absence of a company that requires a large amount of disinfectant, a shortage of expenses for medical care, or a proper disposal This is because of the circumstances.

  Thus, with the recent increase in attention to disaster medicine and medical care in underdeveloped countries, development of a disinfectant that can overcome the above two problems is eagerly desired.

Japanese Patent Laid-Open No. 7-8544

  An object of the present invention is to provide a sterilizing material that is inexpensive, can be easily disposed of, and has an excellent sterilizing effect.

  As a result of diligent research, the present inventor has found that the above-described problems can be solved by using a water-absorbing resin as a base material and a base material in which the aqueous formaldehyde solution is held as a disinfectant.

  That is, this invention includes what has the following structure.

  Item 1. A sterilizing material comprising a water-absorbing resin and an aqueous formaldehyde solution retained by the water-absorbing resin.

  Item 2. Item 2. The sterilizing material according to Item 1, wherein the water absorbent resin is an acrylic acid polymer.

  Item 3. Item 3. The sterilizing material according to Item 1 or 2, wherein the formaldehyde aqueous solution is a 10-50% formaldehyde aqueous solution.

  Item 4. Item 4. The sterilizing material according to any one of Items 1 to 3, wherein the mass ratio of the water-absorbing resin and the aqueous formaldehyde solution retained by the water-absorbing resin is a mass ratio in the range of 1:20 to 1:60.

  Item 5. Item 5. The sterilizing material according to any one of Items 1 to 4, wherein the water absorbent resin and the aqueous formaldehyde solution retained by the water absorbent resin are retained in a non-woven bag.

Item 6. Item 6. A sterilizer kit containing the sterilizer according to any one of Items 1 to 5 and a formaldehyde neutralizer.

  Item 7. Item 6. A method for sterilizing an object to be sterilized, wherein the sterilizing material and the object to be sterilized according to any one of Items 1 to 5 are placed in a sealed space and left to stand.

  Moreover, the sterilization case preferably used when performing the sterilization method of this invention has the following structure.

A case main body having a sterilization target object storage space capable of storing a sterilization target object therein, and a lid for sealing the case main body,
The lid has a housing part having a sterilizing material housing space capable of housing a sterilizing material, and a holding unit for holding the housing part,
The holding portion has at least one through-hole communicating with the sterilization object containing space,
The accommodating portion includes a plug portion that closes the through hole of the holding portion so as to be freely opened and closed, and a vent hole that is located on the through hole and can communicate with the sterilization object accommodating space and the sterilizing material accommodating space. A sterilization case characterized by that.

  In a preferred embodiment of the sterilization case having the above-described configuration, the accommodating portion is rotatable at least within a predetermined angle range with respect to the holding portion, and the ventilation hole is formed on the through hole by the rotation of the accommodating portion. Is located.

  In another preferred embodiment, the plug portion is provided in the housing portion so as to be slidable in the horizontal direction, and the vent hole located on the through hole is provided by sliding of the plug portion. It is said.

  According to the present invention, it is possible to provide a sterilizing material that is inexpensive, can be easily disposed of, and has an excellent sterilizing effect. Moreover, according to the sterilizing material of the present invention, an object to be sterilized can be sufficiently sterilized in a short time. Furthermore, since the excellent sterilizing action can be continuously exhibited even when used multiple times, the sterilization cost can be further reduced.

It is a disassembled perspective view of a lid | cover. (A) is a top view of a top-plate part, (B) is sectional drawing which follows an AA line. (A) is a top view of a saucer, (B) is sectional drawing which follows a BB line. (A) is a top view of a cover, (B) is a side view. It is sectional drawing of a sterilization case. It is sectional drawing of the sterilization case in the sterilization process.

(1) Disinfectant The disinfectant of the present invention is a disinfectant containing a water-absorbing resin and an aqueous formaldehyde solution held by the water-absorbing resin.

  The water absorbent resin is not particularly limited as long as the aqueous formaldehyde solution can be retained. For example, a water-absorbing resin capable of absorbing pure water having a mass of 50% or more, preferably 100% or more, more preferably 200 to 600% of the mass of the water-absorbing resin. Specifically, acrylic acid polymer, polyvinyl alcohol polymer, starch-acrylic acid graft copolymer polymer, saponified starch-acrylonitrile graft copolymer, acrylamide polymer, carboxymethyl cellulose polymer, isobutylene -Maleic acid copolymer polymer, saponified vinyl acetate-acrylic acid ester copolymer, or vinyl alcohol-acrylic acid polymer. Among these, an acrylic acid polymer is preferable. The above may be used alone or in combination of two or more.

  In the acrylic acid polymer, an acrylic acid monomer (acrylic acid monomer, organic salt of acrylic acid monomer, or inorganic salt of acrylic acid monomer) is a constituent monomer of 70 to 100, preferably 90 to 100, more preferably. Is a polymer occupying 98 to 100% by mass. The acrylic monomer is preferably a mixture of an acrylic acid monomer and an inorganic salt of an acrylic acid monomer. As an inorganic salt, an alkali metal salt or an alkaline earth metal salt is mentioned, for example, Preferably a sodium salt is mentioned. The above may be used alone or in combination of two or more.

  As the water-absorbing resin, various commercially available resins may be used as they are, or those produced by a known method may be used.

  The shape of the water absorbent resin is not particularly limited as long as the aqueous formaldehyde solution can be retained. An example is granular. The particle size is not particularly limited, and examples include a particle size in the range of 50 to 1000 μm, preferably 100 to 900 μm, more preferably 150 to 800 μm.

  The formaldehyde aqueous solution is not particularly limited as long as it is an aqueous solution containing formaldehyde. For example, an aqueous solution containing 5 to 80% (w / w) formaldehyde (5 to 80% aqueous formaldehyde solution), preferably an aqueous solution containing 10 to 50% (w / w) (10 to 50% aqueous formaldehyde solution), more preferably Is an aqueous solution (20 to 45% formaldehyde aqueous solution) containing 25 to 45% (w / w), more preferably an aqueous solution (35 to 40 formaldehyde aqueous solution) containing 35 to 40% (w / w). The aqueous formaldehyde solution may contain, for example, 1 to 15% (w / w), preferably 5 to 12% (w / w) of a formaldehyde stabilizer. Examples of the stabilizer include methanol. You may use a stabilizer in combination of 1 type, or 2 or more types.

  The mass ratio of the water-absorbing resin and the aqueous formaldehyde solution retained in the water-absorbing resin is not particularly limited as long as it can exert a bactericidal action, but the bactericidal performance of the bactericidal material, the formaldehyde release rate from the bactericidal material, And preferably from 1:10 to 1: 200, more preferably from 1:15 to 1: 100, still more preferably from 1:20 to 1:60, and still more preferably from the viewpoint of the sustainability of formaldehyde emission from the sterilizing material. A mass ratio in the range of 1:35 to 1:45 can be mentioned.

  The water-absorbing resin and the aqueous formaldehyde solution retained by the water-absorbing resin (hereinafter sometimes referred to as “water-absorbing resin retaining the aqueous formaldehyde solution”) can be obtained, for example, by allowing the water-absorbing resin to retain the aqueous formaldehyde solution. Specifically, a method of impregnating the water-absorbing resin with the formaldehyde aqueous solution by dropping a formaldehyde aqueous solution into the water-absorbing resin or immersing the water-absorbing resin in the formaldehyde aqueous solution can be mentioned.

  The water-absorbing resin holding the aqueous formaldehyde solution thus obtained may be used as it is as the sterilizing material of the present invention, for example, what is held in a non-woven bag may be used as the sterilizing material of the present invention. . The form in which the water-absorbing resin for holding the aqueous formaldehyde solution is held in the non-woven bag is not particularly limited. For example, the form in which the water-absorbing resin is contained in the non-woven bag (the bag is open or closed). May be included). In order to prevent formaldehyde from diffusing due to volatilization, the sterilizing material may be sealed with a confidential sealing material or the like.

  The sterilizing material of the present invention is very inexpensive because the water-absorbing resin is inexpensive. Further, since no toxic gas such as hydrogen sulfide gas is generated, a special disposal method is not required and the disposal is simple. Furthermore, the sterilizing material of the present invention exhibits an excellent sterilizing action when used in the sterilizing method described below. And the bactericidal action lasts stably even after multiple uses.

(2) Disinfectant kit The disinfectant kit of the present invention is
It is a sterilizer kit containing the aforementioned sterilizer and a formaldehyde neutralizer.

  The formaldehyde neutralizing agent contained in the sterilizing material kit can neutralize the remaining formaldehyde contained in the sterilizing material after use, thereby detoxifying it.

  The formaldehyde neutralizing agent is not particularly limited as long as it is a chemical substance that can accelerate the decomposition of formaldehyde, and a known formaldehyde neutralizing agent can be used. For example, it is not particularly limited as long as it is a chemical substance capable of promoting the decomposition of formaldehyde, but a safe substance that does not adversely affect the environment and is easy to handle is preferable. Specific examples include alkali compounds such as ammonia solution, slaked lime, sodium hydroxide, potassium hydroxide, and sodium hypochlorite. These may be in the form of a solution, a suspension or a solid (powder, granule, tablet, etc.) molded with an appropriate carrier. Among these, an ammonia solution is preferable.

  The form of the sterilizing material kit is not particularly limited, and examples thereof include a form in which a sterilizing material is packaged with a single sealing material and an ampoule containing an ammonia solution is placed in a container (for example, a metal can).

  For example, when the formaldehyde neutralizer is an ammonia solution, the neutralization may be performed by placing the sterilizing material and the formaldehyde neutralizer in the sealed space and leaving them. According to this method, ammonia volatilized from the ammonia solution fills the sealed space, and formaldehyde remaining in the sterilizing material and formaldehyde gas volatilized from the sterilizing material can be neutralized.

  According to the sterilizing material kit of the present invention, it is possible to provide a sterilizing material kit that is inexpensive and easy to discard. This sterilizing material kit exhibits an excellent sterilizing action when used in the sterilizing method described below. And the bactericidal action lasts stably even after multiple uses.

(3) Sterilization method The sterilization method of the present invention is a sterilization method for an object to be sterilized, wherein the sterilizing material and the object to be sterilized are placed in a sealed space and left to stand.

  According to the sterilization method of the present invention, the formaldehyde gas volatilized from the sterilizing material is filled in the sealed space, and the bacteria present on the surface of the sterilization target can be sterilized by the formaldehyde gas.

  The object to be sterilized is not particularly limited as long as it requires sterilization. For example, a medical instrument is mentioned. Specifically, as medical instruments, disinfecting forceps, Mikulitz forceps, weak wrinkle kelly, right angle kelly, weak wrinkle pair, long mosquito, alice mucosal forceps, intestinal forceps, cloth forceps, flat wrinkle, plate sputum, lever sputum, kocher , Pean, Mosquito Peane, Straight scissors, Cooper scissors, Mechchen scissors, Mayo scissors, Mattou needle holder, Diamond needle holder, female pattern, measure, flexible spatula, Nakayama retractor, metal cup, cup of medicine, pus bonsai, A petri dish, a thread bag, a set cotton ball, etc. are mentioned.

  The sealed space can be created by a container made of metal, glass or plastic, for example. The sealed space need not be a completely sealed space without a slight gap as long as the formaldehyde gas released from the sterilizing material can be filled, but is preferably completely sealed.

  The mass of the disinfectant to be arranged is not particularly limited. From the viewpoint of the sterilizing performance of the sterilizing material, the formaldehyde emission rate from the sterilizing material, and the sustainability of formaldehyde emission from the sterilizing material, it is preferable to arrange 1 g of the sterilizing material per 5-30 L of sealed space. More preferably, 1 g of disinfectant is disposed per sealed space having a volume of 8 to 20 L.

  In this method, the sterilizing material and the sterilizing object are arranged in a sealed space. Although the arrangement | positioning aspect is not specifically limited, When there are two or more sterilization objects, it is preferable to arrange | position through a moderate clearance gap. Moreover, it is preferable that the sterilizing material is arranged as evenly as possible in the sealed space so that the sealed space can be filled with formaldehyde gas evenly.

  The time to leave is not particularly limited as long as the object to be sterilized is appropriately sterilized. For example, 30 minutes or more, preferably 30 to 120 minutes, more preferably 45 minutes to 90 minutes. According to the sterilization method of the present invention, an object to be sterilized can be sufficiently sterilized even in such a short time.

  Since the sterilizing material of the present invention is excellent in sustainability of formaldehyde gas release, it can be used again after being used in the sterilizing method. That is, the sterilization object can be sterilized by placing the sterilizing material present in the sealed space after completion of the sterilization method together with a new sterilization target in another sealed space and leaving it to stand.

  In addition, the sterilization method of the present invention is particularly preferably performed using the following sterilization case.

  As shown in FIGS. 5 and 6, the sterilization case 1 includes a case main body 2 that can accommodate the sterilization target 6 therein and a lid 3 that seals the case main body 2.

  The case body 2 and the lid 3 are preferably formed of a synthetic resin such as plastic. Particularly, even plastic, plastic that can withstand the use of not only formalin sterilization as in the present invention but also autoclave sterilization (for example, polypropylene, poly Methylpentene, polycarbonate, polytetrafluoroethylene, or perfluoroalkoxy fluororesin is preferred). As a result, the sterilization case 1 can be used as a case for autoclave sterilization during normal times, and as a case for formalin sterilization during disasters. Moreover, it is preferable that the magnitude | size of the case body 2 and the lid | cover 3 is a magnitude | size (for example, 285 mm x 294 mm x 150 mm) substantially the same as the magnitude | size of the existing autoclave sterilization case.

  The case body 2 and the lid 3 do not necessarily need to be formed of a plastic that can withstand the use of autoclave sterilization, and are exclusively used for formalin sterilization, that is, inexpensive plastics that cannot be used for autoclave sterilization (for example, polyethylene, Polystyrene, polyvinyl chloride, etc. may be mentioned). Further, it may be made of metal or glass.

  As shown in FIGS. 5 and 6, the case body 2 is a box-shaped container in which four side plates 21 are integrally provided on the periphery of a bottom plate 20 having a rectangular shape in plan view. A space surrounded by 21 is an accommodation space 22 for the sterilization target 6.

  As shown in FIGS. 1, 5, and 6, the lid 3 has a top plate portion 30 that is rectangular in plan view and closes the upper surface opening 23 of the case body 2, and a frame-like shape that hangs down from the periphery of the top plate portion 30. The peripheral part 31 and the sterilizing material accommodation part 4 for accommodating the sterilizing material 5 are provided. The peripheral portion 31 of the lid 3 and the side plate 21 of the case main body 2 are provided with fixing means (not shown) for fixing both, so that the lid 3 can be detachably fixed to the case main body 2. It has become.

  As shown in FIGS. 1 and 2, the top plate portion 30 includes a lower step surface portion 30a having a circular shape in plan view, and an upper step surface portion 30b that is positioned higher than the lower step surface portion 30a around the lower step surface portion 30a. The center portion is provided with a recess 32 serving as a holding portion for the sterilizing material housing portion 4. The sterilizing material container 4 is held in the top plate 30 by being fitted in the recess 32.

  The lower step surface portion 30a is provided with a plurality of through holes 33 penetrating the lower step surface portion 30a up and down. The through holes 33 are formed as small holes having a small diameter in the illustrated example, and three through hole groups 34 in which a plurality of through holes 33 are grouped in an arbitrary arrangement are provided at three equiangular positions.

  As shown in FIGS. 1, 5, and 6, the sterilizing material container 4 includes a tray 40 that can store the sterilizing material 5 and a cover 41 that seals the tray 40.

  As shown in FIGS. 1 and 3, the tray 40 is a box-shaped container in which a side peripheral plate 40B is integrally provided on the periphery of a bottom plate 40A having a circular shape in plan view. A space surrounded by 40 </ b> B is a storage space 40 </ b> C for the sterilizing material 5. The sterilizing material container 4 has an outer shape that is substantially the same size as the recess 32, and is rotatably fitted in the recess 32.

  The bottom plate 40A of the tray 40 is provided with a plurality of vent holes 42 that penetrate the bottom plate 40A vertically. This vent 42 is similar to the through-hole 33 provided in the lower surface portion 30a of the top plate portion 30, and a vent group 43 in which a plurality of small-diameter vent holes 42 are grouped in an arbitrary arrangement is placed at an equiangular position. It is provided at three locations, and is positioned on the corresponding through hole 33 by the rotation of the tray 40 so as to coincide with the through hole 33. Thereby, the sterilization material accommodation space 40 </ b> C of the tray 40 and the sterilization object accommodation space 22 of the case body 2 communicate with each other. On the other hand (see FIG. 6), when the tray 40 is rotated and the vent hole 42 of the tray 40 is shifted so as not to overlap the through hole 33 of the top plate portion 30, the bottom plate 40A of the tray 40 functions as a plug portion. Since the through-hole 33 of the top plate portion 30 is closed, the communication between the sterilizing material accommodation space 40C of the tray 40 and the sterilization object accommodation space 22 of the case body 2 is blocked (see FIG. 5).

  Further, at the upper end portion of the side circumferential plate 40B of the tray 40, there are provided three engagement recesses 44 at equiangular positions, and each engagement recess 44 is positioned between three vent hole groups 43, respectively. Are arranged as follows.

  As shown in FIGS. 1 and 4, the cover 41 has a first lid portion 45 having a circular shape in plan view that fits into the upper surface opening 40 </ b> D of the tray 40 and seals the sterilizing material accommodation space 40 </ b> C, and a first lid. A second lid portion 46 having a circular shape in plan view, which is provided in the upper portion of the portion 45 and is fitted into the upper surface opening 32A of the recess 32 so as to seal the recess 32, and is provided in an upper portion of the second lid portion 46. And a knob 47.

  On the outer peripheral surface of the first lid portion 45, three engaging convex portions 48 that engage with the engaging concave portions 44 of the tray 40 are provided at equiangular positions. By attaching the cover 41 to the receiving tray 40 so that each engaging convex part 48 engages with each engaging concave part 44, both rotate integrally.

  The knob 47 includes a disc 47A and three projecting members 47B provided integrally on the disc 47A, and the user can grasp each projecting member 47B by hand so that the cover member The tray 40 can be easily rotated via 41. The three protruding members 47B extend radially from the center of the disk 47A at an equal angle, and the tips thereof are located on the respective engaging convex portions 48.

  Six marks 35 are provided at equiangular positions on the upper surface 30 b of the top plate 30. Of the six marks 35, three marks 35 are provided at positions corresponding to the through-hole group 34, and "OFF" is displayed in the vicinity of the marks. On the other hand, the remaining three marks 35 are provided so as to be positioned between the respective through-hole groups 34, and “ON” is displayed in the vicinity of the marks. A mark 49 is also provided at the tip of each protruding member 47B of the knob 47.

  These marks 35 and 49 are misaligned between the vent hole 42 of the tray 40 and the through hole 33 of the top plate portion 30 if the mark 49 of each projecting member 47B coincides with the mark 35 indicating "OFF". The communication between the sterilization material accommodation space 40C of the tray 40 and the sterilization object accommodation space 22 of the case body 2 is blocked, while the mark 49 of each projecting member 47B is displayed as “ON”. If it coincides with the mark 35, the vent hole 42 of the tray 40 and the through hole 33 of the top plate portion 30 overlap each other, and the sterilizing material storage space 40 C of the tray 40 and the sterilization object storage space 22 of the case body 2 communicate with each other. It plays the role of teaching the user what they are doing.

  Next, a method for sterilizing the sterilization object 6 using the sterilization case 1 having the above-described configuration will be described.

  First, the sterilization object 6 is disposed in the sterilization object accommodation space 22 of the case body 2. When there are a plurality of objects to be sterilized 6, they are arranged at an appropriate interval. At this time, it is desirable that communication between the sterilizing material accommodation space 40C of the tray 40 and the sterilization object accommodation space 22 of the case body 2 is blocked (see FIG. 5). Thereafter, the case main body 2 is sealed with the lid 3 and both are fixed via fixing means (not shown).

  Next, the cover 41 is removed from the lid 3 to expose the sterilizing material accommodation space 40C of the tray 40, and the sterilizing material 5 is disposed in the sterilizing material accommodation space 40C. Thereafter, the cover 41 is again put on the tray 40 to seal the sterilizing material accommodation space 40C.

  Then, by gripping the knob 47 and rotating the cover member 41 and the tray 40 until the mark 49 coincides with the mark 35 indicating “ON”, the sterilizing material housing space 40C of the tray 40 and the case body 2 are sterilized. The object storage space 22 communicates (see FIG. 6), and formaldehyde gas volatilized from the sterilizing material 5 fills the sterilization object storage space 22 of the case body 2. Thereby, the microbe which exists in the surface of the sterilization target object 6 etc. can be sterilized with formaldehyde gas.

  When the sterilization is completed, the knob part 47 is gripped and the cover member 41 and the tray 40 are rotated until the mark 49 coincides with the mark 35 indicating “OFF”. The communication with the sterilization object accommodating space 22 of the main body 2 is blocked (see FIG. 5). Then, the sterilization object 6 is recovered by removing the lid 3 from the case body 2.

  In addition, since the disinfectant 5 of the present invention is excellent in sustainability of formaldehyde gas release, it can be used again even after the above-described disinfection is completed. Therefore, the new sterilization object 6 can be continuously sterilized by arranging the new sterilization object 6 in the sterilization object accommodation space 22 of the case body 2 and repeating the above-described steps.

  In the above-described embodiment, the through holes 33 and the vent holes 42 are configured by small holes having a small diameter, and the plurality of through holes 33 and the vent holes 42 are grouped so that the through hole group 34 and the vent hole group 43 are the top. Although it forms in the board part 30 and the receiving tray 40, it is not necessarily restricted to this, The through-hole 33 and the vent hole 42 which were comprised with the large diameter large hole are replaced with the through-hole group 34 and the vent-hole group 43. The top plate 30 and the tray 40 may be formed.

  Further, in the above-described embodiment, the sterilizing material accommodation space 4 (rotation tray 40) is rotated and the through hole 33 and the vent hole 42 are overlapped to communicate the sterilizing material accommodation space 40C and the sterilization object accommodation space 22. For example, in the bottom plate 40A of the sterilizing material container 4 (the receiving tray 40), a plug portion that is slidable in the horizontal direction at a position corresponding to the through hole 33 of the top plate portion 30, and the plug The sterilizing material accommodation space 40C and the sterilization object accommodation space 22 are provided by providing a vent hole exposed by sliding the part, and sliding the stopper part and positioning the vent hole on the through hole 33 during the sterilization process. It can also be configured to communicate.

  According to the sterilization method of the present invention, an object to be sterilized can be sufficiently sterilized. Furthermore, the sterilization target can be effectively sterilized in a short time due to the high formaldehyde gas release rate of the sterilizing material and the high formaldehyde gas emission sustainability.

  EXAMPLES The present invention will be described in detail below based on examples, but the present invention is not limited to these examples.

Example 1. Manufacture of disinfectant 1
Put 1g of super water-absorbing resin (sales product number No.110-985, manufactured by Kennis Co., Ltd., Sanyo Kasei Kogyo Sun Fresh Aqua Pearl (cross-linked acrylic acid polymer sodium salt)) in a non-woven tea bag and spread it evenly in the tea bag. It was. Place this tea bag in a plastic petri dish (90φ) and put 30 ml of formaldehyde aqueous solution (Wako Pure Chemical Industries special grade reagent 064-00406, stabilizer methanol 5-10%, formaldehyde 36.0-38.0% mass / mass) in the petri dish, The aqueous formaldehyde solution was left until it was completely absorbed by the super absorbent resin in the tea bag. The obtained product was used as a sterilizing material according to Example 1 in Example 3 below.

Example 2 Production of disinfectant 2
It was produced in the same manner as in Example 1 except that 40 ml of formaldehyde aqueous solution was used. The obtained product was used as a sterilizing material according to Example 2 in Examples 4 and 5 below.

Example 3 Sterilization test 1 using sterilizing material
The bactericidal effect was examined using the bactericidal material according to Example 1.

(Usage and materials used)
(1) Glass desiccator with a 30φ rubber cap on the lid (volume is a little larger than the volume of a disinfecting case to be put into practical use, about 13L) The rubber plug is a standard glass tube with two holes.
(2) Biological Indicator (Bacillus subtilis, thermotolerant sample) …… STERIS VERIFY ^R (Dual Species Self-Contained Biological Indicator): A filter paper in which two bacteria have permeated into a plastic vial where gas can easily enter. Exists. After the formaldehyde gas exposure, the visceral glass ampule is broken by pushing the cap into the transparent culture solution. Thereafter, Bacillus subtilis is cultured at 37 ° C. for 24 hours, and heat-resistant bacteria are cultured at 55 ° C. for 48 hours, and if there is a color change and turbidity of the clear liquid, it can be determined that the bacteria are alive.
(3) Formaldehyde gas measuring instrument …… Gastech Co., Ltd.
(4) Formaldehyde detector tube …… GASTEC.No.91 M (IM0091MJ2)
(5) Temperature / humidity measuring instrument in the desiccator
(6) Disinfectant according to Example 1 (sealed in a petri dish)
(7) Ammonia water (Kenei Pharmaceutical Group 3 Pharmaceutical, 9.5-10.5w / v%)
(Experimental procedure)
The glass tube was previously melted and sealed at the blind end. The Biological Indicator was tied with a thin thread, loosened the rubber stopper, and inserted into the desiccator through the hole in the desiccator lid so that the sample could be removed in time. A petri dish containing the temperature / humidity meter and the sterilizing material according to Example 1 was placed on the middle plate of the desiccator, and Biological Indicator (Bacillus subtilis, heat-resistant bacteria sample) hung from the lid of the desiccator was placed in the desiccator. The petri dish lid containing the sterilizing material according to Example 1 was opened, the lid of the desiccator was closed, and the sterilization time measurement was started. At the end of 20 minutes, the glass tube of the rubber stopper was pulled out, the detector tube attached to GASTECH was inserted, the formaldehyde concentration was measured, and the glass tube was closed. By the same operation, the formaldehyde concentration was also measured after 30 minutes, 40 minutes, 60 minutes, 90 minutes, and 120 minutes. After measuring the formaldehyde concentration at the lapse of 120 minutes, the petri dish containing the disinfectant according to Example 1 was covered, and the remaining formaldehyde gas inside the desiccator was ventilated and released. The above experiment was designated as the “first” experiment.

  The experiment similar to the 1st time was done using the petri dish in which the sterilizer which concerns on Example 1 after the completion of the 1st time experiment was contained. This experiment was designated as the “second” experiment.

  The experiment similar to the 1st time and the 2nd time was done using the petri dish in which the disinfectant concerning Example 1 entered after the end of the 2nd experiment. This experiment was designated as the “third” experiment.

  The sterilizing material according to Example 1 after completion of the third experiment was placed in a sealed can filled with ammonia gas to neutralize formaldehyde.

(result)
The results are shown in Table 1 below.

  From Table 1, although the rate of increase in formaldehyde concentration was slow at the third time, a good increase in formaldehyde concentration was observed at least until the second time. Also in the third time, it was shown that when 120 minutes passed, the formaldehyde concentration reached the same level as when 120 minutes passed in the first and second times.

Example 4 Sterilization test 2 using disinfectant
The bactericidal effect was examined using the bactericidal material according to Example 2.

  Biological indicators (Bacillus subtilis, heat-resistant bacteria sample) are taken out when 60 minutes and 90 minutes have elapsed, and whether Bacillus subtilis and heat-resistant bacteria in the Biological Indicator are sterilized. The same procedure as in Example 3 was performed except that the above was investigated.

  Whether Bacillus subtilis and heat-resistant bacteria in the Biological Indicator were sterilized was examined as follows. From the Biological Indicators (Bacillus subtilis, thermotolerant sample) taken at 60 minutes and 90 minutes in each of the first, second, and third experiments, the culture solution was leached as described above, and the culture solution was The cells were cultured under specific conditions (Bacillus subtilis sample: 24 hours at 37 ° C, heat-resistant bacteria sample: 48 hours at 55 ° C). After culturing, the color change and turbidity of the culture solution were determined to examine whether Bacillus subtilis and heat-resistant bacteria in the Biological Indicator were sterilized.

  The results are shown in Table 2 below.

  In Table 2, in Bacillus subtilis culture results or heat-resistant bacteria culture results, “(−)” indicates that there was no color change and no turbidity after the culture, and sterilization was sufficiently performed. On the other hand, “(+)” indicates color change and turbidity after culturing, indicating that sterilization was not sufficiently performed.

  From Table 2, instead of the sterilizing material according to Example 1 (holding 30 mL of formaldehyde aqueous solution with respect to 1 g of water-absorbing resin), the sterilizing material according to Example 2 (holding 40 mL of aqueous formaldehyde solution with respect to 1 g of water-absorbing resin) As a result, the rate of increase in formaldehyde concentration was observed in the third round as well as in the first and second rounds. That is, in all of the first to third times, it was shown that the formaldehyde concentration reached 1000 ppm or more within about 60 minutes. In all of the first to third times, it was shown that sterilization was sufficiently performed when 60 minutes passed and when 90 minutes passed.

Example 5 FIG. Sterilization test 3 using sterilizing material
The bactericidal effect was examined using the bactericidal material according to Example 2.

  The experiment was performed in the same manner as in Example 4 except that the conditions of the experimental environment (temperature, humidity, etc.) were different. Biological indicators were taken out after 60 minutes.

  The results are shown in Table 3 below.

  In Table 3, in Bacillus subtilis culture results or heat-resistant bacteria culture results, “(−)” indicates that there was no color change and turbidity after the culture, and sterilization was sufficiently performed. On the other hand, “(+)” indicates color change and turbidity after culturing, indicating that sterilization was not sufficiently performed.

  From Table 3, in the first experiment where the experimental environmental temperature is low (20 ° C. or less), the rate of increase of the formaldehyde concentration was slow (550 ppm after 60 minutes), and sterilization was insufficient. On the other hand, in the second and third experiments where the temperature was relatively high, the rate of increase of the formaldehyde concentration was good and sterilization was sufficiently performed. However, in the first experiment, if it was left for a longer time (for example, 90 minutes), it was assumed that the increase in formaldehyde concentration increased to about 1000 ppm, and sterilization was sufficiently performed.

Comparative Example 1 Production of disinfectant 3
While stirring 300 g of dried iwamilite, 30 mL of a 20% (w / v) formalin aqueous solution was gradually added dropwise so that all the iwamilite was impregnated with the formalin aqueous solution. The obtained product was used as a sterilizing material according to Comparative Example 1 in the following Comparative Test Example 1.

Comparative Test Example 1 Sterilization test 4 using sterilizing material
The bactericidal effect was examined using the bactericidal material according to Comparative Example 1.

  The disinfectant (330 g) according to Comparative Example 1 was transferred to a box with a capacity of 6.5 L (this time was taken as 0 minutes), 4 minutes, 7 minutes, 15 minutes, 30 minutes, 60 minutes, 180 minutes, When 300 minutes passed, the formaldehyde gas concentration was measured with a formaldehyde gas detector tube (Gastech). After measuring the formaldehyde gas concentration after 300 minutes, the air in the box was replaced. The above experiment was the first experiment.

  The experiment similar to the 1st time was done using the bactericidal material which concerns on the comparative example 1 after completion | finish of the 1st time experiment (2nd experiment). The formaldehyde gas concentration in the second experiment was measured at 30 minutes, 150 minutes, and 900 minutes. The results are shown in Table 4.

  As shown in Table 4, the concentration of formaldehyde gas in the box rapidly increased to 500 ppm at 4 min and reached a saturation concentration of about 900 ppm at 30 min (first time in Table 4). When the formaldehyde emission after the replacement of the air in the box with fresh air was measured again (second time in Table 4), the formaldehyde gas concentration reached 750 ppm after 30 min. It gradually decreased with time. Since the weight of iwamilite after releasing formaldehyde gas was 327.85 g, the weight of iwamilite containing formalin water was reduced by 2.15 g (330-327.85 = 2.15 g). This weight loss can be attributed to the release of 2.15 g of formaldehyde out of 2.2 g of formaldehyde soaked in iwamilite. That is, almost all of the dropped formaldehyde is vaporized.

  In order to sterilize by fumigation of formaldehyde, the formaldehyde gas concentration in the air must be maintained at least 600 ppm and the concentration must be maintained for 5-7 hours. In this experiment, since most of the formalin soaked in iwamilite is not bound to iwamilite, it has been shown that it is difficult to retain the formaldehyde necessary for bactericidal action for a long time.

Claims (7)

A disinfectant containing a water-absorbing resin and a 10-50% aqueous formaldehyde solution retained by the water-absorbing resin. The sterilizing material according to claim 1, wherein the water-absorbing resin is an acrylic acid polymer. The sterilizing material according to claim 1 or 2 , wherein a mass ratio of the water-absorbing resin and an aqueous formaldehyde solution retained by the water-absorbing resin is a mass ratio in a range of 1:20 to 1:60. The disinfectant according to any one of claims 1 to 3 , wherein the water absorbent resin and the aqueous formaldehyde solution retained by the water absorbent resin are retained in a non-woven bag. Water resin and sterilization material containing aqueous formaldehyde solution held in the water-absorbent resin, as well as biocidal material kits containing <br/> formaldehyde neutralizer. A sterilization method for an object to be sterilized, wherein a water-absorbing resin, a sterilizing material containing an aqueous formaldehyde solution held by the water-absorbing resin, and an object to be sterilized are placed in a sealed space and left standing. A case main body having a sterilization target object storage space capable of storing a sterilization target object therein, and a lid for sealing the case main body,
The lid has a housing part having a sterilizing material housing space containing a water-absorbing resin and a sterilizing material containing a formaldehyde aqueous solution held in the water-absorbing resin, and a holding part for holding the housing part,
The holding portion has at least one through-hole communicating with the sterilization object containing space,
The accommodating portion includes a plug portion that closes the through hole of the holding portion so as to be freely opened and closed, and a vent hole that is located on the through hole and can communicate with the sterilization object accommodating space and the sterilizing material accommodating space. A sterilization case characterized by that.

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