DE3200391C2 - Vorrichtung zur Messung der Fluoreszenzpolarisation - Google Patents
Vorrichtung zur Messung der FluoreszenzpolarisationInfo
- Publication number
- DE3200391C2 DE3200391C2 DE3200391A DE3200391A DE3200391C2 DE 3200391 C2 DE3200391 C2 DE 3200391C2 DE 3200391 A DE3200391 A DE 3200391A DE 3200391 A DE3200391 A DE 3200391A DE 3200391 C2 DE3200391 C2 DE 3200391C2
- Authority
- DE
- Germany
- Prior art keywords
- sample
- light
- polarization
- polarizer
- plane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002875 fluorescence polarization Methods 0.000 title claims abstract description 8
- 230000010287 polarization Effects 0.000 claims abstract description 23
- 230000005284 excitation Effects 0.000 claims abstract description 21
- 239000004973 liquid crystal related substance Substances 0.000 claims abstract description 16
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 5
- 239000007788 liquid Substances 0.000 claims abstract description 5
- 238000012360 testing method Methods 0.000 claims description 9
- 230000005684 electric field Effects 0.000 claims description 8
- 230000005669 field effect Effects 0.000 claims description 5
- 238000011156 evaluation Methods 0.000 claims 1
- 230000001678 irradiating effect Effects 0.000 claims 1
- 230000003287 optical effect Effects 0.000 abstract description 3
- 229910052721 tungsten Inorganic materials 0.000 abstract description 3
- 239000010937 tungsten Substances 0.000 abstract description 3
- -1 tungsten halogen Chemical class 0.000 abstract description 3
- 238000012545 processing Methods 0.000 abstract description 2
- 238000012806 monitoring device Methods 0.000 abstract 1
- 239000006096 absorbing agent Substances 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- NJDNXYGOVLYJHP-UHFFFAOYSA-L disodium;2-(3-oxido-6-oxoxanthen-9-yl)benzoate Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=CC(=O)C=C2OC2=CC([O-])=CC=C21 NJDNXYGOVLYJHP-UHFFFAOYSA-L 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 101710081722 Antitrypsin Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000006117 anti-reflective coating Substances 0.000 description 1
- 230000001475 anti-trypsic effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000006059 cover glass Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000002532 enzyme inhibitor Substances 0.000 description 1
- 229940125532 enzyme inhibitor Drugs 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Substances N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6445—Measuring fluorescence polarisation
Landscapes
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22363381A | 1981-01-09 | 1981-01-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3200391A1 DE3200391A1 (de) | 1982-07-29 |
| DE3200391C2 true DE3200391C2 (de) | 1985-10-24 |
Family
ID=22837366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3200391A Expired DE3200391C2 (de) | 1981-01-09 | 1982-01-08 | Vorrichtung zur Messung der Fluoreszenzpolarisation |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS57136142A (enrdf_load_stackoverflow) |
| AU (1) | AU544788B2 (enrdf_load_stackoverflow) |
| BE (1) | BE891736A (enrdf_load_stackoverflow) |
| CA (1) | CA1165585A (enrdf_load_stackoverflow) |
| DE (1) | DE3200391C2 (enrdf_load_stackoverflow) |
| FR (1) | FR2497951B1 (enrdf_load_stackoverflow) |
| GB (1) | GB2090971B (enrdf_load_stackoverflow) |
| IT (1) | IT1149428B (enrdf_load_stackoverflow) |
| NZ (1) | NZ199413A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19544481A1 (de) * | 1995-11-29 | 1997-06-05 | Laser Sorter Gmbh | Beleuchtungseinrichtung mit Halogen-Metalldampflampen |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU581917B2 (en) * | 1984-09-25 | 1989-03-09 | Richard Distl | Dual-beam real-time polarimeter |
| JPS6350741A (ja) * | 1986-08-20 | 1988-03-03 | Nippon Tectron Co Ltd | 蛍光偏光分析装置 |
| EP0454834A1 (en) * | 1989-11-21 | 1991-11-06 | Scource Scientific Systems, Inc. | Optics and method for measuring fluorescence polarization |
| US5387527A (en) * | 1992-06-26 | 1995-02-07 | Beckman Instruments, Inc. | Use of pH dependence for scatter correction in fluorescent methods |
| US7880396B2 (en) | 2007-06-14 | 2011-02-01 | Seiko Epson Corporation | Projector device employing ballast with flyback converter |
| JP2022187791A (ja) | 2021-06-08 | 2022-12-20 | キヤノン株式会社 | 検体検査用偏光発光粒子 |
| JP7728106B2 (ja) | 2021-06-08 | 2025-08-22 | キヤノン株式会社 | 偏光異方性の測定に基づく標的物質の検出、測定方法およびそのための粒子 |
| EP4435048A1 (en) | 2021-11-26 | 2024-09-25 | Canon Kabushiki Kaisha | Particles for specimen examinations |
| US20230366826A1 (en) | 2022-05-13 | 2023-11-16 | Canon Kabushiki Kaisha | Analysis method and analysis apparatus each employing measurement based on polarization anisotropy |
| CN119173758A (zh) | 2022-05-13 | 2024-12-20 | 佳能株式会社 | 利用基于偏振各向异性的测量的分析方法和分析设备 |
| US20230366818A1 (en) | 2022-05-13 | 2023-11-16 | Canon Kabushiki Kaisha | Analysis method involving measurement based on polarization anisotropy, test kit, and test reagent |
| JP2025040358A (ja) | 2023-09-11 | 2025-03-24 | キヤノン株式会社 | 標的物質の濃度を算出する解析方法、解析装置および解析キット |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB903165A (en) * | 1955-01-26 | 1962-08-15 | Zeiss Stiftung | Improvements in or relating to photo-electric polarimeters |
| US3679309A (en) * | 1970-05-04 | 1972-07-25 | Japan Spectroacopic Co Ltd | Instruments for measuring molecular orientations with the aid of fluorescence |
| DD107989A1 (enrdf_load_stackoverflow) * | 1973-06-07 | 1974-08-20 | ||
| IL43224A (en) * | 1973-09-14 | 1979-07-25 | Yeda Res & Dev | Fluorescence polarization measurements |
| JPS5356078A (en) * | 1976-10-30 | 1978-05-22 | Nippon Bunko Kogyo Kk | Poralized fluorescence measuring apparatus |
| US4203670A (en) * | 1977-04-21 | 1980-05-20 | Bromberg Nathan S | System and method of fluorescence polarimetry |
| US4115699A (en) * | 1977-06-16 | 1978-09-19 | Kabushiki Kaisha Nihon Kotai Kenkyujo | Apparatus for sensitive detection and quantitative analysis of biological and biochemical substances |
| JPS5468263A (en) * | 1977-11-10 | 1979-06-01 | Stanley Electric Co Ltd | Liquid crystal indicator |
-
1981
- 1981-12-30 CA CA000393388A patent/CA1165585A/en not_active Expired
-
1982
- 1982-01-05 AU AU79194/82A patent/AU544788B2/en not_active Ceased
- 1982-01-06 NZ NZ199413A patent/NZ199413A/en unknown
- 1982-01-07 GB GB8200381A patent/GB2090971B/en not_active Expired
- 1982-01-08 FR FR8200226A patent/FR2497951B1/fr not_active Expired
- 1982-01-08 IT IT19044/82A patent/IT1149428B/it active
- 1982-01-08 DE DE3200391A patent/DE3200391C2/de not_active Expired
- 1982-01-08 JP JP57001090A patent/JPS57136142A/ja active Granted
- 1982-01-08 BE BE0/207021A patent/BE891736A/fr not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19544481A1 (de) * | 1995-11-29 | 1997-06-05 | Laser Sorter Gmbh | Beleuchtungseinrichtung mit Halogen-Metalldampflampen |
Also Published As
| Publication number | Publication date |
|---|---|
| CA1165585A (en) | 1984-04-17 |
| IT8219044A0 (it) | 1982-01-08 |
| FR2497951A1 (fr) | 1982-07-16 |
| NZ199413A (en) | 1985-08-30 |
| DE3200391A1 (de) | 1982-07-29 |
| IT1149428B (it) | 1986-12-03 |
| JPS57136142A (en) | 1982-08-23 |
| FR2497951B1 (fr) | 1985-06-28 |
| JPH0352575B2 (enrdf_load_stackoverflow) | 1991-08-12 |
| GB2090971A (en) | 1982-07-21 |
| BE891736A (fr) | 1982-07-08 |
| GB2090971B (en) | 1984-04-26 |
| AU7919482A (en) | 1982-07-15 |
| AU544788B2 (en) | 1985-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OP8 | Request for examination as to paragraph 44 patent law | ||
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |