DE3071391D1 - 2-hydroxyaclacinomycin a, pharmaceutical composition containing it; 2-hydroxyaclavinone and fermentative process for preparing same - Google Patents

2-hydroxyaclacinomycin a, pharmaceutical composition containing it; 2-hydroxyaclavinone and fermentative process for preparing same

Info

Publication number
DE3071391D1
DE3071391D1 DE8080105306T DE3071391T DE3071391D1 DE 3071391 D1 DE3071391 D1 DE 3071391D1 DE 8080105306 T DE8080105306 T DE 8080105306T DE 3071391 T DE3071391 T DE 3071391T DE 3071391 D1 DE3071391 D1 DE 3071391D1
Authority
DE
Germany
Prior art keywords
hydroxyaclavinone
hydroxyaclacinomycin
pharmaceutical composition
composition containing
preparing same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8080105306T
Other languages
English (en)
Inventor
Toshikazu Oki
Akihiro Yoshimoto
Kageaki Kouno
Taiji Inui
Tomio Takeuchi
Hamao Umezawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mercian Corp
Original Assignee
Sanraku Ocean Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP11552079A external-priority patent/JPS5649341A/ja
Priority claimed from JP9288080A external-priority patent/JPS5718672A/ja
Application filed by Sanraku Ocean Co Ltd filed Critical Sanraku Ocean Co Ltd
Application granted granted Critical
Publication of DE3071391D1 publication Critical patent/DE3071391D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P29/00—Preparation of compounds containing a naphthacene ring system, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C12R2001/48—Streptomyces antibioticus ; Actinomyces antibioticus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8080105306T 1979-09-07 1980-09-04 2-hydroxyaclacinomycin a, pharmaceutical composition containing it; 2-hydroxyaclavinone and fermentative process for preparing same Expired DE3071391D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP11552079A JPS5649341A (en) 1979-09-07 1979-09-07 Anthracyclinone and its preparation
JP9288080A JPS5718672A (en) 1980-07-07 1980-07-07 Novel anthracycline antibiotic and its preparation

Publications (1)

Publication Number Publication Date
DE3071391D1 true DE3071391D1 (en) 1986-03-13

Family

ID=26434256

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8080105306T Expired DE3071391D1 (en) 1979-09-07 1980-09-04 2-hydroxyaclacinomycin a, pharmaceutical composition containing it; 2-hydroxyaclavinone and fermentative process for preparing same

Country Status (4)

Country Link
US (1) US4386198A (de)
EP (1) EP0030255B1 (de)
CA (1) CA1156577A (de)
DE (1) DE3071391D1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5731696A (en) * 1980-08-01 1982-02-20 Sanraku Inc Anthracycline derivative
EP0050724B1 (de) * 1980-10-27 1985-01-09 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Herstellung von Anthracyclinglycosiden
CA1187434A (en) * 1981-08-11 1985-05-21 Akihiro Yoshimoto Anthracycline antibiotics and their preparation method
US4405713A (en) * 1981-12-28 1983-09-20 Hoffmann-La Roche Inc. Process for the preparation of optically active anthracycline glycosides A and B
US4471052A (en) * 1982-01-18 1984-09-11 Adria Laboratories, Inc. Biosynthesis of simplified anthracyclines
JPS5982395A (ja) * 1982-11-02 1984-05-12 Microbial Chem Res Found アントラサイクリン化合物、その製造法およびその用途
DE69100679T2 (de) * 1990-07-23 1994-04-28 Mitsubishi Heavy Ind Ltd Vergasende Verbrennungsmethode und vergasende Energieerzeugungsmethode.
CN108484553B (zh) * 2018-03-21 2020-10-20 杭州唯铂莱生物科技有限公司 一种具有抗生作用的ozk1和ozk2化合物及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4020270A (en) * 1974-05-02 1977-04-26 Societa' Farmaceutici Italia S.P.A. L-lyxohex-1-enopyranose derivative
JPS5134915B2 (de) * 1974-07-27 1976-09-29
JPS52136159A (en) * 1976-04-07 1977-11-14 Microbial Chem Res Found Anti/malignanttumor containing the same as active ingredients
CH637160A5 (fr) * 1976-10-05 1983-07-15 Microbial Chem Res Found Procede de fabrication de glucosides anthracyclines.
JPS5543012A (en) * 1978-09-20 1980-03-26 Sanraku Inc Novel anthracycline derivatine and its preparation

Also Published As

Publication number Publication date
EP0030255A3 (en) 1981-09-02
EP0030255A2 (de) 1981-06-17
EP0030255B1 (de) 1986-01-29
CA1156577A (en) 1983-11-08
US4386198A (en) 1983-05-31

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: SANRAKU INC., TOKIO/TOKYO, JP

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MERCIAN CORP., TOKIO/TOKYO, JP

8328 Change in the person/name/address of the agent

Free format text: DEUFEL, P., DIPL.-WIRTSCH.-ING.DR.RER.NAT. HERTEL, W., DIPL.-PHYS. LEWALD, D., DIPL.-ING., PAT.-ANWAELTE, 8000 MUENCHEN

8339 Ceased/non-payment of the annual fee