DE3067376D1 - Stabilizer for liquid vaccines and liquid vaccine containing said stabilizer - Google Patents

Stabilizer for liquid vaccines and liquid vaccine containing said stabilizer

Info

Publication number
DE3067376D1
DE3067376D1 DE8080401527T DE3067376T DE3067376D1 DE 3067376 D1 DE3067376 D1 DE 3067376D1 DE 8080401527 T DE8080401527 T DE 8080401527T DE 3067376 T DE3067376 T DE 3067376T DE 3067376 D1 DE3067376 D1 DE 3067376D1
Authority
DE
Germany
Prior art keywords
stabilizer
liquid
vaccine containing
vaccines
liquid vaccine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8080401527T
Other languages
English (en)
Inventor
William J Mcaleer
Henry Z Markus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3067376D1 publication Critical patent/DE3067376D1/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
    • C12N2760/18434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
DE8080401527T 1979-10-29 1980-10-28 Stabilizer for liquid vaccines and liquid vaccine containing said stabilizer Expired DE3067376D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8906879A 1979-10-29 1979-10-29
US11870380A 1980-02-05 1980-02-05

Publications (1)

Publication Number Publication Date
DE3067376D1 true DE3067376D1 (en) 1984-05-10

Family

ID=26780218

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8080401527T Expired DE3067376D1 (en) 1979-10-29 1980-10-28 Stabilizer for liquid vaccines and liquid vaccine containing said stabilizer

Country Status (7)

Country Link
EP (1) EP0028563B1 (de)
DE (1) DE3067376D1 (de)
DK (1) DK159100C (de)
ES (1) ES8202584A1 (de)
GR (1) GR70319B (de)
IE (1) IE50276B1 (de)
PT (1) PT71926B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5716823A (en) * 1980-07-03 1982-01-28 Green Cross Corp:The Live mumps vaccine pharmaceutical and stabilizing method
US4554101A (en) * 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
MX7528E (es) * 1981-01-09 1989-08-02 New York Blood Center Inc Procedimiento para la preparacion de una vacuna sintetica
FR2505657A1 (fr) * 1981-05-13 1982-11-19 Pasteur Institut Perfectionnements apportes aux agents de stabilisation de virus vivants pour la preparation de vaccins, et vaccins stabilises contenant lesdits agents de stabilisation
FR2532548B1 (fr) * 1982-09-03 1985-11-08 Pasteur Institut Nouveau procede de production de vaccins presentant un titre eleve de virus et vaccins tres purifies, a titre eleve de virus, ainsi obtenus
ZA874625B (en) * 1986-06-30 1988-10-26 Smith Kline Rit Stabilizers for live vaccines,process for their preparation and vaccines containing them
JPS63307827A (ja) * 1987-06-08 1988-12-15 Kitasato Inst:The 安定化された生ウイルスワクチンおよびその製造法
ZA923548B (en) * 1991-05-17 1992-12-30 Merck & Co Inc Non-stinging vaccine composition
AU2088992A (en) * 1992-05-05 1993-11-11 Research Foundation For Microbial Diseases Of Osaka University, The Stabilized live vaccine
US6403098B1 (en) * 1996-09-26 2002-06-11 Merck & Co., Inc. Rotavirus vaccine formulations
WO1998028000A1 (en) * 1996-12-20 1998-07-02 Merck & Co., Inc. Stabilizers for lyophilized vaccines
US6051238A (en) * 1996-12-20 2000-04-18 Merck & Co., Inc. Stabilizers for lyophilized mumps vaccines
GB9808922D0 (en) * 1998-04-24 1998-06-24 Cantab Pharmaceuticals Res Ltd Virus preparations
AU2001278337A1 (en) * 2000-07-31 2002-02-13 Aventis Pasteur Limited Respiratory syncytial virus vaccine
CA2584815C (en) * 2004-11-05 2014-03-25 Wellstat Biologics Corporation Stable and filterable enveloped virus formulations
US20060141483A1 (en) * 2004-12-23 2006-06-29 Calton Gary J Stabilization of viral compositions
EP1973406B1 (de) 2005-12-28 2014-03-12 Advanced Bionutrition Corporation Abgabekonstituens für probiotische bakterien umfassend eine trockene matrix aus polysacchariden, sacchariden und polyolen in glasform
CA2673120C (en) 2006-12-18 2012-08-07 Advanced Bionutrition Corporation A dry food product containing live probiotic
ES2908047T3 (es) 2009-03-27 2022-04-27 Intervet Int Bv Vacunas en micropartículas para la vacunación oral o nasal y el refuerzo de animales incluidos los peces
NZ597053A (en) 2009-05-26 2014-02-28 Advanced Bionutrition Corp Stable dry powder composition comprising biologically active microorganisms and/or bioactive materials and methods of making
EP2529004B1 (de) 2010-01-28 2017-06-07 Advanced Bionutrition Corporation Trockenglaszusammensetzung mit einem bioaktiven material
US9504750B2 (en) 2010-01-28 2016-11-29 Advanced Bionutrition Corporation Stabilizing composition for biological materials
RU2573324C2 (ru) 2010-08-13 2016-01-20 Эдванст Байоньютришн Корпорейшн Стабилизирующая композиция для сухого хранения биологических материалов (варианты)
EP3246400B1 (de) 2012-01-09 2019-10-23 Sanofi Pasteur Biologics, LLC Aufreinigung von herpesvirus
WO2013177172A2 (en) 2012-05-21 2013-11-28 Sanofi Pasteur Limited Herpesvirus compositions and related methods
US9314519B2 (en) 2012-08-21 2016-04-19 Intervet Inc. Liquid stable virus vaccines
US9480739B2 (en) 2013-03-15 2016-11-01 Intervet Inc. Bovine virus vaccines that are liquid stable
US9393298B2 (en) 2013-03-15 2016-07-19 Intervet Inc. Liquid stable bovine virus vaccines
AR097762A1 (es) 2013-09-27 2016-04-13 Intervet Int Bv Formulaciones secas de vacunas que son estables a temperatura ambiente
AR099470A1 (es) * 2014-02-17 2016-07-27 Intervet Int Bv Vacunas de virus de aves de corral líquidas
TWI670085B (zh) * 2014-02-19 2019-09-01 荷蘭商英特威國際公司 液體穩定之豬病毒疫苗
WO2017019273A1 (en) 2015-07-29 2017-02-02 Advanced Bionutrition Corporation Stable dry probiotic compositions for special dietary uses
US11813322B2 (en) 2019-06-10 2023-11-14 Boehringer Ingelheim Animal Health USA Inc. Stabilized liquid live vaccine

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE665076A (de) * 1963-12-23 1965-12-08
BE641705A (de) * 1963-12-23 1964-06-23
FR2076787A5 (en) * 1970-01-28 1971-10-15 Merieux Inst Lyophilisation stabiliser - for viruses contg potassium phosphate lactose and albumin
NL7115348A (de) * 1970-11-25 1972-05-29
US3783098A (en) * 1971-08-10 1974-01-01 Cornell Res Foundation Inc Highly potent,viable and stable cellfree virus preparations from cells infected with cell-associated viruses and method for obtaining the same
IL44143A0 (en) * 1973-02-07 1974-05-16 Wellcome Found Method of inactivating viruses and vaccines prepared thereby
US3915794A (en) * 1973-02-09 1975-10-28 Rit Rech Ind Therapeut Stabilizing compositions for cell-free viruses and cell-free virus preparations containing them
US4147772A (en) * 1976-02-03 1979-04-03 Merck & Co., Inc. Vaccine stabilizer
DE2816349A1 (de) * 1978-04-14 1979-10-25 Merck & Co Inc Vaccinstabilisator
FR2424031A1 (fr) * 1978-04-24 1979-11-23 Merck & Co Inc Stabilisateur de vaccin
BE866330A (fr) * 1978-04-25 1978-10-25 Merck & Co Inc Procede de fabrication d'un agent de stabilisation de vaccin
LU79529A1 (fr) * 1978-04-26 1978-11-28 Merck & Co Inc Procede de fabrication d'un agent de stabilisation de vaccin

Also Published As

Publication number Publication date
ES496358A0 (es) 1982-02-01
IE50276B1 (en) 1986-03-19
DK159100C (da) 1991-02-11
PT71926B (en) 1982-03-31
DK455880A (da) 1981-04-30
IE802225L (en) 1981-04-29
GR70319B (de) 1982-09-10
PT71926A (en) 1980-11-01
EP0028563A1 (de) 1981-05-13
DK159100B (da) 1990-09-03
EP0028563B1 (de) 1984-04-04
ES8202584A1 (es) 1982-02-01

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