DE2928204A1 - LURE WITH HIGH CAPACITY FOR PERSONAL FLIES - Google Patents

Description

DIPL.-ING. SCHWAPE DR DR. SANDMAIR

PATENT LAWYERS? 9? 8? ΩΔ

P.O. Box 8602 45 8000 Munich 86

Lawyer deed; 30 246 A 2. Ju / f

Airwick AG
Basel, Switzerland

Bait with a high attractiveness for people nuisance

To fly

909884/0882

t (019) 911272 Wrtrwnmr Bank accounts: Hypo-Bink Manchen 4410122850

9 (1273 BERGSTAfFPATENT Manchen (BLZ 70020011) Swift Code: HYFO DE MM

918274 TELEX: Btyet Veniosbuik Munich 453100 (BLZ 70020270)

983310 052454OBEROd PmtsdicdcMOndien 65343-808 (BLZ 70010080)

Case 2-11916 / AFR 107 / +

Bait with a high attractiveness for people nuisance

To fly

The present invention relates to compositions for use as bait used in combating nuisances Flies are intended and have a very high attractiveness for these flies, a process for the production of these baits and their use.

Flies that are nuisance to humans are insects that are annoying and / or harmful to humans, in particular because of the germs that they transmit (trypanosomes, rickettsiae, tubercle bacillus, leprosy bacillus, Cholera bacillus, typhus bacillus, dysentery bacillus, anthrax bacteria, diphtheria bacillus, amoeba, various Protozoa and viruses of fever with rash), the larvae of which also cause intestinal or cutaneous myases can. It is easy to understand why man all over the world exterminated insects aspires to this category. These include in particular the Diptera of the families Muscidae, Sarcophagidae and Tachinidae.

Numerous means of destruction have been devised, such as powders, liquids, aerosols and insecticidal vapors, however, are all of these agents because of the toxic substances they put on surfaces and / or spread in the atmosphere, more or less dangerous for the user and even more generally for the environment.

The use of bait and especially small

909884/0882

Benden and / or toxic bait generally does not have these disadvantages; on the other hand, their effectiveness depends However, it depends on the level of their attractiveness on the insects, since the latter have to come to eat with it the poison can work or allow the insect to get through catches a suitable device combined with the bait.

Various substances have been proposed to play the role of attractant in as Compositions that can be used as bait for man-nuisance flies to take over.

These are in particular malt (French patent specification 1 141 605 <ier Pechiney-Progil), nutritional products such as sugar or raw products containing sugar (French patent specification 1 218 013 from JR GEIGY), a mixture of sugar and partially hydrolyzed yeast (French patent specification 1 319 152 from CIBA) , a carbohydrate such as sucrose (French patent 1 403 320), orange peel essence (French patent 1 605 359 by Gentil), vanillin (French patent 2 303 by Sterling Drug and German patent 2 510 450 by Schuelke and Mayr), sodium sulfide (J. Council Sci. Ind. Res., 1934, 7, 147), terpineol, farnesol, geraniol or phenylethanol (French patent 2 303 477 from Sterling Drug), hydrolysates of living cells (French patent 2 325 327 from Ajinomoto), ammonium carbonate (J. Econ . Entomol., 1951, 44, 1004), Skatol (Acta Soc. Entomol. Czechosl., 1958, 55_, 316), formaldehyde (British patent 597 822 by William et al.), Associations of tertiary Ami Nines and carboxylic acids (US Pat. No. 3,996,349), aliphatic lactones (Japanese application 76.79 727 by Ajinomoto), isovaleraldehyde (Science, 1952, 115 , 141), ethylamine (Z. Comparison. Physiol., 1942, 3_Q, 1) _; chlorinated alkenes (Japanese application 76.70 825 from Kuraray), aucuba fruit extracts (Japanese application 72.37 011 from Ahsu Seiyaku), aliphatic polyol mono-

909884/0882

esters (Japanese application 73.58 126 of Riken) and higher alkenes such as cis-Trikosen-9 (French application 2 207 649 from Thuron Industries).

The applicant has now found that containing a flavor known under the name of caramel Baits have a very high attractiveness towards dipteras such as flies, which means that these baits do not to be used only when moist, but also when dry or completely anhydrous.

Caramel is a long-known product used as a flavoring and / or food coloring. It is readily available by prolonged heating of sugar or by more sophisticated methods using a caramelization catalyst such as that described in US Pat. No. 1,031,602 to Gilman and Spencer, US Pat. No. 1,316,019 to Arnold Daniel, and the article by Clark, J. . Inst. Brewing, 1950 , pp. 258 et seq., And also in United States patents 2,533,221, 2,582,261, 2,637,655, 2,701,768, 2,784,118, 2,873,193 and 2,902,393 to Union Starch & Refining Co. and in U.S. Patents 2,767,108 and 2,767,109 to Standard Brands Inc.

Compared to the other known attractants, caramel initially has the three-fold advantage that it is a natural product, is toxicity-free and one has an extremely economical production price; none of the known attractants possesses at the same time these three properties.

Furthermore, it offers the unexpected advantage of having the attractiveness of another attractant such as cis-Trikosen-9 increase in a synergistic manner, this synergism creating baits with very high levels Lure for flies that nuisance humans permitted.

The invention relates in particular to a composition for use as a bait for combating nuisance flies, which

909884/0882

indicates that it is one of carbohydrates, proteins, peptides, amino acids and mixtures of these Compounds selected nutrient and approximately 0.5 Ms 10 wt .-% caramel, based on the total weight of the Bait, contains.

The invention also relates to a composition for use as bait for combating human nuisance flies, which is characterized in that it contains a nutrient as defined above, 0.5 to 10 wt .-% caramel and 0.01 to 3 wt .-% contains cis-Trikosen-9, whereby these proportions relate to the total weight of the bait.

The inventive composition is in generally combined with a bird glue and / or an insecticidal substance, which are intended to be used by the Bait immobilize attracted insects.

Further supplementary agents can optionally be present in the composition; one chooses this among dyes, stabilizers, known attractants, inert carriers and binders.

If the composition according to the invention contains an insecticidal substance, its concentration can be in the composition vary. It is preferably between about 0.01 and 8% by weight and particularly preferred between 0.2 and 5% by weight, the percentages being based on the total weight of the bait composition relate.

The caramel concentration in the composition is expediently between approximately 0.5 and 10% and particularly preferably between 1 and 8% by weight.

The lining material is preferably in solid form before and contains one or more preferably dehydrated components, which one under proteins, carbohydrates and in particular selects water-soluble carbohydrates and substances which contain at least one of these components.

909884/0882

The following can be mentioned as usable lining materials, for example:

- sugars such as sucrose, maltose, lactose, glucose, fructose, galactose, raffinose, Invert sugar and honey;

- Dried fruits such as raisins, prunes, apples, pears, peaches and apricots;

- Meat and fish meals as well as egg, milk or yeast powder.

Of great interest are those baits that contain at least one carbohydrate and at least one aminated Substance selected from amino acids, peptides and proteins, and in particular from a mixture Carbohydrate and protein built bait. Such a bait particularly preferably contains at least 25% proteins.

The addition of about 0.5 to 10% by weight of caramel to the feed or the replacement of part of this feed with an equivalent amount of caramel leads to an unforeseeable increase in the attractiveness of the bait for nuisance flies, especially if the feed mixture is about 3 to Contains 15% and preferably 5 to 15% by weight of vegetable protein hydrolyzate.

This enhancement of the attractiveness is particularly important when the caramel is mixed with a carbohydrate, Proteins and protein hydrolysates composed feed mixture is combined. The preferred feed mix contains about 2 parts by weight of carbohydrates and about 6 parts by weight of protein per 1 part by weight of vegetable Protein hydrolyzate.

The bait composition according to the invention can be combined with a glue made of a sticky compound such as polyisobutylene rubber, one of a Copolymer of styrene and butadiene composed of rubber, a neoprene-based rubber, etc. Other sticky substances can be used, which are

909834/0882

different natural resins such as rosin, its derivatives, polyterpene resins, coumarone-indene resins, etc. «

On the other hand, the bait preferably contains an insecticidal substance which is selected from among all such substances that act on insects through ingestion; preferred insecticidal substances are selected from N-substituted ones aromatic or heteroaromatic carbamic acid esters and organophosphorus compounds.

Examples of suitable carbamic acid esters are: dimethylcarbamic acid 3-methylpyrazolyl-5-ester, Dimethylcarbamic acid 1-dimethylcarbamyl-5-methylpyrazolyl-3-ester (Dirnetilan), methylearbamic acid 2-isopropoxyphenyl ester (Arprocarb), dimethylcarbamic acid-1-phenyl-3-methylpyrazolyl-5-ester (Pyrolan), dimethylcarbamic acid ^ -propyl- ^ methylpyrimidyl-6-ester (Pyramat), methylcarbamic acid 2- (1,3-dioxolanyl-2) phenyl ester (Dioxacarb), N-methylcarbamic acid-5,6,7,8-tetrahydronaphthyl-2-ester, N-methylcarbamic acid-2-methylquinolyl-8-ester, N-methylcarbamic acid ortho-tert-butylphenyl ester, N-methylcarbamic acid ortho-tert-butoxyphenyl ester, N-methylcarbamic acid ortho-2-propynyloxyphenyl ester, N-methylcarbamic acid ortho-sec-butylphenyl ester, N-methylcarbamic acid ortho-k-butoxyphenyl ester, 2,6-di-tert-butylphenyl N-methylcarbamic acid, 2,6-disec.-butylphenyl N-methylcarbamic acid, N-methylcarbamic acid 2,6-diisopropylphenyl ester, N-methylcarbamic acid 2-tert.-butyl-6-methylphenyl ester, Dimethylcarbamic acid 5,5-dimethyl-1-cyclohexen-3-onyl ester (Dirnetan) and N-methylcarbamic acid-2,3-isopropylidenedioxyphenyl ester (Bendiocarb),

Most preferred among these insecticides is dimetilane.

Examples of suitable organophosphorus compounds include: 0, O-dimethyl-0- (2,2-dichlorovinyl) phosphate (Dichlorvos), O, O-dimethyl-O- (1,2-dibromo-2,2-dichloroethyl) phosphate (Dibromo), 0,0-dimethyl-S-

909834 / Qd @ I

(A-aza-6-chloro-2-oxobenzoxazolyl-3) methyl thiophosphate (Azamethiphos), 2- (Dimethoxy-thioxo-phosphoranylthio) -succinic acid ethyl ester (Malathion), 'O, O-diethyl-0- (2-isopropyl-6-methylpyrimidyl-4) thiophosphate (Diazinon), 0,0-dimethyl-0- (4-bromo-2,5-dichlorophenyl) thiophosphate (Bromophosethyl), 0, O-dimethyl-0- (3-methyl-4-nitrophenyl) thiophosphate (Fenitrothion), 0, O-dimethyl-0- (2-methoxycarbonyl-1-propenyl) thiophosphate, 0, O-diethyl-O- (3,5,6-trichloropyridyl-2) -thiophosphate, 0, O-Dimethyl-0- (2,4,5-trichloroph'enyl) thiophosphate (Fenchlorphos), 0, O-dimethyl-0- (2,5-dichloro-4-iodophenyl) thiophosphate (Jodfenphos) and dimethyl (2,2,2-trichloro-1-hydroxyethyl) phosphonate (Trichlorophone).

Among these insecticidal substances, azamethiphos is most particularly preferred.

In addition to the carbamic acid esters and organophosphorus compounds or in combination with these substances, further insecticidal substances can be used, such as natural ones Pyrethrins, Rotenone, synthetic pyrethrinoids, Ν, Ν-dibutyl-parachlorobenzene-sulfonamide, 1,2,4,5,6,7,8,8-0ctachlor-3a, 4,7,7a-tetrahydro-4: 7-methanoindane, the gamma stereoisomer of 1,2,3,4,5,6-hexachlorocyclohexane, endo-exo-1,2,3,4,10,10-hexachloro-6,7-epoxy-1, 4,4a, 5,6,7,8,8a-octahydro-1: 4,5: 8- dimethanonaphthalene, Sodium fluoride and boric acid and its salts.

Among these insecticidal substances, preference is generally given to those which are not volatile, that is to say have a very low vapor pressure at ordinary temperature, preferably below 0.01 Torr at 20 ^° C.

Optionally, the bait can also comprise other attractants and / or appetite substances, selected from those which are known to the person skilled in the art, such as natural or artificial cheese, meat and fruit flavors, Amino acids, pollen extracts, thymol, skatole, indole, eugenol, paraformaldehyde, hexamethylenetetramine, Ammonium carbamate, aliphatic amines, papain, pancreatin,

909884/0882

- - <y -

aliphatic acids, vanillin, 3-chloro-3-methyl-butene-l, l-chloro-3-methyl-butene-2 and higher alkenes with 20 to 27 carbon atoms like cis-tricosen-9.

Bait compositions according to the invention which contain approximately 0.01 to 3% and preferably 0.01 to 1% by weight Containing cis-Trikosen-9, are particularly effective because they have a higher attractiveness than the skilled person reasonably could have expected.

In fact, the bait compositions which, together with a solid feed, contain a mixture of 0.5 to 10% caramel and approximately 0.01 to 3% cis-tricose-9, have a very high attractiveness against man-annoying flies because of the combination Caramel + cis-Trikosen-9 has a completely unexpected synergistic attraction.

Particularly effective bait compositions according to the invention are specifically those which (α) approximately 1 to 8% by weight caramel, (β) approximately 0.1 to 1% by weight cis-Tricosen-9, (Ύ) about 10 to 98.7% by weight of one Sugar or sugar mixture, (δ) 0 to 75% by weight of one or more aminated feed materials and (ε) 0.2 to 5% by weight of an insecticidal carbamic acid ester and insecticidal organophosphorus compounds of selected insecticidal substance, the above proportions refer to the total weight of the bait.

The compositions preferred according to the invention include very particularly those which (α) approximately 1 to 8% by weight of caramel, (β) approximately 0.1 to 1% by weight of cis-tricose-9, (Y) approximately 10 to 60% % By weight of a sugar or sugar mixture, (δ-,) about 35.7 to 75% by weight of a meat meal, (δ ₂ ) about 3 to 15% by weight of a protein hydrolyzate and (ε) about 0.2 to 5% by weight of an insecticidal substance selected from insecticidal carbamic acid esters and non-volatile insecticidal organophosphorus compounds.

Furthermore, the bait can optionally contain a binding agent like a natural or synthetic glue

909884/0882

■ and / or a dye or a pigment and / or a Contain stabilizer and / or an inert carrier of mineral or organic origin.

The preparation of the compositions according to the invention is generally done by simply mixing the ingredients, but in certain cases it is to better distribute the attractants and, if necessary, the insecticides and the coloring agent, proceed as follows:

a) Mixing the feed ingredients and the caramel;

b) Dissolving the other attracting agents and possibly the insecticides and the dye in one "sufficiently volatile" solvents such as acetone or methylene chloride;

c) spraying the solution b over the mixture a;

d) complete evaporation of the volatile solvent.

The optimum particle size of the composition will vary with the species of insect that it is intended to destroy is; As a general rule, the smaller the insect for which, the finer the particle size should be the bait is determined. This is preferably between 0.05 mm and 1 mm.

The invention also relates to a new method which allows bait with a high attractiveness for human-nuisance flies, this process being characterized in that:

(a) a solid caramel containing 0.5 to 10% by weight Mixture of selected from among carbohydrates, proteins, peptides, amino acids and mixtures of these compounds Nutrients ground into a powder, the mean particle size of which varies from about 0.5 to 1 mm, and that

(b) on this powdery carrier (a) 0.01 to

3% by weight of cis-Tricosen-9 and 0.1 to 8% by weight of one under Insecticidal carbamic acid esters ^ and insecticidal organophosphorus compounds selected insecticidal substance evenly distributed and the powdery and dry bait on one for human harassment

909884/0882

_ Al

lowing flies freely accessible carrier applies or sticks, with all weight percentages refer to the total weight of the bait.

The bait can be in the form of a free flowing powder or also in with or without the help of a binder agglomerated form such as granules or tablets are present.

The bait can also be fixed on an inert carrier or absorbed therein, this being inert Carrier for example made of paper, blotting paper, cardboard, plastic such as polystyrene, polyvinyl chloride, Polyvinyl acetate and cellulose acetate, glass, pumice stone, broken marble or silicon dioxide or silicate minerals can exist.

The following experiments demonstrate the importance of the bait according to the invention. TRIAL A

Make the following baits A-O and A-I (Percentages by weight), the first containing no caramel and the second containing part of the lining Caramel is replaced.

Table I.

composition A-O A-I sugar
Meat meal
Vegetable protein hydrolyzate 20.2
63.5
10.1 19.0
60.3
9.5 Dimetilane (a) 4.7 4.7 Caramel - ■ 5.0 Red dye
Potassium sorbinate
cis-tricots-9 0.8
0.5
0.2 0.8
0.5
0.2

(a) NjN-Dimethylcarbamic acid-1-dimethylcarbamyl-S-methylpyrazolyl-3-ester.

909884/0882

Every two grams of this bait, crushed into a homogeneous powder, is brought to the ground after it is dry a parallelepiped black cardboard box obtained by cutting, folding and gluing; the Dimensions of the bottom of the box are 100 χ 100 cm, and the height is 5 cm; in the top are two

2 elongated openings of 10 cm each cut.

The devices constructed in this way are set up in a ^{40-nr room kept at a temperature of 25 °} C. and a relative humidity of 40; then Musca domestica flies are released and the number of dead flies in each device is counted every 15 minutes for two hours. This test is repeated six times with the respective permutation of the devices.

The overall results of the test group are summarized in the table below (mean number of dead flies counted per test).

Table II

Elapsed time in minutes Number of dead flies A-I 15th A-O 37.7 30th 21.0 45.5 45 25.2 49.4 60 27.6 50.5 90 28.6 52.6 120 30.2 .53.8 30.9

These results show that the total number of flies killed by the bait according to the invention is already after 15 minutes is significantly higher than the number of flies killed by a known type of bait after 2 hours, although the latter contains two attractants such as cis-tricose-9 and a living cell hydrolyzate. After these two hours the effectiveness of the

909884/0882

-.42 -

the bait according to the invention that of the bait of the known type by 74%.
TRIAL B

The following baits - B-I, B-2 and B-3 (percentages by weight) are produced:

Table III

composition BI B-2 B-3 Sucrose 40.0 40.0 40.0 Dimetilan. 2.0 2.0 2.0 Caramel 10.0 - 5.0 cis-tricots-9 - 0.2 0.1 Red dye
Glass powder 0.8
47.2 0.8
57.0 0.8
52.1

These baits, crushed to a fine powder, are each fixed on a 9x9 cm large, to make them sticky Polystyrene plate soaked in methylene chloride and then placed the coated and dried plate in a glass dome 15 cm in diameter.

The devices constructed in this way are placed 2.50 m apart in one at a temperature of 25 ° C and a relative humidity of 40, 40 nr large rooms. Then flies of the species Musca domestica released and the number of dead flies in or around each of the domes for two hours counted every 15 minutes. This test is carried out six times with the respective permutation of the devices repeated.

The overall results of the test group are summarized in the table below (mean number of dead flies counted per test).

909884/0882

- • 35 "table IV

Elapsed time BI number dead flies Observed Ln minutes B-2 B-3 9.2 5.7 Expected 14.6 15th 7.7 8.3 7.0 . 17.6 30th 9.5 13.8 10.7 20.0 45 10.4 16.4 12.9 23.4 60 11.9 18.5 14.4 25.9 90 13.8 20.9 16.4 120 22.3 18.0

These results show that the effectiveness of the bait according to the invention is 30 to 4496 higher than the potency that would result from simply adding up the attractiveness of the caramel and the Exercise cis-Trikosen-9 with separate effects on the flies.

909884/0882

Claims (10)

: -1 ..- 1N3. SCKWACJE DR. DR. SA. : AIR f ATEN -ANWÄLTE 8 KiONOHEN WO · MAUERKIRCHERSTR. 45 Lawyers' files: 30 246 patent claims 1. Composition for use as a bait for the Combating flies that are nuisance to humans, characterized in that it is one of carbohydrates, proteins, Peptides, amino acids and mixtures of these compounds selected nutrient and about 0.5 to 10 wt .-% Caramel, based on the total weight of the bait. 2. Composition according to Claim 1, characterized in that it is based on 0.01 to 3% by weight of cis-tricose-9 on the total weight of the bait. 3. Composition according to claim 1, characterized in that the nutrient consists of a mixture of carbohydrates with at least 25% by weight of proteins and 5 to 15% by weight of vegetable protein hydrolyzate, wherein the percentages relate to the total weight of the bait. 4. Composition according to claim 1, characterized in that it is about 0.1 to 8 wt .-%, based on the total weight of the bait, one of the insecticidal carbamic acid esters ^! and organophosphorus insecticidal compounds selected insecticidal substance. 5. Composition according to claim 4, characterized in that the insecticidal substance under Dimetilan and Azamethiphos is selected. 6. Composition according to claim 1, characterized in that that it is in a solid and dry state. 7. Composition according to claim 1, characterized in that it is in the granulated state with a mean particle size varying from about 0.05 to 1 mm. 8. Method of making a bait according to a of claims 1 to 7, characterized in that (a) a solid, 0.5 to 10 wt .- ⁰ A caramel containing mixture of carbohydrates, proteins, peptides, 909884/0882 ORIGINAL INSPECTED Amino acids and mixtures of these compounds selected nutrients are ground to a powder, the mean particle size of which varies from about 0.5 to 1 mm, and that (b) on this powdery carrier (a) 0.01 to 3% by weight of cis-tricoses uniformly distributed% of an insecticide substance selected from insecticides carbamic acid esters and insecticidal organophosphorus compounds and applying or aufklebt the thus obtained powdery and dry bait on a freely accessible to menschenbelästigende fly support, wherein all weight percentages based on the - -9 and 0.1 to 8 wt. Refer to the total weight of the bait. 9. The method according to claim 8, characterized in that the cis-Trikosen-9 and the insecticidal substance in a volatile solvent and on the powder containing the feed and the caramel Sprayed mixture, whereupon the volatile solvent is evaporated. 10. Use of a composition according to any one of claims 1 to 9 for combating human nuisances To fly. 909884/0682