DE2862002D1 - Cis-platinum (ii) complexes of 1,2-diamino-cyclohexane and pharmaceutical composition containing them - Google Patents

Cis-platinum (ii) complexes of 1,2-diamino-cyclohexane and pharmaceutical composition containing them

Info

Publication number
DE2862002D1
DE2862002D1 DE7878100871T DE2862002T DE2862002D1 DE 2862002 D1 DE2862002 D1 DE 2862002D1 DE 7878100871 T DE7878100871 T DE 7878100871T DE 2862002 T DE2862002 T DE 2862002T DE 2862002 D1 DE2862002 D1 DE 2862002D1
Authority
DE
Germany
Prior art keywords
diamino
cis
cyclohexane
complexes
platinum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE7878100871T
Other languages
English (en)
Inventor
Yoshinori Kidani
Masahide Noji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE2862002D1 publication Critical patent/DE2862002D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE7878100871T 1977-09-12 1978-09-12 Cis-platinum (ii) complexes of 1,2-diamino-cyclohexane and pharmaceutical composition containing them Expired DE2862002D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP52108921A JPS5829957B2 (ja) 1977-09-12 1977-09-12 新規な白金錯体

Publications (1)

Publication Number Publication Date
DE2862002D1 true DE2862002D1 (en) 1982-10-14

Family

ID=14497015

Family Applications (1)

Application Number Title Priority Date Filing Date
DE7878100871T Expired DE2862002D1 (en) 1977-09-12 1978-09-12 Cis-platinum (ii) complexes of 1,2-diamino-cyclohexane and pharmaceutical composition containing them

Country Status (4)

Country Link
US (2) US4200583A (de)
EP (1) EP0001126B1 (de)
JP (1) JPS5829957B2 (de)
DE (1) DE2862002D1 (de)

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NL7807334A (nl) * 1978-07-06 1980-01-08 Tno Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een genees- middel met toepassing van een dergelijk platina-dia- minecomplex voor de behandeling van kanker, alsmede al- dus verkregen gevormd geneesmiddel.
US4271085A (en) * 1979-06-20 1981-06-02 Engelhard Minerals & Chemicals Corporation Cis-platinum (II) amine lactate complexes
US4405757A (en) * 1979-09-14 1983-09-20 Howell Bobby A Macromolecular complexes of amidocarbonylic water-soluble polymers and square planar platinous and equivalent organometallics
US4283342A (en) * 1980-01-31 1981-08-11 University Of Delaware Anticancer agents and methods of manufacture
GR75598B (de) * 1980-04-29 1984-08-01 Sanofi Sa
JPS56154493A (en) * 1980-04-30 1981-11-30 Shionogi & Co Ltd Novel platinum complex
JPS5716895A (en) * 1980-07-05 1982-01-28 Otsuka Chem Co Ltd Platinum 2 complex and antitumor agent containing the same as active principle
JPS57123198A (en) * 1981-01-23 1982-07-31 Shionogi & Co Ltd Novel platinum complex
DE3108842A1 (de) * 1981-03-09 1982-09-16 Basf Ag, 6700 Ludwigshafen Cis-platin(ii)-komplexe mit saccharid-derivaten als liganden
JPS57156416A (en) * 1981-03-24 1982-09-27 Otsuka Chem Co Ltd Platinum (2) complex and antitumor agent comprising it as active ingredient
JPS5921697A (ja) * 1982-06-24 1984-02-03 Yoshinori Kitani 新規な白金錯体
US4560782A (en) * 1982-11-19 1985-12-24 Research Corporation Anti-tumor diplatinum coordination compounds
JPS59112995A (ja) * 1982-12-21 1984-06-29 Shionogi & Co Ltd 新規グリコ−ル酸白金錯体
US4533502A (en) * 1983-02-22 1985-08-06 Rochon Fernande D Platinum (II) compounds and their preparation
US4565884A (en) * 1983-05-10 1986-01-21 Andrulis Research Corporation Bis-platinum complexes as antitumor agents
US4720504A (en) * 1983-05-10 1988-01-19 Andrulis Research Corporation Use of bis-platinum complexes as antitumor agents
AU558747B2 (en) * 1983-05-10 1987-02-05 Andrulis Research Corporation Bis-platinum complexes as antitumor agents
US4661516A (en) * 1983-06-20 1987-04-28 Research Corporation Diaminocyclohexane platinum complexes
GR82129B (de) * 1983-06-20 1984-12-13 Research Corp
US4758588A (en) * 1983-06-20 1988-07-19 Research Corporation Technologies Diaminocyclohexane platinum complexes
DE3477788D1 (en) * 1983-08-05 1989-05-24 Yoshinori Kidani Cytostatic platinum complexes
JPS6034982A (ja) * 1983-08-05 1985-02-22 Yoshinori Kitani １，２−ジアミノシクロヘキサン白金（２）錯体
FR2557572B1 (fr) * 1983-12-30 1986-05-30 Centre Nat Rech Scient Complexe bis(trihydroxo) du platine (ii), sa preparation et son application therapeutique
US4599352A (en) * 1984-03-01 1986-07-08 The United States Of America As Represented By The Department Of Health And Human Services Antineoplastic platinum (IV) complexes and compositions
US4562275A (en) * 1984-03-23 1985-12-31 Bristol-Myers Co. Antitumor platinum complexes
US4588831A (en) * 1984-11-09 1986-05-13 Natec Platinum complex compounds of substituted 5,8-dihydroxyl-1,4-naphthoquinone, and process for their production and use
US4587331A (en) * 1984-12-17 1986-05-06 American Cyanamid Company Platinum complexes of polyhydroxylated alkylamines and 2-polyhydroxylated alkyl-1,2-diaminoethanes
US4665210A (en) * 1984-12-17 1987-05-12 American Cyanamid Company Platinum complexes of aliphatic tricarboxylic acids
US4739087A (en) * 1985-01-10 1988-04-19 Bristol-Myers Company Antineoplastic platinum complexes
US4567285A (en) * 1985-07-10 1986-01-28 Yoshinori Kidani Complex compounds of platinum
US5041581A (en) * 1985-10-18 1991-08-20 The University Of Texas System Board Of Regents Hydrophobic cis-platinum complexes efficiently incorporated into liposomes
US5384127A (en) * 1985-10-18 1995-01-24 Board Of Regents, The University Of Texas System Stable liposomal formulations of lipophilic platinum compounds
US5117022A (en) * 1985-10-18 1992-05-26 The Board Of Regents, The University Of Texas System Hydrophobic cis-platinum complexes efficiently incorporated into liposomes
US4680308A (en) * 1985-12-26 1987-07-14 Andrulis Research Corporation Stable soluble 1,2-diaminocyclohexane platinum complexes
JP2562134B2 (ja) * 1986-09-19 1996-12-11 喜徳 喜谷 新規な白金−ステロイド錯体
JPH0319673Y2 (de) * 1986-10-15 1991-04-25
US5011959A (en) * 1986-11-17 1991-04-30 The Board Of Regents, The University Of Texas System 1,2-diaminocyclohexane-platinum complexes with antitumor activity
US4956459A (en) * 1987-07-17 1990-09-11 Georgetown University Platinum compounds suitable for use as pharmaceuticals
US4931553A (en) * 1988-05-11 1990-06-05 Gill Devinder S Platinum-polymer complexes and their use as antitumor agents
CA1339034C (en) * 1988-08-22 1997-04-01 Paul A. Tremblay Platinum complexes of single isomer neoalkyl acids
US5041578A (en) * 1988-11-22 1991-08-20 Board Of Regents, The University Of Texas System Water soluble 1,2-diaminocyclohexane platinum (IV) complexes as antitumor agents
US5393909A (en) * 1988-11-22 1995-02-28 Board Of Regents, The University Of Texas System Diamine platinum complexes as antitumor agents
US5434256A (en) * 1988-11-22 1995-07-18 Board Of Regents, The University Of Texas System Diamine platinum complexes as antitumor agents
JP2740919B2 (ja) * 1989-03-30 1998-04-15 塩野義製薬株式会社 白金錯体およびこれらを有効成分として含有する抗腫瘍剤
US5843475A (en) * 1996-12-06 1998-12-01 Board Of Regents, The University Of Texas System Delivery and activation through liposome incorporation of diaminocyclohexane platinum (II) complexes
EP2289549A3 (de) 1999-10-01 2011-06-15 Immunogen, Inc. Immunokonjugate für Krebsbehandlung
US7429399B2 (en) * 2001-06-18 2008-09-30 Solae, Llc Modified oilseed material
US20040219281A1 (en) * 2000-11-21 2004-11-04 Cargill, Incorporated Modified oilseed material
US6630195B1 (en) 2000-11-21 2003-10-07 Cargill, Incorporated Process for producing oilseed protein products
JP2004521642A (ja) 2000-11-21 2004-07-22 カーギル インコーポレイテッド 改変された脂肪種子物質
US20070160656A1 (en) * 2003-05-02 2007-07-12 Dziewiszek Krzysztof J Lipid platinum complexes and methods of use thereof
US7354616B2 (en) * 2003-11-25 2008-04-08 Solae, Llc Modified oilseed material with a high gel strength
PT1695991E (pt) * 2003-12-10 2010-03-02 Toudai Tlo Ltd Complexo de coordenação de diaminociclohexano platina (ii) com copolímero de bloco contendo segmento poli(ácido carboxílico) e agente antitumoral compreendendo o mesmo
US20050220978A1 (en) * 2004-03-31 2005-10-06 Cargill, Incorporated Dispersible protein composition
AU2005271897B2 (en) 2004-07-09 2008-06-19 Robert Sabin Compositions and methods of use for treatment of mammalian diseases
KR20070048706A (ko) * 2004-07-12 2007-05-09 시코르, 인크. ｃｉｓ-디요오도-(ｔｒａｎｓ-Ｌ-1,2-시클로헥산디아민)백금(Ⅱ) 착물 및 고순도 옥살리플라틴의 제조 방법
EP2474310B1 (de) * 2005-06-09 2013-08-21 NanoCarrier Co., Ltd. Verfahren zur Herstellung einer polymerisierten Koordinationsverbindung eines Platinkomplexes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3712948A (en) * 1967-09-25 1973-01-23 Synergistics Inc Antiperspirant action by bimetallic salts of gluconic,glucuronic and galacturonic acids
GB1432563A (en) * 1972-04-10 1976-04-22 Rustenburg Platinum Mines Ltd Platinum- co-ordination compounds
US4046047A (en) * 1975-08-11 1977-09-06 Warwick Electronics Inc. Note selector circuit for electronic musical instrument
US4115418A (en) * 1976-09-02 1978-09-19 Government Of The United States Of America 1,2-diaminocyclohexane platinum (ii) complexes having antineoplastic activity
JPS6041077B2 (ja) 1976-09-06 1985-09-13 喜徳 喜谷 １，２‐ジアミノシクロヘキサン異性体のシス白金（２）錯体

Also Published As

Publication number Publication date
US4256652A (en) 1981-03-17
EP0001126A1 (de) 1979-03-21
JPS5444620A (en) 1979-04-09
JPS5829957B2 (ja) 1983-06-25
EP0001126B1 (de) 1982-08-18
US4200583A (en) 1980-04-29

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