DE281538C - - Google Patents
Info
- Publication number
- DE281538C DE281538C DENDAT281538D DE281538DA DE281538C DE 281538 C DE281538 C DE 281538C DE NDAT281538 D DENDAT281538 D DE NDAT281538D DE 281538D A DE281538D A DE 281538DA DE 281538 C DE281538 C DE 281538C
- Authority
- DE
- Germany
- Prior art keywords
- gold
- tubercle bacilli
- bacilli
- tubercle
- found
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 244000052616 bacterial pathogens Species 0.000 claims description 14
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 12
- 239000010931 gold Substances 0.000 claims description 12
- 229910052737 gold Inorganic materials 0.000 claims description 12
- 150000002343 gold Chemical class 0.000 claims description 3
- 239000001963 growth media Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 235000015097 nutrients Nutrition 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 201000008827 tuberculosis Diseases 0.000 claims description 2
- 150000002344 gold compounds Chemical class 0.000 claims 1
- 239000002609 media Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241000031711 Cytophagaceae Species 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002070 germicidal Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000001225 therapeutic Effects 0.000 description 1
- 229960001005 tuberculin Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
KAISERLICHESIMPERIAL
PATENTAMT.PATENT OFFICE.
PATENTSCHRIFTPATENT LETTERING
- M 281538 KLASSE 30 h. GRUPPE- M 281538 CLASS 30 h. GROUP
in HÖCHST A. M.Verfahren zur Herstellung wirksamer Tuberkuloseheilmittel. Patentiert im Deutschen Reiche vom 26. Januar 1913 ab.in HÖCHST A.M. process for the production of effective tuberculosis remedies. Patented in the German Empire on January 26, 1913.
Es ist bekannt, daß den Goldsalzen eine hervorragend keimtötende und entwicklungshemmende Wirkung auf Tuberkelbazillen zukommt; dementsprechend bewirkt,.wie Koch festgestellt hat, der Zusatz von Goldlösungen zu den Nährböden die völlige Entwicklungshemmung der Tuberkelbazillen. Demgegenüber wurde nun gefunden, daß es gelingt, durch allmähliche Gewöhnung der TuberkelbazillenIt is known that gold salts have an excellent germicidal and developmental inhibiting effect Effect on tubercle bacilli; accordingly, like Koch has found that the addition of gold solutions to the culture media completely inhibits development of tubercle bacilli. On the other hand, it has now been found that it succeeds by gradually getting used to the tubercle bacilli
ίο an goldhaltige Nährsubstrate ihre Empfindlichkeit gegenüber den Goldsalzen abzustumpfen. Hierbei nehmen, wie weiterhin gefunden wurde, die Tuberkelbazillen wesentliche Mengen feinst verteilten metallischen Goldes in ihre Leibessubstanz auf, und es gelingt auf diese Weise, Tuberkelbazillen-Präparate zu erhalten, welche eine außerordentlich gesteigerte therapeutische Wirksamkeit besitzen.ίο their sensitivity to gold-containing nutrient substrates to dull compared to the gold salts. Here take, as was further found, the tubercle bacilli contained substantial quantities of finely distributed metallic gold in their body on, and in this way it is possible to obtain tubercle bacilli preparations which have an extraordinarily increased therapeutic effectiveness.
ao Beispiele. ao examples.
i. Man züchtet Tuberkelbazillen auf einer geeigneten Bouillon, welche außer den üblichen Bestandteilen einen Zusatz von Cyangold im Verhältnis von 1:10 Millionen besitzt, und überträgt die Bazillen nach dem Wachstum auf frische Nährböden, die Cyangold im Verhältnis von ι: 5 Millionen enthalten. Indem man dies Verfahren weiter fortführt und jedesmal den Gehalt der Bouillon an Cyangold erhöht, gelangt man schließlich zu Tuberkelbazillenkulturen, welche sich selbst bei einem Gehalt der Bouillon von 1:50000, ja selbst von ι: 10 000 entwickeln.i. Tubercle bacilli are grown on a suitable broth, in addition to the usual ones Components has an addition of cyan gold in a ratio of 1:10 million, and transfers the bacilli after growth on fresh culture media, the cyangold in proportion of ι: 5 million included. By continuing this process and each time the If the cyan gold content of the bouillon is increased, tubercle bacilli cultures are ultimately obtained, which even with a content of the bouillon of 1: 50000, even of ι: 10,000 develop.
2. Derartige goldfeste und goldhaltige Bazillen werden abgetötet und mit glycerinwasser zu feinen Emulsionen verarbeitet.2. Such gold-solid and gold-containing bacilli are killed and treated with glycerine water processed into fine emulsions.
3. Derartige goldhaltige Bazillen werden in Kugelmühlen fein zerrieben und sodann mit Glycerinwasser zu feinen Emulsionen verarbeitet. 3. Such gold-containing bacilli are finely ground in ball mills and then with Glycerine water processed into fine emulsions.
4. Aus goldhaltigen Tuberkelbazillen wird nach den obigen Methoden Tuberkulin hergestellt. 4. Tuberculin is produced from gold-containing tubercle bacilli according to the above methods.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE281538C true DE281538C (en) |
Family
ID=537271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT281538D Active DE281538C (en) |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE281538C (en) |
-
0
- DE DENDAT281538D patent/DE281538C/de active Active
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