DE264390C - - Google Patents

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Publication number
DE264390C
DE264390C DENDAT264390D DE264390DA DE264390C DE 264390 C DE264390 C DE 264390C DE NDAT264390 D DENDAT264390 D DE NDAT264390D DE 264390D A DE264390D A DE 264390DA DE 264390 C DE264390 C DE 264390C
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DE
Germany
Prior art keywords
glutamic acid
iron
air
water
aqueous solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DENDAT264390D
Other languages
German (de)
Publication of DE264390C publication Critical patent/DE264390C/de
Active legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Description

KAISERLICHESIMPERIAL

PATENTAMT.PATENT OFFICE.

PATENTSCHRIFTPATENT LETTERING

- M 264390 KLASSE 12 #. GRUPPE- M 264390 CLASS 12 #. GROUP

Patentiert im Deutschen Reiche vom 22. Februar 1913 ab.Patented in the German Empire on February 22, 1913.

Abderhalden und Kautzsch (Zeitschrift für physiologische Chemie, Bd. 64 [1910], S. 456) haben gefunden, daß der Herstellung von Eisensalzen der Glutaminsäure Schwierigkeiten entgegenstehen. So beobachteten sie beim Kochen einer wässerigen Lösung von Glutaminsäure mit überschüssigem Eisenoxyd keine Einwirkung; ebenso konnte Glutaminsäure mit pulverisiertem Eisensulfid beim Kochen nicht in Reaktion gebracht werden.Abderhalden and Kautzsch (Journal of Physiological Chemistry, Vol. 64 [1910], p. 456) have found that the production of iron salts of glutamic acid has difficulties oppose. So they observed boiling an aqueous solution of glutamic acid no action with excess iron oxide; also could glutamic acid with powdered iron sulfide will not react when boiled.

Es wurde nun die überraschende Beobachtung gemacht, daß es gelingt, Eisensalze der Glutaminsäure dadurch herzustellen, daß man wässerige Lösungen von Glutaminsäure längere Zeit mit metallischem Eisen kocht. Man erhält auf diese Weise eine Verbindung, welche als Ferrosalz der Glutaminsäure anzusprechen ist. Es treten 2 Mol. Glutaminsäure mit 1 Mol. zweiwertigem Eisen in Verbindung, so daß dem Salz wahrscheinlich folgende Konstitution zuzuschreiben ist:The surprising observation has now been made that iron salts of the To produce glutamic acid by making aqueous solutions of glutamic acid for longer Time boiling with metallic iron. In this way you get a connection, which is to be addressed as the ferrous salt of glutamic acid. There are 2 moles of glutamic acid with 1 mole. bivalent iron in connection, so that the salt probably has the following constitution is attributable to:

CH9 CH 9

,CH-(NH2J-COOH COOH-, CH- (NH 2 J-COOH COOH-

CH2-COO-CH 2 -COO-

FeFe -(NH2J-CHs -0OC-CH2-- (NH 2 J-CHs -0OC-CH 2 -

-CH9.-CH 9 .

Ferroverbindungen der Glutaminsäure sind bis jetzt noch nicht bekannt. Es war auch nach den Versuchen von Abderhalden und Kautzsch keineswegs wahrscheinlich, daß es gelingen würde, solche herzustellen.Ferro compounds of glutamic acid are not yet known. It was too according to the experiments by Abderhalden and Kautzsch, it is by no means likely that it would be possible to produce such.

Bei der Bedeutung, welche die Eisen- und namentlich die Ferroverbindungen für den Organismus besitzen, ist eine reiche Verwendungsmöglichkeit für das Ferrosalz der Glutaminsäure für pharmazeutische Zwecke zu erwarten. With the importance which the iron and especially the ferrous compounds for the Own organism is a rich use for the ferrous salt of glutamic acid expected for pharmaceutical purposes.

Beispiel.Example.

100 Teile Glutaminsäure werden in wässeriger Lösung mit überschüssigem entfettetem Eisenstaub im Kohlensäurestrom am Rückflußkühler gekocht. Die Lösung wird unter Ausschluß von Luft vom Eisenstaub abfiltriert und im Kohlensäurestrom auf dem Dampfbade unter vermindertem Druck zur Trockne eingedampft. Das dadurch erhaltene farblose oder höchstens schwach gefärbte Ferrosalz ist Berechnet
für (C5H8NO^Fe: 100 parts of glutamic acid are boiled in an aqueous solution with excess defatted iron dust in a stream of carbon dioxide on a reflux condenser. The solution is filtered off from the iron dust with the exclusion of air and evaporated to dryness in a stream of carbonic acid on a steam bath under reduced pressure. The colorless or at most slightly colored ferrous salt thus obtained is calculated
for (C 5 H 8 NO ^ Fe:

Fe = 16,1 Prozent, Fe = 16.1 percent,

Gefunden:
Fe == 16,8 Prozent.Found:
Fe == 16.8 percent.

Claims (1)

Patent-AnsPRUcη :Patent claim: in trockenem Zustande luftbeständig. In Wasser löst es sich leicht. Beim Stehen an der Luft wird die wässerige Lösung dunkel Dabei verwandelt sich der größte Teil des zweiwertigen Eisens in dreiwertiges Eisen.Resistant to air when dry. It dissolves easily in water. When standing in line The aqueous solution becomes dark in the air. Most of the water is transformed divalent iron into trivalent iron. λ ιλ ι Analyse:Analysis:
DENDAT264390D Active DE264390C (en)

Publications (1)

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DE264390C true DE264390C (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2766268A (en) * 1953-10-13 1956-10-09 Int Minerals & Chem Corp Production of ferrous salts of monoamino lower aliphatic dicarboxylic acids
EP0202936A1 (en) * 1985-05-24 1986-11-26 Albion Laboratories, Inc. Pure amino acid chelates

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2766268A (en) * 1953-10-13 1956-10-09 Int Minerals & Chem Corp Production of ferrous salts of monoamino lower aliphatic dicarboxylic acids
EP0202936A1 (en) * 1985-05-24 1986-11-26 Albion Laboratories, Inc. Pure amino acid chelates

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