DE276134C - - Google Patents
Info
- Publication number
- DE276134C DE276134C DENDAT276134D DE276134DA DE276134C DE 276134 C DE276134 C DE 276134C DE NDAT276134 D DENDAT276134 D DE NDAT276134D DE 276134D A DE276134D A DE 276134DA DE 276134 C DE276134 C DE 276134C
- Authority
- DE
- Germany
- Prior art keywords
- water
- gold
- ecm
- percent
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 150000003839 salts Chemical class 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 5
- 150000007530 organic bases Chemical class 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- IZLAVFWQHMDDGK-UHFFFAOYSA-N gold(1+);cyanide Chemical compound [Au+].N#[C-] IZLAVFWQHMDDGK-UHFFFAOYSA-N 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 239000010931 gold Substances 0.000 description 10
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 6
- 229910052737 gold Inorganic materials 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 2
- 229960001231 choline Drugs 0.000 description 2
- 239000000155 melt Substances 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- XTFKWYDMKGAZKK-UHFFFAOYSA-N potassium;gold(1+);dicyanide Chemical compound [K+].[Au+].N#[C-].N#[C-] XTFKWYDMKGAZKK-UHFFFAOYSA-N 0.000 description 2
- DFCFJTMCJBUFSX-UHFFFAOYSA-N ClO.C1CNCCN1 Chemical compound ClO.C1CNCCN1 DFCFJTMCJBUFSX-UHFFFAOYSA-N 0.000 description 1
- WOFVPNPAVMKHCX-UHFFFAOYSA-N N#C[Au](C#N)C#N Chemical class N#C[Au](C#N)C#N WOFVPNPAVMKHCX-UHFFFAOYSA-N 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 150000002343 gold Chemical class 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/005—Compounds containing elements of Groups 1 or 11 of the Periodic Table without C-Metal linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
KAISERLICHESIMPERIAL
PATENTAMT.PATENT OFFICE.
PATENTSCHRIFTPATENT LETTERING
~J& 276134 KLASSE 12p. GRUPPE ~ J & 276134 CLASS 12p. GROUP
Patentiert im Deutschen Reiche vom 25. Januar 1913 ab.Patented in the German Empire on January 25, 1913.
Es ist bekannt, daß Goldcyansalze eine starke abtötende Kraft auf Mikroorganismen ausüben und dadurch, in den infizierten Tierkörper eingeführt, eine heilende Wirkung entfalten. Es wurde nun gefunden, daß diese desinfizierende Kraft im tierischen Organismus gesteigert wird, wenn die labilen Goldcyanverbindungen vor der sofortigen Reduktion geschützt werden durch Bildung von salzartigen Doppelverbindungen mit organischen Basen, ausgenommen das Kantharidyläthylendiamin, da das Verfahren zur Darstellung von salzartigen Doppelverbindungen aus dieser Base mit Goldsalzen bereits den Gegenstand des Patents 269661, Kl. 12 q, bildet. Als besonders vorteilhaft hat sich die Verwendung von i-Phenyl-2 · 3-dimethyl-4-amino-5-pyrazolon und dessen 4-N-Alkylderivaten erwiesen. Das Verfahren besteht darin, daß man die betreffenden organischen Basen oder deren Salze mit Goldcyanwasserstoffsäure oder deren Salzen umsetzt.It is known that gold cyanide salts exert a strong killing power on microorganisms and thereby, when introduced into the infected animal body, develop a healing effect. It has now been found that this disinfecting power in the animal organism is increased if the labile gold cyan compounds are protected from immediate reduction by the formation of salt-like double compounds with organic bases, with the exception of cantharidylethylenediamine, since the process for the preparation of salt-like double compounds from this base with Gold salts already form the subject of patent 269661, class 12 q. The use of i-phenyl-2 · 3-dimethyl-4-amino-5-pyrazolone and its 4-N-alkyl derivatives has proven to be particularly advantageous. The process consists in reacting the relevant organic bases or their salts with gold cyanide or their salts.
Die neuen Doppelverbindungen sollen gegen Tuberkulose und luetische Erkrankungen therapeutische Verwendung finden.The new double compounds are said to be therapeutic against tuberculosis and syphilitic diseases Find use.
i. 4,5 g salzsaures i-Phenyl-2 · 3-dimethyl-4-amino-5-pyrazolon, in 25 ecm Wasser gelöst, werden mit einer Lösung von 7 g Kaliumaurieyanid, die ebenfalls in 25 ecm Wasser gelöst sind, versetzt. Nach kurzer Zeit scheidet sich das Doppelsalz kristallinisch ab. Es bildet schwach gelbbraun gefärbte Blatt chen vom Schmelzpunkt 196 bis 198 °. In Wasser lösen sie sich im Verhältnis ι: 120. Der Goldgehalt beträgt 39,19 Prozent; theoretisch Au = 39,01 Prozent, ■i. 4.5 g hydrochloric acid i-phenyl-2 · 3-dimethyl-4-amino-5-pyrazolone, dissolved in 25 ecm of water, with a solution of 7 g of potassium aurieyanide, which are also dissolved in 25 ecm of water. After a short time the double salt separates in crystalline form. It forms pale yellow-brown colored leaves from melting point 196 to 198 °. In water they dissolve in the ratio ι: 120. The gold content is 39.19 percent; theoretically Au = 39.01 percent, ■
2. 5 g salzsaures i-Phenyl-2 · ß-dimethyl-4-dimethylamino-5-pyrazolon werden in 25 ecm Wasser gelöst und mit einer Lösung von 7 g Kaliumauricyanid in 25 ecm Wasser versetzt. Das Doppelsalz scheidet sich sofort kristallinisch ab. Es bildet kleine farblose Blättchen vom Schmelzpunkt 183 bis 185 °. In kaltem Wasser ist das Salz mäßig löslich. Der Goldgehalt wurde zu 37,21 Prozent gefunden, während sich für2. 5 g of i-phenyl-2 · ß-dimethyl-4-dimethylamino-5-pyrazolone hydrochloric acid are dissolved in 25 ecm of water and with a solution of 7 g Potassium auricyanide is added to 25 ecm of water. The double salt separates out immediately in crystalline form. It forms small, colorless leaflets with a melting point of 183 to 185 °. In The salt is sparingly soluble in cold water. The gold content was found to be 37.21 percent, while for
C13H17ON3HCN, Au(CN)3 C 13 H 17 ON 3 HCN, Au (CN) 3
36,96 Prozent Au berechnet.36.96 percent Au calculated.
3. 5 g Kaliumaurocyanid werden mit 10 ecm Wasser gut verrührt und 3 g Cholinchlorhydrat zugefügt; hierbei tritt vollständige Lösung ein. Nach eintägigem Stehen wird das entstandene" Chlorkalium mit absolutem Alkohol gefällt und das alkoholische Filtrat im Vakuum eingedampft. Die zurückbleibende Kristallmasse wird auf Tonteller abgepreßt und über konzentrierter Schwefelsäure getrocknet. Das Cholinaurocyanid schmilzt bei 80 bis 83 °; es ist sehr leicht in Wasser löslich. Der Goldgehalt entspricht der Formel3. 5 g of potassium aurocyanide are stirred well with 10 ecm of water and 3 g of choline chlorohydrate added; complete solution occurs here. After standing for a day it will the resulting "potassium chloride is precipitated with absolute alcohol and the alcoholic filtrate evaporated in vacuo. The remaining crystal mass is pressed onto a clay plate and dried over concentrated sulfuric acid. The choline aurocyanide melts at 80 to 83 °; it is very easily soluble in water. The gold content corresponds to the formula
HOCH2CH2N(CHg)3CN, AuCN.HIGH 2 CH 2 N (CHg) 3 CN, AuCN.
4. 4 g Piperazinchlorhydrat werden in 50 ecm Wasser gelöst und eine Lösung von 9 g Kaliumaurocyanid in 100 ecm Wasser hinzugegeben. Das Golddoppelsalz scheidet sich sofort in langen, schwach rosa gefärbten Na-4. 4 g of piperazine chlorohydrate are dissolved in 50 ecm of water and a solution of 9 g of potassium aurocyanide added in 100 ecm of water. The gold double salt separates immediately in long, pale pink colored Na-
dein aus; diese werden abgesaugt und mit kaltem Wasser gewaschen. Piperazinaurocyanidyours off; these are suctioned off and washed with cold water. Piperazine aurocyanide
C4H10N22HCN1AuCNC 4 H 10 N 22 HCN 1 AuCN
beginnt bei etwa 240 ° zusammenzusintern und schmilzt bei 252 bis 255 °; in Wasser ist es ziemlich schwer löslich. Der Goldgehalt wurde zu 67,29 Prozent gefunden; berechnet 67,24 Prozent Au.begins to sinter together at about 240 ° and melts at 252 to 255 °; in water it is quite difficult to dissolve. The gold grade was found to be 67.29 percent; calculated 67.24 percent Au.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE191401837X | 1913-01-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE276134C true DE276134C (en) |
Family
ID=32523291
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT276134D Active DE276134C (en) | 1913-01-24 | ||
| DENDAT276135D Active DE276135C (en) | 1913-01-24 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT276135D Active DE276135C (en) | 1913-01-24 |
Country Status (2)
| Country | Link |
|---|---|
| DE (2) | DE276135C (en) |
| GB (1) | GB191401837A (en) |
-
0
- DE DENDAT276134D patent/DE276134C/de active Active
- DE DENDAT276135D patent/DE276135C/de active Active
-
1914
- 1914-01-23 GB GB191401837D patent/GB191401837A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE276135C (en) | |
| GB191401837A (en) | 1914-06-04 |
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