DE261082C - - Google Patents
Info
- Publication number
- DE261082C DE261082C DENDAT261082D DE261082DA DE261082C DE 261082 C DE261082 C DE 261082C DE NDAT261082 D DENDAT261082 D DE NDAT261082D DE 261082D A DE261082D A DE 261082DA DE 261082 C DE261082 C DE 261082C
- Authority
- DE
- Germany
- Prior art keywords
- mercury
- pyrazolone
- sulfamino
- dimethyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 claims description 4
- 150000002730 mercury Chemical class 0.000 claims description 3
- 229940100892 mercury compound Drugs 0.000 claims description 2
- 150000002731 mercury compounds Chemical class 0.000 claims description 2
- JEXVQSWXXUJEMA-UHFFFAOYSA-N pyrazol-3-one Chemical class O=C1C=CN=N1 JEXVQSWXXUJEMA-UHFFFAOYSA-N 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 5
- 229910052753 mercury Inorganic materials 0.000 description 5
- 239000000243 solution Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 2
- 229910000474 mercury oxide Inorganic materials 0.000 description 2
- UKWHYYKOEPRTIC-UHFFFAOYSA-N mercury(ii) oxide Chemical compound [Hg]=O UKWHYYKOEPRTIC-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- -1 acetic acid mercury oxide Chemical compound 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/10—Mercury compounds
- C07F3/103—Mercury compounds without C-Mercury linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
KAISERLICHESIMPERIAL
PATENTAMT.PATENT OFFICE.
PATENTSCHRIFTPATENT LETTERING
KLASSE 12/?. GRUPPE 8./v^ CLASS 12 / ?. GROUP 8./v^
LEON GIVAUDAN in GENF und EMIL SCHEITLIN in BASEL.LEON GIVAUDAN in GENEVA and EMIL SCHEITLIN in BASEL.
Zusatz zum Patent 261081.Addendum to patent 261081.
Patentiert im Deutschen Reiche vom 12. Mai 1912 ab. Längste Dauer: 20. Dezember 1926.Patented in the German Empire on May 12, 1912. Longest duration: December 20, 1926.
Durch das Hauptpatent 261081 ist ein Verfahren zur Darstellung einer therapeutisch wertvollen Quecksilberverbindung der Pyrazolonreihe geschützt, welches darin besteht, daß man i-Phenyl-2-3-dimethyl-4-sulfamino-5-pyrazolon in wässeriger Lösung so lange mit Quecksilberoxyd in der Wärme behandelt, bis das Quecksilberoxyd nahezu ganz in Lösung gegangen ist.The main patent 261081 is a process for the representation of a therapeutically valuable mercury compound of the pyrazolone series protected, which consists in that i-phenyl-2-3-dimethyl-4-sulfamino-5-pyrazolone so long treated in an aqueous solution with mercury oxide in the heat until the mercury oxide has almost entirely gone into solution.
Es wurde nun gefunden, daß man mercurierte Verbindungen des i-Phenyl-2'3-Dimethyl-4-sulfamino-5-pyrazolons auch durch Behandeln von wasserlöslichen Salzen des Sulfaminopyrazolons mit zweiwertigen Quecksilbersalzen in der Wärme erhalten kann.It has now been found that one can use mercured compounds of i-phenyl-2'3-dimethyl-4-sulfamino-5-pyrazolone also by treating water-soluble salts of sulfaminopyrazolone with divalent mercury salts can get in the warmth.
Die erhaltenen Körper zeichnen sich gegenüber dem nach dem Verfahren des Hauptpatents erhaltenen Produkt durch einen höheren Quecksilbergehalt, etwa 65 bis 68 Prozent Hg, Compared to the product obtained by the process of the main patent, the bodies obtained have a higher mercury content, about 65 to 68 percent Hg,
1Z10 Molekül ι - Phenyl - 2 -3 - dimethyl - 4 - sulfamino-5-pyrazolon-Natrium, gelöst in il Wasser, und 1J10 Molekül essigsaures Quecksilberoxyd, das man zu der Lösung gibt, läßt man bei Wasserbadtemperatur so lange aufeinander einwirken, bis der größte Teil des Quecksilber-30 1 Z 10 molecule ι - phenyl - 2 -3 - dimethyl - 4 - sulfamino-5-pyrazolone sodium, dissolved in il water, and 1 J 10 molecule of acetic acid mercury oxide, which is added to the solution, is left at water bath temperature for so long interact until most of the mercury is 30
acetats gelöst ist, wozu etwa 1Z2 bis 3Z4 Stunden erforderlich sind.acetate is dissolved, for which about 1 Z 2 to 3 Z 4 hours are required.
Aus der Lösung scheidet sich beim Erkalten ein grünlich weißes Pulver mit einem Gehalt von 67 bis 68 Prozent Hg ab.When the solution cools, a greenish white powder with a content of 67 to 68 percent Hg separates .
Durch Behandeln mit wässerigen Alkalien wird auch aus dieser Verbindung der größte Teil des Quecksilbers als Oxydul abgespalten, und es verbleiben Lösungen mit dem gleichen Quecksilbergehalt (etwa 24 Prozent Hg), wie sie aus dem nach dem Beispiel des Hauptpatents dargestellten Produkt erhalten werden.By treating with aqueous alkalis, most of the mercury is split off as oxide from this compound, and solutions remain with the same mercury content (about 24 percent Hg) as are obtained from the product shown according to the example of the main patent.
Im übrigen sind, abgesehen von dem höheren Gehalt an Quecksilber und der dadurch bedingten verschiedenen Färbung, die Eigenschaften des Produktes die gleichen wie diejenigen des nach dem Verfahren des Hauptpatents erhaltenen Quecksilberderivates.In addition, apart from the higher mercury content and the resulting conditional different coloring, the properties of the product the same as those of the mercury derivative obtained by the process of the main patent.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE261082C true DE261082C (en) |
Family
ID=518665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT261082D Active DE261082C (en) |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE261082C (en) |
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0
- DE DENDAT261082D patent/DE261082C/de active Active
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