DE246482C - - Google Patents
Info
- Publication number
- DE246482C DE246482C DENDAT246482D DE246482DA DE246482C DE 246482 C DE246482 C DE 246482C DE NDAT246482 D DENDAT246482 D DE NDAT246482D DE 246482D A DE246482D A DE 246482DA DE 246482 C DE246482 C DE 246482C
- Authority
- DE
- Germany
- Prior art keywords
- blood
- immune substances
- substances
- immune
- freed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000126 substance Substances 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 6
- 241000031711 Cytophagaceae Species 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 210000004369 Blood Anatomy 0.000 description 8
- 239000008280 blood Substances 0.000 description 8
- 239000000203 mixture Substances 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 210000000601 Blood Cells Anatomy 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating Effects 0.000 description 1
- 230000001147 anti-toxic Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 230000005592 electrolytic dissociation Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000002101 lytic Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Description
Zusatz zum Patent 238162 vom 25. März 1908.Addendum to patent 238162 from March 25, 1908.
Patentiert im Deutschen Reiche vom 17. September 1908 ab. Längste Dauer: 24. März 1923.Patented in the German Empire on September 17, 1908. Longest duration: March 24, 1923.
Durch das Patent 238162 ist ein Verfahren zur Gewinnung von Immunstoffen geschützt, das darin besteht, daß man die Blutzellen auf chemischem, physiologischem oder mechanischem Wege oder durch Kombination dieser Wege aufschließt. Die nach diesem Verfahren gewonnenen, hervorragend wirksamen Präparate, deren Wirkung noch durch starke Verdünnung infolge elektrolytischer Dissoziation gesteigert wird, sind aber vorteilhaft nur für die Einverleibung in artgleiches Blut zu verwenden. The patent 238162 protects a process for the production of immune substances, that consists in treating the blood cells chemically, physiologically or mechanically Unlocks paths or a combination of these paths. The highly effective preparations obtained by this process, their effect still through strong dilution as a result of electrolytic dissociation is increased, but are advantageously only to be used for incorporation into blood of the same species.
Es wurde nun gefunden, daß die Immunstoffe mit der gleichen Wirkung auch artfremdem Blut einverleibt werden können, wenn man aus ihnen noch die Spuren Blutfarbstoff und das Eiweiß entfernt.It has now been found that the immune substances are also alien with the same effect Blood can be incorporated if you still have traces of blood pigment from them and the egg white removed.
Die Reinigung der Immunstoffe kann z. B. in folgender Weise geschehen:The cleaning of the immune substances can, for. B. can be done in the following way:
Das in Karbol-Kochsalzlösung aufgefangene Blut wird im Brutschrank längere Zeit stehen gelassen und filtriert oder vorteilhaft unter Zusatz einer stark verdünnten Säurelösung (1:1000 bis 1:100 000) 24 bis 48 Stunden bei 37° gehalten, dann leicht alkalisch gemacht und nach weiteren 24 bis 48 Stunden filtriert.The blood collected in carbolic saline solution will remain in the incubator for a long time left and filtered or, advantageously, with the addition of a very dilute acid solution (1: 1000 to 1: 100,000) 24 to 48 hours at Maintained 37 °, then made slightly alkaline and filtered after a further 24 to 48 hours.
Das Filtrat enthält die vom Blutfarbstoff und den Eiweißstoffen befreiten, gereinigten Immunstoffe. The filtrate contains the purified immune substances that have been freed from blood pigments and proteins.
Wie die Immunstoffe des Hauptpatents wirken auch diese in saurem Zustande vornehmlich lytisch, in alkalischem Zustande mehr antitoxisch.Like the immune substances in the main patent, these also mainly have an acidic effect lytic, more antitoxic in an alkaline state.
Da die nach vorliegendem Verfahren erhältlichen Immunstoffe auch nicht artgleichem Blut einverleibt werden können, so ist die Möglichkeit gegeben, Immunstoffe tierischen und menschlichen Ursprungs miteinander zu mischen und derartige Mischungen dann zu verwenden. Man hat es auf diese Weise vollständig in der Hand, polyvalente Immunstoffe · verschiedenster Zusammensetzung herzustellen.Since the immune substances obtainable according to the present process are also not of the same type Blood can be incorporated, so there is the possibility of animal immune substances and of human origin to mix with one another and then to mix such mixtures use. In this way you have it completely in your hand, polyvalent immune substances to produce a wide variety of compositions.
Pa ten τ- Anspruch :Pat τ claim:
4545
Weitere Ausbildung des Verfahrens zur Gewinnung von Immunstoffen' nach dem Patent 238162, darin bestehend, daß man die nach dem Verfahren des Hauptpatents durch Aufschließen des Blutes erhaltenen Immunstoffe von Eiweiß und den letzten Spuren des Blutfarbstoffs befreit.Further training of the process for the production of immune substances' after Patent 238162, which consists in the process of the main patent Immune substances obtained by digesting the blood are freed from protein and the last traces of the blood pigment.
HERLIN. GEDRUCKT 1IN DER RF.ICHSDRUCKEREI.HERLIN. PRINTED 1 IN THE RF.ICHSDRUCKEREI.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE246482C true DE246482C (en) |
Family
ID=505356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT246482D Active DE246482C (en) |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE246482C (en) |
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0
- DE DENDAT246482D patent/DE246482C/de active Active
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