DE2406198C2 - Verfahren zur Herstellung von neuen 2-Amino-6-dialkylamino-dihydropyridinen - Google Patents

Verfahren zur Herstellung von neuen 2-Amino-6-dialkylamino-dihydropyridinen

Info

Publication number
DE2406198C2
DE2406198C2 DE2406198A DE2406198A DE2406198C2 DE 2406198 C2 DE2406198 C2 DE 2406198C2 DE 2406198 A DE2406198 A DE 2406198A DE 2406198 A DE2406198 A DE 2406198A DE 2406198 C2 DE2406198 C2 DE 2406198C2
Authority
DE
Germany
Prior art keywords
dihydropyridines
amino
ester
alkyl
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2406198A
Other languages
German (de)
English (en)
Other versions
DE2406198A1 (de
Inventor
Friedrich Dr. 5600 Wuppertal Bossert
Horst Dr. Meyer
Kurt Dr. 5600 Wuppertal Stoepel
Wulf Dr. 5670 Opladen Vater
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to DE2406198A priority Critical patent/DE2406198C2/de
Priority to US05/545,202 priority patent/US4004014A/en
Priority to CA219,375A priority patent/CA1032539A/en
Priority to AU77863/75A priority patent/AU484384B2/en
Priority to FI750324A priority patent/FI750324A/fi
Priority to BE153108A priority patent/BE825245A/xx
Priority to NL7501430A priority patent/NL7501430A/xx
Priority to ES434546A priority patent/ES434546A1/es
Priority to CH1631577A priority patent/CH613446A5/xx
Priority to ZA00750790A priority patent/ZA75790B/xx
Priority to CH150675A priority patent/CH605754A5/xx
Priority to IE247/75A priority patent/IE40589B1/xx
Priority to HUBA3201A priority patent/HU168482B/hu
Priority to ES434545A priority patent/ES434545A1/es
Priority to DD184073A priority patent/DD117452A5/xx
Priority to JP50015500A priority patent/JPS5943460B2/ja
Priority to IL46593A priority patent/IL46593A/en
Priority to DK44075*#A priority patent/DK44075A/da
Priority to SE7501388A priority patent/SE402458B/xx
Priority to FR7503895A priority patent/FR2260345B1/fr
Priority to GB5312/75A priority patent/GB1498495A/en
Priority to LU71813A priority patent/LU71813A1/xx
Priority to AT96975A priority patent/AT342590B/de
Publication of DE2406198A1 publication Critical patent/DE2406198A1/de
Priority to AT868676A priority patent/AT342593B/de
Application granted granted Critical
Publication of DE2406198C2 publication Critical patent/DE2406198C2/de
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE2406198A 1974-02-09 1974-02-09 Verfahren zur Herstellung von neuen 2-Amino-6-dialkylamino-dihydropyridinen Expired DE2406198C2 (de)

Priority Applications (24)

Application Number Priority Date Filing Date Title
DE2406198A DE2406198C2 (de) 1974-02-09 1974-02-09 Verfahren zur Herstellung von neuen 2-Amino-6-dialkylamino-dihydropyridinen
US05/545,202 US4004014A (en) 1974-02-09 1975-01-29 2-Amino-6-dialkylaminodihydropyridines, their production, pharmaceutical compositions and methods of use thereof
CA219,375A CA1032539A (en) 1974-02-09 1975-02-04 2-amino-6-dialkylaminodihydropyridines, their production, pharmaceutical compositions and methods of use thereof
AU77863/75A AU484384B2 (en) 1974-02-09 1975-02-04 New 2-amin o-6-dialkylaminodihydropyridines their production and their medicinal use
BE153108A BE825245A (fr) 1974-02-09 1975-02-06 Nouvelles 2-amino-6-dialkylaminodihydropyridines leur procede de preparation et medicament les contenant
NL7501430A NL7501430A (nl) 1974-02-09 1975-02-06 Werkwijze voor het bereiden van aminodihydro- inen, werkwijze voor het bereiden van ge- iddelen alsmede gevormde geneesmiddelen.
FI750324A FI750324A (US06811534-20041102-M00003.png) 1974-02-09 1975-02-06
ES434545A ES434545A1 (es) 1974-02-09 1975-02-07 Procedimiento para la obtencion de 2-amino-6-dialquil-ami- nodihidropiridinas.
ZA00750790A ZA75790B (en) 1974-02-09 1975-02-07 New 2-amino-6-dialkylaminodihydropyridines their production and their medicinal use
CH150675A CH605754A5 (US06811534-20041102-M00003.png) 1974-02-09 1975-02-07
IE247/75A IE40589B1 (en) 1974-02-09 1975-02-07 New 2-amino-6-tertiaryaminodihydropyridines, their production and their medicinal use
HUBA3201A HU168482B (US06811534-20041102-M00003.png) 1974-02-09 1975-02-07
ES434546A ES434546A1 (es) 1974-02-09 1975-02-07 Procedimiento para la obtencion de 2-amino-6-dialquil-amino-dihidropiridinas.
CH1631577A CH613446A5 (US06811534-20041102-M00003.png) 1974-02-09 1975-02-07
JP50015500A JPS5943460B2 (ja) 1974-02-09 1975-02-07 2−アミノ−6−ジアルキルアミノジヒドロピリジンの製造方法
IL46593A IL46593A (en) 1974-02-09 1975-02-07 2-amino-6-dialkylamino-dihydropyridines their production and pharmaceutical compositions containing them
DK44075*#A DK44075A (US06811534-20041102-M00003.png) 1974-02-09 1975-02-07
SE7501388A SE402458B (sv) 1974-02-09 1975-02-07 Sett att framstella nya 2-amino-6-dialkylamino-dihydropyridiner
FR7503895A FR2260345B1 (US06811534-20041102-M00003.png) 1974-02-09 1975-02-07
GB5312/75A GB1498495A (en) 1974-02-09 1975-02-07 2-amino-6-tertiary aminodihydropyridines their production and their medicinal use
LU71813A LU71813A1 (US06811534-20041102-M00003.png) 1974-02-09 1975-02-07
DD184073A DD117452A5 (US06811534-20041102-M00003.png) 1974-02-09 1975-02-07
AT96975A AT342590B (de) 1974-02-09 1975-02-10 Verfahren zur herstellung von neuen 2-amino-6-dialkylaminodihydropyridinen
AT868676A AT342593B (de) 1974-02-09 1976-11-23 Verfahren zur herstellung von neuen 2-amino-6-dialkylaminodihydropyridinen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2406198A DE2406198C2 (de) 1974-02-09 1974-02-09 Verfahren zur Herstellung von neuen 2-Amino-6-dialkylamino-dihydropyridinen

Publications (2)

Publication Number Publication Date
DE2406198A1 DE2406198A1 (de) 1975-08-14
DE2406198C2 true DE2406198C2 (de) 1983-12-15

Family

ID=5906982

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2406198A Expired DE2406198C2 (de) 1974-02-09 1974-02-09 Verfahren zur Herstellung von neuen 2-Amino-6-dialkylamino-dihydropyridinen

Country Status (20)

Country Link
US (1) US4004014A (US06811534-20041102-M00003.png)
JP (1) JPS5943460B2 (US06811534-20041102-M00003.png)
AT (1) AT342590B (US06811534-20041102-M00003.png)
BE (1) BE825245A (US06811534-20041102-M00003.png)
CA (1) CA1032539A (US06811534-20041102-M00003.png)
CH (2) CH605754A5 (US06811534-20041102-M00003.png)
DD (1) DD117452A5 (US06811534-20041102-M00003.png)
DE (1) DE2406198C2 (US06811534-20041102-M00003.png)
DK (1) DK44075A (US06811534-20041102-M00003.png)
ES (2) ES434545A1 (US06811534-20041102-M00003.png)
FI (1) FI750324A (US06811534-20041102-M00003.png)
FR (1) FR2260345B1 (US06811534-20041102-M00003.png)
GB (1) GB1498495A (US06811534-20041102-M00003.png)
HU (1) HU168482B (US06811534-20041102-M00003.png)
IE (1) IE40589B1 (US06811534-20041102-M00003.png)
IL (1) IL46593A (US06811534-20041102-M00003.png)
LU (1) LU71813A1 (US06811534-20041102-M00003.png)
NL (1) NL7501430A (US06811534-20041102-M00003.png)
SE (1) SE402458B (US06811534-20041102-M00003.png)
ZA (1) ZA75790B (US06811534-20041102-M00003.png)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2210687C3 (de) * 1972-03-06 1981-09-24 Bayer Ag, 5090 Leverkusen 2,6-Diamino-3,5-diäthoxycarbonyldihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
JPS5232217A (en) * 1975-09-05 1977-03-11 Matsushita Electric Ind Co Ltd Ghost eliminating equipment
CA1050587A (en) * 1975-09-30 1979-03-13 Fmc Corporation Rotating gas diffuser
DE2738153A1 (de) * 1977-08-24 1979-03-08 Bayer Ag 2-pyridyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
JPS57171968A (en) * 1981-04-17 1982-10-22 Kyowa Hakko Kogyo Co Ltd 1,4-dihydropyridine derivative
JPS61108258U (US06811534-20041102-M00003.png) * 1984-12-21 1986-07-09
JPH01181681A (ja) * 1988-01-13 1989-07-19 Komori Printing Mach Co Ltd 印刷機のプラウ折り装置

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3860601A (en) * 1972-03-06 1975-01-14 Horst Meyer 2,6-diamino-1,4-dihydropyridine derivatives
DE2210687C3 (de) * 1972-03-06 1981-09-24 Bayer Ag, 5090 Leverkusen 2,6-Diamino-3,5-diäthoxycarbonyldihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel

Also Published As

Publication number Publication date
AT342590B (de) 1978-04-10
LU71813A1 (US06811534-20041102-M00003.png) 1975-12-09
HU168482B (US06811534-20041102-M00003.png) 1976-05-28
ES434546A1 (es) 1977-04-01
AU7786375A (en) 1976-08-05
CA1032539A (en) 1978-06-06
SE402458B (sv) 1978-07-03
FI750324A (US06811534-20041102-M00003.png) 1975-08-10
DK44075A (US06811534-20041102-M00003.png) 1975-10-06
SE7501388L (US06811534-20041102-M00003.png) 1975-08-11
IE40589B1 (en) 1979-07-04
FR2260345A1 (US06811534-20041102-M00003.png) 1975-09-05
IL46593A (en) 1977-11-30
IL46593A0 (en) 1975-04-25
DD117452A5 (US06811534-20041102-M00003.png) 1976-01-12
IE40589L (en) 1975-08-09
JPS5943460B2 (ja) 1984-10-22
NL7501430A (nl) 1975-08-12
DE2406198A1 (de) 1975-08-14
ATA96975A (de) 1977-08-15
BE825245A (fr) 1975-08-06
ES434545A1 (es) 1976-12-16
FR2260345B1 (US06811534-20041102-M00003.png) 1980-01-11
US4004014A (en) 1977-01-18
CH613446A5 (US06811534-20041102-M00003.png) 1979-09-28
CH605754A5 (US06811534-20041102-M00003.png) 1978-10-13
GB1498495A (en) 1978-01-18
JPS50108268A (US06811534-20041102-M00003.png) 1975-08-26
ZA75790B (en) 1976-02-25

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee