DE2250078A1 - ORAL AND DENTAL CARE PRODUCTS - Google Patents

Description

Priority: October 20, 197-1, Great Britain, No. 48 671/71

Oral hygiene compositions for use in cleaning teeth consist essentially of a surface active agent and one Polishes and are usually prepared in the form of liquids or semi-solids. The polish promotes that Removal of tooth stains and discoloration of the tooth surface. Oral hygiene products are used to produce special effects, e.g. bacteriostatic compounds, effective against caries Compounds, aromas and fragrances incorporated »The surface-active agent used is a wetting agent which, together with the polishing agent promotes the removal of food residues, their breakdown products and tooth stains from the tooth surface. That Polish is a mild abrasive that is finely divided Powder is present. The hardness of this powder is an important factor: If the powder develops too strong an abrasive effect, the enamel is damaged; but if the sole effect is too low, the result is insufficient cleaning of the teeth.

A variety of polishing agents are already in use known in dental care products. Usually used as · polishing agents

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Dicalcium phosphate, insoluble sodium metaphoophosphate, calcium silicate and 'calcium carbonate is used. Furthermore, it was already common Silica proposed as a polishing agent. However, the aforementioned compound comes in various forms, of which many have a hardness associated with too high a grinding effect have, whereby these forms are excluded from general use.

However, US Pat. No. 3,538,230 proposed "translucent and to manufacture clear dentifrices which are the primary cleaning and polishing agent in particulate form present, synthetic, amorphous porous silica xerogel in amounts of about 5 to about 50 percent by weight, based on the Dentifrice contains. The aforementioned patent contains the finding that dentifrices that contain these special, Containing silicon dioxide forms, after brushing the teeth with such agents, give the teeth a high shine, level the teeth Excessively abrading enamel or dentin. It should also be noted that this special silica Shapes are xerogels with a porous, almost spongy, particle structure, where the particle size is of importance. By definition, this xerogel has an average particle diameter from about 2 to about 20 microns, preferably from about 3 to about 15 microns. The specially recommended forms of silica have particle diameters of 5 to 10 microns.

After the disclosure of the aforementioned Potentschrift one should assume that a silica xerogel with one above the above specified maximum particle size because of its too high ochloif effect on tooth enamel and dentin al3 polishing agent 'un-

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suitable is. When testing the effect of dog hygiene products, the silica-xerogel with an average particle diameter contain over 20 microns, however, it has surprisingly been found on the human dentin that these agents have a fairly mild abrasive effect. That finding was therefore doubly surprising, since such agents can feel sandy, which is before carrying out an appropriate test suggests that the expected excessive abrasive effect entry. The sandy feel is even an advantage since a clear gel toothpaste gives the consumer the impression that the usual finely divided polishing agent could not be included. Because of this, the consumer can choose such a toothpaste considered inferior to the common opaque species.

Furthermore, surprisingly, oral hygiene products containing xerogels with the aforementioned large particle diameters obtain a better cleaning effect than with the agents described in the aforementioned patent.

The present invention is therefore based on the discovery that Kiesol Xerogelo with average particle diameters of 22 to 50 microns, preferably 25 to 30 microns, are suitable Cleaning and polishing preparations for making improved oral hygiene preparations are.

The present invention thus relates to oral and dental care products containing a silica xerogel as a polishing agent, which is composed of 1 to 50 percent by weight of a silica xerogel with an average tea diameter of 22 to 5-0 microns. αΐΐοίηίςαα odor main.

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ÖAD ORIGINAL

Polishing agents are marked,

The gowns according to the invention preferably contain polishing agents a silica xerogel with an average particle size of 25 to 30 microns.

The silica xerogel used according to the invention is in particle form present, synthetic, amorphous and porous silicon dioxide, which by slow evaporation of the water from a silica hydrogel, e.g. by hot air drying. The evaporation of the water takes a long time, until the desired average particle size is reached, but not exceeded. If desired, this can Xerogel with a silica xerogel with a lower average Particle size, provided that the average particle diameter, i.e., that of the average weight based mean diameter of the particles of the silica-xerogel mixture is in the aforementioned range according to the invention.

The silica hydrogel is prepared by adding a solution of a dilute acid to a weakly alkaline metal silicate, the resulting mixture being allowed to convert into a gel (cf. US Pat. No. 3,528,2JO and British Pat. No. 1,186,706).

In the last-mentioned patent der'spezifischen surface of the silica-xerogel is used, special attention, v / obei is noted that the specific surface of at least a value of 600 m / g, preferably from

2
about 700 m / g. In the present invention it was found, however, that the specific surface area is not of great importance and that silica .lerogels with specific

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Surfaces of 250 bio 800 m / g may perish / end, provided that the xerogel has an average particle diameter in the above-specified range according to the invention. The Kieael xerogel used in the present invention preferably has

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a particle density from 1.00 to 1.20 g / cm-. ⁵

The agents of the invention, which in particular contain a surface active agent normally can indeed be present in any conventional form, and any common component of dentifrices contain \ particularly suitable dentifrices include, but to that described in U.S. Patent No. 3,528,230 and in the GB-PS 1 186 706 described translucent gel type. Such agents usually contain at least 3 percent by weight, preferably about 8 to about 20 percent by weight, of silica xerogel as a polishing agent.

The silica xerogels used according to the invention are also used for the production of liquid dentifrices of the mouthwash type. In such agents a liquid medium is used which does not give a gel-like product. Nevertheless Ein.solches mouthwash is preferably present as · Although flowable but _t before viscous liquid. This is achieved through the use of higher proportions of liquid media that are more viscous than water, in particular through the use of high proportions of, for example, sorbitol and glycerine.

One according to the invention belonging to the translucent gel type. In addition to the xerogel described above, based on weight; the Zahnpf le _t; emit means of, 0.5 to 20 percent, preferably from 2 to 15 percent of a synthetic silica having thickening and GelbiMungseigenschaitöa """'301817/1134

contain. Such synthetic ones in particulate form Silica forms have an average particle diameter below 4 microns and a specific surface area un '^ er 400 m / g. Examples of such silica porraen are pyrogens Silicas and silica aerogels. These silica forms are unable to remove stains from teeth.

The dental care agents according to the invention can contain up to about 10 percent by weight common abrasives such as water-insoluble sodium metaphosphate.

The agents according to the invention can also contain various known optional components, such as a soap or a synthetic one Detergent as a foam or wetting agent, especially sodium lauryl sulfate in amounts of about 1.0 to about 1.5 percent, flavorings, Riffer, sweeteners such as saccharin, humectants, preservatives, Colorants, opacifying agents, such as titanium dioxide, and powdery polymers, e.g. α-olefin polymers, like polyethylene.

The agents according to the invention can be a carrier and plasticizer and contain a binder in such amounts that the dentifrice has a uniform structure and good flowability to lend. Preferred carriers and plasticizers are glycerine and sorbitol; however, other carriers and plasticizers can also be used. such as propylene glycol and polyethylene glycol can be used. Examples of specific binders that can be used are tragacanth gumrui, Sodium carboxymethyl cellulose, Kydroxyäthyloolluloso, Carrar.er. and its derivatives, starch derivatives and johaiinifibrotguinmi.

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The oral and dental care agents according to the invention can be used prophylactically or therapeutically active compounds, v / ie antibiotics, Astringents or germicidal or fluorine-containing compounds fertilize, be incorporated. Typical examples of the aforementioned additives are tyrothrycin, chlorophylline, hexachlorophene, chlorhexidine, Sarcosinates, astringent, ingating salts and water-soluble, ionizable fluorine-containing compounds, v / ie sodium fluoride, tin (II) fluoride and sodium monofluorophosphate. the prophylactically or therapeutically active compounds are used in an acceptable amount. In the case of water-soluble, Effective against caries fluorine-containing compounds are normally added in such amounts that the invention Agent has a fluorine content of 0.01 to 2 percent.

The agents according to the invention generally contain 5 to 30 percent carrier and plasticizer, 0.5 to 30 percent binder, 0.1 to 5 percent flavoring, up to 60 percent water, 0.01 to 6 percent foaming agent, 0.02 to 10 percent buffer and 0.01 to 2 percent preservative, all percentages being based on the weight of the agent according to the invention.

The agents according to the invention are produced in the usual way, i.e., the silica xerogel with a defined particle size is Diluents, carriers and the other desired ingredients mixed together. The agent obtained in this way can be in tubes or

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other suitable removal containers can be packed.

The abrasive effects of the compositions of the present invention are determined according to the two methods described below.

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According to the • Talysuri 'method, the root of an extracted The tooth is embedded in a plastic block in such a way that its surface can be ground flat and that the tooth is exactly in the "Talysurf ^" measuring instrument for measuring the surface profile can be introduced, this measuring instrument provides an enlarged cross-section of the tooth surface (horizontal enlargement: 100x, vertical enlargement: 20Ox). If the flatness of the attached tooth is sufficient, make it at right angles with a single tuft of toothbrushes brushed in a machine that under standard conditions such as the length and speed of the tuft stroke, the thinning the toothpaste, the temperature, the pretreatment and the loading of the tuft and the stirring force, 'is operated so that the toothpaste used is the only variable. After 1000 brush strokes the tooth surface is measured again using the "Talysurf" instrument. By comparison with the original The measured value is the abraded cross-sectional area and thus the abrasion caused by brushing with the used Toothpaste was caused. The values given in the examples These values represent the volume of the rubbed i during the test nen dentin. Using this method, certain values of up to 40 can be described as quite safe with regard to abrasion will. Some commercially available dentifrices give higher values in the "Talysurf" test than the agents according to the invention. The ten care products described in US-PS $ 538 230 result in usually "Talysurf" values in the range of 5 to 20 units.

To determine the "RDA" value extracted teeth are first irradiated in a neutron flux and thereby made radioactive.

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A dentin surface is then made under standard conditions brushed and the radioactivity of the slurry surrounding the teeth determined after the teeth are removed. Currently Commercially available dentifrices have "RD A-V / er te up to 2U 45O units, so that all lower values are accepted can be.

The examples illustrate the invention.

Examples 1 to 6

In Examples 1 to 6, gowns are in shape according to the invention transparent or translucent gels described. The Kiesel-Xerogel Silica GM has an average particle diameter of about 25 microns and a specific surface area

from 675 ro / g · The silica airgel used by W «R. Grace and Co. under the trademark SYLOID 244. In Example 6, the aforementioned silica xerogel with the im Mixes commercially available silica xerogel SYLOID 63, which has an average particle diameter of 12 microns and a "

has a specific surface of 800 m / g. The latter Silica xerogel is used in amounts such that the average particle diameter of the entire xerogel mixture larger than 22 microns. "

Table I below shows the composition of the agents according to the invention and the results of the "Talysurf" and the ^H RDA "tests.

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Table I.

Components 1 B oi game, weight steep 6th 3.00 2 3 U 5 5.00 Pebble xerogel
(Silica CM) - S ₁ CO 7.50 10.00 IU ₁ OO 2.00 Pebble xerogel
(Syloid 63) 7.50 - - - - 9.00 Silica airgel
CSyIοid 244) 1.25 9.00 7.50 7.50 7.50 1, U5 Sodium carboxy
methyl cellulose 3O ₁ OO 1.1 + 5 1.00 1.25 1.25 21.00 Glycerin 3U, O5 22.00 30.00 30.00 30.00 U7.33 Sorbitol (70 percent) 0.20 * U8, 33 3U, 3O 31.55 31.55 0.20 Saccharin, sodium salt 0.20 0.20 0 _f 20 0.20 0.20 0.20 Sodium benzoate 0.20 0.20 0.20 0.20 1.50 Ammonium lauryl
sulfate M5 1.50 1.15 1.15 1.15 1.22 Flavoring agent 1.22 1.15 1.15 1 »15 0.10 Polyvinyl
pyrrolidone 1.00 0.10 - - - chloroform 20.50 - 1.00 1.00 1.00 11.00 water ΐοο, οο 11.00 16.00 16.00 12.00 100.00 100.00 100.00 100.00 100.00 Abrasion test 5, U e, u Talysurf 89 7.0 8.6 7, U 9, U - RDA - 1" 217 279

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From "Table I it can be seen that the one with the erfindungsgeraektiven Medium-induced abrasion is within perfectly acceptable limits. In any case, a good cleaning effect is obtained.

Examples 7 to 9

From the ingredients listed in Table II below liquid oral hygiene products are produced:

Table II

Components example
7th , Weight percent
8 9 15.00 Pebble xerogel
(Silica CMS) 5.00 10.00 5.00 Silica airgel
(Syloid 244) 5.00 5.00 0, UO Sodium carboxy
methylcellulos-e 0.30 0.30 5.00 Glycerin 7.00 6.00 66.65 Sorbitol (70 percent) 74.00 70.75 0.20 Saccharin, sodium salt 0.20 0.20 0.20 Sodium benzoate 0.20 0.20 1.70 Flavorings and colors 1.70 1.70 1.15 Nat r iumlaury1-
sulfate 1.50 1.15 0.10 Polyvinyl pyrrolidone 0.10 0.10 U, 60 water 5, OO U, 60 100,000 100.00 100.00

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The Silica CMS airgel is similar to Silica CM in that it is an average Particle diameter of 25 microns. However, unlike Silica CM, it does not contain particles with diameters over 60 microns.

Any of those made from the ingredients listed above Products is a * clear, flowable, viscous liquida Dental care products with satisfactory teeth cleaning and Abrasion properties.

Examples 10 to 13

From the ingredients listed in Table III below liquid Zalmpflegemittel according to the invention are produced :.

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Table III

Components Example, parts by weight 11 12th 13th 10 2.50 5, oo 11 *, 00 Pebble xerogel
(Silica CM) 1.00 5-vOO 8.5.0. 7.50 Silica airgel
(Syloid 244). 5.00 0.60 1.00 0.60 Sodium carboxy
methyl cellulose 0.70 7.00 5.53 5.53 Glycerin 7.00 75.35 75.79 68.19 Sorbitol (70 percent) 76.75 0 * 10 - - Calcium carragenate 0.10 0 * 25 0 _r 20 0 * 20 Saccharin, sodium salt 0.25 0.20 0, OS 0.08 Sodium benzoate 0.20 2.00 1.47 1.47 Sodium lauryl sulfate 2.00 1.50 1.15 1> 15 Flavoring agent 1.50 - 0.75 0.75 chloroform 5.50 0 * 53 0.53 * water 5.50 100.00 100.00 100.00 100.00

The cleaning effect of the agents according to Examples 12 and 13 becomes translucent with a commercially available paste Compared gel type made according to US Pat. No. 3,538,230 and contains a silica xerogel with an average internal diameter of about 12 microns.

Human teeth are selected for the cleaning tests, whose enamel has uncalcified elecs on smooth, not de-

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Contains calcified, slightly curved enamel surfaces. A hollow tool is used to transform the tooth enamel

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Cylinder cut out and fastened in black plastic. The optical density of the test pieces is then determined. The specimens are then mixed with one of the dental care products to be tested brushed. DIqs leads to stain removal and there with to change the optical density of the sample. The foregoing Procedure is carried out for each of the dentifrices to be tested, with changes to the order and the one used Test specimens taken to ensure standardization of all variables. The raw scores are saved as optical density χ 100 brushes per minute indicated. These values are then corrected for the test sequence by adding the Sums for the first and third attempt to those in the second attempt received sum can be adjusted. This is done by adding the total for each test (1, 2, and 3) for each dentifrice and determining the total score for each test. The total score for test 1 or 3 wii ^ i then into the total score for Test 2 divided. The result obtained here is the factor by which all values in Test 1 and Test 3 are to be multiplied the corrected values are obtained. In this way the influence of the siesta sequence is eliminated.

In Table IV below are the total values of six 'values obtained in the manner described above for each of the three dental care products received from,

i represents: J

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Table IV

Dentifrices Overall decrease of the optical
Density χ 100 brushes per minute Example 12
Example 15
comparison 51
50
6th

This comparative stain removal test shows that the agents according to the invention have better cleaning properties
as means in which the silica xerogel used has a smaller average particle size »An increase in the
Xerogel amount from 5 to 14 percent does not make a remarkable one
Change in cleaning effect.

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Claims (8)

Claims Q) _r oral and dental care products containing a Kieeel xerogel as the polishing agent, characterized by a content of 1 to 50 percent by weight of a silica xerogel with an average particle diameter of 22 to 50 microns as the sole or main polishing agent. 2. Execution form according to claim 1, characterized by a Silica xerogel with an average particle diameter of 25 to 50 microns. 3. Embodiment according to claim 1 and 2, characterized by a silica xerogel content of 8 to 20 percent by weight. 4-. Embodiment 3 form according to claim 1 to 3 in the form of a translucent Gels also containing a total of 0.5 to 20 percent by weight at least one fumed silicon dioxide and / or silica airgel. 5. Embodiment according to claim 1 to 3 in the form of a flowable, viscous liquid dental care agent. 6 · Embodiment according to claim 1 to 5 »also containing a water-soluble, effective against caries fluorine-containing compound in such amounts that the fluorine content of the agent C, 01 to 2 weight. '? Percent is. 7. Embodiment according to claim 1 in the form of a translucent gel containing
(a) about *> to about 14 percent of a silica xerogen with 3 09 8 Γ / 11? 4 _wm ORIGINAL an average particle diameter of about 25 microns, (b) about 7 »5 to about 10 percent silica aerosol /, (c) about 1.0 to about 1.5 percent sodium carboxyraethylcollulose, (d) about 20 to about 30 percent glycerin, (e) about 20 to about 35 percent sorbitol, (f) about 1.0 to about 1.5 percent sodium lauryl sulfate and V / ater, flavorings and sweeteners, thickeners and Corrosion protection as the rest. 8. Embodiment according to .Anspruch 1 in the form of a viscous containing liquid dental care products (a) about 1 to about 15 percent of a silica xerogel with an average particle diameter of about 25 microns, (b) about 5 to about 8.5 percent silica airgel, (c) about 0.3 to 1.0 percent sodium carboxymethyl cellulose, (d) about 5 to about 7 percent glycerin, (e) about 45 to about 55 percent sorbitol, (f) about 1.0 to about 2.0 percent sodium lauryl sulfate and V / ater, flavorings and sweeteners, thickeners and anti-corrosive agents as the remainder. ■ · 309817/1134 ^BAü