DE2246460A1 - Metallocene und metallocen-derivate mit radioaktivem zentralatom - Google Patents
Metallocene und metallocen-derivate mit radioaktivem zentralatomInfo
- Publication number
- DE2246460A1 DE2246460A1 DE2246460A DE2246460A DE2246460A1 DE 2246460 A1 DE2246460 A1 DE 2246460A1 DE 2246460 A DE2246460 A DE 2246460A DE 2246460 A DE2246460 A DE 2246460A DE 2246460 A1 DE2246460 A1 DE 2246460A1
- Authority
- DE
- Germany
- Prior art keywords
- radioactive
- metallocene
- derivatives
- metallocenes
- central atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002285 radioactive effect Effects 0.000 title claims description 45
- 238000000034 method Methods 0.000 claims description 12
- KTWOOEGAPBSYNW-UHFFFAOYSA-N ferrocene Chemical compound [Fe+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KTWOOEGAPBSYNW-UHFFFAOYSA-N 0.000 claims description 9
- 150000002500 ions Chemical class 0.000 claims description 7
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 4
- -1 ruthenium ions Chemical class 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 229910052742 iron Inorganic materials 0.000 claims description 3
- 229910052751 metal Inorganic materials 0.000 claims description 3
- 239000002184 metal Substances 0.000 claims description 3
- 229910052707 ruthenium Inorganic materials 0.000 claims description 3
- 230000005658 nuclear physics Effects 0.000 claims description 2
- 238000003786 synthesis reaction Methods 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims 2
- 101150054634 melk gene Proteins 0.000 claims 1
- 150000002739 metals Chemical class 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
- FZHCFNGSGGGXEH-UHFFFAOYSA-N ruthenocene Chemical class [Ru+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 FZHCFNGSGGGXEH-UHFFFAOYSA-N 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000009206 nuclear medicine Methods 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 240000005819 Magnolia denudata Species 0.000 description 1
- 235000003415 Michelia alba Nutrition 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 238000012993 chemical processing Methods 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- GPRSOIDYHMXAGW-UHFFFAOYSA-N cyclopenta-1,3-diene cyclopentanecarboxylic acid iron Chemical compound [CH-]1[CH-][CH-][C-]([CH-]1)C(=O)O.[CH-]1C=CC=C1.[Fe] GPRSOIDYHMXAGW-UHFFFAOYSA-N 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 150000002540 isothiocyanates Chemical class 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 150000002902 organometallic compounds Chemical class 0.000 description 1
- 229910052762 osmium Inorganic materials 0.000 description 1
- SYQBFIAQOQZEGI-UHFFFAOYSA-N osmium atom Chemical compound [Os] SYQBFIAQOQZEGI-UHFFFAOYSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000163 radioactive labelling Methods 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000012144 step-by-step procedure Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F17/00—Metallocenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0487—Metallocenes, i.e. complexes based on a radioactive metal complexed by two cyclopentadienyl anions
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2246460A DE2246460A1 (de) | 1972-09-21 | 1972-09-21 | Metallocene und metallocen-derivate mit radioaktivem zentralatom |
| GB4354373A GB1447681A (en) | 1972-09-21 | 1973-09-17 | Metallocenes and metallocene derivatives containing a radio active metal atom |
| IT29149/73A IT1048140B (it) | 1972-09-21 | 1973-09-20 | Metallogeni e derivati di metallogeni con atomo centrale radioattivo |
| JP48106459A JPS49124050A (cg-RX-API-DMAC7.html) | 1972-09-21 | 1973-09-20 | |
| FR7333911A FR2200019B1 (cg-RX-API-DMAC7.html) | 1972-09-21 | 1973-09-21 | |
| US05/399,552 US4028389A (en) | 1972-09-21 | 1973-09-21 | Metallocenes and metallocene derivatives having a radioactive central atom |
| BE135922A BE805174A (fr) | 1972-09-21 | 1973-09-21 | Metallocenes et derives de metallocenes a atome central radio-actif et leur procede de preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2246460A DE2246460A1 (de) | 1972-09-21 | 1972-09-21 | Metallocene und metallocen-derivate mit radioaktivem zentralatom |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2246460A1 true DE2246460A1 (de) | 1974-04-04 |
Family
ID=5857017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2246460A Pending DE2246460A1 (de) | 1972-09-21 | 1972-09-21 | Metallocene und metallocen-derivate mit radioaktivem zentralatom |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4028389A (cg-RX-API-DMAC7.html) |
| JP (1) | JPS49124050A (cg-RX-API-DMAC7.html) |
| BE (1) | BE805174A (cg-RX-API-DMAC7.html) |
| DE (1) | DE2246460A1 (cg-RX-API-DMAC7.html) |
| FR (1) | FR2200019B1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB1447681A (cg-RX-API-DMAC7.html) |
| IT (1) | IT1048140B (cg-RX-API-DMAC7.html) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4584186A (en) * | 1982-12-01 | 1986-04-22 | Mallinckrodt, Diagnostica (Holland) B.V. | Radiolabelled metallocene derivatives |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4298591A (en) * | 1979-04-03 | 1981-11-03 | The United States Of America As Represented By The United States Department Of Energy | Instantaneous radioiodination of rose bengal at room temperature and a cold kit therefor |
| CA2084315A1 (en) * | 1990-06-01 | 1991-12-02 | Martin Wenzel | Cyclopentadienylcarbonyl 99m tc complexes, process for their production as well as their use in diagnostics |
| JP2000281694A (ja) * | 1999-03-29 | 2000-10-10 | Tanaka Kikinzoku Kogyo Kk | 有機金属気相エピタキシー用の有機金属化合物 |
| JP4672897B2 (ja) * | 2001-04-13 | 2011-04-20 | 田中貴金属工業株式会社 | ビス（シクロペンタジエニル）ルテニウム誘導体の製造方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA706905A (en) | 1965-03-30 | O. Schenck Gunther | Production of metal-cyclopentadienyl compounds | |
| GB831382A (en) * | 1956-01-16 | 1960-03-30 | Exxon Research Engineering Co | Radioactive tracers |
| US3045119A (en) * | 1956-01-16 | 1962-07-17 | Exxon Research Engineering Co | Radioactive tracer |
| DE1056608B (de) * | 1957-07-30 | 1959-05-06 | Hoechst Ag | Verfahren zur Herstellung einer hochmolekularen Ru-Indenkomplexverbindung |
| DE1121047B (de) * | 1960-10-11 | 1962-01-04 | Hoechst Ag | Verfahren zur Herstellung von inaktivem oder radioaktivem, gegebenenfalls traegerfreiem Dicyclopentadienylruthenium |
-
1972
- 1972-09-21 DE DE2246460A patent/DE2246460A1/de active Pending
-
1973
- 1973-09-17 GB GB4354373A patent/GB1447681A/en not_active Expired
- 1973-09-20 IT IT29149/73A patent/IT1048140B/it active
- 1973-09-20 JP JP48106459A patent/JPS49124050A/ja active Pending
- 1973-09-21 BE BE135922A patent/BE805174A/xx unknown
- 1973-09-21 US US05/399,552 patent/US4028389A/en not_active Expired - Lifetime
- 1973-09-21 FR FR7333911A patent/FR2200019B1/fr not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4584186A (en) * | 1982-12-01 | 1986-04-22 | Mallinckrodt, Diagnostica (Holland) B.V. | Radiolabelled metallocene derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| US4028389A (en) | 1977-06-07 |
| IT1048140B (it) | 1980-11-20 |
| JPS49124050A (cg-RX-API-DMAC7.html) | 1974-11-27 |
| FR2200019A1 (cg-RX-API-DMAC7.html) | 1974-04-19 |
| BE805174A (fr) | 1974-03-21 |
| FR2200019B1 (cg-RX-API-DMAC7.html) | 1976-09-03 |
| GB1447681A (en) | 1976-08-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OD | Request for examination | ||
| OHN | Withdrawal |