DE2238479C3 - Chemische Analysevorrichtung - Google Patents
Chemische AnalysevorrichtungInfo
- Publication number
- DE2238479C3 DE2238479C3 DE2238479A DE2238479A DE2238479C3 DE 2238479 C3 DE2238479 C3 DE 2238479C3 DE 2238479 A DE2238479 A DE 2238479A DE 2238479 A DE2238479 A DE 2238479A DE 2238479 C3 DE2238479 C3 DE 2238479C3
- Authority
- DE
- Germany
- Prior art keywords
- signal
- sample
- time
- conductivity
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000126 substance Substances 0.000 title claims description 28
- 230000008859 change Effects 0.000 claims description 65
- 238000006243 chemical reaction Methods 0.000 claims description 49
- 239000003153 chemical reaction reagent Substances 0.000 claims description 32
- 238000004458 analytical method Methods 0.000 claims description 28
- 230000000903 blocking effect Effects 0.000 claims description 14
- 239000000470 constituent Substances 0.000 claims description 11
- 238000012544 monitoring process Methods 0.000 claims description 5
- 239000007795 chemical reaction product Substances 0.000 claims description 3
- 239000000523 sample Substances 0.000 description 69
- 238000005259 measurement Methods 0.000 description 33
- 210000002966 serum Anatomy 0.000 description 23
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 19
- 239000004202 carbamide Substances 0.000 description 19
- 238000000034 method Methods 0.000 description 19
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 14
- 239000001099 ammonium carbonate Substances 0.000 description 14
- 235000012501 ammonium carbonate Nutrition 0.000 description 14
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 13
- 239000008103 glucose Substances 0.000 description 13
- 238000006911 enzymatic reaction Methods 0.000 description 12
- 239000001301 oxygen Substances 0.000 description 12
- 229910052760 oxygen Inorganic materials 0.000 description 12
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 11
- 108010046334 Urease Proteins 0.000 description 11
- 230000015572 biosynthetic process Effects 0.000 description 10
- 108090000790 Enzymes Proteins 0.000 description 9
- 102000004190 Enzymes Human genes 0.000 description 9
- 210000004369 blood Anatomy 0.000 description 9
- 239000008280 blood Substances 0.000 description 9
- 229940088598 enzyme Drugs 0.000 description 9
- 239000000376 reactant Substances 0.000 description 9
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 8
- 230000006870 function Effects 0.000 description 7
- 230000002255 enzymatic effect Effects 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 210000002700 urine Anatomy 0.000 description 6
- 238000004737 colorimetric analysis Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 230000001052 transient effect Effects 0.000 description 5
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 4
- 108010015776 Glucose oxidase Proteins 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 239000004366 Glucose oxidase Substances 0.000 description 3
- 229940116332 glucose oxidase Drugs 0.000 description 3
- 235000019420 glucose oxidase Nutrition 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 230000036632 reaction speed Effects 0.000 description 3
- 230000007704 transition Effects 0.000 description 3
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 230000006735 deficit Effects 0.000 description 2
- 230000003544 deproteinization Effects 0.000 description 2
- 239000000174 gluconic acid Substances 0.000 description 2
- 235000012208 gluconic acid Nutrition 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000010355 oscillation Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 102000003992 Peroxidases Human genes 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 230000000246 remedial effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/17—Nitrogen containing
- Y10T436/171538—Urea or blood urea nitrogen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16968771A | 1971-08-06 | 1971-08-06 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2238479A1 DE2238479A1 (de) | 1973-02-15 |
| DE2238479B2 DE2238479B2 (de) | 1977-08-18 |
| DE2238479C3 true DE2238479C3 (de) | 1978-04-13 |
Family
ID=22616754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2238479A Expired DE2238479C3 (de) | 1971-08-06 | 1972-08-04 | Chemische Analysevorrichtung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3765841A (enExample) |
| JP (1) | JPS5647497B2 (enExample) |
| CA (1) | CA972810A (enExample) |
| CH (1) | CH583904A5 (enExample) |
| DE (1) | DE2238479C3 (enExample) |
| DK (1) | DK150805C (enExample) |
| GB (1) | GB1395223A (enExample) |
| IT (1) | IT974628B (enExample) |
| SE (1) | SE389736B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4003705A (en) * | 1975-06-12 | 1977-01-18 | Beckman Instruments, Inc. | Analysis apparatus and method of measuring rate of change of electrolyte pH |
| US4085009A (en) * | 1976-07-28 | 1978-04-18 | Technicon Instruments Corporation | Methods for determination of enzyme reactions |
| US4095272A (en) * | 1977-01-11 | 1978-06-13 | Phillips Petroleum Company | Automatic turbidimetric titration |
| US4271001A (en) * | 1978-03-23 | 1981-06-02 | Asahi Kasei Kogyo Kabushiki Kaisha | Apparatus for measuring membrane characteristics of vesicles |
| FR2439401A1 (fr) * | 1978-10-20 | 1980-05-16 | St Icare | Dispositif d'alcoometre |
| US4256832A (en) * | 1978-12-12 | 1981-03-17 | Bioresearch Inc. | Carcinogen and mutagen screening method and apparatus |
| CA1158720A (en) * | 1979-06-18 | 1983-12-13 | Joseph E. Ahnell | Pulsed voltammetric detection of bacteria |
| US4321322A (en) * | 1979-06-18 | 1982-03-23 | Ahnell Joseph E | Pulsed voltammetric detection of microorganisms |
| US4376026A (en) * | 1980-08-01 | 1983-03-08 | The North American Manufacturing Company | Oxygen concentration measurement and control |
| GB8420116D0 (en) * | 1984-08-08 | 1984-09-12 | Elchemtec Ltd | Apparatus for monitoring redox reactions |
| US4679426A (en) * | 1985-09-09 | 1987-07-14 | Fuller Milton E | Wave shape chemical analysis apparatus and method |
| US4765179A (en) * | 1985-09-09 | 1988-08-23 | Solid State Farms, Inc. | Radio frequency spectroscopy apparatus and method using multiple frequency waveforms |
| US4935346A (en) | 1986-08-13 | 1990-06-19 | Lifescan, Inc. | Minimum procedure system for the determination of analytes |
| GB8622748D0 (en) * | 1986-09-22 | 1986-10-29 | Ici Plc | Determination of biomass |
| US4863868A (en) * | 1987-09-11 | 1989-09-05 | Prolitec Aktiengesellschaft | Apparatus for detecting the presence of micro organism in liquid |
| NL8801073A (nl) * | 1988-04-26 | 1989-11-16 | Univ Twente | Detectiemethode. |
| US5120648A (en) * | 1988-05-26 | 1992-06-09 | Lim Technology Laboratories, Inc. | Chemical analyzer using rf radiation attenuation measurements |
| US5112455A (en) * | 1990-07-20 | 1992-05-12 | I Stat Corporation | Method for analytically utilizing microfabricated sensors during wet-up |
| WO1996008714A1 (en) * | 1994-09-13 | 1996-03-21 | Toto Ltd. | Material concentration measuring method and material concentration measuring apparatus |
| US5882937A (en) * | 1997-07-09 | 1999-03-16 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Ammonia monitor |
| US6458326B1 (en) | 1999-11-24 | 2002-10-01 | Home Diagnostics, Inc. | Protective test strip platform |
| US6541266B2 (en) | 2001-02-28 | 2003-04-01 | Home Diagnostics, Inc. | Method for determining concentration of an analyte in a test strip |
| US6562625B2 (en) | 2001-02-28 | 2003-05-13 | Home Diagnostics, Inc. | Distinguishing test types through spectral analysis |
| US6525330B2 (en) | 2001-02-28 | 2003-02-25 | Home Diagnostics, Inc. | Method of strip insertion detection |
| US20060205082A1 (en) * | 2005-03-10 | 2006-09-14 | Middleton John S | Reaction rate determination |
| CN103760356B (zh) * | 2007-12-10 | 2019-06-28 | 安晟信医疗科技控股公司 | 斜率式补偿 |
| US20210077753A1 (en) * | 2019-04-01 | 2021-03-18 | Bn Intellectual Properties, Inc. | Nebulizer delivery systems and methods |
| EP4019233B1 (en) | 2020-12-22 | 2025-03-12 | Siemens Gamesa Renewable Energy A/S | Method of manufacturing an adaptable carbon-fibre beam |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3458287A (en) * | 1965-04-29 | 1969-07-29 | Medical Laboratory Automation | Method and means of determining endpoint times in blood clotting tests |
| BE758864A (fr) * | 1969-11-13 | 1971-04-16 | Miles Lab | Instrument de mesure de conductivite differentielle |
-
1971
- 1971-08-06 US US00169687A patent/US3765841A/en not_active Expired - Lifetime
-
1972
- 1972-06-05 CA CA143,883A patent/CA972810A/en not_active Expired
- 1972-07-11 IT IT26863/72A patent/IT974628B/it active
- 1972-07-17 CH CH1068972A patent/CH583904A5/xx not_active IP Right Cessation
- 1972-08-03 GB GB3627172A patent/GB1395223A/en not_active Expired
- 1972-08-04 DK DK385972A patent/DK150805C/da not_active IP Right Cessation
- 1972-08-04 JP JP7775872A patent/JPS5647497B2/ja not_active Expired
- 1972-08-04 DE DE2238479A patent/DE2238479C3/de not_active Expired
- 1972-08-04 SE SE7210222A patent/SE389736B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2238479B2 (de) | 1977-08-18 |
| DE2238479A1 (de) | 1973-02-15 |
| IT974628B (it) | 1974-07-10 |
| GB1395223A (en) | 1975-05-21 |
| DK150805C (da) | 1988-01-25 |
| US3765841A (en) | 1973-10-16 |
| SE389736B (sv) | 1976-11-15 |
| CH583904A5 (enExample) | 1977-01-14 |
| JPS5647497B2 (enExample) | 1981-11-10 |
| JPS4829495A (enExample) | 1973-04-19 |
| CA972810A (en) | 1975-08-12 |
| DK150805B (da) | 1987-06-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) |