DE223796C - - Google Patents

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Publication number
DE223796C
DE223796C DENDAT223796D DE223796DC DE223796C DE 223796 C DE223796 C DE 223796C DE NDAT223796 D DENDAT223796 D DE NDAT223796D DE 223796D C DE223796D C DE 223796DC DE 223796 C DE223796 C DE 223796C
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DE
Germany
Prior art keywords
acid
acids
oxyarylarsinic
diazotized
water
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Expired
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DENDAT223796D
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German (de)
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Publication of DE223796C publication Critical patent/DE223796C/de
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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66Arsenic compounds
    • C07F9/70Organo-arsenic compounds
    • C07F9/74Aromatic compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)

Description

KAISERLICHESIMPERIAL

PATENTAMT.PATENT OFFICE.

PATENTSCHRIFTPATENT LETTERING

- JVl 223796 -KLASSE 12 #. GRUPPE - JVl 223796 - CLASS 12 #. GROUP

Verfahren zur Darstellung von Oxyarylarsinsäuren.Process for the preparation of oxyarylarsinic acids.

Zusatz zum Patente 205616 vom 7. August 1907.Addendum to patent 205616 of August 7, 1907.

Patentiert im Deutschen Reiche vom 7. August 1907 ab. Längste Dauer: 6. August 1922. Patented in the German Empire on August 7 , 1907 . Longest duration: August 6 , 1922.

Es wurde gefunden, daß man die für medizinische Zwecke wertvollen Oxyarylarsinsäuren, deren Herstellen durch Erhitzen von Phenolen mit Arsensäure durch das Hauptpatent geschützt ist, auch in der Weise herstellen kann, daß man diazotierte Aminophenylarsinsäure und deren Homologen in wäßriger Lösung zersetzt.It has been found that oxyarylarsinic acids, which are valuable for medical purposes, their manufacture by heating phenols with arsenic acid by the main patent is protected, can also be prepared in such a way that diazotized aminophenylarsinic acid and their homologues decomposed in aqueous solution.

■ Beispiel:■ Example:

217 Gewichtsteile ρ -.Aminophenylarsinsäure werden in 4000 Teilen 5 prozentiger Schwefelsäure gelöst und mit 74 Teilen Natriumnitrit diazotiert. Die Diazolösung wird auf dem Dampfbade erwärmt, bis die Stickstoffentwicklung beendet ist. Um das gebildete Phenolderivat zu isolieren, kann man die Schwefelsäure mit Barytwasser ausfällen und die filtrierte Flüssigkeit im Vakuum zur Trockne dampfen. Das Natriumsalz der p-Oxyphenylarsinsäure bleibt als schwach gelbliche Kristallmasse zurück; es läßt sich durch Umkristallisieren aus verdünntem Alkohol rein gewinnen. Durch Eindampfen des Natriumsalzes mit berechneter Menge Schwefelsäure, am besten im Vakuum, und Extraktion des Rückstands mit Aceton erhält man nach dem Verdampfen des letzteren die freie Oxyphenylarsinsäure als in Wasser leicht lösliches, schwach gelbliches, bald erstarrendes öl.217 parts by weight of ρ-aminophenylarsinic acid are dissolved in 4000 parts of 5 percent sulfuric acid and 74 parts of sodium nitrite diazotized. The diazo solution is heated on the steam bath until the evolution of nitrogen is finished. Sulfuric acid can be used to isolate the phenol derivative formed precipitate with barite water and the filtered liquid to dryness in a vacuum steam. The sodium salt of p-oxyphenylarsinic acid remains as a pale yellowish crystal mass return; it can be obtained in pure form by recrystallization from dilute alcohol. By evaporating the sodium salt with the calculated amount of sulfuric acid, preferably im Vacuum, and extraction of the residue with acetone is obtained after evaporation of the the latter the free oxyphenylarsinic acid as easily soluble in water, slightly yellowish, soon solidifying oil.

Durch Kristallisation aus Eisessig gewinnt man die Oxyphenylarsinsäure in kleinen gelblichen Prismen, die bei 173 bis 174 ° unter Zersetzung schmelzen. Sie ist leicht löslich in kaltem Wasser, Alkohol, Aceton und verdünnten Mineralsäuren, in Äther und Essigester dagegen schwer löslich. Die Alkalisalze sind in Wasser leicht löslich und kristallisieren aus verdünntem Alkohol in Nadeln.By crystallizing from glacial acetic acid, the oxyphenylarsinic acid is obtained in small, yellowish forms Prisms that melt at 173 to 174 ° with decomposition. It is easily soluble in cold water, alcohol, acetone and dilute mineral acids, in ether and ethyl acetate on the other hand hardly soluble. The alkali salts are easily soluble in water and crystallize from diluted alcohol in needles.

In analoger Weise werden aus anderen Aminoarylarsinsäuren die entsprechenden Oxyarylarsinsäuren erhalten.In an analogous manner, other aminoarylarsinic acids are converted into the corresponding oxyarylarsinic acids obtain.

Claims (1)

Patent-An Spruch:Patent-An saying: Verfahren zur Darstellung von Oxyarylarsinsäuren, darin bestehend, daß man diazotierte Aminoarylarsinsäuren in wäßriger Lösung zersetzt.Process for the preparation of oxyarylarsinic acids, consisting in that one diazotized aminoarylarsinic acids decomposed in aqueous solution. BERLIft. ÖEÖRUCKt IU DER REICHiSDRUCKEREl.BERLIft. ÖEÖRUCKt IU DER REICHiSDRUCKEREl.
DENDAT223796D Expired DE223796C (en)

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DE223796T

Publications (1)

Publication Number Publication Date
DE223796C true DE223796C (en) 1910-07-02

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DENDAT223796D Expired DE223796C (en)
DENDAT205616D Expired DE205616C (en)

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DENDAT205616D Expired DE205616C (en)

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DE (2) DE205616C (en)

Also Published As

Publication number Publication date
DE205616C (en) 1900-01-01

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