DE2040425A1 - Medicament against meteorism - combining artichoke extract with methylpolysiloxane and pancreatin - Google Patents

Medicament against meteorism - combining artichoke extract with methylpolysiloxane and pancreatin

Info

Publication number
DE2040425A1
DE2040425A1 DE19702040425 DE2040425A DE2040425A1 DE 2040425 A1 DE2040425 A1 DE 2040425A1 DE 19702040425 DE19702040425 DE 19702040425 DE 2040425 A DE2040425 A DE 2040425A DE 2040425 A1 DE2040425 A1 DE 2040425A1
Authority
DE
Germany
Prior art keywords
pancreatin
meteorism
dimethylpolysiloxane
coated
cynarae
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19702040425
Other languages
German (de)
Inventor
Otfried Dr Honecker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GALENIKA DR HETTERICH GmbH
Original Assignee
GALENIKA DR HETTERICH GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GALENIKA DR HETTERICH GmbH filed Critical GALENIKA DR HETTERICH GmbH
Priority to DE19702040425 priority Critical patent/DE2040425A1/en
Publication of DE2040425A1 publication Critical patent/DE2040425A1/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

The addn. of an extract of artichokes to methylpolysiloxane and pancreatin supplements the known action of the two latter in a medicament against meteorism by stimulating the secretions of the stomach, bile liver and pancreas, e.g. 2 kg pancreatin and auxiliary substances are compressed to cores each contg. 200 mg. active agent, and enterically coated. The dragee-coating includes 2.15 kg dimethylpolysiloxane-emulsion and 1 kg extr. cynarae aquosum siccum.

Description

mittel gegen Meteorismus" Die Erfindung bezieht sich auf ein Mittel gegen Meteorismus, bei welchem es sich um eine der häufigsten Darmbeschwerden handelt, deren erfolgreiche Behandlung bisher ein schwieriges, nicht zufriedenstellend gelöstes Problem ist. agent against meteorism "The invention relates to an agent against meteorism, which is one of the most common intestinal problems, the successful treatment of which has so far been a difficult one, which has not been satisfactorily resolved Problem is.

Es ist bekannt, dass Methylpolysiloxane, insbesondere Dimethylpolysiloxan unter Zusatz von Siliciumdioxyd und von Emulgatoren bei krankhaftem Xeteorismus Linderung schaffen können. Es wird dadurch eine entschäumende Wirkung und eine erleichternde Gasabfuhr erreicht. It is known that methylpolysiloxanes, especially dimethylpolysiloxane with the addition of silicon dioxide and emulsifiers for pathological xeteorism Can provide relief. It has a defoaming and a relieving effect Gas discharge achieved.

Es ist ausserdem bekannt, dass Pankreatin die körpereigene Verdauung unterstUtzt und fordert.It is also known that pancreatin affects the body's digestion supports and challenges.

Trotzdem ist bisher eine befriedigende Behandlung des Meteorismus nicht möglich gewesen, weil die Ursachen der Erkrankung nicht behoben werden konnten.Even so, so far has been a satisfactory treatment of meteorism was not possible because the causes of the disease could not be remedied.

Es wurde nun gefunden, dass ein Mittel gegen Meteorismus, welches neben Dimethylpolysiloxan und Pankreatin auch Artischockenextrakt enthält, einen dauerhaften Therapieerfolg gewährleistet. Während Dimethylpolysiloxan als Entschäumer fungiert und Pankreatin die körpereigene Verdauung fordert und erleichtert, wird durch den Artischockenextrakt die Sekretion von Magen, Galle, Leber, Pankreas sowie die Cholekinese, die Cholerese und die Regenerierung des Leberparenchyis angeregt. Es hat sich gezeigt, dass ein solches Mittel symptomatisch und kausal angreift und dass infolgedessen die Ursachen der Erkrankung behoben werden. Besonders vorteilhaft ist, dass sich, wie klinische Versuche ergaben, ein rasch einsetzender therapeutischer Erfolg einstellt.It has now been found that a remedy for meteorism, which in addition to dimethylpolysiloxane and pancreatin also contains artichoke extract, one permanent therapeutic success guaranteed. While dimethylpolysiloxane acts as a defoamer functions and pancreatin promotes and facilitates the body's digestion through the artichoke extract the secretion of the stomach, gall bladder, liver, pancreas as well as stimulates cholekinesis, choleresis and the regeneration of the liver parenchyis. It has been shown that such an agent acts symptomatically and causally and that as a result, the causes of the disease are eliminated. Particularly beneficial is that, as clinical trials have shown, a rapid onset of therapeutic Success sets.

Der verwendete Artischockenextrakt kann aus der ganzen getrockneten oder der frischen Pflane oder aus bestimmton Pflanzenteilen hergestellt werden. Zur Herstellung des Extrakts können Wasser oder aliphatische ein- oder mehrwertige Alkohole oder Gemische aus diesen Stoffen sowie andere organische Lösung d ttel verwendet werden.The artichoke extract used can be dried from the whole or the fresh plant or from certain parts of the plant. To produce the extract, water or aliphatic monovalent or polyvalent can be used Alcohols or mixtures of these substances and other organic solutions be used.

Nachstehend sind einige Beispiele von erfindungsgemäss hergestellten Mitteln gegen Heteorismus erläutert.Below are some examples of those made in accordance with the invention Means against heteorism explained.

Beispiel 1: 2 kg Pankreatin werden mit Hilfsstoffen zu lo ooo Kernen mit je 200 mg Wirkstoff gepresst und mit einem geeigneten Stoff (Schellack, cAP, Eudragit) magensaftresistent überzogen. In die Drageedecke werden 2,15 kg einer ca. 18,6 %igen Dimethylpolysiloxanemulsion und 1 kg Extr. Cynarae aquosum siccum eingearbeitet.Example 1: 2 kg of pancreatin are converted into lo, ooo kernels with excipients each with 200 mg of active ingredient pressed and with a suitable substance (shellac, CAP, Eudragit) enteric coated. 2.15 kg are placed in the dragee cover approx. 18.6% dimethylpolysiloxane emulsion and 1 kg extr. Cynarae aquosum siccum incorporated.

Beispie; 2: 3 kg Pankreatin werden mit o,2 kg Dimethylpolysiloxan und Hilfsstoffen zu lo ooo Kernen mit je 300 mg Pankreatin und 20 mg Dimethylpolysiloxan gepresst und wie im Beispiel 1 magensaftresistent verarbeitet. In die Drageedecke werden 0,75 kg Extr. Cynarae spirituosum siccum eingearbeitet.Example; 2: 3 kg of pancreatin are mixed with 0.2 kg of dimethylpolysiloxane and auxiliaries for lo, ooo cores each containing 300 mg pancreatin and 20 mg dimethylpolysiloxane pressed and processed enteric-coated as in Example 1. In the dragee blanket 0.75 kg of Extr. Cynarae spirituosum siccum are incorporated.

BeisPiel 3: 1,5 kg Pankreatin werden als Granulat mit geeigneten Stoffen (CAP, Eudragit # , Schellack oder ähnlichem) magensaftresistent umhüllt, Mit 2,15 kg einer ca.Example 3: 1.5 kg of pancreatin are used as granules with suitable substances (CAP, Eudragit #, shellac or similar) coated with gastric juice resistant, with 2.15 kg an approx.

18,6 %igen Emulsion von Dimethylpolysiloxan, 1 kg Extr. Cynarae siccum aus Frischpflanzen gewonnen und Hilfsstoffen werden lo ooo Kerne gepresst, die auf dem üblichen Weg zu Dragees verarbeitet werden.18.6% emulsion of dimethylpolysiloxane, 1 kg Extr. Cynarae siccum obtained from fresh plants and auxiliary materials are lo ooo Pressed cores, which are processed into coated tablets in the usual way.

Claims (4)

Patentansj,rüche:Patent app, smells: 1) Mittel gegen Meteorismus, dadurch gekennzeichnet, dass es neben Methylpolysiloxanen und Pankreatin auch Artischockenextrakt enthält.1) means against meteorism, characterized in that it is next Methylpolysiloxanes and pancreatin also contain artichoke extract. 2) Mittel nach Anspruch 1), dadurch gekennzeichnet, dass Pankreatin vermischt mit Hilfsstoffen magensaftresistent überzogen und in die Drageedecke Dimethylpolysiloxanemulsion und Extr. Cynarae aquosum bzw.2) means according to claim 1), characterized in that pancreatin mixed with adjuvants, coated with gastric juice-resistant coating and put into the dragee cover dimethylpolysiloxane emulsion and Extr. Cynarae aquosum resp. spirituosum siccum eingearbeitet ist. spirituosum siccum is incorporated. 3) Mittel nach Anspruch 1), dadurch gekennzeichnet, dass Pankreatin vermischt mit Dimethylpolysiloxan und Hilfsstoffen magensaftresistent überzogen und in die Drageedecke Extr. Cynarae aquosum bzw. spirituosum siccum eingearbeitet ist.3) means according to claim 1), characterized in that pancreatin mixed with dimethylpolysiloxane and auxiliaries, coated with gastric juice-resistant coating and incorporated into the tablet cover Extr. Cynarae aquosum or spirituosum siccum is. 4) Mittel nach Anspruch 1), dadurch gekennzeichnet, dass Pankreatin magensaftresistent umhütllt und mit einer Emulsion von Dimethylpolysiloxan, Extr. Cynarae siccum und Hilfsstoffen zu Dragees verarbeitet ist.4) means according to claim 1), characterized in that pancreatin enteric coated and coated with an emulsion of dimethylpolysiloxane, extr. Cynarae siccum and additives are processed into coated tablets.
DE19702040425 1970-08-14 1970-08-14 Medicament against meteorism - combining artichoke extract with methylpolysiloxane and pancreatin Pending DE2040425A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19702040425 DE2040425A1 (en) 1970-08-14 1970-08-14 Medicament against meteorism - combining artichoke extract with methylpolysiloxane and pancreatin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19702040425 DE2040425A1 (en) 1970-08-14 1970-08-14 Medicament against meteorism - combining artichoke extract with methylpolysiloxane and pancreatin

Publications (1)

Publication Number Publication Date
DE2040425A1 true DE2040425A1 (en) 1972-02-17

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0968720A2 (en) * 1998-07-02 2000-01-05 Amano Pharmaceutical Co., Ltd. Gastric emptying-promoting composition
DE202008015430U1 (en) * 2008-11-20 2009-12-24 Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh Composition for the treatment of indigestion

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0968720A2 (en) * 1998-07-02 2000-01-05 Amano Pharmaceutical Co., Ltd. Gastric emptying-promoting composition
EP0968720A3 (en) * 1998-07-02 2003-01-22 Amano Enzyme Inc. Gastric emptying-promoting composition
US6656464B2 (en) 1998-07-02 2003-12-02 Amano Pharmaceutical Co., Ltd. Gastric emptying-promoting composition
DE202008015430U1 (en) * 2008-11-20 2009-12-24 Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh Composition for the treatment of indigestion

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