DE102006031441B4 - Oral creatine supplement, and method of making the same - Google Patents

Abstract

Oral creatine supplement with creatine monohydrate and / or creatine phosphate and / or creatine pyruvate and / or creatine citrate or other creatine salts, said ingredient or said ingredients being arranged within at least one enteric coating or capsule (1) that is soluble in the small intestine is or are, characterized in that the sheaths and the capsules are each provided with a sucrose-containing coating on their insides.

Description

The invention relates to an oral creatine supplement according to the preamble of claim 1.

Supplement means supplementation below. Creatine compounds such as creatine monohydrate etc dissolve in acidic aqueous solution, such as in gastric juice, and rapidly convert to creatinine.

Creatinine, however, is recognized in the body as a metabolic breakdown of the muscles and rapidly degraded in the kidneys, and then excreted. A delivery of the valuable starting creatine is prevented by this process of conversion to creatinine, because creatine is excreted instead of absorbed. Muscle building and muscle maintenance is largely prevented. Practice has shown that orally taken creatine or creatine salt is so quickly converted into creatinine in stomach acid that only a tiny fraction of it can be absorbed by the body. Creatinine is then immediately broken down by the kidneys and excreted.

If one wanted to compensate this effect conventionally, then one would have to make such a high Creatinaufnahme that the kidneys would be charged. This is absolutely necessary to prevent.

From the US Pat. No. 6,399,661 B1 For example, there is known a method of making a product, as well as a product itself, in which creatine is mixed with an alkaline powder with the intention of stopping or slowing down the conversion of creatine to creatinine in the acidic gastric environment, such that a larger portion of the creatine Starting material passes into the small intestine and is absorbed there directly.

The disadvantage here is that with an admixture of an alkaline powder, the acid level in the stomach would have to be down regulated so far that the entire stomach would be at an unnaturally low acid level. This can have further lasting adverse effects, not least in terms of further general digestion, especially if the preparation is to support the buildup of muscle during a workout.

When sodium bicarbonate is used as an acid buffer, it is also broken down in the stomach into sodium chloride and carbon dioxide, which may lead to anemia of the stomach as well as to further hypersecretion and thus to further hyperacidity. This is because the stomach produces even more stomach acid.

This would do exactly the opposite and very quickly creatine will be converted into the unwanted creatinine.

From the US 2005/0197321 A1 Creatine phosphate with an enteric coating is already known. Envelopes of this active ingredient of cellulose are in the US 2003/0215506 A1 described. Hartkapselausführungen with hard gelatin are from the EP 0 947 194 B1 known.

The invention is therefore based on the object, an oral creatine supplement d. H. To condition creatine supplements to the extent that a conversion into creatinine is actually largely prevented.

The stated object is achieved with an oral creatine supplement according to the invention by the features of claim 1.

Further advantageous embodiments are specified in the dependent claims 2 to 7.

The essence of the invention is to move the creatine or creatine salt largely unscathed through the stomach and only in the much more alkaline small intestine directly to the absorption as creatine. This is done by arranging said ingredient (s) within an enteric-coated and small-intestine-soluble wrapper or capsule. This prevents the entire stomach from having to be alkalized to prevent conversion to creatinine.

The creatine starting product is thus at least largely unscathed through the stomach through to the small intestine, in which then the sheath dissolved and the creatine starting material can be almost completely absorbed.

Creatine is needed in muscle building phases both during convalescence in the sick, but also in the training of athletes.

During such a build-up phase, permanent gastriceralization of the prior art would be problematic.

For this reason, in the present invention, the creatine starting product is passed through the acidic gastric environment into the much more alkaline small intestinal level.

This has the advantage that compared to the above-cited prior art significantly smaller amounts of creatine can be dosed, because much more creatine is preserved to the small intestine, and also a complication-prone acid buffering of the stomach is completely unnecessary.

Instead, the creatine effectively enters the small intestine's absorption zone and creatine supplementation is avoided, thereby avoiding additional stress on the kidneys. Unwanted infections are thus avoided.

The fact that the acid level of the stomach remains completely undisturbed, the bactericidal function of gastric acid level is retained. This in turn leaves the rest of the digestion undisturbed.

In a further advantageous embodiment, it is stated that the ingredient or the ingredients are subdivided into several quantity portions, such that each quantity portion is arranged in a separate further envelope or capsule, so that a capsule-in-capsule form or a coated dragee in capsule form.

As a result, an advantageous temporally distributed uptake of creatine in the small intestine can be achieved.

A simple but very effective way to achieve this is that at least part of the active ingredient is in the form of coated microcapsules, which in turn are arranged in a larger capsule.

Nutritional physiological optimization is achieved by adding the following further ingredients,
Vitamins, and / or trace elements, and / or
Minerals, and / or amino acids, and / or proteins, and / or enzymes, and / or animal and / or vegetable fats and / or fruit acids.

In an advantageous embodiment, it is stated that the supplement is designed as a modular system with which substance permutations of specified creatine and supplemental substances are present in isolated form and can be introduced into corresponding size-nested capsules.

The wrappers or capsules are each provided on their insides with a sugary coating. The sucrose-containing coating on the inside of the capsule or wrapper ensures that this sugar is not available in the stomach but only in the small intestine. The intake of creatine in the small intestine is significantly improved by the additional local supply of sugar. It is important that the sugar is not already dissolved by the placement of sugar on the inside of the wrapper or capsule, but only at the place in the small intestine, at the same time there is also the creatine, also brings with it. Overall, this leads to an additional improvement in creatine absorption, wherein the sugar is dissolved and absorbed only in the small intestine because of the inner placement.

The wrapper or capsule is made of shellac or other gastric acid-resistant substances.

The invention is illustrated in the drawing and described in more detail below.

It shows:

1 : first embodiment with capsule and Mikroperls

2 : Capsule with gel-like substance

3 : Capsule with microperls dispersed in gel

1 shows a first embodiment of the invention in which the active ingredient creatine, for example as creatine monohydrate and / or creatine phosphate and / or creatine pyruvate and / or creatine citrate or creatine salts in so-called small Mikroperls 2 pressed. These are in a capsule 1 portioned, which is externally enteric-coated but soluble in the small intestine. As a result, this happens intact the stomach and is only dissolved in the small intestine. This prevents creatinine formation in an acidic environment. In the meantime, the named active ingredient creatine is first dissolved in the much more alkaline environment of the small intestine and immediately absorbed there. A conversion into creatinine is thus practically no longer.

In order to further promote the absorption of creatine in the small intestine, the capsule is in this embodiment 1 on its inside with a sucrose-containing coating 5 Mistake.

The placement of this coating on the inside causes that they also first in the small intestine, d. H. parallel to the uptake of creatine in the small intestine is available. This then leads to a further optimization of the local creatine uptake by the body.

The capsule can be filled with other admixtures, including, for example
Vitamins, and / or trace elements, and / or
Minerals, and / or amino acids, and / or proteins,
and / or enzymes, and / or animal and / or vegetable fats, and / or herbal extracts and / or fruit acids,
belong.

2 shows another embodiment, which is an enteric-coated and small intestine-soluble capsule 1 contains. This points as in 1 a sucrose-containing inner coating 5 on.

In this embodiment, the creatine and optionally admixtures are dispersed or dissolved in a gel. This is then absorbed in the small intestine. Likewise, the gel may be sugary.

Overall, the oral creatine supplement can be easily prepared, but creatine-in-creatinine conversion in the acid level of the stomach is reliably prevented. The kidneys are thus relieved, and creatine uptake in the muscle area is significantly optimized.

Due to the modular principle, the microperls or dragees can be provided with different thicknesses of casing, or it can be smaller portion capsules in a large capsule 1 filled with time delay one after the other dissolve in the small intestine and the creatine is absorbed over a long period of time.

LIST OF REFERENCE NUMBERS

1

capsule

2

Mikroperls

2 '

Mikroperl coating

3

Admixtures, vitamins etc

4

gel

5

sugary coating

Claims (7)

Oral creatine supplement with creatine monohydrate and / or creatine phosphate and / or creatine pyruvate and / or creatine citrate or other creatine salts wherein said ingredient (s) within at least one enteric coated and small intestine soluble capsule or capsule ( 1 ) is arranged or are, characterized in that the sheaths and the capsules are each provided on their inner sides with a sucrose-containing coating. Oral creatine supplement according to claim 1, characterized in that the ingredient or the ingredients are subdivided into several quantity portions such that each quantity portion in a separate further envelope or capsule ( 1 ) so as to give a capsule-in-capsule form or a coated dragee-in-capsule form. Oral creatine supplement according to claim 1 or 2, characterized in that at least part of the active ingredient in the form of coated microcapsules ( 2 ), which in turn is contained in a larger capsule ( 1 ) are arranged. Oral creatine supplement according to claim 2 or 3, characterized in that the sheaths ( 1 ) are added in portions to the delayed dissolution in the small intestine and are nested one inside the other. Oral creatine supplement according to one of claims 1 to 4, characterized, that the following further ingredients are added, Vitamins, and / or trace elements, and / or minerals, and / or amino acids, and / or proteins, and / or enzymes, and / or animal and / or vegetable fats, and / or plant extracts, and / or fruit acids. Oral creatine supplement according to one of claims 1 to 5, characterized in that the supplement is designed as a kit with which substance permutations of specified creatine and supplements are present in isolated form and can be introduced into corresponding size nested capsules. Oral creatine supplement according to one of claims 1 to 9, characterized in that the envelope ( 2 ' ) or the capsule ( 1 ) consists of shellac.

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