DE102006031441A1 - Oral creatine supplement comprises creatine monohydrate, -phosphate, -pyruvate, -citrate or other -salts, which are enclosed within an encasement that is resistant to gastric juice and soluble in the small intestine - Google Patents

Abstract

Oral creatine supplement (I) comprises creatine monohydrate, creatine phosphate, creatine pyruvate, creatine citrate or other creatine salts, where the ingredient(s) is/are enclosed within at least an encasement or coating or capsule (1) that is resistant to gastric juice and soluble in the small intestine. An independent claim is included for producing (I).

Description

The The invention relates to an oral creatine supplement, and a method for the production thereof, according to the preamble of the claims 1 and 11.

With Supplement is meant after nutritional supplementation. Creation connections How to solve creatine monohydrate etc yourself in sour watery Solution, as for example in gastric juice, and build up very fast into creatinine.

creatinine gets in the body however, recognized as a metabolic breakdown product of the musculature and in the Kidneys degrade very quickly, and then excreted. A feeder of the valuable source of creatine is through this process of Conversion into creatinine prevented because creatine excreted instead is recorded. Muscle building and muscle maintenance is largely prevented.

The Practice has shown that orally ingested creatine or creatine salt so fast in the stomach acid Rebuilding in creatinine is just a vanishingly minor Part of the body can be included.

creatinine but is then immediately broken down by the kidneys and excreted becomes.

Would you this effect conventional would like to compensate you take such a high creatine intake that the kidneys would be charged. This is absolutely to prevent.

From the US 6,399,661 For example, there is known a method of making a product, as well as a product itself, in which creatine is mixed with an alkaline powder with the intention of stopping or slowing down the conversion of creatine to creatinine in the acidic gastric environment, such that a major portion of the creatine Starting material passes into the small intestine and is absorbed there directly.

adversely here is that when admixing an alkaline powder, the acidity level in the stomach should be down regulated so far that the whole Stomach on an unnatural low acid level would be located. This can be further lasting adverse effects not least in Terms of further general digestion, especially then if the drug while building muscle to support a workout.

at a use of sodium bicarbonate as an acid buffer this is also split in the stomach in sodium chloride and Carbon dioxide, which causes it on the one to a flatulence of the stomach, as well as to a further hypersecretion and thus can lead to further hyperacidity. This is because the stomach produces even more stomach acid.

So would be accurate the opposite effect and very quickly creatine rebuilt into the unwanted creatinine become.

Of the The invention is therefore based on the object, an oral creatine supplement i.e. Creatine supplements to condition that a conversion to creatinine actually largely is prevented.

The asked task is in an oral creatine supplement according to the invention the features of claim 1 solved.

Further Advantageous embodiments are in the dependent claims 2 to 10 indicated.

Regarding a method for producing the oral according to the invention Creatine supplements according to the invention by the features of claim 11 solved.

A further advantageous embodiment is specified in claim 12.

core The invention is the creatine or creatine salt largely unscathed to move through the stomach and only in the much more alkaline small intestine directly to the absorption as creatine. That is done by said Ingredient or said ingredients within a gastro-resistant and small intestine soluble wrapping or capsule is arranged or are. This prevents that the entire stomach needs to be alkalized in order to be converted into Prevent creatinine.

The Creatine starting product is thus at least largely undamaged through the stomach into the small intestine, in which then the wrapping disbanded and the creatine starting product can be almost completely absorbed.

creatine is used in muscle building phases both during convalescence Sick, but also needed during training of athletes.

During one such a construction phase would be a Permanent alkalization of the stomach, according to the state described above the technology be problematic.

For this reason, at the present Invention, the creatine starting product through the acidic gastric environment into the much more alkaline small intestinal level slid.

This has the advantage over that the above-cited prior art much smaller creatine levels can be dosed because much more creatine is preserved to the small intestine, and also a complication-endangered acid buffering of the stomach completely unnecessary becomes.

Instead Creatine effectively enters the absorption zone of the small intestine and the onset of creatinine is avoided, creating an extra Stress on the kidneys is avoided as well. Unwanted infections are thus avoided.

Thereby that the acid level of the stomach completely undisturbed remains, remains the bactericidal function of the gastric acid level receive. This in turn leaves and the rest Digestion undisturbed.

In Another advantageous embodiment is specified that the ingredient or the ingredients are divided into several quantity portions, such that each quantity portion in a separate further envelope or Capsule is arranged so that a capsule-in-capsule shape and / or a coated-dragee-in-capsule form results.

Thereby let yourself achieve an advantageous temporally distributed uptake of creatine in the small intestine.

A simple but very effective way to accomplish this is by doing so given that at least part of the active ingredient in the form of coated microcapsules is present, which in turn are arranged in a larger capsule.

Nutritional physiological optimization is achieved by adding the following further ingredients,
Vitamins, and / or trace elements, and / or minerals, and / or amino acids, and / or proteins, and / or enzymes, and / or animal and / or vegetable fats and / or fruit acids.

In Advantageous embodiment is indicated that the supplement as Construction kit executed is with what substance permutations of specified creatine and supplements present in isolated form and in corresponding size nested Capsules are introduced.

A particularly advantageous embodiments is that the sheaths and / or the capsules on their insides each with a sugary Coating are provided. The sugary coating on the Inside the capsule or wrapping guaranteed that this sugar is not available in the stomach but only in the small intestine. The intake of creatine in the small intestine is through the additional local provision of sugar is still significantly improved.

Important Here is that by placing the sugar on the inside serving or Capsule, the sugar is not solved before, but only at the Place in the small intestine, at the same time there is also the creatine, also brings with it. this leads to overall an additional improvement creatine absorption, the sugar because of the inside placement also only in small intestine disbanded and recorded. Akternativ to the sugar but also easy into the gastric acid resistant Capsule or the correspondingly wrapped Dragee filled with or be added.

In a possible advantageous embodiment, the envelope and / or the capsule consists of soft or hard gelatin.

A Alternative is that the wrapping and / or the capsule can be made of cellulose.

A Another alternative is that the sheath and / or the capsule off Shellac or other fortifying agents Substances may exist.

in the With regard to a method for producing a creatine supplement with creatine monohydrate and / or creatine phosophate and / or creatine pyruvate and / or creatine citrate or other creatine salts wherein said Ingredient or said ingredients within a gastro-resistant and small intestine-soluble wrapping or capsule, becomes a simple but effective manufacture provided by a creatine supplement, which later included Creatine product is not dissolved in the stomach, where it is the harmful creatinine forms, but first in the small intestine, where then essentially avoiding Creatininumbaues the creatine can be absorbed effectively.

A advantageous embodiment is that the creatine supplement is pressed as microcapsules, consisting of a portioned stock taken and in an enteric-coated and small intestine-soluble capsule in a freely determinable amount filled become.

The Invention is shown in the drawing and below described in more detail.

It shows:

1 : first embodiment with capsule and Mikroperls

2 : Capsule with gel-like substance

3 : Capsule with microperls dispersed in gel

1 shows a first embodiment of the invention in which the active ingredient creatine, for example as creatine monohydrate and / or creatine phosphate and / or creatine pyruvate and / or creatine citrate or creatine salts in so-called small Mikroperls 2 pressed. These are in a capsule 1 portioned, which is externally enteric-coated but soluble in the small intestine. As a result, this happens intact the stomach and is only dissolved in the small intestine. This prevents creatinine formation in an acidic environment. In the meantime, the named active ingredient creatine is first dissolved in the much more alkaline environment of the small intestine and immediately absorbed there. A conversion into creatinine is thus practically no longer.

In order to further promote the absorption of creatine in the small intestine, the capsule is in this embodiment 1 on its inside with a sugary coating 5 or sugar is added to the capsule. The placement of this coating on the inside or the other addition of sugar causes that it is also available only in the small intestine, ie parallel to the uptake of creatine in the small intestine. This then leads to a further optimization of the local creatine uptake by the body.

The capsule can be filled with other admixtures, including, for example
Vitamins, and / or trace elements, and / or minerals, and / or amino acids, and / or proteins, and / or enzymes, and / or animal and / or vegetable fats, and / or herbal extracts and / or fruit acids,
belong.

Basically depending on the application, there are two options.

1st option:

The capsule 1 is enteric-coated and soluble in small intestine, and coated with sugar on the inside. The creatine present as microperls or as a powder and, if appropriate, the admixtures are filled into the capsule and not additionally coated.

2nd option:

The capsule 1 is already soluble in gastric juice, as are the admixtures. Only the microperls or dragées with creatine are enteric-coated and soluble in the small intestine. In contrast to the first option, the admixtures in the form of vitamins etc are already dissolved in the stomach because the capsule is already there 1 dissolves. As the microperls or dragées, which contain creatine, however, are resistant to gastric juice and are soluble in the intestine, they pass undissolved through the stomach and are absorbed only in the small intestine.

So can be any combined, and combined with other substances Partial absorption are achieved, respectively, where the said substances absorb better.

2 shows another embodiment, which is an enteric-coated and small intestine-soluble capsule 1 contains. This can be like in 1 a sugar-containing inner coating 5 or adding sugar to the capsule. In this embodiment, the creatine and optionally admixtures are dispersed or dissolved in a gel. This is then absorbed in the small intestine. Likewise, the gel may be sugary.

3 shows an embodiment in which the capsule 1 with a gel 4 is filled, in which the creatine as Mikroperls 2 is dispersed. The gel may contain further admixtures as described above.

Also There are 2 options.

1st option:

The capsule 1 can be gastric juice-soluble, while the microperls are enteric-coated and soluble in the small intestine.

2nd option:

The Capsule may be enteric and small intestine soluble, while the Mikroperls are without further coating.

All in all let yourself making the oral creatine supplement easy, but creatine-in-creatinine remodeling in the acid level of the stomach is reliable prevented. The kidneys are relieved, and the creatine intake in the muscle area is clearly optimized.

Due to the modular principle, the microperls or dragees can be provided with different thicknesses of casing, or it can be smaller portion capsules in a large capsule 1 filled with time delay one after the other dissolve in the small intestine and the creatine is absorbed over a long period of time.

1

capsule

2

Mikroperls

2 '

Mikroperl coating

3

admixtures Vitamins etc

4

gel

5

sugary coating

Claims (12)

Oral creatine supplement with creatine monohydrate and / or creatine phosophate and / or creatine pyruvate and / or creatine citrate or other creatine salts, wherein said ingredient or said ingredients are contained within at least one enteric coating and coating ( 2 ' ) or capsule ( 1 ) is arranged or are. Oral creatine supplement according to claim 1, characterized in that the ingredient or the ingredients are subdivided into several quantity portions such that each quantity portion in a separate further envelope or capsule ( 1 ), so as to give a capsule-in-capsule form and / or a coated dragee-in-capsule form. Oral creatine supplement according to claim 1 or 2, characterized in that at least part of the active ingredient in the form of coated microcapsules ( 2 ), which in turn is contained in a larger capsule ( 1 ) are arranged. Oral creatine supplement according to claim 2 or 3, characterized in that the sheaths ( 1 ) or ( 2 ' ) are added in portions to the delayed dissolution in the small intestine and are nested one inside the other. Oral creatine supplement according to one of claims 1 to 4, characterized, the following additional ingredients are mixed in, Vitamins, and / or trace elements, and / or Minerals, and / or amino acids, and / or proteins, and / or enzymes, and / or animal and / or vegetable Fats, and / or herbal extracts, and / or fruit acids. Oral creatine supplement according to one of claims 1 to 5, characterized in that the supplement is designed as a kit, with which substance permutations of specified creatine and supplements present in isolated form and in corresponding size nested Capsules are introduced. Oral creatine supplement according to one of claims 1 to 6, characterized in that the sheaths and / or the capsules each provided with a sugar-containing coating on their insides, or the capsule filled with sugar are. Oral creatine supplement according to one of claims 1 to 7, characterized in that the envelope ( 2 ' ) and / or the capsule ( 1 ) consists of soft or hard gelatin. Oral creatine supplement according to one of claims 1 to 8, characterized in that the envelope ( 2 ' ) and / or the capsule ( 1 ) consists of celluslose. Oral creatine supplement according to one of claims 1 to 9, characterized in that the envelope ( 2 ' ) and / or the capsule ( 1 ) consists of shellac. Process for the preparation of a creatine supplement with creatine monohydrate and / or creatine phosophate and / or creatine pyruvate and / or creatine citrate or other creatine salts, said Ingredient or said ingredients within a gastro-resistant and small intestine soluble wrapping or capsule. Method according to claim 11, characterized in that that the creatine supplement be pressed as microcapsules, the taken from a portioned stock and in an enteric and small intestine soluble capsule be filled in a freely determinable amount.