DE202008016372U1 - Vitamin-containing composition - Google Patents

Abstract

Vitamin-containing composition, in particular suitable for nutritive balanced supplementation of the diet in inner ear diseases, wherein the composition comprises as active ingredients the substances:
At least one vitamin or vitamin mixture selected from the group comprising vitamin A, vitamin C, vitamin E, vitamin B ₁ , vitamin B ₂ , nicotinamide, vitamin B ₆ , vitamin B ₁₂ , vitamin D, folic acid, pantothenic acid and / or biotin;
- At least one mineral, trace element or mixture thereof selected from the group comprising magnesium, selenium, zinc, manganese, copper, chromium and / or molybdenum;
At least one amino acid or amino acid mixture selected from the group comprising lysine, cysteine, acetylcysteine and / or cystine;
At least one secondary plant substance selected from the group comprising carotenoids and / or flavonoids;
At least one secondary plant substance selected from the group comprising polyphenols and / or anthocyanins;
At least one micronutrient selected from the group comprising coenzyme Q10, carnitine, taurine, inositol and / or α-lipoic acid, and
- Omega-3 fatty acids.

Description

The The present invention relates to a vitamin-containing composition, especially for nutritive balanced supplementation of the diet Inner ear disease is suitable.

The Inner ear serves as a warning, communication and navigation organ. For this complex functions consumes the inner ear already in normal operation size Amounts of energy. Already healthy individuals need for their auditory physiological processes and for the permanent, necessary repair processes as a result of extreme mechanical stress on the hair cells much energy in the form of adenosine triphosphate (ATP). So are for the maintenance of the potassium-rich endolymph, the strengthening and filtering function the outer hair cells, the production of the resting state after the depolarization and Hair cell repair processes require large amounts of ATP.

physical Stressors such as audiovisual overstimulation as well as mental Stressors can to cochleen Microcirculation disorders to lead, these being metabolic disorders partly ultimately to apoptotic or necrotic cell death and thus an irrevocable, lifelong hearing loss lead with or without accompanying sinusitis can. Furthermore, about 5 to 10 percent of adults suffer from one more or less severe tinnitus. Due to the increasing noise and Stress is assumed to be that number in the future will continue to increase.

A variety of drug treatments for inner ear disease with various substances such as glucocorticoids, vasodilators, calcium channel blockers or circulation enhancing agents for improving the circulation of the brain and the inner ear is known. The prior art further discloses the use of vitamin preparations in tinnitus. Known vitamin and mineral products contain various compositions of vitamins, often in particular vitamin B ₁₂ and folic acid.

adversely in the known preparations However, that is the increased and complex nutritional needs the stress-damaged Inner ear not sufficiently taken into account by coordinated preparations becomes.

In a society in which stress and overstimulation continue to increase, There is also a need for a means that improves performance of the inner ear. About that There is also a need for a means to provide a supply for the service of the inner ear can ensure necessary micronutrients.

It is therefore the object of the present invention, a means for disposal to provide at least one of the aforementioned disadvantages of The state of the art overcomes. In particular, it is the object of the present invention to provide a Composition available which is suitable for use in tinnitus.

• – wenigstens ein Vitamin oder Vitamingemisch ausgewählt aus der Gruppe umfassend Vitamin A, Vitamin C, Vitamin E, Vitamin B₁, Vitamin B₂, Nicotinamid, Vitamin B₆, Vitamin B₁₂, Vitamin D, Folsäure, Pantothensäure und/oder Biotin;
• – wenigstens einen Mineralstoff, Spurenelement oder deren Gemisch ausgewählt aus der Gruppe umfassend Magnesium, Selen, Zink, Mangan, Kupfer, Chrom und/oder Molybdän;
• – wenigstens eine Aminosäure oder Aminosäurengemisch ausgewählt aus der Gruppe umfassend Lysin, Cystein, Acetylcystein und/oder Cystin;
• – wenigstens einen sekundären Pflanzenstoff ausgewählt aus der Gruppe umfassend Carotinoide und/oder Flavonoide;
• – wenigstens einen sekundären Pflanzenstoff ausgewählt aus der Gruppe umfassend Polyphenole und/oder Anthocyane;
• – wenigstens einen Mikronährstoff ausgewählt aus der Gruppe umfassend Coenzym Q10, Carnitin, Taurin, Inositol und/oder α-Liponsäure, und
• – Omega-3-Fettsäuren.

This object is achieved by a vitamin-containing composition, in particular suitable for nutritive balanced supplementation of the diet in inner ear diseases, wherein the composition comprises as active ingredients the substances:

• At least one vitamin or vitamin mixture selected from the group comprising vitamin A, vitamin C, vitamin E, vitamin B ₁ , vitamin B ₂ , nicotinamide, vitamin B ₆ , vitamin B ₁₂ , vitamin D, folic acid, pantothenic acid and / or biotin;
• - At least one mineral, trace element or mixture thereof selected from the group comprising magnesium, selenium, zinc, manganese, copper, chromium and / or molybdenum;
• At least one amino acid or amino acid mixture selected from the group comprising lysine, cysteine, acetylcysteine and / or cystine;
• At least one secondary plant substance selected from the group comprising carotenoids and / or flavonoids;
• At least one secondary plant substance selected from the group comprising polyphenols and / or anthocyanins;
• At least one micronutrient selected from the group comprising coenzyme Q10, carnitine, taurine, inositol and / or α-lipoic acid, and
• - Omega-3 fatty acids.

For the purposes of this invention, the term "substance" is to be understood as meaning the substances which deprive the vitamin containing composition, in particular vitamins, minerals and trace elements, amino acids, phytochemicals selected from the group comprising carotenoids, flavonoids, anthocyanins and polyphenols, coenzyme Q10, carnitine, taurine, inositol, α-lipoic acid and omega-3 fatty acids.

Surprised could be found that a complementary diet with the vitamin according to the invention composition containing otoprotektive effects in particular an improvement in hearing loss after a hearing loss can cause.

Surprised In particular, it has been found that by the composition according to the invention a comprehensive support of the inner ear especially in stress-related inner ear diseases such as sudden hearing loss, Tinnitus, noise-induced and ototoxic hearing loss can be effected.

Under the term "stress-related Inner ear diseases "are For the purposes of this invention, inner ear diseases are to be understood, which through physical and / or mental stressors, such as audiovisual Sensory overload or metabolic disorders caused.

Under The term "tinnitus" are in the sense of this Invention not objectible ear noises to understand the a permanent one Excitement of the auditory sensory cell passed as a signal to the brain and in the cortex as tinnitus be perceived.

Under A "hearing loss" are in the sense of this Invention without apparent cause suddenly occurring in the rule one-sided sensorineural hearing loss of different Severity to understand about deafness. Parallel to the acute hearing impairment often Ringing in the ears (Tinnitus) on, partly also feeling of pressure in the ear, double-tone hearing as well as over-loud Perceiving noises and dizziness.

The Vitamin according to the invention containing composition Omega-3 fatty acids. In preferred embodiments In the composition, the omega-3 fatty acids are selected from the group comprising docosahexaenoic acid and / or eicosapentaenoic acid, being docosahexaenoic acid is particularly preferred. Preferably, omega-3 fatty acids are in Form of fish oil usable.

Prefers is the weight ratio of docosahexaenoic acid to eicosapentaenoic acid in the range of ≥ 1: 1 to ≤ 5: 1, preferably in the range of ≥ 1.2: 1 up to ≤ 2.5: 1, more preferably in the range of ≥ 1.4: 1 to ≤ 1.8: 1.

Without Being committed to a particular theory, it is believed that a surplus on docosahexaenoic acid across from eicosapentaenoic acid to improve the positive effects of the composition according to the invention on hemostasis and blood rheology.

In preferred embodiments contains the composition α-lipoic acid. From The advantage is that administration of α-lipoic acid in particular damage Hair cells can positively influence. In particular, by administration of α-lipoic acid the ototoxicity be reduced by cisplatin. Ototoxicity and tinnitus are common side effects chemotherapy with platinum derivatives, especially cisplatin. Chemotherapy with platinum derivatives, especially cisplatin especially in the pediatric Oncology a high priority, side effect of cisplatin therapy However, tinnitus and ototoxicity are most common. Especially the hair cells are affected, leading to deafness to lead can. Therefore, administration of the vitamin according to the invention composition further comprising α-lipoic acid Of particular benefit to chemotherapy with cisplatin.

Further can be a supplementary nutrition and / or a supporting one dietetic Containing treatment with a composition according to the invention furthermore α-lipoic acid in advantageous Way a significant strengthening of the inner ear in stress-related inner ear diseases. In particular, seems a combination of omega-3 fatty acids and secondary Plant substances, in particular flavonoids, polyphenols and anthocyanins Contained in extracts of citrus fears, blueberries, red wine grapes and elderberries with α-lipoic acid a surprising good synergistic effect in the treatment of stress-related inner ear diseases like hearing loss, Tinnitus, noise-induced and ototoxic hearing loss to effect.

In preferred embodiments the composition comprises flavonoids obtainable from citrus fruits, in particular Bioflavonoids. Preference is given to using flavonoids in particular Bioflavonoids in the form of extracts of citrus fruits.

Under The term "extract" is used in the sense this invention extracts of solid, liquid and / or oily texture understood by plants, especially their fruits or seeds. Taking a "citrus extract" is appropriate an extract of citrus fruits to understand. An advantage of useful extracts lies in the natural Composition of the constituents, in particular of the flavonoids contained. A particular advantage is that the bioavailability of those contained in extracts Flavonoids higher may be than using synthetic compositions. Furthermore, there is an advantage in improved nutritional effectiveness. Without being bound by theory it is believed that this on the synergistic effect of those contained in the complex mixture Substances is due.

Under Flavonoids available from citrus fruits For the purposes of this invention, flavonoids are those found in citrus fruits are. Under the term "bioflavonoids" are in the sense of this Invention relates to the family of flavonoids associated biologically active flavonoids to understand. Under the term "citrus bioflavonoids" are correspondingly to understand biologically active flavonoids contained in citrus fruits are.

Usable according to the invention Carotenoids preferably include carotenoids selected from the group comprising beta-carotene, lutein and / or lycopene. Preferably mixed carotenoids are used. Under "mixed carotenoids" is in the sense of this Invention a mixture of different different carotenoids and / or carotenoid derivatives understood.

In further preferred embodiments the composition comprises polyphenols obtainable from red wine grapes and / or Anthocyanins available from blueberries, red grapes and / or elderberries. Prefers usable are polyphenols and anthocyanins in the form of extracts from blueberries, red grapes and / or elderberries.

Especially preferably usable are polyphenols in the form of extracts from Red wine grapes. Preferred polyphenols are in particular selected from the group comprising oligomeric proanthocyanidins (OPC), proanthocyanidins, Resveratrol and / or catechins.

In In particular, extracts of red wine grapes are advantageous usable. The polyphenols contained in extracts of red wine grapes can due to the balanced composition of the extracts compared to synthetic Compositions cause better bioavailability of the contained polyphenols.

Further anthocyanins in the form of extracts are particularly preferred from blueberries, red grapes and / or elderberries. Under Anthocyanins are the glycosides for the purposes of the present invention to understand the anthocyanidins. The sugar residues are preferred Bound O-glycosidically. Preferred anthocyanins are selected from the group comprising glycosides of pelargonidin, cyanidin, delphinidin, petunidin, peonidine and / or malvidin.

Further advantageous are extracts of blueberries, red grapes and / or Elderberries usable. Again, it is believed that the in Extracts of blueberries, red grapes and elderberries contained Anthocyanins by the balanced composition of the extracts over synthetic Compositions a better bioavailability of the contained anthocyanins can effect.

It has been surprising shown in particular by the use of extracts from Citrus fruits, Red wine grapes, blueberries and / or elderberries the holistic quality of the composition can be significantly improved.

Further advantageous properties result from the on a long-term Strengthening the increased nutritional requirements the stress-damaged Inner ear tuned composition of the substances contained, to a strengthening of the inner ear.

The composition comprises at least one vitamin or vitamin mixture selected from the group comprising vitamin A, vitamin C, vitamin E, vitamin B ₁ , vitamin B ₂ , nicotinamide, vitamin B ₆ , vitamin B ₁₂ , vitamin D, folic acid, pantothenic acid and / or biotin , Preferably, the composition comprises vitamin A, vitamin C, vitamin E, vitamin B _1, vitamin B _2, nicotinamide, vitamin B _6, vitamin B _12, vitamin D, folic acid, pantothenic acid and biotin. Contained vitamin D is preferably vitamin D ₃ .

Vitamin E which can be used according to the invention preferably comprises tocotrienols, alpha-tocopherol and Gamma-tocopherol. Natural alpha-tocopherols are particularly preferred, but synthetic vitamin E and / or mixtures of natural and synthetic vitamin E are also usable.

The advantageous properties of the composition will continue by an adequate supply of minerals and trace elements, such as magnesium, selenium, zinc, manganese, copper, chromium and / or molybdenum reinforced. Prefers has the composition magnesium, selenium, zinc, manganese, copper, Chromium and molybdenum on.

Farther the composition comprises at least one amino acid or Amino acid mixture selected from the group comprising lysine, cysteine, acetylcysteine and / or cystine, preferably lysine and cystine. Preference is given to L-lysine, L-cysteine, N-acetyl-L-cysteine and L-cystine.

Further Preferably, the composition comprises coenzyme Q10, carnitine in particular L-carnitine, taurine and inositol.

• – α-Liponsäure im Bereich von ≥ 10 mg bis ≤ 600 mg; und/oder
• – Vitamin A im Bereich von ≥ 0,3 mg bis ≤ 1 mg; und/oder
• – Vitamin C im Bereich von ≥ 100 mg bis ≤ 1500 mg; und/oder
• – Vitamin E im Bereich von ≥ 50 mg bis ≤ 400 mg; und/oder
• – Vitamin B₁ im Bereich von ≥ 1 mg bis ≤ 25 mg; und/oder
• – Vitamin B₂ im Bereich von ≥ 1 mg bis ≤ 25 mg; und/oder
• – Nicotinamid im Bereich von ≥ 5 mg bis ≤ 75 mg; und/oder
• – Vitamin B₆ im Bereich von ≥ 1 mg bis ≤ 25 mg; und/oder
• – Vitamin B₁₂ im Bereich von ≥ 1 μg bis ≤ 100 μg; und/oder
• – Vitamin D₃ im Bereich von ≥ 1 μg bis ≤ 20 μg; und/oder
• – Folsäure im Bereich von ≥ 0,1 mg bis ≤ 2 mg; und/oder
• – Pantothensäure im Bereich von ≥ 5 mg bis ≤ 50 mg; und/oder
• – Biotin im Bereich von ≥ 50 μg bis ≤ 250 μg; und/oder
• – Magnesium im Bereich von ≥ 100 mg bis ≤ 400 mg; und/oder
• – Selen im Bereich von ≥ 10 μg bis ≤ 300 μg; und/oder
• – Zink im Bereich von ≥ 2 mg bis ≤ 50 mg; und/oder
• – Mangan im Bereich von ≥ 0,5 mg bis ≤ 5 mg; und/oder
• – Kupfer im Bereich von ≥ 0,1 mg bis ≤ 2,5 mg; und/oder
• – Chrom im Bereich von ≥ 10 μg bis ≤ 200 μg; und/oder
• – Molybdän im Bereich von ≥ 10 μg bis ≤ 200 μg; und/oder
• – Lysin im Bereich von ≥ 50 mg bis ≤ 1000 mg; und/oder
• – Cystin und/oder Acetylcystein im Bereich von ≥ 20 mg bis ≤ 200 mg; und/oder
• – Flavonoide, insbesondere erhältlich aus Citrusfrüchten im Bereich von ≥ 2 mg bis ≤ 100 mg; und/oder
• – Carotinoide, umfassend Carotinoide ausgewählt aus der Gruppe umfassend Beta- Carotin, Lutein und Lycopin im Bereich von ≥ 2 mg bis ≤ 25 mg;
• – Anthocyane insbesondere erhältlich aus Heidelbeeren, Rotweintrauben und/oder Holunderbeeren im Bereich von ≥ 5 mg bis ≤ 500 mg; und/oder
• – Polyphenole insbesondere erhältlich aus Rotweintrauben im Bereich von ≥ 5 mg bis ≤ 500 mg; und/oder
• – Coenzym Q10 im Bereich von ≥ 5 mg bis ≤ 100 mg; und/oder
• – Carnitin im Bereich von ≥ 50 mg bis ≤ 500 mg; und/oder
• – Taurin im Bereich von ≥ 50 mg bis ≤ 500 mg; und/oder
• – Inositol im Bereich von ≥ 50 mg bis ≤ 300 mg; und/oder
• – Omega-3-Fettsäuren im Bereich von ≥ 0,1 g bis ≤ 2 g.

In preferred embodiments, the vitamin-containing composition, based on a daily dose of the vitamin-containing composition, comprises as active ingredients the substances:

• - α-lipoic acid in the range of ≥ 10 mg to ≤ 600 mg; and or
• - Vitamin A in the range of ≥ 0.3 mg to ≤ 1 mg; and or
• - Vitamin C in the range of ≥ 100 mg to ≤ 1500 mg; and or
• - Vitamin E in the range of ≥ 50 mg to ≤ 400 mg; and or
• - Vitamin B ₁ in the range of ≥ 1 mg to ≤ 25 mg; and or
• - Vitamin B ₂ in the range of ≥ 1 mg to ≤ 25 mg; and or
• - Nicotinamide in the range of ≥ 5 mg to ≤ 75 mg; and or
• - Vitamin B ₆ in the range of ≥ 1 mg to ≤ 25 mg; and or
• - Vitamin B ₁₂ in the range of ≥ 1 μg to ≤ 100 μg; and or
• - Vitamin D ₃ in the range of ≥ 1 μg to ≤ 20 μg; and or
• - Folic acid in the range of ≥ 0.1 mg to ≤ 2 mg; and or
• - pantothenic acid in the range of ≥ 5 mg to ≤ 50 mg; and or
• - biotin in the range of ≥ 50 μg to ≤ 250 μg; and or
• - Magnesium in the range of ≥ 100 mg to ≤ 400 mg; and or
• - selenium in the range of ≥ 10 μg to ≤ 300 μg; and or
• - zinc in the range of ≥ 2 mg to ≤ 50 mg; and or
• Manganese in the range of ≥ 0.5 mg to ≤ 5 mg; and or
• - copper in the range of ≥ 0.1 mg to ≤ 2.5 mg; and or
• - Chromium in the range of ≥ 10 μg to ≤ 200 μg; and or
• - Molybdenum in the range of ≥ 10 μg to ≤ 200 μg; and or
• - Lysine in the range of ≥ 50 mg to ≤ 1000 mg; and or
• - cystine and / or acetylcysteine in the range of ≥ 20 mg to ≤ 200 mg; and or
• - Flavonoids, in particular obtainable from citrus fruits in the range of ≥ 2 mg to ≤ 100 mg; and or
• Carotenoids comprising carotenoids selected from the group comprising beta-carotene, lutein and lycopene in the range of ≥ 2 mg to ≤ 25 mg;
• - anthocyanins, in particular obtainable from bilberries, red grapes and / or elderberries in the range of ≥ 5 mg to ≤ 500 mg; and or
• Polyphenols, in particular obtainable from red wine grapes in the range of ≥ 5 mg to ≤ 500 mg; and or
• Coenzyme Q10 in the range of ≥ 5 mg to ≤ 100 mg; and or
• - carnitine in the range of ≥ 50 mg to ≤ 500 mg; and or
• Taurine in the range of ≥ 50 mg to ≤ 500 mg; and or
• - inositol in the range of ≥ 50 mg to ≤ 300 mg; and or
• - Omega-3 fatty acids in the range of ≥ 0.1 g to ≤ 2 g.

Under The term "daily dose" is used in the sense of this Signed understanding the amount of the vitamin-containing composition which fed per day is or fed should be, with this amount within the specified Quantity ranges of the respective substances may be.

It It has been found that the composition of the invention has an improved Effect regarding a balanced supply of the inner ear with vitamins, trace elements, Amino acid, secondary Plant substances, micronutrients and omega-3 fatty acids combined with optimized benefits and compatibility can.

In preferred embodiments includes the vitamin-containing composition, based on a Daily dose of the vitamin-containing composition, ≥ 100 mg to ≤ 500 mg, preferably ≥ 160 mg to ≤ 350 mg, preferably ≥ 210 mg to ≤ 280 mg docosahexaenoic acid.

• – α-Liponsäure im Bereich von ≥ 20 mg bis ≤ 300 mg, vorzugsweise im Bereich von ≥ 40 mg bis ≤ 160 mg; und/oder
• – Vitamin A im Bereich von ≥ 450 μg bis ≤ 900 μg, vorzugsweise im Bereich von ≥ 700 μg bis ≤ 850 μg; und/oder
• – Vitamin C im Bereich von ≥ 250 mg bis ≤ 800 mg, vorzugsweise im Bereich von ≥ 475 mg bis ≤ 600 mg; und/oder
• – Vitamin E im Bereich von ≥ 100 mg bis ≤ 300 mg, vorzugsweise im Bereich von ≥ 140 mg bis ≤ 250 mg; und/oder
• – Vitamin B₁ im Bereich von ≥ 2 mg bis ≤ 10 mg, vorzugsweise im Bereich von ≥ 3 mg bis ≤ 6 mg; und/oder
• – Vitamin B₂ im Bereich von ≥ 3 mg bis ≤ 12 mg, vorzugsweise im Bereich von ≥ 4 mg bis ≤ 10 mg; und/oder
• – Nicotinamid im Bereich von ≥ 15 mg bis ≤ 65 mg, vorzugsweise im Bereich von ≥ 40 mg bis ≤ 60 mg; und/oder
• – Vitamin B₆ im Bereich von ≥ 3 mg bis ≤ 20 mg, vorzugsweise im Bereich von ≥ 4 mg bis ≤ 15 mg; und/oder
• – Vitamin B₁₂ im Bereich von ≥ 5 μg bis ≤ 25 μg, vorzugsweise im Bereich von ≥ 7 μg bis ≤ 15 μg; und/oder
• – Vitamin D₃ im Bereich von ≥ 2 μg bis ≤ 10 μg, vorzugsweise im Bereich von ≥ 4 μg bis ≤ 7 μg; und/oder
• – Folsäure im Bereich von ≥ 400 μg bis ≤ 1,2 mg, vorzugsweise im Bereich von ≥ 650 μg bis ≤ 1 mg; und/oder
• – Pantothensäure im Bereich von ≥ 10 mg bis ≤ 30 mg, vorzugsweise im Bereich von ≥ 14 mg bis ≤ 24 mg; und/oder
• – Biotin im Bereich von ≥ 80 μg bis ≤ 200 μg, vorzugsweise im Bereich von ≥ 120 μg bis ≤ 180 μg; und/oder
• – Magnesium im Bereich von ≥ 140 mg bis ≤ 300 mg, vorzugsweise im Bereich von ≥ 160 mg bis ≤ 200 mg; und/oder
• – Selen im Bereich von ≥ 25 μg bis ≤ 100 μg, vorzugsweise im Bereich von ≥ 40 μg bis ≤ 60 μg; und/oder
• – Zink im Bereich von ≥ 4 mg bis ≤ 25 mg, vorzugsweise im Bereich von ≥ 8 mg bis ≤ 12 mg; und/oder
• – Mangan im Bereich von ≥ 1 mg bis ≤ 3 mg, vorzugsweise im Bereich von ≥ 1,5 mg bis ≤ 2,5 mg; und/oder
• – Kupfer im Bereich von ≥ 0,5 mg bis ≤ 1,8 mg, vorzugsweise im Bereich von ≥ 0,8 mg bis ≤ 1,2 mg; und/oder
• – Chrom im Bereich von ≥ 25 μg bis ≤ 100 μg, vorzugsweise im Bereich von ≥ 40 μg bis ≤ 75 μg; und/oder
• – Molybdän im Bereich von ≥ 25 μg bis ≤ 100 μg, vorzugsweise im Bereich von ≥ 40 μg bis ≤ 75 μg; und/oder
• – Lysin im Bereich von ≥ 400 mg bis ≤ 650 mg, vorzugsweise im Bereich von ≥ 450 mg bis ≤ 550 mg; und/oder
• – Cystin und/oder Acetylcystein im Bereich von ≥ 50 mg bis ≤ 120 mg, vorzugsweise im Bereich von ≥ 70 mg bis ≤ 100 mg; und/oder
• – Flavonoide, insbesondere erhältlich aus Citrusfrüchten im Bereich von ≥ 4 mg bis ≤ 75 mg, vorzugsweise im Bereich von ≥ 5 mg bis ≤ 25 mg; und/oder
• – Carotinoide, umfassend Carotinoide ausgewählt aus der Gruppe umfassend Beta- Carotin, Lutein und Lycopin im Bereich von ≥ 3 mg bis ≤ 15 mg, vorzugsweise im Bereich von ≥ 4 mg bis ≤ 8 mg;
• – Anthocyane insbesondere erhältlich aus Heidelbeeren, Rotweintrauben und/oder Holunderbeeren im Bereich von ≥ 20 mg bis ≤ 120 mg, vorzugsweise im Bereich von ≥ 40 mg bis ≤ 75 mg; und/oder
• – Polyphenole insbesondere erhältlich aus Rotweintrauben im Bereich von ≥ 25 mg bis ≤ 200 mg, vorzugsweise im Bereich von ≥ 70 mg bis ≤ 150 mg; und/oder
• – Coenzym Q10 im Bereich von ≥ 10 mg bis ≤ 50 mg, vorzugsweise im Bereich von ≥ 12 mg bis ≤ 18 mg; und/oder
• – Carnitin im Bereich von ≥ 150 mg bis ≤ 350 mg, vorzugsweise im Bereich von ≥ 180 mg bis ≤ 240 mg; und/oder
• – Taurin im Bereich von ≥ 200 mg bis ≤ 400 mg, vorzugsweise im Bereich von ≥ 280 mg bis ≤ 350 mg; und/oder
• – Inositol im Bereich von ≥ 70 mg bis ≤ 200 mg, vorzugsweise im Bereich von ≥ 80 mg bis ≤ 120 mg; und/oder
• – Omega-3-Fettsäuren im Bereich von ≥ 300 mg bis ≤ 600 mg, vorzugsweise im Bereich von ≥ 400 mg bis ≤ 500 mg.

In preferred embodiments, the composition comprises, based on a daily dose of the composition, as active ingredients:

• Α-lipoic acid in the range of ≥ 20 mg to ≤ 300 mg, preferably in the range of ≥ 40 mg to ≤ 160 mg; and or
• - Vitamin A in the range of ≥ 450 μg to ≤ 900 μg, preferably in the range of ≥ 700 μg to ≤ 850 μg; and or
• Vitamin C in the range of ≥ 250 mg to ≤ 800 mg, preferably in the range of ≥ 475 mg to ≤ 600 mg; and or
• Vitamin E in the range of ≥ 100 mg to ≤ 300 mg, preferably in the range of ≥ 140 mg to ≤ 250 mg; and or
• Vitamin B ₁ in the range of ≥ 2 mg to ≤ 10 mg, preferably in the range of ≥ 3 mg to ≤ 6 mg; and or
• Vitamin B ₂ in the range of ≥ 3 mg to ≤ 12 mg, preferably in the range of ≥ 4 mg to ≤ 10 mg; and or
• Nicotinamide in the range of ≥ 15 mg to ≤ 65 mg, preferably in the range of ≥ 40 mg to ≤ 60 mg; and or
• Vitamin B ₆ in the range of ≥ 3 mg to ≤ 20 mg, preferably in the range of ≥ 4 mg to ≤ 15 mg; and or
• - Vitamin B ₁₂ in the range of ≥ 5 μg to ≤ 25 μg, preferably in the range of ≥ 7 μg to ≤ 15 μg; and or
• - Vitamin D ₃ in the range of ≥ 2 μg to ≤ 10 μg, preferably in the range of ≥ 4 μg to ≤ 7 μg; and or
• Folic acid in the range of ≥ 400 μg to ≤ 1.2 mg, preferably in the range of ≥ 650 μg to ≤ 1 mg; and or
• Pantothenic acid in the range of ≥ 10 mg to ≤ 30 mg, preferably in the range of ≥ 14 mg to ≤ 24 mg; and or
• - Biotin in the range of ≥ 80 μg to ≤ 200 μg, preferably in the range of ≥ 120 μg to ≤ 180 μg; and or
• Magnesium in the range of ≥ 140 mg to ≤ 300 mg, preferably in the range of ≥ 160 mg to ≤ 200 mg; and or
• Selenium in the range of ≥ 25 μg to ≤ 100 μg, preferably in the range of ≥ 40 μg to ≤ 60 μg; and or
• Zinc in the range of ≥ 4 mg to ≤ 25 mg, preferably in the range of ≥ 8 mg to ≤ 12 mg; and or
• Manganese in the range of ≥ 1 mg to ≤ 3 mg, preferably in the range of ≥ 1.5 mg to ≤ 2.5 mg; and or
• - copper in the range of ≥ 0.5 mg to ≤ 1.8 mg, preferably in the range of ≥ 0.8 mg to ≤ 1.2 mg; and or
• Chromium in the range of ≥ 25 μg to ≤ 100 μg, preferably in the range of ≥ 40 μg to ≤ 75 μg; and or
• - molybdenum in the range of ≥ 25 μg to ≤ 100 μg, preferably in the range of ≥ 40 μg to ≤ 75 μg; and or
• Lysine in the range of ≥ 400 mg to ≤ 650 mg, preferably in the range of ≥ 450 mg to ≤ 550 mg; and or
• Cystine and / or acetylcysteine in the range of ≥ 50 mg to ≤ 120 mg, preferably in the range of ≥ 70 mg to ≤ 100 mg; and or
• Flavonoids, in particular obtainable from citrus fruits in the range of ≥ 4 mg to ≤ 75 mg, preferably in the range of ≥ 5 mg to ≤ 25 mg; and or
• Carotenoids comprising carotenoids selected from the group comprising beta-carotene, lutein and lycopene in the range of ≥ 3 mg to ≤ 15 mg, preferably in the range of ≥ 4 mg to ≤ 8 mg;
• Anthocyanins, in particular obtainable from blueberries, red wine grapes and / or elderberries in the range of ≥ 20 mg to ≤ 120 mg, preferably in the range of ≥ 40 mg to ≤ 75 mg; and or
• Polyphenols, in particular obtainable from red wine grapes in the range of ≥ 25 mg to ≤ 200 mg, preferably in the range of ≥ 70 mg to ≤ 150 mg; and or
• Coenzyme Q10 in the range of ≥ 10 mg to ≤ 50 mg, preferably in the range of ≥ 12 mg to ≤ 18 mg; and or
• Carnitine in the range of ≥ 150 mg to ≤ 350 mg, preferably in the range of ≥ 180 mg to ≤ 240 mg; and or
• Taurine in the range of ≥ 200 mg to ≤ 400 mg, preferably in the range of ≥ 280 mg to ≤ 350 mg; and or
• Inositol in the range of ≥ 70 mg to ≤ 200 mg, preferably in the range of ≥ 80 mg to ≤ 120 mg; and or
• - omega-3 fatty acids in the range of ≥ 300 mg to ≤ 600 mg, preferably in the range of ≥ 400 mg to ≤ 500 mg.

It It is advantageous that the dosage of the composition according to the invention no harmful side effects and / or incompatibilities shows.

The Composition can be solid, liquid and / or gel available. Preferably, the composition is in dosage forms selected from the group comprising tablets, capsules, powders, granules, solutions and / or Effervescent tablets of the same or different composition in front. Advantageously, the composition one and / or several capsule (s) and / or granules (s) are the same and / or different Include content of active ingredients.

Prefers the composition is in the form of at least two separately present Dosage forms preferably in the form of at least three, four or five separate present dosage forms selected from the group comprising Containing tablets, capsules, powders, granules, solutions and / or effervescent tablets same or different composition of active ingredients in front. Preferably, the composition is in the form of capsules and / or granules, preferably in the form of 1 to 5 capsules, preferably 2 to 4 capsules and 1 to 3 granules, preferably 1 to 2 granules.

• – wenigstens ein Granulat enthaltend Vitamine ausgewählt aus der Gruppe umfassend Vitamin A, Vitamin C, Vitamin B₁, Vitamin B₂, Nicotinamid, Vitamin B₆, Vitamin B₁₂, Vitamin D₃, Folsäure, Pantothensäure und/oder Biotin, Spurenelemente ausgewählt aus der Gruppe umfassend Magnesium, Zink, Selen, Mangan, Kupfer, Chrom und/oder Molybdän, und wirksame Bestandteile ausgewählt aus der Gruppe umfassend L-Lysin, L-Cystin, L-Cystein, N-Acetyl-L-Cystein, Taurin und/oder Inositol;
• – wenigstens eine Kapsel enthaltend L-Carnitin, Coenzym Q10, Carotinoide, Flavonoide insbesondere Bioflavonoide erhältlich aus Citrusfrüchten, und/oder Vitamin E;
• – wenigstens eine Kapsel enthaltend Anthocyane erhältlich aus Extrakten aus Heidelbeeren, Rotweintrauben und/oder Holunderbeeren, Polyphenole erhältlich aus Extrakten aus Rotweintrauben, α-Liponsäure und/oder Omega-3-Fettsäuren;
• – wenigstens eine Kapsel enthaltend Omega-3-Fettsäuren.

In preferred embodiments, the composition comprises:

• - At least one granules containing vitamins selected from the group consisting of vitamin A, vitamin C, vitamin B ₁ , vitamin B ₂ , nicotinamide, vitamin B ₆ , vitamin B ₁₂ , vitamin D ₃ , folic acid, pantothenic acid and / or biotin, selected from trace elements the group comprising magnesium, zinc, selenium, manganese, copper, chromium and / or molybdenum, and active ingredients selected from the group comprising L-lysine, L-cystine, L-cysteine, N-acetyl-L-cysteine, taurine and / or inositol;
• At least one capsule containing L-carnitine, coenzyme Q10, carotenoids, flavonoids, in particular bioflavonoids obtainable from citrus fruits, and / or vitamin E;
• At least one capsule containing anthocyanins obtainable from extracts of blueberries, red grapes and / or elderberries, polyphenols obtainable from extracts of red wine grapes, α-lipoic acid and / or omega-3 fatty acids;
• - At least one capsule containing omega-3 fatty acids.

• – wenigstens ein Granulat enthaltend Vitamine ausgewählt aus der Gruppe umfassend Vitamin A, Vitamin C, Vitamin B₁, Vitamin B₂, Nicotinamid, Vitamin B₆, Vitamin B₁₂, Vitamin D₃, Folsäure, Pantothensäure und/oder Biotin, Spurenelemente ausgewählt aus der Gruppe umfassend Magnesium, Zink, Selen, Mangan, Kupfer, Chrom und/oder Molybdän, und wirksame Bestandteile ausgewählt aus der Gruppe umfassend L-Lysin, L-Cystin, L-Cystein, N-Acetyl-L-Cystein Taurin und/oder Inositol;
• – wenigstens eine Kapsel enthaltend L-Carnitin, Coenzym Q10, Carotinoide, Citrus-Extrakt und/oder Vitamin E;
• – wenigstens eine Kapsel enthaltend Heidelbeer-, Rotweintrauben- und/oder Holunderbeer-Extrakt, α-Liponsäure und/oder Fischöl;
• – wenigstens eine Kapsel enthaltend Fischöl.

In particularly preferred embodiments, the composition comprises:

• - At least one granules containing vitamins selected from the group consisting of vitamin A, vitamin C, vitamin B ₁ , vitamin B ₂ , nicotinamide, vitamin B ₆ , vitamin B ₁₂ , vitamin D ₃ , folic acid, pantothenic acid and / or biotin, selected from trace elements the group comprising magnesium, zinc, selenium, manganese, copper, chromium and / or molybdenum, and active ingredients selected from the group comprising L-lysine, L-cystine, L-cysteine, N-acetyl-L-cysteine taurine and / or inositol;
• At least one capsule containing L-carnitine, coenzyme Q10, carotenoids, citrus extract and / or vitamin E;
• At least one capsule containing bilberry, red wine grape and / or elderberry extract, α-lipoic acid and / or fish oil;
• - At least one capsule containing fish oil.

• – 50 mg α-Liponsäure;
• – 750 μg Vitamin A;
• – 530 mg Vitamin C;
• – 150 mg Vitamin E;
• – 4 mg Vitamin B₁;
• – 5 mg Vitamin B₂;
• – 50 mg Nicotinamid;
• – 5 mg Vitamin B₆;
• – 9 μg Vitamin B₁₂;
• – 5 μg Vitamin D₃;
• – 800 μg Folsäure;
• – 18 mg Pantothensäure;
• – 150 μg Biotin;
• – 180 mg Magnesium;
• – 50 μg Selen;
• – 10 mg Zink;
• – 2 mg Mangan;
• – 1 mg Kupfer;
• – 60 μg Chrom;
• – 60 μg Molybdän;
• – 500 mg L-Lysin;
• – 80 mg L-Cystin;
• – 5 mg Flavonoide, umfassend Flavonoide erhältlich aus Citrusfrüchten;
• – 5 mg Carotinoide, umfassend Carotinoide ausgewählt aus der Gruppe umfassend Beta-Carotin, Lutein und Lycopin;
• – 50 mg Anthocyane, umfassend Anthocyane erhältlich aus Heidelbeeren, Rotweintrauben und/oder Holunderbeeren;
• – 75 mg Polyphenole umfassend Polyphenole erhältlich aus Rotweintrauben;
• – 15 mg Coenzym Q10;
• – 200 mg L-Carnitin;
• – 300 mg Taurin;
• – 100 mg Inositol;
• – 425 mg Omega-3-Fettsäuren.

In very particularly preferred embodiments, the composition, based on a daily dose of the composition, comprises as active ingredients the substances:

• - 50 mg of α-lipoic acid;
• - 750 μg vitamin A;
• - 530 mg of vitamin C;
• - 150 mg of vitamin E;
• - 4 mg of vitamin B ₁ ;
• - 5 mg of vitamin B ₂ ;
• - 50 mg nicotinamide;
• - 5 mg of vitamin B ₆ ;
• - 9 μg of vitamin B ₁₂ ;
• - 5 μg vitamin D ₃ ;
• - 800 μg folic acid;
• - 18 mg pantothenic acid;
• - 150 μg biotin;
• - 180 mg of magnesium;
• - 50 μg selenium;
• - 10 mg zinc;
• - 2 mg of manganese;
• - 1 mg of copper;
• - 60 μg of chromium;
• - 60 μg molybdenum;
• - 500 mg L-lysine;
• - 80 mg L-cystine;
• - 5 mg flavonoids, including flavonoids available from citrus fruits;
• 5 mg carotenoids comprising carotenoids selected from the group comprising beta-carotene, lutein and lycopene;
• - 50 mg anthocyanins, comprising anthocyanins obtainable from blueberries, red grapes and / or elderberries;
• - 75 mg polyphenols comprising polyphenols obtainable from red wine grapes;
• - 15 mg coenzyme Q10;
• - 200 mg L-carnitine;
• - 300 mg taurine;
• - 100 mg inositol;
• - 425 mg omega-3 fatty acids.

• – ein Granulat enthaltend Vitamin A, Vitamin C, Vitamin B₁, Vitamin B₂, Nicotinamid, Vitamin B₆, Vitamin B₁₂, Vitamin D₃, Folsäure, Pantothensäure, Biotin, Magnesium, Zink, Selen, Mangan, Kupfer, Chrom, Molybdän, L-Lysin, L-Cystin, Taurin, Inositol;
• – wenigstens eine Kapsel enthaltend L-Carnitin, Coenzym Q10, Carotinoide, Flavonoide, Vitamin E;
• – wenigstens eine Kapsel enthaltend Anthocyane, Polyphenole, α-Liponsäure, Omega-3-Fettsäuren,
• – wenigstens eine Kapsel enthaltend Omega-3-Fettsäuren.

In preferred embodiments, the composition comprises:

• A granulate containing vitamin A, vitamin C, vitamin B ₁ , vitamin B ₂ , nicotinamide, vitamin B ₆ , vitamin B ₁₂ , vitamin D ₃ , folic acid, pantothenic acid, biotin, magnesium, zinc, selenium, manganese, copper, chromium, Molybdenum, L-lysine, L-cystine, taurine, inositol;
• At least one capsule containing L-carnitine, coenzyme Q10, carotenoids, flavonoids, vitamin E;
• At least one capsule containing anthocyanins, polyphenols, α-lipoic acid, omega-3 fatty acids,
• - At least one capsule containing omega-3 fatty acids.

• – ein Granulat enthaltend 750 μg Vitamin A, 530 mg Vitamin C, 4 mg Vitamin B₁, 5 mg Vitamin B₂, 50 mg Nicotinamid, 5 mg Vitamin B₆, 9 μg Vitamin B₁₂, 5 μg Vitamin D₃, 800 μg Folsäure, 18 mg Pantothensäure, 150 μg Biotin, 180 mg Magnesium, 10 mg Zink, 50 μg Selen, 2 mg Mangan, 1 mg Kupfer, 60 μg Chrom, 60 μg Molybdän, 500 mg L-Lysin, 80 mg L-Cystin, 300 mg Taurin, und/oder 100 mg Inositol;
• – wenigstens eine Kapsel enthaltend 200 mg L-Carnitin, 15 mg Coenzym Q10, 5 mg Carotinoide, 5 mg Flavonoide, und/oder 150 mg Vitamin E;
• – zwei Kapseln enthaltend insgesamt 50 mg Anthocyane, 75 mg Polyphenole, 50 mg α-Liponsäure, und/oder 165 mg Omega-3-Fettsäuren;
• – wenigstens eine Kapsel enthaltend 260 mg Omega-3-Fettsäuren.

In particularly preferred embodiments, the composition comprises:

• A granulate containing 750 μg vitamin A, 530 mg vitamin C, 4 mg vitamin B ₁ , 5 mg vitamin B ₂ , 50 mg nicotinamide, 5 mg vitamin B ₆ , 9 μg vitamin B ₁₂ , 5 μg vitamin D ₃ , 800 μg Folic acid, 18 mg pantothenic acid, 150 μg biotin, 180 mg magnesium, 10 mg zinc, 50 μg selenium, 2 mg manganese, 1 mg copper, 60 μg chromium, 60 μg molybdenum, 500 mg L-lysine, 80 mg L-cystine, 300 mg taurine, and / or 100 mg inositol;
• - at least one capsule containing 200 mg L-carnitine, 15 mg coenzyme Q10, 5 mg carotenoids, 5 mg flavonoids, and / or 150 mg vitamin E;
• - two capsules containing a total of 50 mg of anthocyanins, 75 mg of polyphenols, 50 mg of α-lipoic acid, and / or 165 mg of omega-3 fatty acids;
• - At least one capsule containing 260 mg of omega-3 fatty acids.

• – α-Liponsäure im Bereich von ≥ 109 mg bis ≤ 1,6 g, vorzugsweise im Bereich von ≥ 217 mg bis ≤ 870 mg; und/oder
• – Vitamin A im Bereich von ≥ 2,4 mg bis ≤ 4,9 mg, vorzugsweise im Bereich von ≥ 3,8 mg bis ≤ 4,6 mg; und/oder
• – Vitamin C im Bereich von ≥ 1,4 g bis ≤ 4,3 g, vorzugsweise im Bereich von ≥ 2,6 g bis ≤ 3,3 g; und/oder
• – Vitamin E im Bereich von ≥ 543 mg bis ≤ 1,6 g, vorzugsweise im Bereich von ≥ 761 mg bis ≤ 1,4 g; und/oder
• – Vitamin B₁ im Bereich von ≥ 11 mg bis ≤ 54 mg, vorzugsweise im Bereich von ≥ 16 mg bis ≤ 33 mg; und/oder
• – Vitamin B₂ im Bereich von ≥ 16 mg bis ≤ 65 mg, vorzugsweise im Bereich von ≥ 22 mg bis ≤ 54 mg; und/oder
• – Nicotinamid im Bereich von ≥ 82 mg bis ≤ 353 mg, vorzugsweise im Bereich von ≥ 217 mg bis ≤ 326 mg; und/oder
• – Vitamin B₆ im Bereich von ≥ 16 mg bis ≤ 109 mg, vorzugsweise im Bereich von ≥ 22 mg bis ≤ 82 mg; und/oder
• – Vitamin B₁₂ im Bereich von ≥ 27 μg bis ≤ 136 μg, vorzugsweise im Bereich von ≥ 38 μg bis ≤ 82 μg; und/oder
• – Vitamin D₃ im Bereich von ≥ 11 μg bis ≤ 54 μg, vorzugsweise im Bereich von ≥ 22 μg bis ≤ 38 μg; und/oder
• – Folsäure im Bereich von ≥ 2,2 mg bis ≤ 6,5 mg, vorzugsweise im Bereich von ≥ 3,5 mg bis ≤ 5,4 mg; und/oder
• – Pantothensäure im Bereich von ≥ 54 mg bis ≤ 163 mg, vorzugsweise im Bereich von ≥ 76 mg bis ≤ 130 mg; und/oder
• – Biotin im Bereich von ≥ 435 μg bis ≤ 1,1 mg, vorzugsweise im Bereich von ≥ 652 μg bis ≤ 978 μg; und/oder
• – Magnesium im Bereich von ≥ 761 mg bis ≤ 1,6 g, vorzugsweise im Bereich von ≥ 870 mg bis ≤ 1,1 g; und/oder
• – Selen im Bereich von ≥ 136 μg bis ≤ 543 μg, vorzugsweise im Bereich von ≥ 217 μg bis ≤ 326 μg; und/oder
• – Zink im Bereich von ≥ 22 mg bis ≤ 136 mg, vorzugsweise im Bereich von ≥ 43 mg bis ≤ 65 mg; und/oder
• – Mangan im Bereich von ≥ 5,4 mg bis ≤ 16 mg, vorzugsweise im Bereich von ≥ 8,2 mg bis 5 14 mg; und/oder
• – Kupfer im Bereich von ≥ 2,7 mg bis ≤ 9,8 mg, vorzugsweise im Bereich von ≥ 4,4 mg bis ≤ 6,5 mg; und/oder
• – Chrom im Bereich von ≥ 136 μg bis ≤ 543 μg, vorzugsweise im Bereich von 217 μg bis ≤ 408 μg; und/oder
• – Molybdän im Bereich von ≥ 136 μg bis ≤ 543 μg, vorzugsweise im Bereich von ≥ 217 μg bis ≤ 408 μg; und/oder
• – Lysin im Bereich von ≥ 2,2 g bis ≤ 3,5 g, vorzugsweise im Bereich von ≥ 2,4 g bis ≤ 3 g; und/oder
• – Cystin und/oder Acetylcystein im Bereich von ≥ 271 mg bis ≤ 652 mg, vorzugsweise im Bereich von ≥ 380 mg bis ≤ 543 mg; und/oder
• – Flavonoide, insbesondere erhältlich aus Citrusfrüchten im Bereich von ≥ 22 mg bis ≤ 408 mg, vorzugsweise im Bereich von ≥ 27 mg bis ≤ 136 mg; und/oder
• – Carotinoide, umfassend Carotinoide ausgewählt aus der Gruppe umfassend Beta-Carotin, Lutein und Lycopin im Bereich von ≥ 16 mg bis ≤ 82 mg, vorzugsweise im Bereich von ≥ 22 mg bis ≤ 43 mg;
• – Anthocyane insbesondere erhältlich aus Heidelbeeren, Rotweintrauben und/oder Holunderbeeren im Bereich von ≥ 109 mg bis ≤ 652 mg, vorzugsweise im Bereich von ≥ 217 mg bis ≤ 408 mg; und/oder
• – Polyphenole insbesondere erhältlich aus Rotweintrauben im Bereich von ≥ 136 mg bis ≤ 1,1 g, vorzugsweise im Bereich von ≥ 380 mg bis ≤ 815 mg; und/oder
• – Coenzym Q10 im Bereich von ≥ 54 mg bis ≤ 271 mg, vorzugsweise im Bereich von ≥ 65 mg bis ≤ 98 mg; und/oder
• – Carnitin im Bereich von ≥ 815 mg bis ≤ 1,9 g, vorzugsweise im Bereich von ≥ 1 g bis ≤ 1,3 g; und/oder
• – Taurin im Bereich von ≥ 1,1 g bis ≤ 2,2 g, vorzugsweise im Bereich von ≥ 1,5 g bis ≤ 1,9 g; und/oder
• – Inositol im Bereich von ≥ 380 mg bis ≤ 1,1 g, vorzugsweise im Bereich von ≥ 435 mg bis ≤ 652 mg; und/oder
• – Omega-3-Fettsäuren im Bereich von ≥ 1,6 g bis ≤ 3,3 g, vorzugsweise im Bereich von ≥ 2,1 g bis ≤ 2,7 g.

In other embodiments, the composition comprises, based on 100 g of the composition, the weight contents of the individual components being such that the total weight of the components does not exceed 100 g, as active ingredients the substances:

• Α-lipoic acid in the range of ≥109 mg to ≤1.6 g, preferably in the range of ≥217 mg to ≤870 mg; and or
• Vitamin A in the range of ≥ 2.4 mg to ≤ 4.9 mg, preferably in the range of ≥ 3.8 mg to ≤ 4.6 mg; and or
• Vitamin C in the range of ≥ 1.4 g to ≤ 4.3 g, preferably in the range of ≥ 2.6 g to ≤ 3.3 g; and or
• Vitamin E in the range of ≥ 543 mg to ≤ 1.6 g, preferably in the range of ≥ 761 mg to ≤ 1.4 g; and or
• Vitamin B ₁ in the range of ≥ 11 mg to ≤ 54 mg, preferably in the range of ≥ 16 mg to ≤ 33 mg; and or
• Vitamin B ₂ in the range of ≥ 16 mg to ≤ 65 mg, preferably in the range of ≥ 22 mg to ≤ 54 mg; and or
• Nicotinamide in the range of ≥ 82 mg to ≤ 353 mg, preferably in the range of ≥ 217 mg to ≤ 326 mg; and or
• Vitamin B ₆ in the range of ≥ 16 mg to ≤ 109 mg, preferably in the range of ≥ 22 mg to ≤ 82 mg; and or
• - Vitamin B ₁₂ in the range of ≥ 27 μg to ≤ 136 μg, preferably in the range of ≥ 38 μg to ≤ 82 μg; and or
• - Vitamin D ₃ in the range of ≥ 11 μg to ≤ 54 μg, preferably in the range of ≥ 22 μg to ≤ 38 μg; and or
• Folic acid in the range of ≥ 2.2 mg to ≤ 6.5 mg, preferably in the range of ≥ 3.5 mg to ≤ 5.4 mg; and or
• Pantothenic acid in the range of ≥ 54 mg to ≤ 163 mg, preferably in the range of ≥ 76 mg to ≤ 130 mg; and or
• - Biotin in the range of ≥ 435 μg to ≤ 1.1 mg, preferably in the range of ≥ 652 μg to ≤ 978 μg; and or
• Magnesium in the range of ≥ 761 mg to ≤ 1.6 g, preferably in the range of ≥ 870 mg to ≤ 1.1 g; and or
• Selenium in the range of ≥ 136 μg to ≤ 543 μg, preferably in the range of ≥ 217 μg to ≤ 326 μg; and or
• Zinc in the range of ≥ 22 mg to ≤ 136 mg, preferably in the range of ≥ 43 mg to ≤ 65 mg; and or
• Manganese in the range of ≥ 5.4 mg to ≤ 16 mg, preferably in the range of ≥ 8.2 mg to 5 14 mg; and or
• Copper in the range of ≥ 2.7 mg to ≤ 9.8 mg, preferably in the range of ≥ 4.4 mg to ≤ 6.5 mg; and or
• Chromium in the range of ≥ 136 μg to ≤ 543 μg, preferably in the range of 217 μg to ≤ 408 μg; and or
• Molybdenum in the range of ≥ 136 μg to ≤ 543 μg, preferably in the range of ≥ 217 μg to ≤ 408 μg; and or
• Lysine in the range of ≥ 2.2 g to ≤ 3.5 g, preferably in the range of ≥ 2.4 g to ≤ 3 g; and or
• Cystine and / or acetylcysteine in the range of ≥ 271 mg to ≤ 652 mg, preferably in the range of ≥ 380 mg to ≤ 543 mg; and or
• Flavonoids, in particular obtainable from citrus fruits in the range of ≥ 22 mg to ≤ 408 mg, preferably in the range of ≥ 27 mg to ≤ 136 mg; and or
• - Carotenoids comprising carotenoids selected from the group comprising beta-carotene, lutein and lycopene in the range of ≥ 16 mg to ≤ 82 mg, preferably in the range of ≥ 22 mg to ≤ 43 mg;
• Anthocyanins, in particular obtainable from blueberries, red wine grapes and / or elderberries in the range of ≥ 109 mg to ≤ 652 mg, preferably in the range of ≥ 217 mg to ≤ 408 mg; and or
• Polyphenols, in particular obtainable from red wine grapes, in the range of ≥ 136 mg to ≤ 1.1 g, preferably in the range of ≥ 380 mg to ≤ 815 mg; and or
• Coenzyme Q10 in the range of ≥ 54 mg to ≤ 271 mg, preferably in the range of ≥ 65 mg to ≤ 98 mg; and or
• Carnitine in the range of ≥ 815 mg to ≤ 1.9 g, preferably in the range of ≥ 1 g to ≤ 1.3 g; and or
• Taurine in the range of ≥ 1.1 g to ≤ 2.2 g, preferably in the range of ≥ 1.5 g to ≤ 1.9 g; and or
• Inositol in the range of ≥ 380 mg to ≤ 1.1 g, preferably in the range of ≥ 435 mg to ≤ 652 mg; and or
• Omega-3 fatty acids in the range of ≥ 1.6 g to ≤ 3.3 g, preferably in the range of ≥ 2.1 g to ≤ 2.7 g.

The The above quantities are merely exemplary, since the composition also additives, Contain accompanying substances and / or raw materials that may be heavier or are lighter than the actual active ingredients, so that the stated amounts based on a daily dose and / or 100 g lower or higher could be.

• – 272 mg α-Liponsäure;
• – 4,1 mg Vitamin A;
• – 2,9 g Vitamin C;
• – 815 mg Vitamin E;
• – 22 mg Vitamin B₁;
• – 27 mg Vitamin B₂;
• – 272 mg Nicotinamid;
• – 27 mg Vitamin B₆;
• – 49 μg Vitamin B₁₂;
• – 27 μg Vitamin D₃;
• – 4,3 mg Folsäure;
• – 98 mg Pantothensäure;
• – 815 μg Biotin;
• – 978 mg Magnesium;
• – 272 μg Selen;
• – 54 mg Zink;
• – 11 mg Mangan;
• – 5,4 mg Kupfer;
• – 326 μg Chrom;
• – 326 μg Molybdän;
• – 2,7 g L-Lysin;
• – 435 mg L-Cystin;
• – 27 mg Flavonoide, umfassend Flavonoide erhältlich aus Citrusfrüchten;
• – 27 mg Carotinoide, umfassend Carotinoide ausgewählt aus der Gruppe umfassend Beta-Carotin, Lutein und Lycopin;
• – 272 mg Anthocyane, umfassend Anthocyane erhältlich aus Heidelbeeren, Rotweintrauben und/oder Holunderbeeren;
• – 408 mg Polyphenole umfassend Polyphenole erhältlich aus Rotweintrauben;
• – 82 mg Coenzym Q10;
• – 1,1 g L-Carnitin;
• – 1,6 g Taurin;
• – 543 mg Inositol;
• – 2,3 g Omega-3-Fettsäuren.

In further preferred embodiments, the composition comprises, based on 100 g of the composition, wherein the weight contents of the individual components are chosen such that the total weight of the components does not exceed 100 g, as active ingredients the substances:

• - 272 mg of α-lipoic acid;
• 4.1 mg of vitamin A;
• - 2.9 g of vitamin C;
• - 815 mg of vitamin E;
• - 22 mg vitamin B ₁ ;
• - 27 mg of vitamin B ₂ ;
• - 272 mg nicotinamide;
• - 27 mg of vitamin B ₆ ;
• - 49 μg vitamin B ₁₂ ;
• - 27 micrograms vitamin D _3;
• - 4.3 mg folic acid;
• - 98 mg pantothenic acid;
• - 815 μg biotin;
• - 978 mg of magnesium;
• - 272 μg selenium;
• - 54 mg zinc;
• - 11 mg manganese;
• - 5.4 mg of copper;
• - 326 μg chromium;
• - 326 μg molybdenum;
• - 2.7 g of L-lysine;
• - 435 mg L-cystine;
• - 27 mg flavonoids, including flavonoids available from citrus fruits;
• - 27 mg carotenoids comprising carotenoids selected from the group comprising beta-carotene, lutein and lycopene;
• - 272 mg of anthocyanins, comprising anthocyanins obtainable from blueberries, red grapes and / or elderberries;
• - 408 mg of polyphenols comprising polyphenols obtainable from red wine grapes;
• - 82 mg coenzyme Q10;
• 1.1 g of L-carnitine;
• - 1.6 g of taurine;
• - 543 mg inositol;
• - 2.3 grams of omega-3 fatty acids.

The Composition may contain at least one additive, preferably several Additions, to improve bioavailability, to improve texture, to improve solubility and / or to improve the dissolution rate, Disintegrants, fabrics that improve durability, taste-masking Substances, taste-improving substances, substances to increase or Lowering the viscosity, Stabilizers, dyes, fillers, Mold release agents and / or disintegration accelerator have.

Suitable are usual, additives known to the person skilled in the art and adjuvants. Preferred additives are, for example, dyes, preservatives, acidulants, Emulsifiers, stabilizers, sweeteners, Humectants, release agents, thickeners and / or setting agents. The dosage forms according to the invention and formulation fundamentals still common in galenics, have pharmacologically acceptable and / or acceptable excipients.

Accessories and Excipients can selected be from the group comprising dextrose, gelatin, vegetable oil, soybean oil, maltodextrin, citric acid, Gum arabic, glycerin, flavoring, modified starch, sorbitol, silicon dioxide, Acesulfame K, titanium dioxide and / or iron oxide.

The Vitamin-containing composition is for the dietary treatment of inner ear diseases, especially stress-related inner ear diseases, preferably selected from the group comprising acute hearing loss, Tinnitus, noise-induced and ototoxic hearing loss usable. Furthermore, the vitamin-containing composition for the preparation of an agent for the dietary treatment of inner ear diseases, preferably selected from the group comprising acute hearing loss, Tinnitus, noise-induced and ototoxic hearing loss be used. The vitamin-containing composition according to the invention is still suitable as a means of balanced completion of the nutrition in patients with especially stress-related inner ear diseases, preferably selected from the group comprising acute hearing loss, Tinnitus, noise-induced and ototoxic hearing loss. The vitamin according to the invention containing composition is particularly suitable as a supplementary balanced Diet.

Of the Term "dietetic Treatment "is in the EU Directive 1999/21 / EC, which since 01.01.2002 as 10th Regulation to change the diet regulation into German law, explained in more detail.

By containing the beneficial active ingredients of the vitamin This composition can also be part of a nutritional consultation as food, in particular food supplements or means for dietetic Treatment in the form of a supplementary balanced diet be used.

One Another object of the invention is a food, in particular Dietary supplements or Means of dietary Treatment in the form of a supplementary balanced diet, comprising the aforementioned active ingredients. Preferably can the vitamin-containing composition as a nutritive supplement to accompanying or supporting Administration can be used. It has been shown that in particular stress-related inner ear diseases, preferably selected from of the group comprising acute hearing loss, Tinnitus, noise-induced and ototoxic hearing loss dietetic can be positively influenced.

examples which are illustrative of the present invention are indicated below.

It is understood that the dosage forms selected from comprising the group. Tablets, capsules, powders, granules, solutions and / or Effervescent tablets, the usual used for the formulation of the respective dosage forms Have excipients, so that in the examples, only the active ingredients contained listed could be.

example 1

Vitamin-containing composition comprising 4 capsules and 1 granules as follows:
containing granules:
containing 750 μg vitamin A, 530 mg vitamin C, 4 mg vitamin B ₁ , 5 mg vitamin B ₂ , 50 mg nicotinamide, 5 mg vitamin B ₆ , 9 μg vitamin B ₁₂ , 5 μg vitamin D ₃ , 800 μg folic acid, 18 mg pantothenic acid, 150 μg biotin, 180 mg magnesium, 10 mg zinc, 50 μg selenium, 2 mg manganese, 1 mg copper, 60 μg chromium, 60 μg molybdenum, 500 mg L-lysine, 80 mg L-cystine, 300 mg taurine , 100 mg inositol;
a capsule containing:
200 mg L-carnitine, 15 mg coenzyme Q10, 5 mg carotenoids comprising carotenoids selected from the group comprising beta-carotene, lutein and / or lycopene, 5 mg flavonoids obtainable from citrus fruits, 150 mg vitamin E;
two capsules containing in total:
50 mg anthocyanins available from blueberries, red grapes and / or elderberries, 75 mg polyphenols obtainable from red wine grapes, 50 mg α-lipoic acid, 165 mg omega-3 fatty acids and
one capsule containing 260 mg omega-3 fatty acids.

The Granules were in a bag containing a daily dose. The Unless indicated otherwise, weights are based on a daily dose.

Example 2

in the Framework of a non-randomized cohort study in parallel group design The effectiveness of a supplemental balanced diet was conceived Vitamin. composition determined in patients after a hearing loss.

at 43 out of 84 patients underwent standard medical treatment sudden hearing loss by the administration of a vitamin-containing composition a daily dose according to Example 1 over a period of approx. 5 weeks supplemented. There were demographics between the two Treatment groups no significant differences. The hearing loss was in the frequency range between 250 Hz and 6000 Hz with a pure tone audiometer measured. Before treatment, the two treatment groups showed No statistically significant differences in the measured frequencies on.

Table I shows a comparison of the improvement in hearing loss after therapy with and without supplementation with the vitamin-containing composition. Table I Treatment of the hearing loss Improvement of hearing without supplementation with vitamin-containing composition + with supplementation with vitamin-containing composition ++

Of the Table I shows that a significant improvement in the Through hearing achieved the supplementation with the composition according to the invention has been. It showed in particular that the one of the patients perceived tinnitus through the supplementation with vitamin-containing Composition had significantly improved.

This shows that by administration of a vitamin according to the invention containing an increase in hearing and improvement of tinnitus could be achieved.

Claims (18)

Vitamin-containing composition, in particular suitable for nutritive balanced supplementation of the diet in inner ear diseases, wherein the composition comprises as active ingredients the substances: - at least one vitamin or vitamin mixture selected from the group comprising vitamin A, vitamin C, vitamin E, vitamin B ₁ , vitamin B ₂ , nicotinamide, vitamin B ₆ , vitamin B ₁₂ , vitamin D, folic acid, pantothenic acid and / or biotin; - At least one mineral, trace element or mixture thereof selected from the group comprising magnesium, selenium, zinc, manganese, copper, chromium and / or molybdenum; At least one amino acid or amino acid mixture selected from the group comprising lysine, cysteine, acetylcysteine and / or cystine; At least one secondary plant substance selected from the group comprising carotenoids and / or flavonoids; At least one secondary plant substance selected from the group comprising polyphenols and / or anthocyanins; - at least one micronutrient selected from the group comprising coenzyme Q10, carnitine, taurine, inositol and / or α-lipoic acid, and - omega-3 fatty acids. Composition according to Claim 1, characterized that the omega-3 fatty acids are selected from the group comprising docosahexaenoic acid and / or eicosapentaenoic acid, wherein the weight ratio of docosahexaenoic acid to eicosapentaenoic acid preferably in the range of ≥ 1: 1 to ≤ 5: 1, preferably in the range of ≥ 1.2: 1 up to ≤ 2.5: 1, more preferably in the range of ≥ 1.4: 1 up to ≤ 1.8: 1, lies. Composition according to Claim 1 or 2, characterized that the composition flavonoids especially bioflavonoids obtainable from Citrus fruits comprises, preferably in the form of extract of citrus fruits. Composition according to one of the preceding claims, characterized characterized in that the composition polyphenols obtainable from Red wine grapes and / or anthocyanins obtainable from blueberries, red wine grapes and / or elderberries, preferably in the form of extract (s) from blueberries, red grapes and / or elderberries. Composition according to one of the preceding claims, characterized in that the composition, based on a daily dose of the vitamin-containing composition, as active ingredients comprises the substances: - α-lipoic acid in the range of ≥ 10 mg to ≤ 600 mg; and / or - Vitamin A in the range of ≥ 0.3 mg to ≤ 1 mg; and / or - Vitamin C in the range of ≥ 100 mg to ≤ 1500 mg; and / or - Vitamin E in the range of ≥ 50 mg to ≤ 400 mg; and / or - Vitamin B ₁ in the range of ≥ 1 mg to ≤ 25 mg; and / or - Vitamin B ₂ in the range of ≥ 1 mg to ≤ 25 mg; and / or nicotinamide in the range of ≥5 mg to ≤75 mg; and / or - Vitamin B ₆ in the range of ≥ 1 mg to ≤ 25 mg; and / or - vitamin B ₁₂ in the range of ≥ 1 μg to ≤ 100 μg; and / or - vitamin D ₃ in the range from ≥ 1 to ≤ ug 20 ug; and / or - folic acid in the range of ≥ 0.1 mg to ≤ 2 mg; and / or - pantothenic acid in the range of ≥ 5 mg to ≤ 50 mg; and / or - biotin in the range of ≥ 50 μg to ≤ 250 μg; and / or - magnesium in the range of ≥ 100 mg to ≤ 400 mg; and / or selenium in the range of ≥ 10 μg to ≤ 300 μg; and / or - zinc in the range of ≥ 2 mg to ≤ 50 mg; and / or manganese in the range of ≥ 0.5 mg to ≤ 5 mg; and / or - copper in the range of ≥ 0.1 mg to ≤ 2.5 mg; and / or - chromium in the range of ≥ 10 μg to ≤ 200 μg; and / or molybdenum in the range of ≥ 10 μg to ≤ 200 μg; and / or - lysine in the range of ≥ 50 mg to ≤ 1000 mg; and / or - cystine and / or acetylcysteine in the range of ≥ 20 mg to ≤ 200 mg; and / or - flavonoids, in particular obtainable from citrus fruits in the range of ≥ 2 mg to ≤ 100 mg; and / or - carotenoids comprising carotenoids selected from the group comprising beta-carotene, lutein and lycopene in the range of ≥ 2 mg to ≤ 25 mg; - anthocyanins, in particular obtainable from bilberries, red grapes and / or elderberries in the range of ≥ 5 mg to ≤ 500 mg; and / or polyphenols, in particular obtainable from red wine grapes in the range of ≥ 5 mg to ≤ 500 mg; and / or - coenzyme Q10 in the range of ≥ 5 mg to ≤ 100 mg; and / or carnitine in the range of ≥ 50 mg to ≤ 500 mg; and / or - taurine in the range of ≥ 50 mg to ≤ 500 mg; and or - inositol in the range of ≥ 50 mg to ≤ 300 mg; and / or omega-3 fatty acids in the range of ≥ 0.1 g to ≤ 2 g. Composition according to one of the preceding claims, characterized in that the vitamin-containing composition is based to a daily dose of the vitamin-containing composition, ≥ 100 mg to ≤ 500 mg, preferably ≥ 160 mg to ≤ 350 mg, preferably ≥ 210 mg to ≤ 280 mg docosahexaenoic acid. Composition according to one of the preceding claims, characterized in that the composition, based on a daily dose of the composition, as active ingredients comprises the substances: - α-lipoic acid in the range of ≥ 20 mg to ≤ 300 mg, preferably in the range of ≥ 40 mg up to ≤ 160 mg; and / or - vitamin A in the range of ≥ 450 μg to ≤ 900 μg, preferably in the range of ≥ 700 μg to ≤ 850 μg; and / or - Vitamin C in the range of ≥ 250 mg to ≤ 800 mg, preferably in the range of 475 mg to ≤ 600 mg; and / or - Vitamin E in the range of ≥ 100 mg to ≤ 300 mg, preferably in the range of ≥ 140 mg to ≤ 250 mg; and / or - vitamin B ₁ in the range of ≥ 2 mg to ≤ 10 mg, preferably in the range of ≥ 3 mg to ≤ 6 mg; and / or - Vitamin B ₂ in the range of ≥ 3 mg to ≤ 12 mg, preferably in the range of ≥ 4 mg to ≤ 10 mg; and / or nicotinamide in the range of ≥ 15 mg to ≤ 65 mg, preferably in the range of ≥ 40 mg to ≤ 60 mg; and / or - Vitamin B ₆ in the range of ≥ 3 mg to ≤ 20 mg, preferably in the range of ≥ 4 mg to ≤ 15 mg; and / or - vitamin B ₁₂ in the range of ≥ 5 μg to ≤ 25 μg, preferably in the range of ≥ 7 μg to ≤ 15 μg; and / or - vitamin D ₃ in the range of ≥ 2 μg to ≤ 10 μg, preferably in the range of ≥ 4 μg to ≤ 7 μg; and / or - folic acid in the range of ≥ 400 μg to ≤ 1.2 mg, preferably in the range of ≥ 650 μg to ≤ 1 mg; and / or pantothenic acid in the range of ≥ 10 mg to ≤ 30 mg, preferably in the range of ≥ 14 mg to ≤ 24 mg; and / or - biotin in the range of ≥ 80 μg to ≦ 200 μg, preferably in the range of ≥ 120 μg to ≦ 180 μg; and / or - magnesium in the range of ≥ 140 mg to ≤ 300 mg, preferably in the range of ≥ 160 mg to ≤ 200 mg; and / or selenium in the range of ≥ 25 μg to ≤ 100 μg, preferably in the range of ≥ 40 μg to ≤ 60 μg; and / or - zinc in the range of ≥ 4 mg to ≤ 25 mg, preferably in the range of ≥ 8 mg to ≤ 12 mg; and / or manganese in the range of ≥ 1 mg to ≤ 3 mg, preferably in the range of ≥ 1.5 mg to ≤ 2.5 mg; and / or - copper in the range of ≥ 0.5 mg to ≤ 1.8 mg, preferably in the range of ≥ 0.8 mg to ≤ 1.2 mg; and / or - chromium in the range of ≥ 25 μg to ≤ 100 μg, preferably in the range of ≥ 40 μg to ≤ 75 μg; and / or molybdenum in the range of ≥ 25 μg to ≤ 100 μg, preferably in the range of ≥ 40 μg to ≤ 75 μg; and / or - lysine in the range of ≥ 400 mg to ≤ 650 mg, preferably in the range of ≥ 450 mg to ≤ 550 mg; and / or - cystine and / or acetylcysteine in the range of ≥ 50 mg to ≤ 120 mg, preferably in the range of ≥ 70 mg to ≤ 100 mg; and / or - flavonoids, in particular obtainable from citrus fruits in the range of ≥ 4 mg to ≤ 75 mg, preferably in the range of ≥ 5 mg to ≤ 25 mg; and / or - carotenoids comprising carotenoids selected from the group comprising beta-carotene, lutein and lycopene in the range of ≥ 3 mg to ≤ 15 mg, preferably in the range of ≥ 4 mg to ≤ 8 mg; Anthocyanins, in particular obtainable from blueberries, red wine grapes and / or elderberries in the range of ≥ 20 mg to ≤ 120 mg, preferably in the range of ≥ 40 mg to ≤ 75 mg; and / or polyphenols, in particular obtainable from red wine grapes in the range of ≥ 25 mg to ≤ 200 mg, preferably in the range of ≥ 70 mg to ≤ 150 mg; and / or coenzyme Q10 in the range of ≥ 10 mg to ≤ 50 mg, preferably in the range of ≥ 12 mg to ≤ 18 mg; and / or carnitine in the range of ≥ 150 mg to ≤ 350 mg, preferably in the range of ≥ 180 mg to ≤ 240 mg; and / or - taurine in the range of ≥ 200 mg to ≤ 400 mg, preferably in the range of ≥ 280 mg to ≤ 350 mg; and / or - inositol in the range of ≥ 70 mg to ≤ 200 mg, preferably in the range of ≥ 80 mg to ≤ 120 mg; and / or omega-3 fatty acids in the range of ≥ 300 mg to ≤ 600 mg, preferably in the range of ≥ 400 mg to ≤ 500 mg. Composition according to one of the preceding claims, characterized in that the composition is solid, liquid and / or gel is present, preferably the composition is in dosage forms selected from the group comprising tablets, capsules, powders, granules, solutions and / or Effervescent tablets of the same or different composition in front. Composition according to one of the preceding claims, characterized characterized in that the composition is in the form of at least two separately present dosage forms, preferably in the form of at least three, four or five separately present dosage forms, selected from the group comprising Tablets, capsules, powders, granules, solutions and / or effervescent tablets with the same or different composition of effective Ingredients is present. Composition according to one of the preceding claims, characterized characterized in that the composition is in the form of 1 to 5 capsules, preferably 2 to 4 capsules and 1 to 3 granules, preferably 1 to 2 Granules, is present. Composition according to one of the preceding claims, characterized in that the composition comprises: - at least one granulate containing vitamins selected from the group comprising vitamin A, vitamin C, vitamin B _1, vitamin B _2, nicotinamide, vitamin B _6, vitamin B _12, Vitamin D ₃ , folic acid, pantothenic acid and / or biotin, trace elements selected from the group comprising magnesium, zinc, selenium, manganese, copper, chromium and / or molybdenum, and active ingredients selected from the group comprising L-lysine, L-cystine, L-cysteine, N-acetyl-L-cysteine, taurine and / or inositol; At least one capsule containing L-carnitine, coenzyme Q10, carotenoids, flavonoids, in particular bioflavonoids obtainable from citrus fruits, and / or vitamin E; - at least one capsule containing anthocyanins obtainable from extracts of blueberries, red grapes and / or elderberries, polyphenols obtainable from extracts of red wine grapes, α-lipoic acid and / or omega-3 fatty acids, - at least one capsule containing omega-3 fatty acids. Composition according to one of the preceding claims, characterized in that the composition, based on 100 g of the composition, wherein the weight contents of the individual components are chosen so that the total weight of the components does not exceed 100 g, comprises as active ingredients the substances: - α Lipoic acid in the range of ≥ 109 mg to ≦ 1.6 g, preferably in the range of ≥ 217 mg to ≦ 870 mg; and / or - Vitamin A in the range of ≥ 2.4 mg to ≤ 4.9 mg, preferably in the range of ≥ 3.8 mg to 5 4.6 mg; and / or - Vitamin C in the range of ≥ 1.4 g to ≤ 4.3 g, preferably in the range of ≥ 2.6 g to ≤ 3.3 g; and / or - Vitamin E in the range of ≥ 543 mg to ≤ 1.6 g, preferably in the range of ≥ 761 mg to ≤ 1.4 g; and / or - vitamin B ₁ in the range of ≥ 11 mg to ≤ 54 mg, preferably in the range of ≥ 16 mg to ≤ 33 mg; and / or - Vitamin B ₂ in the range of ≥ 16 mg to ≤ 65 mg, preferably in the range of ≥ 22 mg to ≤ 54 mg; and / or nicotinamide in the range of ≥ 82 mg to ≤ 353 mg, preferably in the range of ≥ 217 mg to ≤ 326 mg; and / or - Vitamin B ₆ in the range of ≥ 16 mg to ≤ 109 mg, preferably in the range of ≥ 22 mg to ≤ 82 mg; and / or - vitamin B ₁₂ in the range of ≥ 27 μg to ≤ 136 μg, preferably in the range of ≥ 38 μg to ≤ 82 μg; and / or - vitamin D ₃ in the range of ≥ 11 μg to ≤ 54 μg, preferably in the range of ≥ 22 μg to ≤ 38 μg; and / or folic acid in the range of ≥ 2.2 mg to ≤ 6.5 mg, preferably in the range of ≥ 3.5 mg to ≤ 5.4 mg; and / or pantothenic acid in the range of ≥ 54 mg to ≤ 163 mg, preferably in the range of ≥ 76 mg to ≤ 130 mg; and / or - biotin in the range of ≥ 435 μg to ≤ 1.1 mg, preferably in the range of ≥ 652 μg to ≤ 978 μg; and / or - magnesium in the range of ≥ 761 mg to ≤ 1.6 g, preferably in the range of ≥ 870 mg to ≤ 1.1 g; and / or selenium in the range of ≥ 136 μg to ≤ 543 μg, preferably in the range of 217 μg to ≤ 326 μg; and / or - zinc in the range of ≥ 22 mg to ≤ 136 mg, preferably in the range of ≥ 43 mg to ≤ 65 mg; and / or manganese in the range of ≥ 5.4 mg to ≤ 16 mg, preferably in the range of ≥ 8.2 mg to ≤ 14 mg; and / or - copper in the range of ≥ 2.7 mg to ≤ 9.8 mg, preferably in the range of ≥ 4.4 mg to ≤ 6.5 mg; and / or - chromium in the range of ≥ 136 μg to ≤ 543 μg, preferably in the range of ≥ 217 μg to ≤ 408 μg; and / or molybdenum in the range of ≥ 136 μg to ≤ 543 μg, preferably in the range of ≥ 217 μg to ≤ 408 μg; and / or - lysine in the range of ≥ 2.2 g to ≤ 3.5 g, preferably in the range of ≥ 2.4 g to ≤ 3 g; and / or - cystine and / or acetylcysteine in the range of ≥ 271 mg to ≤ 652 mg, preferably in the range of ≥ 380 mg to ≤ 543 mg; and / or - flavonoids, in particular obtainable from citrus fruits in the range of ≥ 22 mg to ≤ 408 mg, preferably in the range of ≥ 27 mg to ≤ 136 mg; and / or - carotenoids comprising carotenoids selected from the group comprising beta-carotene, lutein and lycopene in the range of ≥ 16 mg to ≤ 82 mg, preferably in the range of ≥ 22 mg to ≤ 43 mg; - Anthocyanins especially available from blueberries, red grapes and / or elderberries in Be ranging from ≥109 mg to ≤652 mg, preferably in the range of ≥217 mg to ≤408 mg; and / or polyphenols, in particular obtainable from red wine grapes in the range from ≥ 136 mg to ≦ 1.1 g, preferably in the range from ≥ 380 mg to ≦ 815 mg; and / or coenzyme Q10 in the range of ≥ 54 mg to ≤ 271 mg, preferably in the range of ≥ 65 mg to ≤ 98 mg; and / or carnitine in the range of ≥ 815 mg to ≤ 1.9 g, preferably in the range of ≥ 1 g to ≤ 1.3 g; and / or - taurine in the range of ≥ 1.1 g to ≤ 2.2 g, preferably in the range of ≥ 1.5 g to ≤ 1.9 g; and / or inositol in the range of ≥ 380 mg to ≤ 1.1 g, preferably in the range of ≥ 435 mg to ≤ 652 mg; and / or omega-3 fatty acids in the range of ≥ 1.6 g to ≤ 3.3 g, preferably in the range of ≥ 2.1 g to ≤ 2.7 g. Composition according to one of the preceding claims, characterized in that the composition, based on a daily dose of the composition, comprises as active ingredients the substances: - 50 mg of α-lipoic acid; - 750 μg vitamin A; - 530 mg of vitamin C; - 150 mg of vitamin E; - 4 mg of vitamin B ₁ ; - 5 mg vitamin B ₂ , - 50 mg nicotinamide; - 5 mg of vitamin B ₆ ; - 9 μg of vitamin B ₁₂ ; - 5 μg vitamin D ₃ ; - 800 μg folic acid; - 18 mg pantothenic acid; - 150 μg biotin; - 180 mg of magnesium; - 50 μg selenium; - 10 mg zinc; - 2 mg of manganese; - 1 mg of copper; - 60 μg of chromium; - 60 μg molybdenum; - 500 mg L-lysine; - 80 mg L-cystine; - 5 mg flavonoids, including flavonoids available from citrus fruits; 5 mg carotenoids comprising carotenoids selected from the group comprising beta-carotene, lutein and lycopene; - 50 mg anthocyanins, comprising anthocyanins obtainable from blueberries, red grapes and / or elderberries; - 75 mg polyphenols comprising polyphenols obtainable from red wine grapes; - 15 mg coenzyme Q10; - 200 mg L-carnitine; - 300 mg taurine; - 100 mg inositol; - 425 mg omega-3 fatty acids. Composition according to any one of the preceding claims, characterized in that the composition comprises: - a granulate containing 750 μg vitamin A, 530 mg vitamin C, 4 mg vitamin B ₁ , 5 mg vitamin B ₂ , 50 mg nicotinamide, 5 mg vitamin B ₆ , 9 μg vitamin B ₁₂ , 5 μg vitamin D ₃ , 800 μg folic acid, 18 mg pantothenic acid, 150 μg biotin, 180 mg magnesium, 10 mg zinc, 50 μg selenium, 2 mg manganese, 1 mg copper, 60 μg chromium, 60 μg molybdenum, 500 mg L-lysine, 80 mg L-cystine, 300 mg taurine and / or 100 mg inositol; - at least one capsule containing 200 mg L-carnitine, 15 mg coenzyme Q10, 5 mg carotenoids, 5 mg flavonoids and / or 150 mg vitamin E; - two capsules containing a total of 50 mg of anthocyanins, 75 mg of polyphenols, 50 mg of α-lipoic acid and / or 165 mg of omega-3 fatty acids; - At least one capsule containing 260 mg of omega-3 fatty acids. Composition according to one of the preceding claims, characterized in that the co Composition, based on 100 g of the composition, wherein the weight contents of the individual components are chosen so that the total weight of the components does not exceed 100 g, as active ingredients includes the substances: - 272 mg of α-lipoic acid; 4.1 mg of vitamin A; - 2.9 g of vitamin C; - 815 mg of vitamin E; - 22 mg vitamin B ₁ ; - 27 mg of vitamin B ₂ ; - 272 mg nicotinamide; - 27 mg of vitamin B ₆ ; - 49 μg vitamin B ₁₂ ; - 27 μg of vitamin D ₃ ; - 4.3 mg folic acid; - 98 mg pantothenic acid; - 815 μg biotin; - 978 mg of magnesium; - 272 μg selenium; - 54 mg zinc; - 11 mg manganese; - 5.4 mg of copper; - 326 μg chromium; - 326 μg molybdenum; - 2.7 g of L-lysine; - 435 mg L-cystine; - 27 mg flavonoids, including flavonoids available from citrus fruits; - 27 mg carotenoids comprising carotenoids selected from the group comprising beta-carotene, lutein and lycopene; - 272 mg of anthocyanins, comprising anthocyanins obtainable from blueberries, red grapes and / or elderberries; - 408 mg of polyphenols comprising polyphenols obtainable from red wine grapes; - 82 mg coenzyme Q10; 1.1 g of L-carnitine; - 1.6 g of taurine; - 543 mg inositol; - 2.3 grams of omega-3 fatty acids. Use of a vitamin-containing composition according to one of the preceding claims for the preparation of an agent for the dietary treatment of inner ear diseases, preferably selected from of the group comprising acute hearing loss, Tinnitus, noise-induced and / or ototoxic hearing loss. Use of a vitamin-containing composition according to one of the preceding claims as a nutritional supplement. Food, in particular dietary supplements, comprising active ingredients according to any one of the preceding claims.