DE19980961D2 - Durchfluss-Scheranalysator für biologisch aktive Moleküle in Flüssigkeitsschichten auf Oberflächen - Google Patents

Durchfluss-Scheranalysator für biologisch aktive Moleküle in Flüssigkeitsschichten auf Oberflächen

Info

Publication number
DE19980961D2
DE19980961D2 DE19980961T DE19980961T DE19980961D2 DE 19980961 D2 DE19980961 D2 DE 19980961D2 DE 19980961 T DE19980961 T DE 19980961T DE 19980961 T DE19980961 T DE 19980961T DE 19980961 D2 DE19980961 D2 DE 19980961D2
Authority
DE
Germany
Prior art keywords
tirf
flow
thickness
interface
analyzer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE19980961T
Other languages
German (de)
English (en)
Inventor
Herbert P Jennissen
Thomas Zumbrink
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE19980961T priority Critical patent/DE19980961D2/de
Application granted granted Critical
Publication of DE19980961D2 publication Critical patent/DE19980961D2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/405—Concentrating samples by adsorption or absorption
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
    • Y10T436/118339—Automated chemical analysis with a continuously flowing sample or carrier stream with formation of a segmented stream

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Length Measuring Devices By Optical Means (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE19980961T 1998-05-25 1999-05-25 Durchfluss-Scheranalysator für biologisch aktive Moleküle in Flüssigkeitsschichten auf Oberflächen Expired - Lifetime DE19980961D2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19980961T DE19980961D2 (de) 1998-05-25 1999-05-25 Durchfluss-Scheranalysator für biologisch aktive Moleküle in Flüssigkeitsschichten auf Oberflächen

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19823301 1998-05-25
DE19980961T DE19980961D2 (de) 1998-05-25 1999-05-25 Durchfluss-Scheranalysator für biologisch aktive Moleküle in Flüssigkeitsschichten auf Oberflächen
PCT/DE1999/001529 WO1999061896A1 (de) 1998-05-25 1999-05-25 Durchfluss-scheranalysator für biologisch aktive moleküle in flüssigkeitsschichten auf oberflächen

Publications (1)

Publication Number Publication Date
DE19980961D2 true DE19980961D2 (de) 2002-01-03

Family

ID=7868841

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19980961T Expired - Lifetime DE19980961D2 (de) 1998-05-25 1999-05-25 Durchfluss-Scheranalysator für biologisch aktive Moleküle in Flüssigkeitsschichten auf Oberflächen
DE59912399T Expired - Lifetime DE59912399D1 (de) 1998-05-25 1999-05-25 Durchfluss-scheranalysator für biologisch aktive moleküle in flüssigkeitsschichten auf oberflächen, verfahren zur analyse einer flüssigkeit und verfahren zur bestimmung der dicke einer ultradünnen flüssigkeitsschicht

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59912399T Expired - Lifetime DE59912399D1 (de) 1998-05-25 1999-05-25 Durchfluss-scheranalysator für biologisch aktive moleküle in flüssigkeitsschichten auf oberflächen, verfahren zur analyse einer flüssigkeit und verfahren zur bestimmung der dicke einer ultradünnen flüssigkeitsschicht

Country Status (9)

Country Link
US (1) US6843963B1 (https=)
EP (1) EP1082601B1 (https=)
JP (1) JP3935317B2 (https=)
AT (1) ATE301831T1 (https=)
AU (1) AU760704B2 (https=)
CA (1) CA2333391C (https=)
DE (2) DE19980961D2 (https=)
ES (1) ES2247820T3 (https=)
WO (1) WO1999061896A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
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PT1383603E (pt) * 2001-04-26 2007-01-31 Univ Bruxelles Processo para a aceleração e intesificação da ligação receptor- alvo e dispositivo para este fim
DE10258048A1 (de) 2002-12-11 2004-06-24 Man Roland Druckmaschinen Ag Gummituchzylinder für Offset-Druckmaschinen
US7417737B2 (en) 2003-12-02 2008-08-26 Fujilfilm Corporation Method for measuring surface plasmon resonance
JP4664298B2 (ja) 2004-08-24 2011-04-06 富士フイルム株式会社 表面プラズモン共鳴分析における解離定数の算出方法
US7449343B2 (en) 2004-09-07 2008-11-11 Fujifilm Corporation Method for measuring surface plasmon resonance
US20070202609A1 (en) * 2004-11-09 2007-08-30 Roper D K Apparatus and methods for increasing lateral mass transfer over molecule sensors
WO2007024798A2 (en) * 2005-08-22 2007-03-01 Applera Corporation Apparatus, system, and method using immiscible-fluid-discrete-volumes
DE102007012866A1 (de) 2007-03-09 2008-09-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Flusskanalsystem und Verfahren zum Anbinden von Analyten an Liganden
JP5033820B2 (ja) * 2009-02-03 2012-09-26 株式会社日立ハイテクノロジーズ 全反射顕微鏡装置、及び蛍光試料分析方法
DE102010041426A1 (de) * 2010-09-27 2012-05-03 Siemens Aktiengesellschaft Messeinheit und Verfahren zur optischen Untersuchung einer Flüssigkeit zur Bestimmung einer Analyt-Konzentration
DE102012102983A1 (de) * 2012-04-05 2013-10-10 Carl Zeiss Microscopy Gmbh Verfahren und Vorrichtung zum Bestimmen eines kritischen Winkels eines Anregungslichtstrahls
EP2677037B1 (en) * 2012-06-21 2016-04-13 Synapse B.V. Simultaneous measurement of thrombin generation and clot strength in plasma and whole blood
JP6991972B2 (ja) * 2016-07-28 2022-01-13 大塚製薬株式会社 検出チップ、検出システムおよび検出方法
ES2947300T3 (es) * 2017-02-15 2023-08-04 Otsuka Pharma Co Ltd Chip de inspección y sistema de inspección
DE102017115661A1 (de) * 2017-07-12 2019-01-17 Endress+Hauser Conducta Gmbh+Co. Kg Optischer Sensor
CN109580482A (zh) * 2018-12-04 2019-04-05 华北电力大学 一种纳米颗粒强化气液传质过程中微观状态观测装置及其方法
JP7482887B2 (ja) * 2019-09-24 2024-05-14 大塚製薬株式会社 検出方法および検出装置

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4028056A (en) * 1976-04-20 1977-06-07 Technicon Instruments Corporation Substance separation technique
US4413505A (en) * 1981-03-09 1983-11-08 Environmental Sciences Associates, Inc. Electrochemical flow cell, particularly use with liquid chromatography
DE3168903D1 (en) * 1980-08-28 1985-03-28 Du Pont Flow analysis
WO1983001112A1 (en) * 1981-09-18 1983-03-31 Carter, Timothy Method for the determination of species in solution with an optical wave-guide
AU588245B2 (en) * 1984-06-13 1989-09-14 Inverness Medical Switzerland Gmbh Devices for use in chemical test procedures
GB8829942D0 (en) * 1988-12-22 1989-02-15 Isis Innovations Ltd Method
RU2095787C1 (ru) * 1994-09-27 1997-11-10 Московский областной научно-исследовательский клинический институт Оптическая кювета для исследования жидкости в тонком слое
US5716852A (en) * 1996-03-29 1998-02-10 University Of Washington Microfabricated diffusion-based chemical sensor
US6184978B1 (en) * 1996-05-15 2001-02-06 International Remote Imaging Systems, Inc. Method and apparatus for verifying uniform flow of a fluid sample through a flow cell and distribution on a slide

Also Published As

Publication number Publication date
ATE301831T1 (de) 2005-08-15
US6843963B1 (en) 2005-01-18
CA2333391A1 (en) 1999-12-02
DE59912399D1 (de) 2005-09-15
AU5149499A (en) 1999-12-13
CA2333391C (en) 2012-01-31
AU760704B2 (en) 2003-05-22
JP2002516993A (ja) 2002-06-11
WO1999061896A1 (de) 1999-12-02
JP3935317B2 (ja) 2007-06-20
EP1082601B1 (de) 2005-08-10
EP1082601A1 (de) 2001-03-14
ES2247820T3 (es) 2006-03-01

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Legal Events

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8141 Disposal/no request for examination